Genetic susceptibility to malaria getting complex

Current Opinion in Genetics and Development

Volumn 10, Issue 3, 2000, Pages 320-324

  Kwiatkowski, Dominic ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROCYTE; GENE LOCUS; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; MALARIA; MOLECULAR GENETICS; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; QUANTITATIVE TRAIT; REVIEW;

PLASMODIUM FALCIPARUM; PROTOZOA;

EID: 0034107362     PISSN: 0959437X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-437X(00)00087-3     Document Type: Review

References (46)

1. Miller L.H., Mason S.J., Clyde D.F., McGinniss M.H. The resistance factor to Plasmodium vivax in blacks. The Duffy-blood-group genotype, FyFy. N Engl J Med. 295:1976;302-304.
2. Chitnis C.E., Miller L.H. Identification of the erythrocyte binding domains of Plasmodium vivax and Plasmodium knowlesi proteins involved in erythrocyte invasion. J Exp Med. 180:1994;497-506.
3. Modiano D., Petrarca V., Sirima B.S., Nebie I., Diallo D., Esposito F., Coluzzi M. Different response to Plasmodium falciparum malaria in west African sympatric ethnic groups. Proc Natl Acad Sci USA. 93:1996;13206-13211.
4. Riley E.M., Olerup O., Bennett S., Rowe P., Allen S.J., Blackman M.J., Troye-Blomberg M., Holder A.A., Greenwood B.M. MHC and malaria: the relationship between HLA class II alleles and immune responses to Plasmodium falciparum. Int Immunol. 4:1992;1055-1063.
5. Modiano D., Chiucchiuini A., Petrarca V., Sirima B.S., Luoni G., Perlmann H., Esposito F., Coluzzi M. Humoral response to Plasmodium falciparum Pf155/ring-infected erythrocyte surface antigen and Pf332 in three sympatric ethnic groups of Burkina Faso. Am J Trop Med Hyg. 58:1998;220-224.
6. Modiano D., Chiucchiuini A., Petrarca V., Sirima B.S., Luoni G., Roggero M.A., Corradin G., Coluzzi M., Esposito F. Interethnic differences in the humoral response to non-repetitive regions of the Plasmodium falciparum circumsporozoite protein. Am J Trop Med Hyg. 61:1999;663-667. Consolidates the evidence that, despite similar exposure to malaria, the Fulani ethnic group have higher anti-malarial antibody responses than other ethnic groups in the same region. The strikingly lower levels of malaria prevalence and higher levels of anti-malarial antibodies seen amongst the Fulani compared to their neighbours suggests that this ethnic group may possess an important and novel genetic determinant of malarial immunity.
7. Abel L., Cot M., Mulder L., Carnevale P., Feingold J. Segregation analysis detects a major gene controlling blood infection levels in human malaria. Am J Hum Genet. 50:1992;1308-1317.
8. Rihet P., Abel L., Traore Y., Traore-Leroux T., Aucan C., Fumoux F. Human malaria: segregation analysis of blood infection levels in a suburban area and a rural area in Burkina Faso. Genet Epidemiol. 15:1998;435-450.
9. Garcia A., Cot M., Chippaux J.P., Ranque S., Feingold J., Demenais F., Abel L. Genetic control of blood infection levels in human malaria: evidence for a complex genetic model. Am J Trop Med Hyg. 58:1998;480-488.
10. Rihet P., Traore Y., Abel L., Aucan C., Traore-Leroux T., Fumoux F. Malaria in humans: Plasmodium falciparum blood infection levels are linked to chromosome 5q31-q33. Am J Hum Genet. 63:1998;498-505.
11. Garcia A., Marquet S., Bucheton B., Hillaire D., Cot M., Fievet N., Dessein A.J., Abel L. Linkage analysis of blood Plasmodium falciparum levels: interest of the 5q31-q33 chromosome region. Am J Trop Med Hyg. 58:1998;705-709.
12. Marquet S., Abel L., Hillaire D., Dessein H., Kalil J., Feingold J., Weissenbach J., Dessein A.J. Genetic localization of a locus controlling the intensity of infection by Schistosoma mansoni on chromosome 5q31-q33. Nat Genet. 14:1996;181-184.
13. Stirnadel H.A., Beck H.P., Alpers M.P., Smith T.A. Heritability and segregation analysis of immune responses to specific malaria antigens in Papua New Guinea. Genet Epidemiol. 17:1999;16-34. An attempt to dissect familial patterns of inheritance of antibody and cellular responses to malaria antigens: the picture is complicated.
14. Jepson A.P., Banya W.A., Sisay-Joof F., Hassan-King M., Bennett S., Whittle H.C. Genetic regulation of fever in Plasmodium falciparum malaria in Gambian twin children. J Infect Dis. 172:1995;316-319.
