Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a

Journal of Neurochemistry

Volumn 84, Issue 3, 2003, Pages 592-601

  Pearlman, Rhonda Jo ^a   Aubrey, Karin R ^a   Vandenberg, Robert J ^a  

^a University of Sydney   (Australia)

Author keywords

Anandamide; Arachidonic acid; Glycine transporter

Indexed keywords

2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; AMIDE; ANANDAMIDE; ARACHIDONIC ACID; CANNABINOID RECEPTOR AGONIST; CARRIER PROTEIN; GLUTAMATE RECEPTOR; GLYCINE TRANSPORTER; INDOMETACIN; LIPOXYGENASE INHIBITOR; METHANANDAMIDE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NORDIHYDROGUAIARETIC ACID; PROSTAGLANDIN SYNTHASE INHIBITOR; PROTEIN KINASE C INHIBITOR; STAUROSPORINE; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; FEMALE; GLIA; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; SYNAPSE;

AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; ANIMALS; ARACHIDONIC ACID; ARACHIDONIC ACIDS; BIOLOGICAL TRANSPORT; GLIOMA; GLYCINE; GLYCINE PLASMA MEMBRANE TRANSPORT PROTEINS; OOCYTES; PATCH-CLAMP TECHNIQUES; POLYUNSATURATED ALKAMIDES; PROTEIN ISOFORMS; RATS; TRANSFECTION; XENOPUS LAEVIS;

ANIMALIA; MAMMALIA;

EID: 0037312280     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.01549.x     Document Type: Article

References (55)

