Redox regulation of neutrophil apoptosis and the systemic inflammatory response syndrome

Clinical Science

Volumn 108, Issue 5, 2005, Pages 413-424

  Melley, Daniel D ^a   Evans, Timothy W ^a   Quinlan, Gregory J ^a  

^a ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; Inflammation; Neutrophil; Surgery; Systemic inflammatory response syndrome

Indexed keywords

CASPASE; NITRIC OXIDE; TRANSITION ELEMENT;

APOPTOSIS; CARDIOPULMONARY BYPASS; CRITICAL ILLNESS; INCIDENCE; LEUKOCYTE ACTIVATION; MITOCHONDRION; NEUTROPHIL; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; SEPSIS; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

APOPTOSIS; CARDIOPULMONARY BYPASS; HUMANS; NEUTROPHIL ACTIVATION; NEUTROPHILS; OXIDATION-REDUCTION; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

EID: 18844456255     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20040228     Document Type: Review

References (137)

1. Levy, J. H. and Tanaka, K. A. (2003) Inflammatory response to cardiopulmonary bypass. Ann. Thorac. Surg. 75, S715-S720
2. (1992) American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference: definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. Crit. Care Med. 20, 864-874
3. Nystrom, P. O. (1998) The systemic inflammatory response syndrome: definitions and aetiology. J. Antimicrob. Chemother. 41 (Suppl. A), 1-7
4. Brun-Buisson, C. (2000) The epidemiology of the systemic inflammatory response. Intensive Care Med. 26 (Suppl. 1), S64-S74
5. Rangel-Frausto, M. S., Pittet, D., Costigan, M., Hwang, T., Davis, C. S. and Wenzel, R. P. (1995) The natural history of the systemic inflammatory response syndrome (SIRS). A prospective study. JAMA, J. Am. Med. Assoc. 273, 117-123
6. Talmor, M., Hydo, L. and Barie, P. S. (1999) Relationship of systemic inflammatory response syndrome to organ dysfunction, length of stay, and mortality in critical surgical illness: effect of intensive care unit resuscitation. Arch. Surg. 134, 81-87
7. Abraham, E. (1999) Why immunomodulatory therapies have not worked in sepsis. Intensive Care Med. 25, 556-566
8. Vincent, J. L. (1997) Dear SIRS, I'm sorry to say that I don't like you. Crit. Care Med. 25, 372-374
9. Alberti, C., Brun-Buisson, C., Goodman, S. V. et al. (2003) Influence of systemic inflammatory response syndrome and sepsis on outcome of critically ill infected patients. Am. J. Respir. Crit. Care Med. 168, 77-84
10. Abraham, E., Matthay, M. A., Dinarello, C. A. et al. (2000) Consensus conference definitions for sepsis, septic shock, acute lung injury, and acute respiratory distress syndrome: time for a reevaluation. Crit. Care Med. 28, 232-235
11. Dellinger, R. P. and Bone, R. C. (1998) To SIRS with love. Crit. Care Med. 26, 178-179
12. Cremer, J., Martin, M., Redl, H. et al. (1996) Systemic inflammatory response syndrome after cardiac operations. Ann. Thorac. Surg. 61, 1714-1720
13. Hensel, M., Volk, T, Docke, W. D. et al. (1998) Hyperprocalcitonemia in patients with noninfectious SIRS and pulmonary dysfunction associated with cardiopulmonary bypass. Anesthesiology 89, 93-104
14. Meisner, M., Rauschmayer, C., Schmidt, J. et al. (2002) Early increase of procalcitonin after cardiovascular surgery in patients with postoperative complications. Intensive Care Med. 28, 1094-1102
