Single gene effects in mouse models of host: Pathogen interactions

Journal of Leukocyte Biology

Volumn 77, Issue 6, 2005, Pages 868-877

  Fortier, Anne ^a   Min Oo, Gundula ^a   Forbes, John ^a   Lam Yuk Tseung, Steven ^a   Gros, Philippe ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Genetic; Host resistance

Indexed keywords

MUTANT PROTEIN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 1; PYRUVATE KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; CELL MEMBRANE; CONFERENCE PAPER; CONTROLLED STUDY; GENE LOCUS; GENE MAPPING; GENE MUTATION; GENETIC CODE; GENETIC SUSCEPTIBILITY; HOST PATHOGEN INTERACTION; HOST RESISTANCE; INBRED STRAIN; LEGIONELLA PNEUMOPHILA; LEISHMANIA; MACROPHAGE; MALARIA; MOLECULAR CLONING; MOUSE; MYCOBACTERIUM; NONHUMAN; PATHOPHYSIOLOGY; PHAGOSOME; PLASMODIUM CHABAUDI; PLEIOTROPY; PRIORITY JOURNAL; SALMONELLA; STRAIN DIFFERENCE; TRANSGENIC MOUSE;

ANIMALS; BACTERIAL INFECTIONS; CATION TRANSPORT PROTEINS; DISEASE MODELS, ANIMAL; GENETIC PREDISPOSITION TO DISEASE; MICE; MICE, TRANSGENIC; MUTATION; PARASITIC DISEASES;

ANIMALIA; LEGIONELLA PNEUMOPHILA; MUS MUSCULUS; MYCOBACTERIUM; PLASMODIUM CHABAUDI; SALMONELLA;

EID: 20044375405     PISSN: 07415400     EISSN: None     Source Type: Journal    
DOI: 10.1189/jlb.1004616     Document Type: Conference Paper

References (96)

1. Rosenberg, C. M., Finlay, B. B. (2003) Phagocyte sabotage: disruption of macrophage signaling by bacterial pathogens. Nat. Rev. Mol. Cell Biol. 4, 385-396.
2. Knodler, L. A., Celli, J., Finlay, B. B. (2001) Pathogen trickery: deception of host cell processes. Nat. Rev. Mol. Cell Biol. 2, 578-588.
3. Dessein, A. J., Chevillard, C., Marquet, S., Henri, S., Hillaire, D., Dessein, H. (2001) Genetics of parasitic infections. Drug Metab. Dispos. 29, 484-488.
4. Segal, S., Hill, A. V. (2003) Genetic susceptibility to infectious diseases. Trends Microbiol. 11, 445-448.
5. Bellamy, R. (2003) Susceptibility to mycobacterial infections: the importance of host genetics. Genes Immun. 4, 4-11.
6. Weatherall, D. J., Clegg, J. B. (2002) Genetic variability in response to infection with malaria and after. Genes Immun. 3, 331-337.
7. Fortin, A., Cardon, L. R., Stevenson, M. M., Gros, P. (2002) Complex genetic control of susceptibility to malaria in mice. Genes Immun. 3, 177-186.
8. Casanova, J. L., Abel, L. (2004) The human model: a genetic dissection of immunity to infection in natural contlitions. Nat. Rev. Immunol. 4, 55-66.
9. Carrington, M., Dean, M., Martin, M. P., O'Brien, S. J. (1999) Genetics of HIV-1 infection: chemokine receptor CCR5 polymorphism and its consequences. Hum. Mol. Genet. 8, 1939-1945.
10. Mira, M. T., Alcais, A., Nguyen, V. T., Moraes, M. O., Di Flumeri, C., Vu, H. T., Mai, C. P., Nguyen, T. H., Nguyen, N. B., Pham, X. K., Sarno, E. N., Alter, A., Montpetit, A., Moraes, M. E., Moraes, J. R., Dore, C., Gallant, C. J., Lepage, P., Verner, A., Van De Vosse, E., Hudson, T. J., Abel, L., Schurr, E. (2004) Susceptibility to leprosy is associated with PARK2 and PACRG. Nature 427, 636-640.
11. Lam-Yuk-Tseung, S., Gros, P. (2003) Genetic control of susceptibility to bacterial infections in mouse models. Cell. Microlilol. 5, 299-313.
12. Tuite, A., Mullick, A., Gros, P. (2004) Genetic analysis of innate immunity in resistance to Candida albicans. Genes Immun. 5, 576-587.
