Regulation of splicing: The importance of being translatable

RNA

Volumn 10, Issue 1, 2004, Pages 1-4

  Miriami, Elana ^a   Sperling, Ruth ^a   Sperling, Joseph ^b   Motro, Uzi ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^b WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

Latent 5 splice sites; Splice site selection; Stop codons; Suppression of splicing (SOS); Translatability

Indexed keywords

MESSENGER RNA; MESSENGER RNA PRECURSOR;

BINDING SITE; GENE CONTROL; HUMAN; INTRON; NONHUMAN; OPEN READING FRAME; PRIORITY JOURNAL; REVIEW; RNA SEQUENCE; RNA SPLICING; RNA TRANSLATION; STOP CODON;

HUMANS; INTRONS; OPEN READING FRAMES; PROTEIN BIOSYNTHESIS; RNA PRECURSORS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA SPLICING; RNA, MESSENGER;

EID: 0347623203     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1261/rna.5112704     Document Type: Review

References (9)

1. Clark, F., and Thanaraj, T.A. 2002. Categorization and characterization of transcript-confirmed constitutively and alternatively spliced introns and exons from human. Hum. Mol. Genet. 11: 451-464.
2. Engelbrecht, J., Knudsen, S., and Brunak, S. 1992. G+C-rich tract in 5′ end of human introns. J. Mol. Biol. 227: 108-113.
3. Li, B., Wachtel, C., Miriami, E., Yahalom, G., Friedlander, G., Sharon, G., Sperling, R., and Sperling, J. 2002. Stop codons affect 5′ splice site selection by surveillance of splicing. Proc. Natl. Acad. Sci. 99: 5277-5282.
4. Mendell, J.T., ap Rhys, C.M.J., and Dietz, H.C. 2002. Separable roles for rent1/hUpf1 in altered splicing and decay of nonsense transcripts. Science 298: 419-422.
5. Miriami, E., Sperling, J., and Sperling, R. 1994. Heat shock affects 5′ splice site selection, cleavage and ligation of CAD pre-mRNA in hamster cells, but not its packaging in lnRNP particles. Nucleic Acids Res. 22: 3084-3091.
6. Miriami, E., Motro, U., Sperling, J., and Sperling, R. 2002. Conservation of an open-reading frame as an element affecting 5′ splice site selection. J. Struct. Biol. 140: 116-122.
7. Nussinov, R. 1989. Conserved signals around the 5′ splice sites in eukaryotic nuclear precursor mRNAs: G-runs are frequent in the introns and C in the exons near both 5′ and 3′ splice sites. J. Biomol. Struct. Dyn. 6: 985-1000.
8. Wang, J., Hamilton, J.I., Carter, M.S., Li, S., and Wilkinson, M.F. 2002. Alternatively spliced TCR mRNA induced by disruption of reading frame. Science 297: 108-110.
9. Zhang, X., Lee, J., and Chasin, L.A. 2003. The effect of nonsense codons on splicing: A genomic analysis. RNA 9: 637-639.