Obesity and metabolic disease: Is adipose tissue the culprit?

Proceedings of the Nutrition Society

Volumn 64, Issue 1, 2005, Pages 7-13

  Frayn, Keith N ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

Adipose tissue; Blood flow; Insulin resistance; Lipolysis

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; PEPTIDE DERIVATIVE; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ADIPOSE TISSUE BLOOD FLOW; BODY MASS; CARDIOVASCULAR DISEASE; CONFERENCE PAPER; DOWN REGULATION; ENERGY BALANCE; HUMAN; INSULIN RESISTANCE; INSULIN SENSITIVITY; LIPOLYSIS; METABOLIC DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; RISK FACTOR;

ADIPONECTIN; ADIPOSE TISSUE; DIABETES MELLITUS, TYPE 2; HUMANS; INSULIN RESISTANCE; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIPOLYSIS; OBESITY;

EID: 18844436264     PISSN: 00296651     EISSN: None     Source Type: Journal    
DOI: 10.1079/PNS2004403     Document Type: Conference Paper

References (71)

1. Aitman TJ, Godsland IF, Farren B, Crook D, Wong HJ & Scott J (1997) Defects of insulin action on fatty acid and carbohydrate metabolism in familial combined hyperlipidemia. Arteriosclerosis, Thrombosis and Vascular Biology 17, 748-754.
2. Arita Y, Kihara S, Ouchi N, Takahashi M, Maeda K, Miyagawa J et al. (1999) Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity. Biochemical and Biophysical Research Communications 257, 79-83.
3. Boden G, Chen X, Ruiz J, White JV & Rossetti L (1994) Mechanisms of fatty acid-induced inhibition of glucose uptake. Journal of Clinical Investigation 93, 2438-2446.
4. Boden G, Cheung P, Stein TP, Kresge K & Mozzoli M (2002) FFA cause hepatic insulin resistance by inhibiting insulin suppression of glycogenolysis. American Journal of Physiology 283, E12-E19.
5. Bogardus C, Lillioja S, Mott DM, Hollenbeck C & Reaven G (1985) Relationship between degree of obesity and in vivo insulin action in man. American Journal of Physiology 248, E286-E291.
6. Campbell PJ, Carlson MG & Nurjhan N (1994) Fat metabolism in human obesity. American Journal of Physiology 266, E600-E605.
7. Carpentier A, Mittelman SD, Lamarche B, Bergman RN, Giacca A & Lewis GF (1999) Acute enhancement of insulin secretion by FFA in humans is lost with prolonged FFA elevation. American Journal of Physiology 276, E1055-E1066.
8. Charles MA, Eschwege E, Thibult N, Claude JR, Warnet JM, Rosselin GE, Girard J & Balkau B (1997) The role of non-esterified fatty acids in the deterioration of glucose tolerance in Caucasian subjects: results of the Paris Prospective Study. Diabetologia 40, 1101-1106.
9. Clausen JO, Borch-Johnsen K, Ibsen H, Bergman RN, Hougaard P, Winther K & Pedersen O (1996) Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and lifestyle factors. Journal of Clinical Investigation 98, 1195-1209.
10. Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL & Caro JF (1996) Serum immunoreactive-leptin concentrations in normal-weight and obese humans. New England Journal of Medicine 334, 292-295.
11. Eriksson JW, Smith U, Waagstein F, Wysocki M & Jansson PA (1999) Glucose turnover and adipose tissue lipolysis are insulin-resistant in healthy relatives of type 2 diabetes patients: is cellular insulin resistance a secondary phenomenon? Diabetes 48, 1572-1578.
12. Ferrannini E, Barrett EJ, Bevilacqua S & DeFronzo RA (1983) Effect of fatty acids on glucose production and utilization in man. Journal of Clinical Investigation 72, 1737-1747.
13. Ferrannini E, Buzzigoli G, Bonadonna R, Giorico MA, Oleggini M, Graziadei L, Pedrinelli R, Brandi L & Bevilacqua S (1987) Insulin resistance in essential hypertension. New England Journal of Medicine 317, 350-357.
14. Flatt J-P (1972) Role of the increased adipose tissue mass in the apparent insulin insensitivity of obesity. American Journal of Clinical Nutrition 25, 1189-1192.