13. Roy, M-F., Malo, D. (2002) Genetic regulation of host responses to Salmonella infection in mice. Genes Immun. 3, 381-393.
14. Vidal, S. M., Malo, D., Vogan, K., Skamene, E., Gros, P. (1993) Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell 73, 469-486.
15. Cooper, A. M., Dalton, D. K., Stewart, T. A., Griffin, J. P., Russell, D. G., Orme, I. M. (1993) Disseminated tuberculosis in interferon-γ gene disrupted mice. J. Exit. Med. 178, 2243-2247.
16. Cooper, A. M., Magram, J., Ferrante, J., Orme, I. M. (1997) Interleukin-12 is crucial for the development of protective immunity in mice intravenously infected with Mycobacterium tuberculosis. J. Exp. Med. 186, 39-45.
17. De Jong, R., Altare, F., Haagen, I. A., Elferink, D. G., Boer, T., van Breda Vriesman, P. J., Kabel, P. J., Draaisma, J. M., van Dissel, J. T., Kroon, F. P., Casanova, J. L., Ottenhoff, T. H. (1998) Severe mycobacterial and Salmonella infections in interleukin-12 deficient patients. Science 280, 1435-1438.
18. Juanguy, E., Lamhamedi-Cherradi, S., Lamas, D., Dorman, S. E., Fondaneche, M. C., Dupuis, S., Doffinger, R., Altare, F., Girdlestone, J., Emile, J. F., Ducoulombier, H., Edgar, D., Clarke, J., Oxelius, V. A., Brai, M., Novelli, V., Heyne, K., Fischer, A., Holland, S. M., Kumararatne, D. S., Schreiber, R. D., Casanova, J. L. (1999) A human IFNGR1 small deletion hotspot associated with dominant susceptibility to mycobacterial infections. Nat. Genet. 21, 370-378.
19. Dupuis, S., Jouanguy, E., Al-Hajjar, S., Fieschi, C., Al-Mohsen, I. Z., Al-Jumaah, S., Yang, K., Chapgier, A., Eidenschenk, C., Eid, P., Al Ghonaium, A., Tufenkeji, H., Frayha, H., Al-Gazlan, S., Al-Rayes, H., Schreiber, R. D., Gresser, I., Casanova, J. L. (2003) Impaired response to interferon-α/ β and lethal viral disease in human STAT1 deficiency. Nat. Genet. 33, 388-391.
20. Greenwood, C. M., Fujiwara, T. M., Boothroyd, L. J., Miller, M. A., Frappier, D., Fanning, E. A., Schurr, E., Morgan, K. (2000) Linkage of tuberculosis to chromosome 2q35 loci, including NRAMP1, in a large aboriginal Canadian family. Am. J. Hum. Genet. 67, 405-416.
21. Plant, J., Glynn, A. A. (1976) Genetics of resistance with Salmonella typhimurium in mice. J. Infect. Dis. 133, 72-78.
22. Bradley, D. J., Taylor, B. A., Blackwell, J., Evans, E. P., Freeman, J. (1979) Regulation of Leishmania populations within the host. III. Mapping of the locus controlling susceptibility to visceral leishmaniasis in the mouse. Clin. Exp. Immunol. 37, 7-14.
23. Gros, P., Skamene, E., Forget, A. (1981) Genetic control of natural resistance to Mycobacterium bovis (BCG) in mice. J. Immunol. 127, 2417-2423.
24. Crocker, P. R., Blackwell, J. M., Bradley, D. J. (1984) Expression of the natural resistance gene Lsh in resident liver macrophages. Infect. Immun. 43, 1033-1040.
25. Lissner, C. R., Swanson, R. N., O'Brien, A. D. (1983) Genetic control of the innate resistance of mice to Salmonella typhimurium: expression of the Ity gene in peritoneal and splenic macrophages isolated in vitro. J. Immunol. 131, 3006-3013.
26. Stach, J. L., Gros, P., Forget, A., Skamene, E. (1984) Phenotypic expression of genetically controlled natural resistance to Mycobacterium bovis (BCG). J. Immunol. 132, 888-892.
27. Skamene, E., Gros, P., Forget, A., Kongshavn, P. A. L., St. Charles, C., Taylor, B. A. (1982) Genetic regulation of resistance to intracellular pathogens. Nature 297, 506-509.
