Endocytosing the death sentence

Journal of Cell Biology

Volumn 160, Issue 2, 2003, Pages 155-156

  Griffiths, Gillian M ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN B RECEPTOR;

CELL DEATH; CELL MEMBRANE; CYTOTOXIC T LYMPHOCYTE; ENDOCYTOSIS; IMMUNE SYSTEM; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN TRANSPORT; REVIEW; TARGET CELL;

ANIMALS; APOPTOSIS; ENDOCYTOSIS; GRANZYMES; HUMANS; KILLER CELLS, NATURAL; LYSOSOMES; MEMBRANE GLYCOPROTEINS; PORE FORMING CYTOTOXIC PROTEINS; RECEPTOR, IGF TYPE 2; SERINE ENDOPEPTIDASES; SIGNAL TRANSDUCTION; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0037455556     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.200212143     Document Type: Review

References (17)

1. Barry, M., and R.C. Bleackley. 2002. Cytotoxic T lymphocytes: all roads lead to death. Nat. Rev. Immunol. 2:401-409.
2. Bashford, C.L., G. Menestrina, P.A. Henkart, and C.A. Pasternak. 1988. Cell damage by cytolysin. Spontaneous recovery and reversible inhibition by divalent cations. J. Immunol. 141:3965-3974.
3. Browne, K.A., E. Blink, V.R. Sutton, C.J. Froelich, D.A. Jans, and J.A. Trapani. 1999. Cytosolic delivery of granzyme B by bacterial toxins: evidence that endosomal disruption, in addition to transmembrane pore formation, is an important function of perforin. Mol. Cell. Biol. 19:8604-8615.
4. Froelich, C.J., V.M. Dixit, and X. Yang. 1998. Lymphocyte granule-mediated apoptosis: matters of viral mimicry and deadly, proteases. Immunol. Today. 19:30-36.
5. Griffiths, G.M., and S. Isaaz. 1993. Granzymes A and B are targeted to the lyric granules of lymphocytes by the mannose-6-phosphate receptor. J. Cell Biol 120:885-896.
6. Kupfer, A., S.J. Singer, and G. Dennert. 1986. On the mechanism of unidirectional killing in mixtures of two cytotoxic T lymphocytes. Unidirectional polarization of cytoplasmic organelles and the membrane-associated cytoskeleton in the effector cell. J. Exp. Med. 163:489-498.
7. Kuto, A.E., C.R. Reynolds, and P.A. Henkart. 1989. Mechanism of lysis by a large granular lymphocyte granule cytolysin: generation of a stable cytlysin-RBC intermediate. J. Immunol. 142:4378-4384.
8. Lowin, B., M.C. Peitsch, and J. Tschopp. 1995. Perforin and granzymes: crucial effector molecules in cytolytic T lymphocyte and natural killer cell-mediated cytotoxicity. Curr. Top. Microbiol. Immunol. 198:1-24.
9. Lyubchenko, T.A., G.A. Wurth, and A. Zweifach. 2001. Role of calcium influx in cytotoxic T lymphocyte lyric granule exocytosis during target cell killing. Immunity. 15:847-859.
10. Motyka, B., G. Korbutt, M.J. Pinkoski, J.A. Heibein, A. Caputo, M. Hobman, M. Barry, I. Shostak, T. Sawchuk, C.F. Holmes, et al. 2000. Mannose 6-phosphate/insulin-like growth factor II receptor is a death receptor for granzyme B during cytotoxic T cell-induced apoptosis. Cell. 103:491-500.
11. Norbury, C.C., L.J. Hewlett, A.R. Prescott, N. Shastri, and C. Watts. 1995. Class I MHC presentation of exogenous soluble antigen via macropinocytosis in bone marrow macrophages. Immunity. 3:783-791.
12. Reddy, A., E.V. Caler, and N.W. Andrews. 2001. Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomes. Cell. 106:157-169.
13. Rodriguez, A., A. Regnault, M. Kleijmeer, P. Ricciardi-Castagnoli, and S. Amigorena. 1999. Selective transport of internalized antigens to the cytosol for MHC class I presentation in dendritic cells. Nat. Cell Biol. 1:362-368.
14. Schiavo, G., and F.G. van der Goot. 2001. The bacterial toxin toolkit. Nat. Rev. Mol. Cell Biol. 2:530-537.
15. Stinchcombe, J.C., G. Bossi, S. Booth, and G.M. Griffiths. 2001. The immunological synapse of CTL contains a secretory domain and membrane bridges. Immunity. 15:751-761.
16. Trapani, J.A., V.A. Sutton, K.Y.T. Thia, Y.Q. Li, C.J. Froehlich, D.A. Jans, M.S. Sandrin, and K.A. Browne. 2002. A clathrin/dynamin- and mannose-6-phosphate receptor-independent pathway for granzyme B-induced cell death. J. Cell Biol. 160:223-233.
17. Watts, C. 1999. Dendritic cells spill the beans. Nat. Cell Biol. 1:E152-E154.