15. Frayn KN (2001) Adipose tissue and the insulin resistance syndrome. Proceedings of the Nutrition Society 60, 375-380.
16. Frayn KN (2002) Adipose tissue as a buffer for daily lipid flux. Diabetologia 45, 1201-1210.
17. Frayn KN, Williams CM & Arner P (1996) Are increased plasma non-esterified fatty acid concentrations a risk marker for coronary heart disease and other chronic diseases? Clinical Science 90, 243-253.
18. Friihbeck G, Gomez-Ambrosi J, Muruzabal FJ & Burrell MA (2001) The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. American Journal of Physiology 280, E827-E847.
19. Frühbeck G & Salvador J (2000) Relation between leptin and the regulation of glucose metabolism. Diabetologia 43, 3-12.
20. Haffner SM, Miettinen H, Gaskill SP & Stern MP (1996) Metabolic precursors of hypertension. The San Antonio Heart Study. Archives of Internal Medicine 156, 1994-2000.
21. Hokanson JE & Austin MA (1996) Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. Journal of Cardiovascular Risk 3, 213-219.
22. Hotamisligil GS (2003) The irresistible biology of resistin. Journal of Clinical Investigation 111, 173-174.
23. Hotta K, Funahashi T, Arita Y, Takahashi M, Matsuda M, Okamoto Y et al. (2000) Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arteriosclerosis, Thrombosis and Vascular Biology 20, 1595-1599.
24. Hotta K, Funahashi T, Bodkin NL, Ortmeyer HK, Arita Y, Hansen BC & Matsuzawa Y (2001) Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys. Diabetes 50, 1126-1133.
25. Insel PA, Liljenquist JE, Tobin JD, Sherwin RS, Watkins P, Andres R & Berman M (1975) Insulin control of glucose metabolism in man. A new kinetic analysis. Journal of Clinical Investigation 55, 1057-1066.
26. Jansson PA, Larsson A & Lonnroth PN (1998) Relationship between blood pressure, metabolic variables and blood flow in obese subjects with or without non-insulin-dependent diabetes mellitus. European Journal of Clinical Investigation 28, 813-818.
27. Kamohara S, Burcelin R, Halaas JL, Friedman JM & Charron MJ (1997) Acute stimulation of glucose metabolism in mice by leptin. Nature 389, 374-377.
28. Karpe F, Fielding BA, Ilic V, Macdonald IA, Summers LKM & Frayn KN (2002) Impaired postprandial adipose tissue blood flow response is related to aspects of insulin sensitivity. Diabetes 51, 2467-2473.
29. Kelley DE, Goodpaster BH & Storlien L (2002) Muscle triglyceride and insulin resistance. Annual Review of Nutrition 22, 325-346.
30. Kern PA, Ranganathan S, Li C, Wood L & Ranganathan G (2001) Adipose tissue tumor necrosis factor and interleukin-6 expression in human obesity and insulin resistance. American Journal of Physiology 280, E745-E751.
31. Koistinen HA, Bastard JP, Dusserre E, Ebeling P, Zegari N, Andreelli F et al. (2000) Subcutaneous adipose tissue expression of tumour necrosis factor-α is not associated with whole body insulin resistance in obese nondiabetic or in type-2 diabetic subjects. European Journal of Clinical Investigation 30, 302-310.
32. Kubota N, Terauchi Y, Yamauchi T, Kubota T, Moroi M, Matsui J et al. (2002) Disruption of adiponectin causes insulin resistance and neointimal formation. Journal of Biological Chemistry 277, 25863-25866.
33. Large V, Reynisdottir S, Langin D, Fredby K, Klannemark M, Holm C & Arner P (1999) Decreased expression and function of adipocyte hormone-sensitive lipase in subcutaneous fat cells of obese subjects. Journal of Lipid Research 40, 2059-2066.
34. Lehrke M & Lazar MA (2004) Inflamed about obesity. Nature Medicine 10, 126-127.
35. Lind L, Fugmann A, Branth S, Vessby B, Millgård J, Berne C & Lithell H (2000) The impairment in endothelial function induced by non-esterified fatty acids can be reversed by insulin. Clinical Science 99, 169-174.