15. Jepson A., Sisay-Joof F., Banya W., Hassan-King M., Frodsham A., Bennett S., Hill A.V., Whittle H. Genetic linkage of mild malaria to the major histocompatibility complex in Gambian children: study of affected sibling pairs. BMJ. 315:1997;96-97.
16. Tournamille C., Colin Y., Cartron J.P., Le Van Kim C. Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals. Nat Genet. 10:1995;224-228.
17. Stirnadel H.A., Stockle M., Felger I., Smith T., Tanner M., Beck H.P. Malaria infection and morbidity in infants in relation to genetic polymorphisms in Tanzania. Trop Med Int Health. 4:1999;187-193.
18. Allen S.J., Bennett S., Riley E.M., Rowe P.A., Jakobsen P.H., O'Donnell A., Greenwood B.M. Morbidity from malaria and immune responses to defined Plasmodium falciparum antigens in children with sickle cell trait in The Gambia. Trans R Soc Trop Med Hyg. 86:1992;494-498.
19. Hill A.V., Allsopp C.E., Kwiatkowski D., Anstey N.M., Twumasi P., Rowe P.A., Bennett S., Brewster D., McMichael A.J., Greenwood B.M. Common west African HLA antigens are associated with protection from severe malaria. Nature. 352:1991;595-600.
20. Pasvol G., Weatherall D.J., Wilson R.J. Cellular mechanism for the protective effect of haemoglobin S against P. falciparum malaria. Nature. 274:1978;701-703.
21. Shear H.L., Roth E.F. Jr., Fabry M.E., Costantini F.D., Pachnis A., Hood A., Nagel R.L. Transgenic mice expressing human sickle hemoglobin are partially resistant to rodent malaria. Blood. 81:1993;222-226.
22. Ruwende C., Khoo S.C., Snow R.W., Yates S.N., Kwiatkowski D., Gupta S., Warn P., Allsopp C.E., Gilbert S.C., Peschu N.et al. Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria. Nature. 376:1995;246-249.
23. Usanga E.A., Luzzatto L. Adaptation of Plasmodium falciparum to glucose 6-phosphate dehydrogenase-deficient host red cells by production of parasite- encoded enzyme. Nature. 313:1985;793-795.
24. Allen S.J., O'Donnell A., Alexander N.D., Alpers M.P., Peto T.E.A., Clegg J.B., Weatherall D.J. alpha+-Thalassemia protects children against disease caused by other infections as well as malaria. Proc Natl Acad Sci USA. 94:1997;14736-14741.
25. Pattanapanyasat K., Yongvanitchit K., Tongtawe P., Tachavanich K., Wanachiwanawin W., Fucharoen S., Walsh D.S. Impairment of Plasmodium falciparum growth in thalassemic red blood cells: further evidence by using biotin labeling and flow cytometry. Blood. 93:1999;3116-3119. The authors use flow cytometry to demonstrate that parasite multiplication rates are reduced in thalassaemic erythrocytes. Although it has long been supposed that thalassaemia may protect against malaria by suppressing parasite growth, this is one of the few pieces of evidence to support that hypothesis.
26. Williams T.N., Maitland K., Bennett S., Ganczakowski M., Peto T.E., Newbold C.I., Bowden D.K., Weatherall D.J., Clegg J.B. High incidence of malaria in alpha-thalassaemic children. Nature. 383:1996;522-525.
27. Hill A.V., Elvin J., Willis A.C., Aidoo M., Allsopp C.E., Gotch F.M., Gao X.M., Takiguchi M., Greenwood B.M., Townsend A.R.et al. Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature. 360:1992;434-439.
28. Gilbert S.C., Plebanski M., Gupta S., Morris J., Cox M., Aidoo M., Kwiatkowski D., Greenwood B.M., Whittle H.C., Hill A.V. Association of malaria parasite population structure, HLA, and immunological antagonism. Science. 279:1998;1173-1177.
29. McGuire W., Hill A.V., Allsopp C.E., Greenwood B.M., Kwiatkowski D. Variation in the TNF-alpha promoter region associated with susceptibility to cerebral malaria. Nature. 371:1994;508-510.
30. Knight J.C., Udalova I., Hill A.V., Greenwood B.M., Peshu N., Marsh K., Kwiatkowski D. A polymorphism that affects OCT-1 binding to the TNF promoter region is associated with severe malaria. Nat Genet. 22:1999;145-150. DNA footprinting is here used to identify a potentially functional SNP as a candidate for disease association studies in Gambian and Kenyan children. This study explores the utility of DNA footprinting as a means of identifying functional regulatory polymorphisms within a candidate gene region, prior to testing for disease association in different populations.
