Neuroprotection for ischemic stroke;Neuroprotektion beim schlaganfall. Eine kritische bestandsaufnahme

Nervenarzt

Volumn 70, Issue 2, 1999, Pages 101-110

  Block, F ^a   Schwarz, M ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Cerebral ischemia; Neuroprotection; Pathophysiology

Indexed keywords

CALCIUM ANTAGONIST; GLUTAMATE RECEPTOR ANTAGONIST; SCAVENGER;

APOPTOSIS; BRAIN ISCHEMIA; BRAIN PROTECTION; CEREBROVASCULAR ACCIDENT; DRUG ACTIVITY; DRUG RESEARCH; HUMAN; INFLAMMATION; NEUROPROTECTION; NONHUMAN; PATHOPHYSIOLOGY; REVIEW;

ANIMALS; BRAIN; BRAIN DAMAGE, CHRONIC; BRAIN ISCHEMIA; CEREBROVASCULAR DISORDERS; HUMANS; NEUROPROTECTIVE AGENTS; PROGNOSIS; TREATMENT OUTCOME;

EID: 0033035133     PISSN: 00282804     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001150050409     Document Type: Review

References (98)

1. Anderson AJ, Su JH, Cotman CW (1996) DNA damage and apoptosis in Alzheimer's disease: colocalization with c-Jun immunoreactivity, relationship to brain area, and effect of postmortem delay. J Neurosci 16:1710-1719
2. Aronowski J, Strong R, Grotta JC (1996) Treatment of experimental focal ischemia in rats with lubeluzole. Neuropharmacology 35:689-693
3. Arvin B, Neville LF, Barone FC, Feuerstein GZ (1996) The role of inflammation and cytokines in brain injury. Neurosci Biobehav Rev 20:445-452
4. Astrup J, Siesjö BK, Symon L (1981) Thresholds in cerebral ischemia: the ischemic penumbra. Stroke 12:723-725
5. Back T, Nedergaard M, Ginsberg MD (1998) The ischemic penumbra: pathophysiology and relevance of spreading depression-like phenomena. In: Ginsberg MD, Bogousslavsky J (eds) Cerebrovascular disease: pathophysiology, diagnosis and management, vol 1. Blackwell, Malden, MA, pp 276-286
6. Beamer NB, Coull BM, Clark WM, Hazel JS, Silberger JR (1995) Interleukin-6 and interleukin-1 receptor antagonist in acute stroke. Ann Neurol 37:800-804
7. Berlit P, Popescu O, Klötzsch C, Diehl RR, Berg-Dammer E (1997) Behandlung des akuten Schlaganfalls auf der Stroke Unit. Nervenarzt 68:122-128
8. Block F, Jaspers RMA, Heim C, Sontag K-H (1990) S-emopamil ameliorates ischemic brain damage in rats: histological and behavioural approaches. Life Sci 47:1511-1518
9. Block F, Pergande G, Schwarz M (1997) Flupirtine reduces functional deficits and neuronal damage after global ischemia. Brain Res 754:279-284
10. Block F, Schmitt W, Schwarz M (1995) The antioxidant LY231617 ameliorates ischemic functional and morphological sequelae induced by global ischemia in rats. Brain Res 694:308-311
11. Block F, Schwarz M (1996) Dextromethorphan reduces functional deficits and neuronal damage after global ischemia in rats. Brain Res 741:153-159
12. Block F, Schwarz M (1998) Global ischemic neuronal damage relates to behavioural deficits: a pharmacological approach. Neuroscience 82:791-803
13. Block F, Tondar A, Schmidt W, Schwarz M (1997) Delayed treatment with rolipram protects against neuronal damage following global ischemia in rats. NeuroReport 8:3829-3832
14. Buchan A, Pulsinelli WA (1990) Hypothermia but not the N-methyl-D-aspartate antagonist, MK-801, attenuates neuronal damage in gerbils subjected to transient global ischemia. J Neurosci 10:321-326
15. Bullock R, Zauner A, Woodward J, Young HF (1995) Massive persistent release of excitatory amino acids following human occlusive stroke. Stroke 26:2187-2189
16. Chiu D, Krieger D, Villar-Cordova C, Kasner SE, Morgenstern LB, Bratina PL, Yatsu FM, Grotta JC (1998) Intravenous tissue plasminogen activator for acute ischemic stroke. Stroke 29:18-22