36. Ma K, Cabrero A, Saha PK, Kojima H, Li L, Chang BH-J, Paul A & Chan L (2002) Increased β-oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. Journal of Biological Chemistry 277, 34658-34661.
37. Maeda N, Shimomura I, Kishida K, Nishizawa H, Matsuda M, Nagaretani H et al. (2002) Diet-induced insulin resistance in mice lacking adiponectin/ACRP30. Nature Medicine 8, 731-737.
38. Mohamed-Ali V, Goodrick S, Rawesh A, Katz DR, Miles JM, Yudkin JS, Klein S & Coppack SW (1997) Subcutaneous adipose tissue secretes interleukin-6 but not tumor necrosis-factor-a in vivo. Journal of Clinical Endocrinology and Metabolism 82, 4196-4200.
39. Mohamed-Ali V, Pinkney JH & Coppack SW (1998) Adipose tissue as an endocrine and paracrine organ. International Journal of Obesity 22, 1145-1158.
40. Opie LH & Walfish PG (1963) Plasma free fatty acid concentrations in obesity. New England Journal of Medicine 268, 757-760.
41. Oral EA, Simha V, Ruiz E, Andewelt A, Premkumar A, Snell P, Wagner AJ, DePaoli AM, Reitman ML, Taylor SI, Gorden P & Garg A (2002) Leptin-replacement therapy for lipodystrophy. New England Journal of Medicine 346, 570-578.
42. Pallett AL, Morton NM, Cawthorne MA & Emilsson V (1997) Leptin inhibits insulin secretion and reduces insulin mRNA levels in rat isolated pancreatic islets. Biochemical and Biophysical Research Communications 238, 267-270.
43. Pankow JS, Duncan BB, Schmidt MI, Ballantyne CM, Couper DJ, Hoogeveen RC & Golden SH (2004) Fasting plasma free fatty acids and risk of type 2 diabetes: the atherosclerosis risk in communities study. Diabetes Care 27, 77-82.
44. Paolisso G, Tataranni PA, Foley JE, Bogardus C, Howard BV & Ravussin E (1995) A high concentration of fasting plasma non-esterified fatty acids is a risk factor for the development of NIDDM. Diabetologia 38, 1213-1217.
45. Perez C, Fernandez Galaz C, Fernandez Agullo T, Arribas C, Andres A, Ros M & Carrascosa JM (2004) Leptin impairs insulin signaling in rat adipocytes. Diabetes 53, 347-353.
46. Petersen KF, Oral EA, Dufour S, Befroy D, Ariyan C, Yu C, Cline GW, DePaoli AM, Taylor SI, Gorden P & Shulman GI (2002) Leptin reverses insulin resistance and hepatic steatosis in patients with severe lipodystrophy. Journal of Clinical Investigation 109, 1345-1350.
47. Pittas AG, Joseph NA & Greenberg AS (2004) Adipocytokines and insulin resistance. Journal of Clinical Endocrinology and Metabolism 89, 447-452.
48. Prentice AM, Black AE, Coward WA, Davies HL, Goldberg GR, Murgatroyd PR, Ashford J, Sawyer M & Whitehead RG (1986) High levels of energy expenditure in obese women. British Medical Journal 292, 983-987.
49. Randle PJ, Garland PB, Hales CN & Newsholme EA (1963) The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet i, 785-789.
50. Riemens SC, Sluiter WJ & Dullaart RPF (2000) Enhanced escape of non-esterified fatty acids from tissue uptake: its role in impaired insulin-induced lowering of total rate of appearance in obesity and Type II diabetes mellitus. Diabetologia 43, 416-426.
51. Ruan H & Lodish HF (2004) Regulation of insulin sensitivity by adipose tissue-derived hormones and inflammatory cytokines. Current Opinion in Lipidology 15, 297-302.
52. Ryysy L, Häkkinen A-M, Goto T, Vehkavaara S, Westerbacka J, Halavaara J & Yki-Järvinen H (2000) Hepatic fat content and insulin action on free fatty acids and glucose metabolism rather than insulin absorption are associated with insulin requirements during insulin therapy in type 2 diabetic patients. Diabetes 49, 749-758.
53. Saghizadeh M, Ong JM, Garvey WT, Henry RR & Kern PA (1996) The expression of TNFα by human muscle. Relationship to insulin resistance. Journal of Clinical Investigation 97, 1111-1116.
