Dextromethorphan reduces functional deficits and neuronal damage after global ischemia in rats

Brain Research

Volumn 741, Issue 1-2, 1996, Pages 153-159

  Block, F ^a,b   Schwarz, M ^b  

^a MAX PLANCK INSTITUTE OF EXPERIMENTAL MEDICINE   (Germany)

^b UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

behavior; cerebral ischemia; dextromethorphan; glutamate; rat

Indexed keywords

DEXTROMETHORPHAN; GLUTAMATE RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; CONTROLLED STUDY; HISTOLOGY; INTRAPERITONEAL DRUG ADMINISTRATION; LEARNING; LOCOMOTION; MALE; MAZE TEST; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN ISCHEMIA; DEXTROMETHORPHAN; MALE; MAZE LEARNING; MEMORY; MOTOR ACTIVITY; N-METHYLASPARTATE; NERVE DEGENERATION; NEURONS; NEUROPROTECTIVE AGENTS; RATS; RATS, WISTAR;

EID: 0030602016     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(96)00916-X     Document Type: Article

References (38)

1. [1] Apland, J.P. and Braitman, D.J., Effects of non-opioid antitussives on epileptiform activity and NMDA responses in hippocampal and olfactory cortex slices, Brain Res., 529 (1990) 277-285.
2. [2] Auer, R.N., Jensen, M.L. and Wishaw, I.Q., Neurobehavioural deficit due to ischemic brain damage limited to half of the CA1 sector of the hippocampus, J. Neurosci., 9 (1989) 1641-1647.
3. [3] Benveniste, H., Drejer, J., Schousboe, A. and Diemer, N.H., Elevation of the extracellular concentrations of glutamate and aspartate in rat hippocampus during transient cerebral ischemia monitored by intracerebral microdialysis, J. Neurochem., 43 (1984) 1369-1374.
4. [4] Block, F., Kunkel, M. and Schwarz, M., Quinolinic acid lesion of the striatum induces impairment in spatial learning and motor performance in rats, Neurosci. Lett., 149 (1993) 126-128.
5. [5] Block, F., Kunkel, M. and Sontag, K.-H., Posttreatment with EPC-K1, an inhibitor of lipid peroxidation and of phospholipase A2 activity, reduces functional deficits after global ischemia in rats, Brain Res. Bull., 36 (1995) 257-260.
6. [6] Block, F., Jaspers, R.M.A., Heim, C. and Sontag, K.-H., S-Emopamil ameliorates ischemic brain damage in rats: histological and behavioural approaches, Life Sci., 47 (1990) 1511-1518.
7. [7] Block, F., Schmitt, W. and Schwarz, M., The antioxidant LY 231617 ameliorates functional and morphological sequelae induced by global ischemia in rats, Brain Res., 694 (1995) 308-311.
8. [8] Block, F. and Schwarz, M., N-Methyl-D-aspartate (NMDA)-mediated muscle relaxant action of dextromethorphan in rats, NeuroReport, 4 (1993) 941-943.
9. [9] Boast, C.A., Gerhardt, S.C., Pastor, G., Lehmann, J., Etienne, P.E. and Liebmann, J.M., The N-methyl-D-aspartate antagonists CGS 19755 and CPP reduce ischemic brain damage in gerbils, Brain Res., 442 (1988) 345-348.
10. [10] Bokesch, P.M., Marchand, J.E., Connelly, C.S., Wurm, H. and Kream, R.M., Dextromethorphan inhibits ischemia-induced c-fos expression and delayed neuronal death in hippocampal neurons, Anesthesiology, 81 (1994) 470-477.
11. [11] Buchan, A. and Pulsinelli, W.A., Hypothermia but not the N-methyl-D-aspartate receptor antagonist, MK 801, attenuates neuronal damage in gerbils subjected to transient global ischemia, J. Neurosci., 10 (1990) 311-316.
12. [12] Chandler, M.J., DeLeo, J. and Carney, J.W., An unanesthetized-gerbil model of cerebral ischemia-induced behavioral changes, J. Pharmacol. Methods, 14 (1985) 137-146.
13. [13] Colbourne, F. and Corbett, D., Delayed and prolonged post-ischemic hypothermia is neuroprotective in the gerbil, Brain Res., 654 (1994) 265-272.
14. [14] Corbett, D., Evans, S., Thomas, C., Wang, D. and Jonas, R.A., MK 801 reduces cerebral injury by inducing hypothermia, Brain Res., 514 (1990) 300-314.
15. [15] Gerhardt, S.C. and Boast, C.A., Motor activity changes following cerebral ischemia in gerbils are correlated with the degree of neuronal degeneration in hippocampus, Behav. Neurosci., 102 (1988) 301-303.
16. [16] Gotti, B., Benavides, J., MacKenzie, E.T. and Scatton, B., The pharmacotherapy of focal cortical ischemia in the mouse, Brain Res., 522 (1990) 290-307.