28. Jabado, N., Lam-Yuk-Tseung, S., Forbes, J. R., Gros, P. (2004) Mouse natural resistance associated macrophage protein 1 (Nramp1): a key player in host innate immunity against infections. In The Nramp Family (M. Cellier, P. Gros, eds.), New York, NY, Kluwer Academic, 1-15.
29. Poon, A., Schurr, E. (2004) The NRAMP genes and human susceptibility to common diseases. In The Nramp Family (M. Cellier, P. Gros, eds.), New York, NY, Kluwer Academic, 29-43.
30. Gruenheid, S., Pinner, E., Desjardins, M., Gros, P. (1997) Natural resistance to infection with intracellular parasites: the Nramp1 protein is recruited to the membrane of the phagosome. J. Exp. Med. 185, 717-730.
31. Searle, S., Bright, N. A., Roach, T. I. A., Atkinson, P. G. P., Barton, H. C., Meleon, R. H., Blackwell, J. (1998) Localization of Nramp1 in macrophages: modulation with activation and infection. J. Cell Sci. 111, 2855-2866.
32. Canonne-Hergaux, F., Calafat, J., Cellier, M., Grinstein, S., Borregaard, N., Gros, P. (2002) Expression and subcellular localization of Nramp1 in human neutrophil granules. Blood 100, 268-275.
33. Govoni, G., Canonne-Hergaux, F., Pfeifer, C. G., Marcus, S., Mills, S., Hackam, D., Grinstein, S., Malo, D., Finlay, B., Gros, P. (1999) Functional expression of Nramp1 in vitro after transfection into the murine macrophage line RAW264.7. Infect. Immun. 67, 2225-2232.
34. Gruenheid, S., Cellier, M., Vidal, S., Gros, P. (1995) Identification and characterization of a second mouse Nramp gene. Genomics 25, 514-525.
35. Forbes, J. R., Gros, P. (2001) Divalent metal transport by Nramp proteins at the interface of host:parasite interactions. Trends Microbiol. 9, 397-403.
36. Cellier, M. F., Bergevin, I., Boyer, E., Richer, E. (2001) Polyphyletic origins of bacterial Nramp transporters. Trends Genet. 17, 365-370.
37. Fleming, M. D., Trenor, C. C., Su, M. A., Foernzler, D., Beier, D. R., Dietrich, W. F., Andrews, N. C. (1997) Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat. Genet. 16, 383-386.
38. Fleming, M. D., Romano, M. A., Su, M. A., Garrick, L. M., Garrick, M. D., Andrews, N. C. (1998) Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc. Natl. Acad. Sci. USA 95, 1148-1153.
39. Supek, F., Supekova, L., Nelson, H., Nelson, N. (1996) A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria. Proc. Natl. Acad. Sci. USA 93, 5105-5110.
40. Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., Hediger, M. A. (1997) Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature 388, 482-488.
41. Canonne-Hergaux, F., Gruenheid, S., Ponka, P., Gros, P. (1999) Cellular and sub-cellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by iron. Blood 93, 4406-4417.
42. Canonne-Hergaux, F., Zhang, A-S., Ponka, P., Gros, P. (2001) Characterization of the iron transporter DMT1 (Nramp2/DCT1) in red blood cells of normal and anemic mk/mk mice. Blood 98, 3823-3830.
43. Gruenheid, S., Canonne-Hergaux, F., Gauthier, S., Hackam, D. J., Grinstein, S., Gros, P. (1999) The iron transport protein Nramp2 is an integral membrane protein that co-localizes with transferrin in recycling endosomes. J. Exp. Med. 189, 831-841.
44. Gly169 or Nramp1Asp169. J. Leukoc. Biol. 66, 113-119.
45. Kuhn, D. E., Lafuse, W. P., Zwilling, B. S. (2001) Iron transport into Mycobacterium avium-containing phagosomes from an Nramp1(Gly169)-transfected RAW264.7 macrophage cell line. J. Leukoc. Biol. 69, 43-49.
46. Goswami, T., Bhattacharjee, A., Babal, P., Searle, S., Moore, E., Li, M., Blackwell, J. M. (2001) Natural-resistance associated macrophage protein 1 is a H+/bivalent cation antiporter. Biochem. J. 354, 511-519.
47. Jabado, N., Jankowsky, A., Dougaparsad, S., Picard, V., Grinstein, S., Gros, P. (2000) Natural resistance to intracellular infections: Nramp1 functions as a pH-dependent manganese transporter at the phagosomal membrane. J. Exp. Med. 192, 1237-1248.