15. Taylor, K. M. (1996) SIRS-the systemic inflammatory response syndrome after cardiac operations. Ann. Thorac. Surg. 61, 1607-1608
16. Abela, C. B. and Homer-Vanniasinkham, S. (2003) Clinical implications of ischaemia-reperfusion injury. Pathophysiology 9, 229-240
17. Zahler, S., Massoudy, P., Hard, H., Hahnel, C., Meisner, H. and Becker, B. F. (1999) Acute cardiac inflammatory responses to postischemic reperfusion during cardiopulmonary bypass. Cardiovasc. Res. 41, 722-730
18. Faymonville, M. E., Pincemail, J., Duchateau, J. et al. (1991) Myeloperoxidase and elastase as markers of leukocyte activation during cardiopulmonary bypass in humans. J. Thorac. Cardiovasc. Surg. 102, 309-317
19. Rinder, C. S., Bonan, J. L., Rinder, H. M., Mathew, J., Hines, R. and Smith, B. R. (1992) Cardiopulmonary bypass induces leukocyte-platelet adhesion. Blood 79, 1201-1205
20. Kirklin, J. K., Westaby, S., Blackstone, E. H., Kirklin, J. W., Chenoweth, D. E. and Pacifico, A. D. (1983) Complement and the damaging effects of cardiopulmonary bypass. J. Thorac. Cardiovasc. Surg. 86, 845-857
21. Moat, N. E., Shore, D. F. and Evans, T. W. (1993) Organ dysfunction and cardiopulmonary bypass: the role of complement and complement regulatory proteins. Eur. J. Cardiothorac. Surg. 7, 563-573
22. Hunt, B. J., Parratt, R. N., Segal, H. C., Sheikh, S., Kallis, P. and Yacoub, M. (1998) Activation of coagulation and fibrinolysis during cardiothoracic operations. Ann. Thorac. Surg. 65, 712-718
23. Brett, S. J., Quinlan, G. J., Mitchell, J., Pepper, J. R. and Evans, T. W. (1998) Production of nitric oxide during surgery involving cardiopulmonary bypass. Crit. Care Med. 26, 272-278
24. Hirai, S. (2003) Systemic inflammatory response syndrome after cardiac surgery under cardiopulmonary bypass. Ann. Thorac. Cardiovasc. Surg. 9, 365-370
25. Sablotzki, A., Friedrich, I., Muhling, J. et al. (2002) The systemic inflammatory response syndrome following cardiac surgery: different expression of proinflammatory cytokines and procalcitonin in patients with and without multiorgan dysfunctions. Perfusion 17, 103-109
26. el-Barbary, M. and Khabar, K. S. (2002) Soluble tumor necrosis factor receptor p55 predicts cytokinemia and systemic inflammatory response after cardiopulmonary bypass. Crit. Care Med. 30, 1712-1716
27. Oudemans-van Straaten, H. M., Jansen, P. G., Hoek, F. J. et al. (1996) Intestinal permeability, circulating endotoxin, and postoperative systemic responses in cardiac surgery patients. J. Cardiothorac. Vasc. Anesth. 10, 187-194
28. Gutteridge, J. M. C. and Halliwell, B. (1998) Free Radicals in Biology and Medicine. 3rd edn, Oxford University Press, Oxford
29. Babior, B. M. (1991) The respiratory burst oxidase and the molecular basis of chronic granulomatous disease. Am. J. Hematol. 37, 263-266
30. Griendling, K. K., Sorescu, D. and Ushio-Fukai, M. (2000) NAD(P)H oxidase: role in cardiovascular biology and disease. Circ. Res. 86, 494-501
31. Quinlan, G. J., Lamb, N. J., Evans, T. W. and Gutteridge, J. M. (1996) Plasma fatty acid changes and increased lipid peroxidation in patients with adult respiratory distress syndrome. Crit. Care Med. 24, 241-246
