Stability and CTL activity of N-terminal glutamic acid containing peptides

Journal of Peptide Research

Volumn 57, Issue 6, 2001, Pages 528-538

  Beck, A ^a   Bussat, M C ^a   Klinguer Hamour, C ^a   Goetsch, L ^a   Aubry, J P ^a   Champion, T ^a   Julien, E ^a   Haeuw, J F ^a   Bonnefoy, J Y ^a   Corvaia, N ^a  

^a INSTITUT DE RECHERCHE PIERRE FABRE   (France)

Author keywords

Clinical grade peptides; CTL epitopes; Glutamic acid; Melanoma; Peptide vaccines; Pyroglutamic acid

Indexed keywords

GLUTAMIC ACID; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; PYROGLUTAMIC ACID DERIVATIVE;

ARTICLE; BINDING AFFINITY; CYTOTOXIC T LYMPHOCYTE; HUMAN; MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN MODIFICATION; PROTEIN STABILITY; VACCINE PRODUCTION;

ANIMALS; ANION EXCHANGE RESINS; ANTIGENS, NEOPLASM; CANCER VACCINES; CELL LINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMIUM; EPITOPES, T-LYMPHOCYTE; GLUTAMIC ACID; HUMANS; IMMUNIZATION; ISOANTIGENS; MELANOMA; MICE; NEOPLASM PROTEINS; PEPTIDE FRAGMENTS; PEPTIDES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; T-LYMPHOCYTES, CYTOTOXIC;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0034976809     PISSN: 1397002X     EISSN: None     Source Type: Journal    
DOI: 10.1034/j.1399-3011.2001.00895.x     Document Type: Article

References (50)

1. Altered helper T lymphocyte function associated with chronic hepatitis B virus infection and its role in response to therapeutic vaccination in humans
2. Immunologic and therapeutic evaluation of a synthetic peptide vaccine for the treatment of patients with metastatic melanoma
3. Cancer immunotherapy in clinical oncology
4. Peptide based cytotoxic T-cell vaccines; delivery of multiple epitopes, help, memory and problems
5. Tumor regressions observed in patients with metastatic melanoma treated with an antigenic peptide encoded by gene MAGE-3 and presented by HLA-A1
6. A phase I trial of an HLA-A1 restricted MAGE-3 epitope peptide with incomplete Freund's adjuvant in patients with resected high-risk melanoma
7. Cytolytic T lymphocyte recognition of the immunodominant HLA-A 0201-restricted Melan-A/MART-1 antigenic peptide in melanoma
8. Enhanced generation of specific tumor-reactive CTL in vitro by selected Melan-A/MART-1 immunodominant peptide analogues
9. SYFPEITHI: Database for MHC ligands and peptide motifs
10. MHCPEP, a database of MHC-binding peptides: Update 1997
11. Multiepitopic B- and T-cell responses induced in human by a human immunodeficiency virus type 1 lipopeptide vaccine
12. The recombinant Klebsiella pneumoniae outer membrane protein OmpA has carrier properties for conjugated antigenic peptides
13. OmpA targets dendritic cells, induces their maturation and antigen delivery into the MHC class I presentation pathway
14. Weak acid-catalyzed pyrrolidon carboxylic acid formation from glutamine during solid phase peptide synthesis
15. Analysis of glutamine, glutamic acid and pyroglutamic acid in protein hydrolysates by high-performance liquid chromatography
16. Quantitative analysis of pyroglutamic acid in peptides
17. Gonadoreline (acétate de)
18. Terminal modifications inhibit proteolytic degradation of an immunogenic Mart-1, 27-35 peptide: Implications for peptide vaccines
19. Preparative reversed phase high performance liquid chromatography: Effects of buffer pH on the purification of synthetic peptides
20. Trifluoroacetate, a contaminant in purified proteins, inhibits proliferation of osteoblasts and chondrocytes
21. Gonadorelin
22. Guideline for residual solvents: ICH Q3C: Impurities
23. A gene encoding an antigen recognized by cytolytic T lymphocytes on a human melanoma
24. Human gene MACE-3 codes for an antigen recognized on a melanoma by autologous cytolytic T-lymphocytes
25. Identification of five Mage-A1 epitopes recognized by cytolytic T lymphocytes obtained by in vitro stimulation with dendritic cells transduced with Mage-A1
26. Identification of gp100-derived, melanoma-specific cytotoxic T-lymphocyte epitopes restricted by HLA-A3 supertype molecules by primary in vitro immunization with peptide-pulsed dendritic cells
27. Translation of a retained intron in tyrosinase-related protein (TRP)2 mRNA generates a new cytotoxic T-lymphocyte (CTL)-defined and shared human melanoma antigen not expressed in normal cells of the melanocytic lineage
28. A mutated intron sequence codes for an antigenic peptide recognized by cytolytic T lymphocytes on a human melanoma
29. Changes in an HER-2 peptide upregulating HLA-A2 expression affect both conformational epitopes and CTL recognition: Implications for optimization of antigen presentation and tumor-specific CTL induction
30. Strategies for the development of vaccines to treat breast cancer
31. Generation of human cytolytic T lymphocyte lines directed against prostate-specific antigen (PSA) employing a PSA oligoepitope peptide
32. Identification of a SART-1-derived peptide capable of inducing HLA-A24-restricted and tumor-specific cytotoxic T lymphocytes
33. Identification of HLA-A24 epitope peptides of carcinoembryonic antigen which induce tumor-reactive cytotoxic T lymphocyte
34. A human minor histocompatibility antigen specific for B cell acute lymphoblastic leukemia
35. The peptide recognized by HLA-A68.2-restricted, squamous cell carcinoma of the lung-specific cytotoxic T lymphocytes is derived from a mutated Elongation Factor 2 gene
36. Mapping the fine specificity of a cytolytic T cell response to HIV-1 nef protein
37. HLA-dependent variations in human immunodeficiency viry Nef protein alter peptide/HLA binding
38. Fine-specificity of cytotoxic T lymphocytes which recognize conserved epitopes of the Gag protein of human immunodeficiency virus type 1
39. Endogenous peptides with distinct amino acid anchor residue motifs bind to HLA-A1 and HLA-B8
40. Six epitopes reacting with human cytotoxic CD8+ T cells in the central region of the HIV-1 nef protein
41. Identification of multiple HIV-1 cytotoxic T-cell epitopes presented by human leucocyte antigen B35 molecules
42. CTL responses of HLA-A2.1-transgenic mice specific for hepatitis C viral peptides predict epitopes for CTL of humans carrying HLA-A2-1
43. HLA-A0201 and HLA-B7 binding peptides in the EBV-encoded EBNA-1, EBNA-2 and BZLF-1 proteins detected in the MHC class I stabilization assay. Low proportion of binding motifs for several HLA class I alleles in EBNA-1
44. Peptide motifs of HLA-A3-A24, and -B7 molecules as determined by pool sequencing
45. Five new cytotoxic T cell epitopes identified within Epsteins-Barr virus nuclear antigen 3
46. Identification of type B-specific and cross-reactive cytotoxic T-lymphocyte responses to Epstein-Barr virus
47. Localization of Epstein-Bart virus cytotoxicity T cell epitopes using recombinant vaccinia: Implications for vaccine development
48. A sequence pattern for peptides presented to cytotoxic T lymphocytes by HLA B8 revealed by analysis of epitopes and eluted peptides
49. Cytotoxic T lymphocytes recognize influenza haemagglutinin that lacks a signal sequence
50. Identification of the immunodominant peptides of the MART-1 human melanoma antigen recognized by the majority of HLA-A2-restricted tumor infiltrating lymphocytes