17. Choi DW, Maulucci-Gedde MA, Kriegstein AR (1987) Glutamate neurotoxicity in cortical cell culture. J Neurosci 7:357-368
18. Chopp M, Zhang RL, Chen H, Li Y, Jiang N, Rusche JR (1994) Postischemic administration of an anti-Mac-1 antibody reduces ischemic cell damage after transient middle cerebral artery occlusion in rats. Stroke 25:869-876
19. Coimbra C, Drake M, Boris-Möller F, Wieloch T (1996) Long-lasting neuroprotective effect of postischemic hypothermia and treatment with an anti-inflammatory/antipyretic drug. Stroke 27:1578-1585
20. Corbett D, Evans S, Thomas C, Want D, Jonas RA (1990) MK-801 reduces cerebral ischemia by inducing hypothermia. Brain Res 515:300-304
21. Davis SM, Albers GW, Diener HC, Lees KR, Norris J (1997) Termination of acute stroke studies involving selfotel treatment. Lancet 349:32
22. Dawson DA, Martin D, Hallenbeck JM (1996) Inhibition of tumor necrosis factor-alpha reduces focal cerebral ischemic injury in the spontaneously hypertensive rat. Neurosci Lett 218:41-44
23. DeRyck M, Keermaeckers R, Duytschaever H, Claes C, Clincke G, Janssen M, Vanreet G (1996) Lubeluzole protects sensorimotor function and reduces infarct size in a photochemical stroke model in rats. J Pharmacol Exp Ther 279:748-758
24. Diener HC (1997) Primär- und Sekundär-prevention des ischämischen Insultes. Dtsch Ärztebl 94:A2195-2201
25. Diener HC, Hacke W, Hennerici M, Radberg J, Hanston L, DeKeyser J (1996) Lubeluzole in acute ischemic stroke. Stroke 27:76-81
26. Dietrich WD, Busto R, Alonso O, Globus MY-T, Ginsberg MD (1993) Intraischemic but not postischemic brain hypothermia protects chronically following global forebrain ischemia in rats. J Cereb Blood Flow Metab 13:541-549
27. DiFiglia M (1990) Excitotoxic injury of the neostriatum: a model for Huntington's disease.Trends Neurosci 13:286-289
28. Dorman PJ, Counsell CE, Sandercock PAG (1996) Recently developed neuroprotective therapies for actue stroke. CNS Drugs 5:457-474
29. Du C, Hu R, Csernansky CA, Hsu CY, Choi DW (1996) Very delayed infarction after mild focal cerebral ischemia: a role for apoptosis. J Cereb Blood Flow Metab 16:195-201
30. Du C, Hu R, Csernansky CA, Liu X, Hsu CY, Choi DW (1996) Additive neuroprotective effects of dextrorphan and cycloheximide in rats subjected to transient focal cerebral ischemia. Brain Res 718:233-236
31. Duverger D, MacKenzie ET (1988) The quantification of cerebral infarction following focal ischemia in the rat: influence of strain, arterial pressure, blood glucose concentration, and age. J Cereb Blood Flow Metab 8:449-461
32. Fix AS, Horn JW, Wightman KA, Johnson CA, Long GG, Storts RW, Farber N, Wozniak DF, Olney JW (1993) Neuronal vacuolization and necrosis induced by the noncompetitive N-methyl-D-aspartate (NMDA) antagonist MK(+)801 (dizocilpine maleate): a light and electron microscopic evaluation of the rat retrosplenial cortex. Exp Neurol 123:204-215
33. Giroux C, Scatton B (1996) Ischemic stroke: treatment on the horizon. Eur Neurol 36:61-64
34. Graham SH, Chen J, Lan JQ, Simon RP (1996) A dose-response study of neuroprotection using the AMPA antagonist NBQX in rat focal cerebral ischemia. J Pharmacol Exp Ther 276:1-4
35. Granger DN, Kvietys PR (1993) Leukocyte-endothelial cell adhesion induced by ischemia and reperfusion. Can J Physiol Pharmacol 71:67-75
36. Grieco G, d'Hollosy M, Culliford AT, Jonas S (1996) Evaluating neuroprotective agents for clinical anti-ischemic benefit using neurological and neuropsychological changes after cardiac surgery under cardiopulmonary bypass. Stroke 27:858-874