32. Kumagai, T., Matsukawa, N., Kaneko, Y., Kusumi, Y., Mitsumata, M. and Uchida, K. (2004) A lipid peroxidation-derived inflammatory mediator: identification of 4-hydroxy-2-nonenal as a potential inducer of cyclooxygenase-2 in macrophages. J. Biol. Chem. 279, 48389-48396
33. Forman, H. J., Torres, M. and Fukuto, J. (2002) Redox signaling. Mol. Cell. Biochem. 234-235, 49-62
34. Droge, W. (2002) Free radicals in the physiological control of cell function. Physiol. Rev. 82, 47-95
35. Finkel, T (2003) Oxidant signals and oxidative stress. Curr. Opin. Cell Biol. 15, 247-254
36. Haddad, J. J. (2003) Science review: redox and oxygen-sensitive transcription factors in the regulation of oxidant-mediated lung injury: role for hypoxia-inducible factor-1α. Crit. Care 7, 47-54
37. Quinlan, G. J., Evans, T. W. and Gutteridge, J. M. (1994) Oxidative damage to plasma proteins in adult respiratory distress syndrome. Free Radical Res. 20, 289-298
38. Quinlan, G. J., Evans, T. W. and Gutteridge, J. M. (1994) Linoleic acid and protein thiol changes suggestive of oxidative damage in the plasma of patients with adult respiratory distress syndrome. Free Radical Res. 20, 299-306
39. Quinlan, G. J., Lamb, N. J., Tilley, R., Evans, T. W. and Gutteridge, J. M. (1997) Plasma hypoxanthine levels in ARDS: implications for oxidative stress, morbidity, and mortality. Am. J. Respir. Crit. Care Med. 155, 479-484
40. Gutteridge, J. M., Quinlan, G. J., Mumby, S., Heath, A. and Evans, T. W. (1994) Primary plasma antioxidants in adult respiratory distress syndrome patients: changes in iron-oxidizing, iron-binding, and free radical-scavenging proteins. J. Lab. Clin. Med. 124, 263-273
41. Quinlan, G. J., Mumby, S., Lamb, N. J., Moran, L. K., Evans, T. W. and Gutteridge, J. M. (2000) Acute respiratory distress syndrome secondary to cardiopulmonary bypass: do compromised plasma iron-binding anti-oxidant protection and thiol levels influence outcome? Crit. Care Med. 28, 2271-2276
42. Messent, M., Sinclair, D. G., Quinlan, G. J., Mumby, S. E., Gutteridge, J. M. and Evans, T. W. (1997) Pulmonary vascular permeability after cardiopulmonary bypass and its relationship to oxidative stress. Crit. Care Med. 25, 425-429
43. Pepper, J. R., Mumby, S. and Gutteridge, J. M. (1995) Blood cardioplegia increases plasma iron overload and thiol levels during cardiopulmonary bypass. Ann. Thorac. Surg. 60, 1735-1740
44. Quinlan, G. J., Mumby, S., Pepper, J. and Gutteridge, J. M. (1994) Plasma 4-hydroxy-2-nonenal levels during cardiopulmonary bypass, and their relationship to the iron-loading of transferrin. Biochem. Mol. Biol. Int. 34, 1277-1282
45. Pepper, J. R., Mumby, S. and Gutteridge, J. M. (1994) Transient iron-overload with bleomycin-detectable iron present during cardiopulmonary bypass surgery. Free Radical Res. 21, 53-58
46. Lamb, N. J., Gutteridge, J. M., Baker, C., Evans, T. W. and Quinlan, G. J. (1999) Oxidative damage to proteins of bronchoalveolar lavage fluid in patients with acute respiratory distress syndrome: evidence for neutrophil-mediated hydroxylation, nitration, and chlorination. Crit. Care Med. 27, 1738-1744
47. Sittipunt, C., Steinberg, K. P., Ruzinski, J. T. et al. (2001) Nitric oxide and nitrotyrosine in the lungs of patients with acute respiratory distress syndrome. Am. J. Respir. Crit. Care Med. 163, 503-510