1. Arriza J. L., Fairman W. A., Wadiche J. I., Murdoch G. H., Kavanaugh M. P. and Amara S. G. (1994) Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex. J. Neurosci. 14, 5559-5569.
2. Asaoka Y., Nakamura S., Yoshida K. and Nishizuka Y. (1992) Protein kinase C, calcium and phospholipid degradation. Trends Biochem. Sci. 17, 414-417.
3. Atkinson B. N., Bell S. C., De Vivo M., Kowalski L. R., Lechner S. M., Ognyanov V. I., Tham C.-S., Tsai C., Jia J., Ashton D. and Klitenick M. A. (2001) ALX 5407: a potent, selective inhibitor of the hGlyT1 glycine transporter. Mol. Pharmacol. 60, 1414-1420.
4. Attwell D., Barbour B. and Szatkowski M. (1993) Nonvesicular release of neurotransmitter. Neuron 11, 401-407.
5. Aubrey K. R., Mitrovic A. D. and Vandenberg R. J. (2000) Molecular basis for proton regulation of glycine transport by GLYT1b. Mol. Pharmacol. 58, 129-135.
6. Aubrey K. R. and Vandenberg R. J. (2001) N[3-(4′-flurophenyl)-3-(4′-phenylphenoxy) propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport. Br J. Pharmacol. 134, 1429-1436.
7. Barbour B., Szatkowski M., Ingledew N. and Attwell D. (1989) Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells. Nature 342, 918-920.
8. Berger A. J., Dieudonne S. and Ascher P. (1998) Glycine uptake governs glycine site occupancy at NMDA receptors of excitatory synapses. J. Neurophysiol. 80, 3336-3340.
9. Bergeron R., Meyer T. M., Coyle J. T. and Greene R. W. (1998) Modulation of N-methyl-D-aspartate receptor function by glycine transport. Proc. Natl Acad. Sci. USA 95, 15730-15734.
10. Borowsky B., Mezey E. and Hoffman B. J. (1993) Two glycine transporter variants with distinct localization in the CNS and peripheral tissues are encoded by a common gene. Neuron 10, 851-863.
11. Casado M. and Ascher P. (1998) Opposite modulation of NMDA receptors by lysophospholipids and arachidonic acid: common features with mechanosensitivity. J. Physiol. 513, 317-330.
12. Chabot C., Gagne J., Giguere C., Bernard J., Baudry M. and Massicotte G. (1998) Bidirectional modulation of AMPA receptor properties by exogenous phospholipase A2 in the hippocampus. Hippocampus 8, 299-309.
13. Christopoulos A. and Wilson K. (2001) Interaction of anandamide with the M1 and M4 muscarinc acetylcholine receptors. Brain Res. 915, 70-78.
14. De Petrocellis L., Bisogno T., Maccarrone M., Davis J. B., Finazzi-Agro A. and Di Marzo V. (2001) The activity of anandamide at vanilloid VR1 receptors requires facilitated transport across the cell membrane and is limited by intracellular metabolism. J. Biol. Chem. 276, 12856-12863.
15. 2 receptor-mediated actions of anandamide in mouse brain. J. Neurochem. 75, 2434-2444.
16. Dumuis A., Pin J. P., Oomagari K., Sebben M. and Bockaert J. (1990) Arachidonic acid released from striatal neurons by joint stimulation of ionotropic and metabotropic quisqualate receptors. Nature 347, 182-184.
17. Fairman W. A., Sonders M. S., Murdoch G. H. and Amara S. G. (1998) Arachidonic acid elicits a substrate-gated proton current associated with the glutamate transporter EAAT4. Nat. Neurosci. 1, 105-113.
18. Guastella J., Brecha N., Weigmann C., Lester H. A. and Davidson N. (1992) Cloning, expression, and localization of a rat brain high-affinity glycine transporter. Proc. Natl Acad. Sci. USA 89, 7189-7193.
19. Hampson A. J., Bomheim L. M., Scanziani M., Yost C. S., Gray A. T., Hansen B. M., Leonoudakis D. J. and Bickler P. E. (1998) Dual effects of anandamide on NMDA receptor-mediated responses and neurotransmission. J. Neurochem. 70, 671-676.
20. Hanley J. G., Jones E. M. and Moss S. J. (2000) GABA receptor rho1 subunit interacts with a novel splice variant of the glycine transporter, GLYT-1. J. Biol. Chem. 275, 840-846.
21. Hillard C. J. (2000) Biochemistry and pharmacology of the endocannabinoids arachidonylethanolamide and 2-arachidonylglyc erol. Prostaglandins Other Lipid Mediat. 61, 3-18.
22. Ingram S. L. and Amara S. G. (2000) Arachidonic acid stimulates a novel cocaine-sensitive cation conductance associated with the human dopamine transporter. J. Neurosci. 20, 550-557.
23. Jacobsson S. O., Wallin T. and Fowler C. J. (2001) Inhibition of rat C6 glioma cell proliferation by endogenous and synthetic cannabinoids. Relative involvement of cannabinoid and vanilloid receptors. J. Pharmacol. Exp. Ther. 299, 951-959.
24. Kanterman R. Y., Ma A. L., Briley E. M., Axelrod J. and Felder C. C. (1990) Muscarinic receptors mediate the release of arachidonic acid from spinal cord and hippocampal neurons in primary culture. Neurosci Lett. 118, 235-237.
25. Kim K. M., Kingsmore S. F., Han H., Yang-Feng T. L., Godinot N., Seldin M. F., Caron M. G. and Giros B. (1994) Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes. Mol. Pharmacol. 45, 608-617.
26. Kolko M., DeCoster M. A., de Turco E. B. and Bazan N. G. (1996) Synergy by secretory phospholipase A2 and glutamate on inducing cell death and sustained arachidonic acid metabolic changes in primary cortical neuronal cultures. J. Biol. Chem. 271, 32722-32728.
27. Kovalchuk Y., Miller B., Sarantis M. and Attwell D. (1994) Arachidonic acid depresses non-NMDA receptor currents. Brain Res. 643, 287-295.
