Histone deacetylase inhibition selectively alters the activity and expression of cell cycle proteins leading to specific chromatin acetylation and antiproliferative effects

Journal of Biological Chemistry

Volumn 274, Issue 49, 1999, Pages 34940-34947

  Sambucetti, Lidia C ^a   Fischer, Denise D ^a   Zabludoff, Sonya ^a   Kwon, Paul O ^a   Chamberlin, Helena ^a,b   Trogani, Nancy ^a   Xu, Hong ^a   Cohen, Dalia ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; CYCLIN B; ENZYME INHIBITOR; HISTONE DEACETYLASE; PROTEIN P21; TRAPOXIN; UNCLASSIFIED DRUG;

ACETYLATION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BREAST CANCER; CHROMATIN; ENZYME INHIBITION; HUMAN; HUMAN CELL; LUNG CANCER; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; TUMOR CELL;

ACETYLATION; ANTI-BACTERIAL AGENTS; CDC2 PROTEIN KINASE; CELL CYCLE; CHROMATIN; CYCLIN E; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; FLOW CYTOMETRY; HISTONE DEACETYLASES; HISTONES; HUMANS; IMMUNOBLOTTING; MICROSCOPY, FLUORESCENCE; PEPTIDES; PHOSPHORYLATION; PRECIPITIN TESTS; PROMOTER REGIONS (GENETICS); RETINOBLASTOMA PROTEIN; STAUROSPORINE; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 0033520944     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.274.49.34940     Document Type: Article

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