48. Gutteridge, J. M., Mumby, S., Quinlan, G. J., Chung, K. F. and Evans, T. W. (1996) Pro-oxidant iron is present in human pulmonary epithelial lining fluid: implications for oxidative stress in the lung. Biochem. Biophys. Res. Commun. 220, 1024-1027
49. Aldridge, A. J. (2002) Role of the neutrophil in septic shock and the adult respiratory distress syndrome. Eur. J. Surg. 168, 204-214
50. Aird, W. C. (2003) The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome. Blood 101, 3765-3777
51. Haslett, C. (1999) Granulocyte apoptosis and its role in the resolution and control of lung inflammation. Am. J. Respir. Crit. Care Med. 160, S5-S11
52. Akgul, C. and Edwards, S. W. (2003) Regulation of neutrophil apoptosis via death receptors. Cell. Mol. Life Sci. 60, 2402-2408
53. Israels, L. G. and Israels, E. D. (1999) Apoptosis. Stem Cells 17, 306-313
54. Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y. and Henson, P. M. (1998) Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-β, PGE2, and PAF. J. Clin. Invest. 101, 890-898
55. Fadok, V. A., Bratton, D. L., Guthrie, L. and Henson, P. M. (2001) Differential effects of apoptotic versus lysed cells on macrophage production of cytokines: role of proteases. J. Immunol. 166, 6847-6854
56. Jimenez, M. F., Watson, R. W., Parodo, J. et al. (1997) Dysregulated expression of neutrophil apoptosis in the systemic inflammatory response syndrome. Arch. Surg. 132, 1263-1269
57. Chello, M., Mastroroberto, P., Quirino, A. et al. (2002) Inhibition of neutrophil apoptosis after coronary bypass operation with cardiopulmonary bypass. Ann. Thorac. Surg. 73, 123-129
58. Akgul, C., Moulding, D. A. and Edwards, S. W. (2001) Molecular control of neutrophil apoptosis. FEBS Lett. 487, 318-322
59. Liles, W., Kiener, P., Ledbetter, J., Aruffo, A. and Klebanoff, S. (1996) Differential expression of Fas (CD95) and Fas ligand on normal human phagocytes: implications for the regulation of apoptosis in neutrophils. J. Exp. Med. 184, 429-440
60. Kasahara, Y., Iwai, K., Yachie, A. et al. (1997) Involvement of reactive oxygen intermediates in spontaneous and CD95(Fas/APO-1)-mediated apoptosis of neutrophils. Blood 89, 1748-1753
61. Murray, J., Barbara, J. A. J., Dunkley, S. A. et al. (1997) Regulation of neutrophil apoptosis by tumor necrosis factor-α: requirement for TNFR55 and TNFR75 for induction or apoptosis in vitro. Blood 90, 2772-2783
62. Salamone, G., Giordano, M., Trevani, A. S. et al. (2001) Promotion of neutrophil apoptosis by TNF-α. J. Immunol. 166, 3476-3483
63. Degterev, A., Boyce, M. and Yuan, J. (2003) A decade of caspases. Oncogene 22, 8543-8567
64. Watson, R. W. (2002) Redox regulation of neutrophil apoptosis. Antioxid. Redox Signaling 4, 97-104
65. Ye, J., Wang, S., Leonard, S. S. et al. (1999) Role of reactive oxygen species and p53 in chromium(VI)-induced apoptosis. J. Biol. Chem. 274, 34974-34980
66. Huang, C., Zhang, Z., Ding, M. et al. (2000) Vanadate induces p53 transactivation through hydrogen peroxide and causes apoptosis. J. Biol. Chem. 275, 32516-32522
67. Hug, H., Strand, S., Grambihler, A. et al. (1997) Reactive oxygen intermediates are involved in the induction of CD95 ligand mRNA expression by cytostatic drugs in hepatoma cells. J. Biol. Chem. 272, 28191-28193
68. Kwon, D., Choi, C., Lee, J. et al. (2001) Hydrogen peroxide triggers the expression of Fas/FasL in astrocytoma cell lines and augments apoptosis. J. Neuroimmunol. 113, 1-9