48. Forbes, J., Gros, P. (2003) Iron and manganese transport by Nramp1 (Slc11a1) and Nramp2 (Slc11a2) expressed at the plasma membrane. Blood 102, 1884-1892.
49. Jabado, N., Cuellar-Mata, P., Grinstein, S., Gros, P. (2003) Iron chelators mimic the Nramp1 effect on the maturation of Salmonella vacuole in macrophages lacking functional Nramp1. Proc. Natl. Acad. Sci. USA 100, 6127-6132.
50. Russell, D. G. (2001) Mycobacterlum tuberculosis: here today, and here tomorrow. Nat. Rev. Mol. Cell Biol. 2, 569-577.
51. Hackam, D. J., Rotstein, O. D., Zhang, W-J., Gruenheid, S., Gros, P., Grinstein, S. (1998) Host resistance to intracellular infections: mutation at Nramp1 impair phagosomal acidification. J. Exp. Med. 188, 351-364.
52. Cuellar-Mata, P., Jabado, N., Liu, J., Finlay, B. B., Gros, P., Grinstein, S. (2002) Nramp1 modifies the fusion of Salmonella typhimurium containing vacuoles with cellular endomembranes in macrophages. J. Biol. Chem. 277, 2258-2265.
53. McDade, J. E., Shepard, C. C., Fraser, D. W., Tsai, T. R., Redus, M. A., Dowdle, W. R. (1977) Legionnaires' disease: isolation of a bacterium and demonstration of its role in other respiratory disease. N. Engl. J. Med. 297, 1197-1203.
54. Roy, C. R., Tilney, L. G. (2002) The road less traveled: transport of Legionella to the endoplasmic reticulum. J. Cell Biol. 158, 415-419.
55. Gao, L. Y., Kwaik, Y. A. (1999) Apoptosis in macrophages and alveolar epithelial cells during early stages of infection by Legionella pneumophila and its role in cytopathogenicity. Infect. Immun. 67, 862-870.
56. Gao, L-Y., Kwaik, Y. A. (1999) Activation of caspase 3 during Legionella pneumophila induced apoptosis. Infect. Immun. 67, 4886-4894.
57. Yamamoto, Y., Klein, T. W., Friedman, H. (1994) Legionella and macrophages, Immunol. Ser. 60, 329-348.
58. Yamamoto, Y., Klein, T. W., Newton, C. A., Widen, R., Friedman, H. (1988) Growth of Legionella pneumophila in thioglycollate-elicited peritoneal macrophages from A/J mice. Infect. Immun. 56, 370-375.
59. Yoshida, S-I., Goto, Y., Mizuguchi, Y., Nomoto, K., Skamene, E. (1991) Genetic control of natural resistance in mouse macrophages regulating intracellular Legionella pneumophila replication in vitro. Infect. Immun. 59, 428-432.
60. Beckers, M-C., Ernst, E., Diez, E., Morissette, C., Gervais, F., Hunter, K., Housman, D., Yoshida, S-I., Skamene, E., Gros, P. (1997) High-resolution linkage map of mouse chromosome 13 in the vicinity of the host resistance locus Lgn1. Genomics 39, 254-263.
61. Dietrih, W. F., Damron, D. M., Isberg, R. R., Lander, E. S., Swanson, M. S. (1995) Lgn1, a gene that determines susceptibility to Legionella pneumophila, maps to mouse chromosome 13. Genomics 26, 443-450.
62. Scharf, J. M., Damron, D., Frisella, A., Bruno, S., Beggs, A. H., Kunkel, L. M., Dietrich, W. F. (1996) The mouse region syntenic for human spinal muscular atrophy lies within the Lgn1 critical interval and contains copies of Naip exon 5. Genomics 38, 405-417.
63. Roy, N., Mahadevan, M. S., McLean, M. D., Shutler, G., Yaraghi, Z., Farahani, R., Baird, S., Besner-Johnston, A., Lefebvre, C., Kang, X., et al. (1995) The gene for neuronal apoptosis inhibitory protein is partially deleted in individuals with spinal muscular atrophy. Cell 80, 167-178.
64. Lefebvre, S., Burglen, L., Reboullet, S., Clermont, O., Burlet, P., Viollet, L., Benichou, B., Cruaud, C., Millasseau, P., Zeviani, M., et al. (1995) Identification and characterization of a spinal muscular atrophy-determining gene. Cell 80, 155-165.
