Efficient downregulation of immunoglobulin μ mRNA with premature translation-termination codons requires the 5′-half of the VDJ exon

Nucleic Acids Research

Volumn 32, Issue 11, 2004, Pages 3304-3315

  Bühler, Marc ^a   Paillusson, Alexandra ^a   Mühlemann, Oliver ^a  

^a UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN MU CHAIN; MESSENGER RNA; IMMUNOGLOBULIN FRAGMENT;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; EXON; GENE DELETION; GENE INSERTION; GENE LOCATION; GENETIC PROCEDURES; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RNA TRANSLATION; SEQUENCE ANALYSIS; STOP CODON; ANIMAL; CHEMISTRY; GENE REARRANGEMENT; GENETICS; HELA CELL; HYBRIDOMA; IMMUNOGLOBULIN VARIABLE REGION; METABOLISM; PROTEIN SYNTHESIS; REGULATORY RNA SEQUENCE; RNA STABILITY;

ANIMALS; CODON, TERMINATOR; DOWN-REGULATION; EXONS; GENE REARRANGEMENT, B-LYMPHOCYTE, HEAVY CHAIN; HELA CELLS; HUMANS; HYBRIDOMAS; IMMUNOGLOBULIN FRAGMENTS; IMMUNOGLOBULIN MU-CHAINS; IMMUNOGLOBULIN VARIABLE REGION; MICE; PROTEIN BIOSYNTHESIS; REGULATORY SEQUENCES, RIBONUCLEIC ACID; RNA STABILITY; RNA, MESSENGER; SEQUENCE DELETION;

EID: 3042796497     PISSN: 03051048     EISSN: None     Source Type: Journal    
DOI: 10.1093/nar/gkh651     Document Type: Article

References (31)