69. Denning, T. L., Takaishi, H., Crowe, S. E., Boldogh, I., Jevnikar, A. and Ernst, P. B. (2002) Oxidative stress induces the expression of Fas and Fas ligand and apoptosis in murine intestinal epithelial cells. Free Radical Biol. Med. 33, 1641-1650
70. Scheel-Toellner, D., Wang, K., Assi, L. K. et al. (2004) Clustering of death receptors in lipid rafts initiates neutrophil spontaneous apoptosis. Biochem. Soc. Trans. 32, 679-681
71. Scheel-Toellner, D., Wang, K., Craddock, R. et al. (2004) Reactive oxygen species limit neutrophil life span by activating death receptor signaling. Blood 104, 2557-2564
72. Kwon, Y. W., Masutani, H., Nakamura, H., Ishii, Y. and Yodoi, J. (2003) Redox regulation of cell growth and cell death. Biol. Chem. 384, 991-996
73. Zhang, B., Hirahashi, J., Cullere, X. and Mayadas, T. N. (2003) Elucidation of molecular events leading to neutrophil apoptosis following phagocytosis: cross-talk between caspase 8, reactive oxygen species, and MAPK/ERK activation. J. Biol. Chem. 278, 28443-28454
74. Fortenberry, J. D., Owens, M. L., Chen, N. X. and Brown, L. A. (2001) S-Nitrosoglutathione inhibits TNF-α-induced NFκB activation in neutrophils. Inflamm. Res. 50, 89-95
75. Chandra, J., Samali, A. and Orrenius, S. (2000) Triggering and modulation of apoptosis by oxidative stress. Free Radical Biol. Med. 29, 323-333
76. Simon, H. U., Haj-Yehia, A. and Levi-Schaffer, F. (2000) Role of reactive oxygen species (ROS) in apoptosis induction. Apoptosis 5, 415-418
77. Kroemer, G. (2003) Mitochondrial control of apoptosis: an introduction. Biochem. Biophys. Res. Commun. 304, 433-435
78. Watson, R. W., O'Neill, A., Brannigen, A. E. et al. (1999) Regulation of Fas antibody induced neutrophil apoptosis is both caspase and mitochondrial dependent. FEBS Lett. 453, 67-71
79. Maianski, N. A., Maianski, A. N., Kuijpers, T. W. and Roos, D. (2004) Apoptosis of neutrophils. Acta Haematol. 111, 56-66
80. Watson, R. W., Redmond, H. P., Wang, J. H., Condron, C. and Bouchier-Hayes, D. (1996) Neutrophils undergo apoptosis following ingestion of Escherichia. coli. J. Immunol. 156, 3986-3992
81. Perskvist, N., Long, M., Stendahl, O. and Zheng, L. (2002) Mycobacterium tuberculosis promotes apoptosis in human neutrophils by activating caspase-3 and altering expression of Bax/Bcl-xL via an oxygen-dependent pathway. J. Immunol. 168, 6358-6365
82. Colamussi, M. L., White, M. R., Crouch, E. and Hartshorn, K. L. (1999) Influenza A virus accelerates neutrophil apoptosis and markedly potentiates apoptotic effects of bacteria. Blood 93, 2395-2403
83. Rollet-Labelle, E., Grange, M. J., Elbim, C., Marquetty, C., Gougerot-Pocidalo, M. A. and Pasquier, C. (1998) Hydroxyl radical as a potential intracellular mediator of polymorphonuclear neutrophil apoptosis. Free Radical Biol. Med. 24, 563-572
84. van den Berg, J. M., Weyer, S., Weening, J. J., Roos, D. and Kuijpers, T. W. (2001) Divergent effects of tumor necrosis factor a on apoptosis of human neutrophils. J. Leukocyte Biol. 69, 467-473
85. Coxon, A., Rieu, P., Barkalow, F. J. et al. (1996) A novel role for the β2 integrin CD11b/CD18 in neutrophil apoptosis: a homeostatic mechanism in inflammation. Immunity 5, 653-666