65. Growney, J. D., Dietrich, W. F. (2000) High resolution genetic and physical map of the Lgn1 interval in C57B1/6J implicates Naip2 and Naip5 in Legionella pneumophila pathogenesis. Genome Res. 10, 1158-1171.
66. Growney, J. D., Scharf, J. M., Kunkel, L. M., Dietrich, W. F. (2000) Evolutionary divergence of the mouse and human Lgn1/SMA repeat structure. Genomics 64, 62-81.
67. Diez, E., Yaraghi, Z., MacKenzie, A., Gros, P. (2000) The apoptosis inhibitor protein NAIP: constitutive and inducible expression in macrophages and candidacy for the host resistance locus Lgn1. J. Immunol. 164, 1470-1477.
68. Diez, E., Lee, S-H., Gauthier, S., Yaraghi, Z., Tremblay, M., Vidal, M., Gros, P. (2003) Birc 1e is the gene within the lgn1 locus associated with resistance to Legionella pneumophila. Nat. Genet. 33, 55-60.
69. Wright, E. K., Goodart, S. A., Growney, J. D., Hadinoto, V., Endrizzi, M. G., Long, E. M., Sadigh, K., Abney, A. L., Bernstein-Hanley, I., Dietrich, W. F. (2003) Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila. Curr. Biol. 13, 27-36.
70. Xu, D. G., Crocker, S. J., Doucet, J-P., St-Jean, M., Tamai, K., Hakim, A., Ikeda, J-E., Liston, P., Thompson, C. S., Korneluk, R. G., MacKenzie, A., Robertson, G. S. (1997) Elevation of neuronal expression of NAIP reduces ischemic damage in the hippocampus. Nat. Med. 3, 997-1004.
71. Liston, P., Roy, N., Tamai, K., Lefebvre, C., Baird, S., Cherton-Horvat, G., Farahani, R., McLean, M., Ikeda, J-E., MacKenzie, A., Korneluk R. G. (1996) Suppression of apoptosis in mammalian cells by Naip and a related family of IAP genes. Nature 379, 349-353.
72. Hozak, R. R., Manji, G. A., Friesen, P. D. (2000) The BIR motifs mediate dominant interference and oligomerization of inhibitor of apoptosis Op-IAP. Mol. Cell. Biol. 20, 1877-1885.
73. Koonin, E. V., Aravind, L. (2000) The NACHT family-a new group of predicted NTPases implicated in apoptosis and MHC transcription activation. Trends Blochem. Sci. 25, 223-224.
74. Holcik, M., Thompson, C. S., Yaraghi, Z., Lefebvre, C. A., MacKenzie, A. E., Komeluk, R. G. (2000) The hippocampal neurons of neuronal apoptosis inhibitory protein 1 (NAIP1)-deleted mice display increased vulnerability to kainic acid-induced injury. Proc. Natl. Acad. Sci. USA 97, 2286-2290.
75. Maier, J. K., Lahoua, Z., Gendron, N. H., Fetni, R., Johnston, A., Davoodi, J., Rasper, D., Roy, S., Slack, R. S., Nicholson, D. W., MacKenzie, A. E. (2002) The neuronal apoptosis inhibitory protein is a direct inhibitor of caspases 3 and 7. J. Neurosci. 22, 2035-2043.
76. Inohara, N., Nunez, G. (2003) NODs: intracellular proteins involved in inflammation and apoptosis. Nat. Rev. Immunol. 3, 371-382.
77. Tschopp, J., Martinon, F., Burns, K. (2003) NALPs: a novel protein family involved in inflammation. Nat. Rev. Mol. Cell Biol. 4, 95-104.
78. Chamaillard, M., Hashimoto, M., Horie, Y., Masumoto, J., Qiu, S., Saab, L., Ogura, Y., Kawasaki, A., Fukase, K., Kusumoto, S., Valvano, M. A., Foster, S. J., Mak, T. W., Nunez, G., Inohara, N. (2003) An essential role for NOD1 in host recognition of bacterial peptidoglycan containing diaminopimelic acid. Nat. Immunol. 4, 702-707.
79. Girardin, S. E., Boneca, I. G., Viala, J., Chamaillard, M., Labigne, A., Thomas, G., Philpott, D. J., Sansonetti, P. J. (2003) Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection. J. Biol. Chem. 278, 8869-8872.