54. Samra JS, Simpson EJ, Clark ML, Forster CD, Humphreys SM, Macdonald IA & Frayn KN (1996) Effects of epinephrine infusion on adipose tissue: interactions between blood flow and lipid metabolism. American Journal of Physiology 271, E834-E839.
55. Scherer PE, Williams S, Fogliano M, Baldini G & Lodish HF (1995) A novel serum protein similar to Clq, produced exclusively in adipocytes. Journal of Biological Chemistry 270, 26746-26749.
56. Seppälä Lindroos A, Vehkavaara S, Häkkinen A-M, Goto T, Westerbacka J, Sovijarvi A, Halavaara J & Yki-Järvinen H (2002) Fat accumulation in the liver is associated with defects in insulin suppression of glucose production and serum free fatty acids independent of obesity in normal men. Journal of Clinical Endocrinology and Metabolism 87, 3023-3028.
57. Starkie R, Ostrowski SR, Jauffred S, Febbraio M & Pedersen BK (2003) Exercise and IL-6 infusion inhibit endotoxin-induced TNF-alpha production in humans. FASEB Journal 17, 884-886.
58. Steensberg A, Fischer CP, Sacchetti M, Keller C, Osada T, Schjerling P, van Hall G, Febbraio MA & Pedersen BK (2003) Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans. Journal of Physiology 548, 631-638.
59. Steinberg HO, Paradisi G, Hook G, Crowder K, Cronin J & Baron AD (2000) Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production. Diabetes 49, 1231-1238.
60. Steppan CM, Bailey ST, Bhat S, Brown EJ, Banerjee RR, Wright CM, Patel HR, Rexford SA & Lazar MA (2001) The hormone resistin links obesity to diabetes. Nature 409, 307-312.
61. Summers LKM, Fielding BA, Herd SL, Ilic V, Clark ML, Quinlan PT & Frayn KN (1999) Use of structured triacylglycerols containing predominantly stearic and oleic acids to probe early events in metabolic processing of dietary fat. Journal of Lipid Research 40, 1890-1898.
62. Summers LKM, Fielding BA, Ilic V, Quinlan PT & Frayn KN (1998) The effect of triacylglycerol-fatty acid positional distribution on postprandial metabolism in subcutaneous adipose tissue. British Journal of Nutrition 79, 141-147.
63. Summers LKM, Samra JS, Humphreys SM, Morris RJ & Frayn KN (1996) Subcutaneous abdominal adipose tissue blood flow: variation within and between subjects and relationship to obesity. Clinical Science 91, 679-683.
64. Virtanen KA, Lönnroth P, Parkkola R, Peltoniemi P, Asola M, Viljanen T, Tolvanen T, Knuuti J, Rönnemaa T, Huupponen R & Nuutila P (2002) Glucose uptake and perfusion in subcutaneous and visceral adipose tissue during insulin stimulation in nonobese and obese humans. Journal of Clinical Endocrinology and Metabolism 87, 3902-3910.
65. Weisberg SP, McCann D, Desai M, Rosenbaum M, Leibel RL & Ferrante AW Jr (2003) Obesity is associated with macrophage accumulation in adipose tissue. Journal of Clinical Investigation 112, 1796-1808.
66. Weyer C, Funahashi T, Tanaka S, Hotta K, Matsuzawa Y, Pratley RE & Tataranni PA (2001) Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. Journal of Clinical Endocrinology and Metabolism 86, 1930-1935.
67. Xu H, Barnes GT, Yang Q, Tan G, Yang D, Chou CJ, Sole J, Nichols A, Ross JS, Tartaglia LA & Chen H (2003) Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance. Journal of Clinical Investigation 112, 1821-1830.
68. Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, Kara K et al. (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nature Medicine 7, 941-946.
69. Yaspelkis BB 3rd, Singh MK, Krisan AD, Collins DE, Kwong CC, Bernard JR & Crain AM (2004) Chronic leptin treatment enhances insulin-stimulated glucose disposal in skeletal muscle of high-fat fed rodents. Life Sciences 74, 1801-1816.
70. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L & Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372, 425-432.
71. Zhou YP & Grill V (1995) Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans. Journal of Clinical Endocrinology and Metabolism 80, 1584-1590.