28. Laneuville O., Breuer D. K., Dewitt D. L., Hla T., Funk C. D. and Smith W. L. (1994) Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal antiinflammatory drugs. J. Pharmacol. Exp. Ther. 271, 927-934.
29. Lazarewicz J. W., Wroblewski J. T., Palmer M. E. and Costa E. (1988) Activation of N-methyl-D-aspartate-sensitive glutamate receptors stimulates arachidonic acid release in primary cultures of cerebellar granule cells. Neuropharmacology 27, 765-769.
30. Liu Q. R., Nelson H., Mandiyan S., Lopez-Corcuera B. and Nelson N. (1992) Cloning and expression of a glycine transporter from mouse brain. FEBS Lett. 305, 110-114.
31. Liu Q. R., Lopez-Corcuera B., Mandiyan S., Nelson H. and Nelson N. (1993) Cloning and expression of a spinal cord- and brain-specific glycine transporter with novel structural features. J. Biol. Chem. 268, 22802-22808.
32. Lopez-Corcuera B., Martinez-Maza R., Nunez E., Roux M., Supplisson S. and Aragon C. (1998) Differential properties of two stably expressed brain-specific glycine transporters. J. Neurochem. 71, 2211-2219.
33. Mackie K., Devane W. A. and Hille B. (1993) Anandamide, an endogenous cannabinoid, inhibits calcium currents as a partial agonist in N18 neuroblastoma cells. Mol. Pharmacol. 44, 498-503.
34. + channel TASK-1. EMBO J. 20, 47-54.
35. McAllister S. D., Griffen G., Satin L. S. and Abood M. E. (1999) Cannabinoid receptors can activate and inhibit G protein-coupled inwardly rectifying potassium channels in an oocyte expression system. J. Pharmacol. Exp. Ther. 291, 618-626.
36. Miller B., Sarantis M., Traynelis S. F. and Attwell D. (1992) Potentiation of NMDA receptor currents by arachidonic acid. Nature 355, 722-725.
37. Ordway R. W., Singer J. J. and Walsh J. V. Jr (1991) Direct regulation of ion channels by fatty acids. Trends Neurosci. 14, 96-100.
38. Poulsen M. V. and Vandenberg R. J. (2001) Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4. J. Physiol. 534, 159-167.
39. Reith M. E., Xu C. and Chen N. H. (1997) Pharmacology and regulation of the neuronal dopamine transporter. Eur. J. Pharmacol. 324, 1-10.
40. Roux M. J. and Supplisson S. (2000) Neuronal and glial glycine transporters have different stoichiometries. Neuron 25, 373-383.
41. Sanchez C., Galve-Roperh I., Canova C., Brachet P. and Guzman M. (1998) Delta9-tetrahydrocanninol induces apoptosis in C6 glioma cells. FEBS Lett. 436, 6-10.
42. Sato K., Betz H. and Schloss P. (1995) The recombinant GABA transporter GATI is downregulated upon activation of protein kinase C. FEBS Lett. 375, 99-102.
43. Smith K. E., Borden L. A., Hartig P. R., Branchek T. and Weinshank R. L. (1992) Cloning and expression of a glycine transporter reveal colocalization with NMDA receptors. Neuron 8, 927-935.
44. Suzuki A., Mitsuda S., Higashio K. and Kumasaka T. (1992) Possible roles of arachidonic acid and its metabolites in induction of tissue plasminogen activator (t-PA) production in human fibroblast, IMR-90 cells by proteose peptone. Biochim. Biophys. Acta 1133, 167-171.
45. Trotti D., Volterra A., Lehre K. P., Rossi D., Gjesdal O., Racagni G. and Danbolt N. C. (1995) Arachidonic acid inhibits a purified and reconstituted glutamate transporter directly from the water phase and not via the phospholipid membrane. J. Biol. Chem. 270, 9890-9895.
46. Tzingounis A. V., Lin C. L., Rothstein J. D. and Kavanaugh M. P. (1998) Arachidonic acid activates a proton current in the rat glutamate transporter EAAT4. J. Biol. Chem. 273, 17315-17317.
47. Vaughan C. W., Connor M., Bagley E. E. and Christie M. J. (2000) Actions of cannabinoids on membrane properties and synaptic transmission in rat periaqueductal gray neurons in vitro. Mol. Pharmacol. 57, 288-295.
48. Volterra A., Trotti D., Cassutti P., Tromba C., Salvaggio A., Melcangi R. C. and Racagni G. (1992) High sensitivity of glutamate uptake to extracellular free arachidonic acid levels in rat cortical synaptosomes and astrocytes. J. Neurochem. 59, 600-606.
49. Volterra A., Trotti D. and Racagni G. (1994) Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms. Mol. Pharmacol. 46, 986-992.
50. Williams J. H., Errington M. L., Lynch M. A. and Bliss T. V. (1989) Arachidonic acid induces a long-term activity-dependent enhancement of synaptic transmission in the hippocampus. Nature 341, 739-742.
51. Zafra F., Alcantara R., Gomeza J., Aragon C. and Gimenez C. (1990) Arachidonic acid inhibits glycine transport in cultured glial cells. Biochem. J. 271, 237-242.
52. Zafra F., Aragon C., Olivares L., Danbolt N. C., Gimenez C. and Storm-Mathisen J. (1995) Glycine transporters are differentially expressed among CNS cells. J. Neurosci. 15, 3952-3969.
53. Zerangue N., Arriza J. L., Amara S. G. and Kavanaugh M. P. (1995) Differential modulation of human glutamate transporter subtypes by arachidonic acid. J. Biol. Chem. 270, 6433-6435.
54. Zhang L. and Reith M. E. (1996) Regulation of the functional activity of the human dopamine transporter by the arachidonic acid pathway. Eur. J. Pharmacol. 315, 345-354.
55. Zygmunt P. M., Julius I., Di Marzo I. and Hogestatt E. D. (2000) Anandamide - the other side of the coin. Trends Pharmacol. Sci. 21, 43-44.