17. [17] Hossmann, K.-A., Post-ischemic resuscitation of the brain: selective vulnerability versus global resistance, Prog. Brain Res., 63 (1985) 3-17.
18. [18] Jaspers, R.M.A., Block, F., Heim, C. and Sontag, K.-H., Spatial learning is affected by transient occlusion of common carotid arteris (2VO): comparison of behavioural and histopathological changes after '2VO' and 'four-vessel-occlusion' in rats, Neurosci. Lett., 117 (1990) 149-153.
19. [19] Kiyota, Y., Miyamoto, M. and Nagaoka, A., Relationship between brain damage and memory impairment in rats exposed to transient forebrain ischemia, Brain Res., 538 (1990) 295-302.
20. [20] Kuroiwa, T., Bonnekoh, P. and Hossmann, K.-H., Locomotor hyper-activity and hippocampal CA1 injury after transient forebrain ischemia of gerbils, Neurosci. Lett., 122 (1991) 141-144.
21. [21] McDonald, J.W. and Johnston, M.V., Pharmacology of N-methyl-D-aspartate-induced brain injury in an in vivo perinatal rat model, Synapse, 6 (1990) 179-188.
22. [22] Monaghan, D.T., Bridges, R.J. and Cotman, C.W., The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system, Annu. Rev. Pharmacol. Toxicol., 29 (1989) 365-402.
23. [23] Moreau, J.L., Pieri, L. and Prud'hon, B., Convulsions induced by centrally administered NMDA in mice: effects of NMDA antagonists, benzodiazepines, minor tranquilizers and anticonvulsants, Br. J. Pharmacol., 98 (1989) 1050-1054.
24. [24] Morris, R.G.M., Garrud, P., Rawlins, J.N.P. and O'Keefe, J., Place navigation impaired in rats with hippocampal lesions, Nature, 297 (1986) 681-683.
25. [25] Nunn, J.A., LePeillet, E., Netto, C.A., Hodges, H., Gray, J.A. and Meldrum, B.S., Global ischemia: hippocampal pathology and spatial deficits in the water maze, Behav. Brain Res., 62 (1994) 41-54.
26. [26] Paxinos, G. and Watson, C., The Rat Brain in Stereotaxic Coordinates, Academic Press, Sydney, 1986.
27. [27] Phillis, J.W., Oxypurinol attenuates ischemia-induced hippocampal damage in the gerbil, Brain Res. Bull., 23 (1989) 467-470.
28. [28] Poignet, H., Beaughard, M., Lecoin, G. and Massingham, R., Functional, behavioral, and histological changes induced by transient global cerebral ischemia in rats: effects of cinnarizine and flunarizine, J. Cereb. Blood Flow Metab., 9 (1989) 646-654.
29. [29] Pulsinelli, W.A., Brierley, J.B. and Plum, F., Temporal profile of neuronal damage in a model of transient forebrain ischemia, Ann. Neurol., 11 (1982) 491-498.
30. [30] Van Rijen, P.C., Verheul, H.B., Van Echteld, C.J., Balazs, R., Lewis, P., Nasim, M.M. and Tulleken, C.A., Effects of dextromethorphan on rat brain during ischemia and reperfusion assessed by magnetic resonance spectroscopy, Stroke, 22 (1991) 343-350.
31. [31] Schmidt-Kastner, R. and Freund, T.F., Selective vulnerability of the hippocampus in brain ischemia, Neuroscience, 40 (1991) 599-636.
32. [32] Steinberg, G.K., George, C.P., DeLaPaz, R., Shibata, D.K. and Gross, T., Dextromethorphan protects against cerebral injury following transient focal ischemia in rabbits, Stroke, 19 (1988) 1112-1118.
33. [33] Swan, J.H. and Meldrum, B.S., Protection by NMDA antagonists against selective cell loss following transient ischemia, J. Cereb. Blood Flow Metab., 10 (1990) 343-351.
34. [34] Szekely, J.I., Sharpe, L.G. and Jaffe, J.H., Induction of phencyclidine-like behaviour in rats by dextrorphan but not dextromethrophan, Pharmacol. Biochem. Behav., 40 (1991) 381-386.
35. [35] Wagemann, E., Schmidt-Kastner, R., Block, F. and Sontag, K.-H., Neuronal degeneration in hippocampus and cerebellum of mutant spastic Han-Wistar rats, Neurosci. Lett., 121 (1991) 102-106.
36. [36] Warner, M.A., Neill, K.H., Nadler, J.V. and Crain, B.J., Regionally selective effects of NMDA receptor antagonists against ischemic brain damage in the gerbil, J. Cereb. Blood Flow Metab., 11 (1991) 600-610.
37. [37] Wood, E.R., Memby, D.G., Pinel, J.P. and Phillips, A.G., Impaired object recognition memory in rats following ischemia-induced damage to the hippocampus, Behav. Neurosci., 107 (1993) 51-62.
38. [38] Wu, D., Otton, S.V., Kalow, W. and Sellers, E.M., Effects of route of administration on dextromethorphan pharmacokinetics and behavioural response in the rat, J. Pharmacol. Exp. Ther., 274 (1995) 1431-1437.