37. Grogaard B, Surer L, Gerdin B, Arfors KE (1989) Delayed hypoperfusion after incomplete forebrain ischemia in the rat. The role of polymorphonuclear leukocytes. J Cereb Blood Flow Metab 9:500-505
38. Grotta J (1997) Lubeluzole treatment of acute ischemic stroke. Stroke 28:2338-2346
39. Hallenbeck JM, Dukta AJ, Tanishima T, Kochanek PM, Kumaroo KK, Thompson CB, Obrenovitch TP, Contreras TJ (1986) Polymorphonuclear leukocyte accumulation in brain regions with low blood flow during the early postischemic period. Stroke 17:246-253
40. Hockenbery D (1995) Defining apoptosis. Am J Pathol 146:16-19
41. Hossmann K-A (1994) Viability thresholds and the penumbra of focal ischemia. Ann Neurol 36:557-565
42. Iadecola C, Zhang F, Casey R, Ross ME (1996) Knockout mice lacking the inducible nitric oxide synthase gene are resistant to cerebral ischemia. Soc Neurosci Abstr 22:1693
43. ladecola C, Zhang F, Xu S, Casey R, Ross ME (1995) Inducible nitric oxide synthase gene expression in brain following cerebral ischemia. J Cereb Blood Flow Metab 15:378-384
44. James A (1997) Stroke treatment trials yield disappointing results. Lancet 349:1673
45. Kato H, Araki T, Itoyama Y, Kogure K (1995) Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil. Eur J Pharmacol 272:107-110
46. Katsuta K, Nakanishi H, Shirakawa K, Yoshida K, Takagi K, Tamura A (1995) The neuroprotective effect of the novel noncompetitive NMDA antagonist, FR115427, in focal cerebral ischemia in rats. J Cereb Blood Flow Metab 15:345-348
47. Kirino T (1982) Delayed neuronal death in the gerbil hippocampus following ischemia. Brain Res 239:57-69
48. Lachmann LB, Brown DC, Dinarello CA (1987) Growth promoting effect of recombinant IL-1 and TNF for human astrocyte cell line. J Immunol 138:2913-2916
49. Lahtinen H, Koistinabo J, Kauppinen R, Haapalinna A, Keinänen R, Sivenius J (1997) Selegeline treatment after transient global ischemia in gerbils enhances the survival of CA1 pyramidal cells in the hippocampus. Brain Res 757:260-267
50. Lassen NA, Losen TS, Hojgaard K, Skriver E (1983) Incomplete infarction: a CT-negative irreversible ischemic brain lesion. J Cereb Blood Flow Metab 3[Suppl 1]:S602-S603
51. Li H, Buchan AM (1993) Treatment with an AMPA antagonist 12 hours following severe normothermic forebrain ischemia prevents CA1 neuronal injury. J Cereb Blood Flow Metab 13:933-939
52. Li H, Buchan AM (1995) Progressive loss of hippocampal CA1 neurons following transient forebrain ischemia. J Cereb Blood Flow Metab 15[Suppl 1]:S 246
53. Li Y, Chopp M, Jiang N, Yao F, Zaloga C (1995) Temporal profile of in situ DNA fragmentation after transient middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 15:389-397
54. Limburg M (1996) Very early nimodipine use in stroke - the first 100 patients - cooperation between GP's and neurologists. Stroke 27:172
55. Linnik MD, Zahos P, Geschwind MD, Federoff HJ (1995) Expression of bcl-2 from a defective herpes simplex virus-1 vector limits neuronal death in focal cerebral ischemia. Stroke 26:1670-1675
56. Linnik MD, Zobrist RH, Hatfield MD (1993) Evidence supporting a role for programmed cell death in focal cerebral ischemia in rats. Stroke 24:2002-2008
57. Loddick SA, Rothwell NJ (1996) Neuroprotective effects of human recombinant interleukin-1 receptor antagonist in focal cerebral ischaemia in the rat. J Cereb Blood Flow Metab 16:932-940
58. Longa E, Weinstein PR, Carlson S, Cummins R (1989) Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 20:84-91
59. Matsumiya N, Koehler RC, Kirsch JR, Traystman RJ (1991) Conjugated superoxide dismutase reduces extent of caudate injury after transient focal ischemia in cats. Stroke 22:1193-1200