1. Hentze,M.W. and Kulozik,A.E. (1999) A perfect message: RNA surveillance and nonsense-mediated decay. Cell, 96, 307-310.
2. Li,S. and Wilkinson,M.F. (1998) Nonsense surveillance in lymphocytes? Immunity, 8, 135-141.
3. Maquat,L.E. (2004) Nonsense-mediated mRNA decay: splicing, translation and mRNP dynamics. Nature Rev. Mol. Cell Biol., 5, 89-99.
4. Mendell,J.T. and Dietz,H.C. (2001) When the message goes awry. Disease-producing mutations that influence mRNA content and performance. Cell, 107, 411-414.
5. Wilusz,C.J., Wang,W. and Peltz,S.W. (2001) Curbing the nonsense: the activation and regulation of mRNA surveillance. Genes Dev., 15, 2781-2785.
6. Belgrader,P. and Maquat,L.E. (1994) Nonsense but not missense mutations can decrease the abundance of nuclear mRNA for the mouse major urinary protein, while both types of mutations can facilitate exon skipping. Mol. Cell. Biol., 14, 6326-6336.
7. Cheng,J., Belgrader,P., Zhou,X. and Maquat,L.E. (1994) Introns are cis effectors of the nonsense-codon-mediated reduction in nuclear mRNA abundance. Mol. Cell. Biol., 14, 6317-6325.
8. Zhang,J. and Maquat,L.E. (1997) Evidence that translation reinitiation abrogates nonsense-mediated mRNA decay in mammalian cells. EMBO J., 16, 826-833.
9. Zhang,J., Sun,X., Qian,Y. and Maquat,L.E. (1998) Intron function in the nonsense-mediated decay of beta-globin mRNA: indications that pre-mRNA splicing in the nucleus can influence mRNA translation in the cytoplasm. RNA, 4, 801-815.
10. Thermann,R., Neu-Yilik,G., Deters,A., Frede,U., Wehr,K., Hagemeier,C., Hentze,M.W. and Kulozik,A.E. (1998) Binary specification of nonsense codons by splicing and cytoplasmic translation. EMBO J., 17, 3484-3494.
11. Nagy,E. and Maquat,L.E. (1998) A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance. Trends Biochem. Sci., 23, 198-199.
12. Le Hir,H., Izaurralde,E., Maquat,L.E. and Moore,M.J. (2000) The spliceosome deposits multiple proteins 20-24 nucleotides upstream of mRNA exon-exon junctions. EMBO J., 19, 6860-6869.
13. Le Hir,H., Moore,M.J. and Maquat,L.E. (2000) Pre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctions. Genes Dev., 14, 1098-1108.
14. Le Hir,H., Gatfield,D., Izaurralde,E. and Moore,M.J. (2001) The exon-exon junction complex provides a binding platform for factors involved in mRNA export and nonsense-mediated mRNA decay. EMBO J., 20, 4987-4997.
15. Lykke-Andersen,J. (2001) mRNA quality control: marking the message for life or death. Curr. Biol., 11, R88-R91.
16. Wilusz,C.J., Wormington,M. and Peltz,S.W. (2001) The cap-to-tail guide to mRNA turnover. Nature Rev. Mol. Cell Biol., 2, 237-246.
17. Schell,T., Kulozik,A.E. and Hentze,M.W. (2002) Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway. Genome Biol., 3, REVIEWS 1006.
18. Dreyfuss,G., Kim,V.N. and Kataoka,N. (2002) Messenger-RNA-binding proteins and the messages they carry. Nature Rev. Mol. Cell Biol., 3, 195-205.
19. Gudikote,J.P. and Wilkinson,M.F. (2002) T-cell receptor sequences that elicit strong down-regulation of premature termination codon-bearing transcripts. EMBO J., 21, 125-134.
20. Carter,M.S., Li,S. and Wilkinson,M.F. (1996) A splicing-dependent regulatory mechanism that detects translation signals. EMBO J., 15, 5965-5975.
21. Wang,J., Gudikote,J.P., Olivas,O.R. and Wilkinson,M.F. (2002) Boundary-independent polar nonsense-mediated decay. EMBO Rep., 15, 15.
22. Connor,A., Wiersma,E. and Shulman,M.J. (1994) On the linkage between RNA processing and RNA translatability. J. Biol. Chem., 269, 25178-25184.
23. Ochi,A., Hawley,R.G., Hawley,T., Shulman,M.J., Traunecker,A., Kohler,G. and Hozumi,N. (1983) Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells. Proc. Natl Acad. Sci. USA, 80, 6351-6355.
24. Penalva,L.O., Lallena,M.J. and Valcarcel,J. (2001) Switch in 3′ splice site recognition between exon definition and splicing catalysis is important for sex-lethal autoregulation. Mol. Cell. Biol., 21, 1986-1996.
25. Kohler,G. and Milstein,C. (1976) Derivation of specific antibody-producing tissue culture and tumor lines by cell fusion. Eur. J. Immunol., 6, 511-519.
26. Muhlemann,O., Mock-Casagrande,C.S., Wang,J., Li,S., Custodio,N., Carmo-Fonseca,M., Wilkinson,M.F. and Moore,M.J. (2001) Precursor RNAs harboring nonsense codons accumulate near the site of transcription. Mol. Cell, 8, 33-43.
27. Sun,X., Moriarty,P.M. and Maquat,L.E. (2000) Nonsense-mediated decay of glutathione peroxidase 1 mRNA in the cytoplasm depends on intron position. EMBO J., 19, 4734-4744.
28. Zuker,M. (2003) Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res., 31, 3406-3415.
29. Enssle,J., Kugler,W., Hentze,M.W. and Kulozik,A.E. (1993) Determination of mRNA fate by different RNA polymerase II promoters. Proc. Natl Acad. Sci. USA, 90, 10091-10095.
30. Buzina,A. and Shulman,M.J. (1999) Infrequent translation of a nonsense codon is sufficient to decrease mRNA level. Mol. Biol. Cell, 10, 515-524.
31. Baumann,B., Potash,M.J. and Kohler,G. (1985) Consequences of frameshift mutations at the immunoglobulin heavy chain locus of the mouse. EMBO J., 4, 351-359.