80. Ogura, Y., Bonen, D. K., Inohara, N., Nicolae, D. L., Chen, F. F., Ramos, R., Britton, H., Moran, T., Karaliuskas, R., Duerr, R. H., Achkar, J. P., Brant, S. R., Bayless, T. M., Kirschner, B. S., Hanauer, S. B., Nunez, G., Cho, J. H. (2001) A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature 411, 603-606.
81. Miceli-Richard, C., Lesage, S., Rybojad, M., Prieur, A. M., Manouvier-Hanu, S., Hafner, R., Chamaillard, M., Zouali, H., Thomas, G., Hugot, J. P. (2001) CARD15 mutations in Blau syndrome. Nat. Genet. 29, 19-20.
82. Lee, S. H., Zafer, A., de Repentigny, Y., Kothary, R., Tremblay, M., Gros, P., Duplay, P., Webb, J. R., Vidal, S. M. (2003) Rescue of susceptibility to cytomegalovirus infection in transgenic mice expressing the activating natural killer receptor transgene Ly49h. J. Exp. Med. 197, 515-526.
83. Kibar, Z., Gauthier, S., Lee, S-H., Vidal, S., Gros, P. (2003) Correction of the neural tube defect of loop-tail mice by a BAC clone containing the ltap gene. Genomics 82, 397-400.
84. Demant, P., Hart, A. A. (1986) Recombinant congenic strains-a new tool for analyzing genetic traits determined by more than one gene. Immunogenetics 24, 416-422.
85. Marsh, K., Snow, R. W. (1997) 30 years of science and technology: the example of malaria. Lancet 349, (suppl. III), 1-2.
86. Kwiatkowski, D. (2000) Genetic susceptibility to malaria getting complex. Curr. Opin. Genet. Dev. 10, 320-324.
87. Foote, S. J., Burt, R. A., Baldwin, T. M., Presente, A., Roberts, A. W., Laural, Y. L., Lew, A. M., Marshall, V. M. (1997) Mouse loci for malaria-induced mortality and the control of parasitaemia. Nat. Genet. 17, 380-381.
88. Fortin, A., Belouchi, A., Tam, M. F., Cardon, L., Skamene, E., Stevenson, M. M., Gros, P. (1997) Genetic control of blood parasitaemia in mouse malaria maps to chromosome 8. Nat. Genet. 17, 382-383.
89. Burt, R. A., Baldwin, T. M., Marshall, V. M., Foote, S. J. (1999) Temporal expression of an H2-linked locus in host response to mouse malaria. Immunogenetics 50, 278-285.
90. Hernandez-Valladares, M., Naessens, J., Gibson, J. P., Musoke, A. J., Nagda, S., Rihet, P., Ole-Moi Yoi, O. K., Iraqi, F. A. (2004) Confirmation and dissection of QTL controlling resistance to malaria in mice. Mamm. Genome 15, 390-398.
91. Fortin, A., Cardon, L. R., Tam, M., Skamene, E., Stevenson, M. M., Gros, P. (2001) Identification of a new malaria susceptibility locus (char4) in recombinant congenic strains of mice. Proc. Natl. Acad. Sci. USA 98, 10793-10798.
92. Min-Oo, G., Fortin, A., Tam, M-F., Nantel, A., Stevenson, M. M., Gros, P. (2003) Pyruvate kinase deficiency in mice protects against malaria. Nat. Genet. 35, 357-362.
93. Hernandez-Valladares, M., Rihet, P., Ole-Moi Yoi, O. K., Iraqi, F. A. (2004) Mapping of a new quantitative trait locus for resistance to malaria in mice by a comparative mapping approach with human chromosome 5q31-q33. Immunogenetics 56, 115-117.
94. Fortin, A., Diez, E., Rochefort, D., Laroche, L., Malo, D., Rouleau, G., Gros, P., Skamene, E. (2001) Recombinant congenic strains derived from A/J and C57B1/6J: a tool for genetic dissection of complex traits. Genomics 74, 21-35.
95. Min-Oo, G., Fortin, A., Tam, M-F., Gros, P., Stevenson, M. M. (2004) Phenotypic expression of pyruvate kinase deficiency and protection against malaria in a mouse model. Genes Immun. 5, 168-175.
96. Van Solinge, W. W., van Kraajenhagen, R. J., Rijksen, G., Nielsen, F. C. (1997) Novel mutations in the human red cell type pyruvate kinase gene: two promoter mutations in cis, a splice site mutation, a nonsense and three missense mutations. Blood 90 (Suppl. 1), 1197.