60. Memezawa H, Smith M-L, Siesjö BK (1992) Penumbral tissues salvaged by reperfusion following middle cerebral artery occlusion in rats. Stroke 23:552-559
61. Mies G, Auer LM, Ebhardt G, Traupe H, Heiss WD (1983) Flow and neuronal density in tissue surrounding chronic infarction. Stroke 14:22-27
62. Minato H, Kikuta C, Fujitani B, Masuda Y (1997) Protective effect of zonisamide, an antiepileptic drug, against transient focal cerebral ischemia with middle cerebral artery occlusion-reperfusion in rats. Epilepsia 38:975-980
63. Mohr JP, Orgogozo JM, Harrison MJG, Wahlgren NG, Gelmers JH, Martinez-Vila E, Dycka J, Tettenborn D (1994) Meta-analysis of oral nimodipine trials in acute ischemie stroke. Cerebrovasc Dis 4:197-203
64. Monaghan DT, Bridges RJ, Cotman CW (1989) The excitatory amino acid receptors: their classes, pharmacology, and distinct properties in the function of the central nervous system. Annu Rev Pharmacol Toxicol 29:365-402
65. Morimoto T, Globus MY, Busto R, Martinez E, Ginsberg MD (1996) Simultaneous measurement of salicylate hydroxylation and glutamate release in the penumbral cortex following transient middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 16:92-99
66. Mossakowski MJ, Gadamski R (1990) Nimodipine prevents delayed neuronal death of sector CA1 pyramidal cells in short-term forebrain ischemia in Mongolian gerbils. Stroke 21[Suppl IV]:120-122
67. Nathan C, Xie Q-W (1994) Nitric oxide synthases: roles, tolls and controls. Cell 78:915-918
68. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group (1995) Tissue plasminogen activator for acute ischemic stroke. N Engl J Med 333:1581-1587
69. Obrenovitch JP, Urenjak J (1997) Altered glutamatergic transmission in neurological disorders: from high extracellular glutamate to excessive synaptic efficacy. Prog Neurobiol 51:39-87
70. Olney JW (1969) Brain lesions, obesity and other disturbances in mice treated with monosodium glutamate. Science 164:719-721
71. Osuga H, Hakim AM (1994) Relevance of interstitial glutamate to selective vulnerability in focal cerebral ischemia. J Cereb Blood Flow Metab 14:343-347
72. Ozyurt E, Graham DI, Woodruff GN, McCulloch J (1988) Protective effect of the glutamate antagonist, MK-801, in focal cerebral ischemia in the cat. J Cereb Blood Flow Metab 8:138-143
73. Peters O, Back T, Lindauer U, Busch C, Megow D, Dreier J, Dirnagl U (1998) Increased formation of reactive oxygen species after permanent and reversible middle cerebral artery occlusion in the rat. J Cereb Blood Flow Metab 18:196-205
74. Portera-Cailliau C, Hedreen JC, Price DL, Koliatsos VE (1995) Evidence for apoptotic cell death in Huntington's disease and excitotoxic animal models. J Neurosci 15:3775-3787
75. Pulsinelli WA, Brierley JB, Plum F (1982) Temporal profile of neuronal damage in a model of transient forebrain ischemia. Ann Neurol 11:491-498
76. Quagliarello VJ, Wispelwey B, Long WJ, Scheld WM (1991) Recombinant human interleukin-1 induces meningitis and blood brain barrier injury in the rat. J Clin Invest 87:1360-1366
77. The RANTTAS Investigators (1996) A randomized trial of tirilazad mesylate in patients with acute stroke (RANTTAS). Stroke 27:1453-1458
78. Roda JM, Carceller F, Diez-Tejedor E, Avendano C (1995) Reduction of infarct size by intra-arterial nimodipine administered at reperfusion in a rat model of partially reversible brain focal ischemia. Stroke 26:1888-1892
79. Roine RO, Raininko R, Erkinjuntti T, Ylikoski A, Kaste M (1993) Magnetic resonance findings associated with cardiac arrest. Stroke 24:1005-1014