31. Knight J.C., Kwiatkowski D. Inherited variability of tumor necrosis factor production and susceptibility to infectious disease. Proc Assoc Am Physicians. 111:1999;290-298.
32. Wattavidanage J., Carter R., Perera K.L., Munasingha A., Bandara S., McGuinness D., Wickramasinghe A.R., Alles H.K., Mendis K.N., Premawansa S. TNFalpha*2 marks high risk of severe disease during Plasmodium falciparum malaria and other infections in Sri Lankans. Clin Exp Immunol. 115:1999;350-355.
33. Abraham L.J., Kroeger K.M. Impact of the -308 TNF promoter polymorphism on the transcriptional regulation of the TNF gene: relevance to disease. J Leukoc Biol. 66:1999;562-566. Further data on this controversial topic suggest that the TNF-308 polymorphism is functional only in the presence of the TNF 3′ untranslated region. This promoter polymorphism has been associated with several infectious diseases but previous studies have differed on its functional significance. These new data suggest that the TNF 3′ untranslated region must be present in order for the polymorphism to upregulate gene expression.
34. McGuire W., Knight J.C., Hill A.V., Allsopp C.E., Greenwood B.M., Kwiatkowski D. Severe malarial anemia and cerebral malaria are associated with different tumor necrosis factor promoter alleles. J Infect Dis. 179:1999;287-290.
35. Complete sequence and gene map of a human major histocompatibility complex. Nature. 401:1999;921-923. The high density of immunological genes in the MHC highlights the need for caution in interpreting disease associations at this locus.
36. Kun J.F., Mordmuller B., Lell B., Lehman L.G., Luckner D., Kremsner P.G. Polymorphism in promoter region of inducible nitric oxide synthase gene and protection against malaria. Lancet. 351:1998;265-266.
37. Burgner D., Xu W., Rockett K., Gravenor M., Charles I.G., Hill A.V., Kwiatkowski D. Inducible nitric oxide synthase polymorphism and fatal cerebral malaria. Lancet. 352:1998;1193-1194.
38. Levesque M.C., Hobbs M.R., Anstey N.M., Vaughn T.N., Chancellor J.A., Pole A., Perkins D.J., Misukonis M.A., Chanock S.J., Granger D.L.et al. Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with Malaria. J Infect Dis. 180:1999;1994-2002.
39. Fernandez-Reyes D., Craig A.G., Kyes S.A., Peshu N., Snow R.W., Berendt A.R., Marsh K., Newbold C.I. A high frequency African coding polymorphism in the N-terminal domain of ICAM-1 predisposing to cerebral malaria in Kenya. Hum Mol Genet. 6:1997;1357-1360.
40. Kun J.F., Klabunde J., Lell B., Luckner D., Alpers M., May J., Meyer C., Kremsner P.G. Association of the ICAM-1Kilifi mutation with protection against severe malaria in Lambarene, Gabon. Am J Trop Med Hyg. 61:1999;776-779.
41. Bellamy R., Kwiatkowski D., Hill A.V. Absence of an association between intercellular adhesion molecule 1, complement receptor 1 and interleukin 1 receptor antagonist gene polymorphisms and severe malaria in a West African population. Trans R Soc Trop Med Hyg. 92:1998;312-316.
42. Rowe J.A., Moulds J.M., Newbold C.I., Miller L.H. P. falciparum rosetting mediated by a parasite-variant erythrocyte membrane protein and complement-receptor 1. Nature. 388:1997;292-295.
43. Urban B.C., Ferguson D.J., Pain A., Willcox N., Plebanski M., Austyn J.M., Roberts D.J. Plasmodium falciparum-infected erythrocytes modulate the maturation of dendritic cells. Nature. 400:1999;73-77. This report highlights the immunological complexity of host-parasite interactions and provides further impetus for genetic analysis of host adhesion molecules. This study finds that parasite adherence to dendritic cells may suppress the immune response to malaria, thus highlighting the potential importance of genetic diversity in relevant host adhesion molecules.
44. Fortin A., Belouchi A., Tam M.F., Cardon L., Skamene E., Stevenson M.M., Gros P. Genetic control of blood parasitaemia in mouse malaria maps to chromosome 8. Nat Genet. 17:1997;382-383.
45. Foote S.J., Burt R.A., Baldwin T.M., Presente A., Roberts A.W., Laural Y.L., Lew A.M., Marshall V.M. Mouse loci for malaria-induced mortality and the control of parasitaemia. Nat Genet. 17:1997;380-381.
46. Burt R.A. Genetics of host response to malaria. Int J Parasitol. 29:1999;973-979.