86. Watson, R. W., Rotstein, O. D., Jimenez, M., Parodo, J. and Marshall, J. C. (1997) Augmented intracellular glutathione inhibits Fas-triggered apoptosis of activated human neutrophils. Blood 89, 4175-4181
87. Fossati, G., Moulding, D. A., Spiller, D. G., Moots, R. J., White, M. R. and Edwards, S. W. (2003) The mitochondrial network of human neutrophils: role in chemotaxis, phagocytosis, respiratory burst activation, and commitment to apoptosis. J. Immunol. 170, 1964-1972
88. Maianski, N. A., Geissler, J., Srinivasula, S. M., Alnemri, E. S., Roos, D. and Kuijpers, T. W. (2004) Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis. Cell Death Differ. 11, 143-153
89. Moulding, D. A., Quayle, J. A., Hart, C. A. and Edwards, S. W. (1998) Mcl-1 expression in human neutrophils: regulation by cytokines and correlation with cell survival. Blood 92, 2495-2502
90. Leuenroth, S. J., Grutkoski, P. S., Ayala, A. and Simms, H. H. (2000) The loss of Mcl-1 expression in human polymorphonuclear leukocytes promotes apoptosis. J. Leukocyte Biol. 68, 158-166
91. Moulding, D. A., Akgul, C., Derouet, M., White, M. R. and Edwards, S. W. (2001) BCL-2 family expression in human neutrophils during delayed and accelerated apoptosis. J. Leukocyte Biol. 70, 783-792
92. Liu, C. Y., Chuang, P. I., Chou, C. L. et al. (2004) Cytoprotective response of A1, a Bcl-2 homologue expressed in mature human neutrophils and promyelocytic HL-60 cells, to oxidant stress-induced cell death. J. Biomed. Sci. 11, 214-227
93. Murphy, B. M., O'Neill, A. J., Adrain, C., Watson, R. W. and Martin, S. J. (2003) The apoptosome pathway to caspase activation in primary human neutrophils exhibits dramatically reduced requirements for cytochrome c. J. Exp. Med. 197, 625-632
94. Maianski, N. A., Roos, D. and Kuijpers, T. W. (2003) Tumor necrosis factor α induces a caspase-independent death pathway in human neutrophils. Blood 101, 1987-1995
95. Hockenbery, D. M., Oltvai, Z. N., Yin, X. M., Milliman, C. L. and Korsmeyer, S. J. (1993) Bcl-2 functions in an antioxidant pathway to prevent apoptosis. Cell 75, 241-251
96. Harter, L., Mica, L., Stocker, R., Trentz, O. and Keel, M. (2003) Mcl-1 correlates with reduced apoptosis in neutrophils from patients with sepsis. J. Am. Coll. Surg. 197, 964-973
97. Hyslop, P. A., Hinshaw, D. B., Scraufstatter, I. U., Cochrane, C. G., Kunz, S. and Vosbeck, K. (1995) Hydrogen peroxide as a potent bacteriostatic antibiotic: implications for host defense. Free Radical Biol. Med. 19, 31-37
98. Kinnula, V. L., Soini, Y., Kvist-Makela, K., Savolainen, E. R. and Koistinen, P. (2002) Antioxidant defense mechanisms in human neutrophils. Antioxid. Redox Signaling 4, 27-34
99. Carmody, R. J. and Cotter, T. G. (2001) Signalling apoptosis: a radical approach. Redox Rep. 6, 77-90
100. Hampton, M. B. and Orrenius, S. (1997) Dual regulation of caspase activity by hydrogen peroxide: implications for apoptosis. FEBS Lett. 414, 552-556
101. Fadeel, B., Ahlin, A., Renter, J. I., Orrenius, S. and Hampton, M. B. (1998) Involvement of caspases in neutrophil apoptosis: regulation by reactive oxygen species. Blood 92, 4808-4818
102. Liu, C. Y., Takemasa, A., Liles, W. C. et al. (2003) Broad-spectrum caspase inhibition paradoxically augments cell death in TNF-α-stimulated neutrophils. Blood 101, 295-304