80. Saito K, Suyama K, Nishida K, Sei Y, Basile A (1996) Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain. Neurosci Lett 206:149-152
81. Sakamoto N, Kogure K, Kato H, Ohtomo H (1986) Disturbed Ca2+ homeostasis in the gerbil hippocampus following brief transient ischemia. Brain Res 364:372-376
82. Sato PH, Hall ED (1992) Tirilazad protects vitamins C and E in brain ischemia-reperfusion injury. J Neurochem 58:2263-2268
83. Sauer D, Weber E, Lüönd G, Da Silva F, Allegrini PR (1995) The competitive NMDA antagonist CGP 40116 permanently reduces brain damage after middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 15:602-610
84. Saunders J Jr (1966) Death in embryonic systems. Science 154:604-612
85. Sauter A, Rudin M (1995) Strain-dependent drug effects in rat middle cerebral artery occlusion model of stroke. J Pharmacol Exp Therapeutics 274:1008-1013
86. Siesjö BK (1992) Pathophysiology and treatment of focal cerebral ischemia. Part I: pathophysiology. J Neurosurg 77:169-184
87. Smith M-L, Auer RN, Siesjö BK (1984) The density and distribution of ischemic brain injury in the rat following 2-10 min of forebrain ischemia. Acta Neuropathol 64:319-332
88. Smith SE, Meldrum BS (1995) Cerebro-protective effect of lamotrigine after focal ischemia in rats. Stroke 26:117-122
89. Spranger M, Lindholm D, Bandtlow C, Heimann G, Naher-Noe M, Thoenen H (1990) Regulation of nerve growth factor (NGF) synthesis in the rat central nervous system: comparison between effects of interleukin-1 and various growth factors in astrocytes culture and in vivo. Eur J Neurosci 2:69-76
90. Steppuhn KG, Turski L (1993) Modulation of the seizure threshold for excitatory amino acids in mice by antiepileptic drugs and anticonvulsants. J Pharmacol Exp Ther 265:1063-1070
91. Sullivan GW, Carper HT, Sullivan J, Murata T, Mandell G (1989) Both recombinant interleukin-1 (beta) and purified human monocyte interleukin-1 prime human neutrophils for increased oxidative activity and promote neutrophil spreading. J Leukocyte Biol 45:389-395
92. Sutherland GR, Dix GA, Auer RN (1996) Effect of age in rodent models of focal and forebrain ischemia. Stroke 27:1663-1668
93. Tamura A, Graham DI, McCulloch J, Teasdale GM (1981) Focal cerebral ischemia in the rat. I. Description of technique and early neuropathological consequences following middle cerebral artery occlusion. J Cereb Blood Flow Metab 1:53-60
94. Tanaka G, Miyasaka Y, Yada K, Ohwada T, Kameya T (1995) Basic fibroblast growth factor increases regional cerebral blood flow and reduces infarct size after experimental ischemia in a rat model. Stroke 26:2154-2159
95. Valtysson J, Hillered L, Andine P, Hagberg H, Persson L (1994) Neuropathological endpoints in experimental stroke pharmacotherapy: the importance of both early and late evaluation. Acta Neurochir Wien 129:58-63
96. Wahlgren NG, MacMahon D, De Keyser J, Indredavik B, Ryman T for the INWEST study group (1994) Intravenous nimodipine West European Stroke (INWEST) of nimodipine in treatment of acute ischaemic stroke. Cerebrovasc Dis 4:204-210
97. Wang Y, Lin S-Z, Chiou A-L, Williams LR, Hoffer BJ (1997) Glial cell line-derived neurotrophic factor protects against ischemia-induced injury in the cerebral cortex. J Neurosci 17:4341-4348
98. Yenari MA, Palmer JT, Sun GH, de Crespigny A, Moseley ME, Steinberg GK (1996) Time-course and treatment response with SNX-111, an N-type calcium channel blocker, in a rodent model of focal cerebral ischemia using diffusion-weighted MRI. Brain Res 739:36-45