Thalamic microglial activation in ischemic stroke detected in vivo by PET and [(11)C]PK11195

Neurology

Volumn 55, Issue 7, 2000, Pages 1052-1054

  Pappata, S ^a,f   Levasseur, M ^c   Gunn, R N ^d   Myers, R ^d   Crouzel, C ^b   Syrota, A ^b   Jones, T ^d   Kreutzberg, G W ^e   Banati, R B ^d  

^a INSERM   (France)

^b SERVICE HOSPITALIER FRÉDÉRIC JOLIOT   (France)

^c Service de Neurologie   (France)

^d HAMMERSMITH HOSPITAL   (United Kingdom)

^e MAX PLANCK INSTITUTE OF NEUROBIOLOGY   (Germany)

^f DIF   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON 11; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE;

ADULT; AGED; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BRAIN ISCHEMIA; CEREBROVASCULAR DISEASE; CLINICAL ARTICLE; FEMALE; HUMAN; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; STROKE; THALAMUS;

EID: 0034633791     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.55.7.1052     Document Type: Article

References (10)

1. Imaging of primary and remote ischaemic and excitotoxic brain lesions. An autoradiographic study of peripheral type benzodiazepine binding sites in the rat and cat
2. Macrophage and astrocyte populations in relation to [3H]PK 11195 binding in rat cerebral cortex following a local ischaemic lesion
3. Temporal changes in glial fibrillary acidic protein messenger RNA and [3H]PK11195 binding in relation to imidazoline-I2-receptor and alpha 2-adrenoceptor binding in the hippocampus following transient global forebrain ischaemia in the rat
4. PK ('peripheral benzodiazepine')-binding sites in the CNS indicate early and discrete brain lesions: Microautoradiographic detection of [3H]PK11195 binding to activated microglia
5. Characterisation of the peripheral-type benzodiazepine receptors in cultured astrocytes: Evidence for multiplicity
6. [3H]PK 11195 and the localisation of secondary thalamic lesions following focal ischaemia in rat motor cortex
7. 11C] methyl-N-(methyl-1 propyl), (chloro-2 phenyl)-1 isoquinoline carboxamide-3 (PK11195): A new ligand for peripheral benzodiazepine receptors
8. Parametric imaging of ligand-receptor binding in PET using a simplified reference region model
9. 11C](R)-PK11195 PET-imaging of activated microglia in vivo in Rasmussen's encephalitis
10. Microglia: A sensor for pathological events in the CNS