103. Lundqvist-Gustafsson, H. and Bengtsson, T. (1999) Activation of the granule pool of the NADPH oxidase accelerates apoptosis in human neutrophils. J. Leukocyte Biol. 65, 196-204
104. Sarih, M., Souvannavong, V. and Adam, A. (1993) Nitric oxide synthase induces macrophage death by apoptosis. Biochem. Biophys. Res. Commun. 191, 503-508
105. Zhou, X., Gordon, S. A., Kim, Y. M. et al. (2000) Nitric oxide induces thymocyte apoptosis via a caspase-1-dependent mechanism. J. Immunol. 165, 1252-1258
106. Lin, K. T., Xue, J. Y., Lin, M. C., Spokas, E. G., Sun, F. F. and Wong, P. Y. (1998) Peroxynitrite induces apoptosis of HL-60 cells by activation of a caspase-3 family protease. Am. J. Physiol. 274, C855-C860
107. Yabuki, M., Tsutsui, K., Horton, A. A., Yoshioka, T. and Utsumi, K. (2000) Caspase activation and cytochrome c release during HL-60 cell apoptosis induced by a nitric oxide donor. Free Radical Res. 32, 507-514
108. Ward, C., Wong, T. H., Murray, J. et al. (2000) Induction of human neutrophil apoptosis by nitric oxide donors: evidence for a caspase-dependent, cyclic-GMP-independent, mechanism. Biochem. Pharmacol. 59, 305-314
109. Dimmeler, S., Haendeler, J., Nehls, M. and Zeiher, A. M. (1997) Suppression of apoptosis by nitric oxide via inhibition of interleukin-1β- converting enzyme (ICE)-like and cysteine protease protein (CPP)-32-like proteases. J. Exp. Med. 185, 601-608
110. Melino, G., Bernassola, F., Knight, R. A., Corasaniti, M. T., Nistico, G. and Finazzi-Agro, A. (1997) S-Nitrosylation regulates apoptosis. Nature (London) 388, 432-433
111. Li, J., Billiar, T. R., Talanian, R. V. and Kim, Y. M. (1997) Nitric oxide reversibly inhibits seven members of the caspase family via S-nitrosylation. Biochem. Biophys. Res. Commun. 240, 419-424
112. Rossig, L., Fichtlscherer, B., Breitschopf, K. et al. (1999) Nitric oxide inhibits caspase-3 by S-nitrosation in vivo. J. Biol. Chem. 274, 6823-6826
113. Mannick, J. B., Hausladen, A., Liu, L. et al. (1999) Fas-induced caspase denitrosylation. Science 284, 651-654
114. Zech, B., Kohl, R., von Knethen, A. and Brune, B. (2003) Nitric oxide donors inhibit formation of the Apaf-1/caspase-9 apoptosome and activation of caspases. Biochem. J. 371, 1055-1064
115. Leist, M., Single, B., Naumann, H. et al. (1999) Inhibition of mitochondrial ATP generation by nitric oxide switches apoptosis to necrosis. Exp. Cell Res. 249, 396-403
116. Kim, Y. M., Chung, H. T., Simmons, R. L. and Billiar, T. R. (2000) Cellular non-heme iron content is a determinant of nitric oxide-mediated apoptosis, necrosis, and caspase inhibition. J. Biol. Chem. 275, 10954-10961
117. Roos, D., Weening, R. S. and Voetman, A. A. (1980) Protection of human neutrophils against oxidative damage. Agents Actions 10, 528-535
118. Narayanan, P. K., Ragheb, K., Lawler, G. and Robinson, J. P. (1997) Defects in intracellular oxidative metabolism of neutrophils undergoing apoptosis. J. Leukocyte Biol. 61, 481-488
119. O'Neill, A. J., O'Neill, S., Hegarty, N. J. et al. (2000) Glutathione depletion-induced neutrophil apoptosis is caspase 3 dependent. Shock 14, 605-609
120. Ogino, T., Packer, L. and Maguire, J. J. (1997) Neutrophil antioxidant capacity during the respiratory burst: loss of glutathione induced by chloramines. Free Radical Biol. Med. 23, 445-452
121. van den Dobbelsteen, D. J., Nobel, C. S., Schlegel, J., Cotgreave, I. A., Orrenius, S. and Slater, A. F. (1996) Rapid and specific efflux of reduced glutathione during apoptosis induced by anti-Fas/APO-1 antibody. J. Biol. Chem. 271, 15420-15427
122. Ohno, Y. and Gallin, J. I. (1985) Diffusion of extracellular hydrogen peroxide into intracellular compartments of human neutrophils. Studies utilizing the inactivation of myeloperoxidase by hydrogen peroxide and azide. J. Biol. Chem. 260, 8438-8446
123. Kim, Y. M., Yamazaki, I. and Piette, L. H. (1994) The effect of hemoglobin, hematin, and iron on neutrophil inactivation in superoxide generating systems. Arch. Biochem. Biophys. 309, 308-314
124. Patruta, S. I., Edlinger, R., Sunder-Plassmann, G. and Horl, W. H. (1998) Neutrophil impairment associated with iron therapy in hemodialysis patients with functional iron deficiency. J. Am. Soc. Nephrol. 9, 655-663
125. Flament, J., Goldman, M., Waterlot, Y., Dupont, E., Wybran, J. and Vanherweghem, J. L. (1986) Impairment of phagocyte oxidative metabolism in hemodialyzed patients with iron overload. Clin. Nephrol. 25, 227-230
126. Kotamraju, S., Chitambar, C. R., Kalivendi, S. V., Joseph, J. and Kalyanaramanm, B. (2002) Transferrin receptor-dependent iron uptake is responsible for doxorubicin-mediated apoptosis in endothelial cells. role of oxidant-induced iron signaling in apoptosis. J. Biol. Chem. 277, 17179-17187
127. Brunk, U. T., Neuzil, J. and Eaton, J. W. (2001) Lysosomal involvement in apoptosis. Redox Rep. 6, 91-97
128. Kamp, D. W., Panduri, V., Weitzman, S. A. and Chandel, N. (2002) Asbestos-induced alveolar epithelial cell apoptosis: role of mitochondrial dysfunction caused by iron-derived free radicals. Mol. Cell. Biochem. 234-235, 153-160
129. Kim, P. K., Kwon, Y. G., Chung, H. T. and Kim, Y. M. (2002) Regulation of caspases by nitric oxide. Ann. NY Acad. Sci. 962, 42-52
130. Gonzalez-Michaca, L., Farrugia, G., Croatt, A. J., Alam, J. and Nath, K. A. (2004) Heme: a determinant of life and death in renal tubular epithelial cells. Am. J. Physiol. Renal Physiol. 286, F370-F377
131. Ferris, C. D., Jaffrey, S. R., Sawa, A. et al. (1999) Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat. Cell Biol. 1, 152-157
132. Hannah, S., Mecklenburgh, K., Rahman, I. et al. (1995) Hypoxia prolongs neutrophil survival in vitro. FEBS Lett. 372, 233-237
133. Mecklenburgh, K. I., Walmsley, S. R., Cowburn, A. S. et al. (2002) Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis. Blood 100, 3008-3016
134. Walmsley, S. R., Print, C., Farahi, N. et al. (2005) Hypoxia-induced neutrophil survival is mediated by HIF-1α-dependent NF-κB activity. J. Exp. Med. 201, 105-115
135. Goda, N., Dozier, S. J. and Johnson, R. S. (2003) HIF-1 in cell cycle regulation, apoptosis, and tumor progression. Antioxid. Redox Signal. 5, 467-473
136. Kagan, V. E., Gleiss, B., Tyurina, Y. Y. et al. (2002) A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis. J. Immunol. 169, 487-499
137. Hampton, M. B., Vissers, M. C., Keenan, J. I. and Winterbourn, C. C. (2002) Oxidant-mediated phosphatidylserine exposure and macrophage uptake of activated neutrophils: possible impairment in chronic granulomatous disease. J. Leukocyte Biol. 71, 775-781