Effects of epinephrine infusion on adipose tissue: Interactions between blood flow and lipid metabolism

American Journal of Physiology - Endocrinology and Metabolism

Volumn 271, Issue 5 34-5, 1996, Pages

  Samra, Jaswinder S ^b   Simpson, Elizabeth J ^b   Clark, Mo L ^b   Forster, C David ^b   Humphreys, Sandy M ^b   Macdonald, Ian A ^b   Frayn, Keith N ^a  

^a RADCLIFFE INFIRMARY   (United Kingdom)

^b NONE

Author keywords

lipid mobilization; lipoprotein lipase; regional perfusion

Indexed keywords

ADRENALIN; CATECHOLAMINE; FATTY ACID; LIPOPROTEIN LIPASE; NORADRENALIN;

ADIPOSE TISSUE; ADULT; ARTICLE; BLOOD SAMPLING; CATECHOLAMINERGIC SYSTEM; ENZYME ACTIVITY; FEMALE; HUMAN; HUMAN EXPERIMENT; LIPID METABOLISM; MALE; METABOLIC REGULATION; NORMAL HUMAN; PRIORITY JOURNAL; REGIONAL PERFUSION; TISSUE BLOOD FLOW;

EID: 0029805162     PISSN: 01931849     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpendo.1996.271.5.e834     Document Type: Article

References (32)

1. Abumrad, N. N., D. Rabin, M. P. Diamond, and W. W. Lacy. Use of heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man. Metab. Clin. Exp. 30 936-940, 1981.
2. Arner, P., I. Liljeqvist, and J. Östman. Metabolism of mono-and diacylglycerols in subcutaneous adipose tissue of obese and normal-weight subjects. Acta Med. Scand 200: 187-194, 1976.
3. Axelrod, L., and L. Levine. Prostacyclin production by isolated adipocytes. Diabetes 30: 163-167, 1981.
4. Benedict, C. R., and D. G. Grahame-Smith. Plasma noradrenalme and adrenaline concentrations and dopamine-β-hydroxylase activity in patients with shock due to septicaemia, trauma and haemorrhage. Q. J. Med. 185: 1-20, 1978.
5. Coppack, S. W., R. D. Evans, R. M. Fisher, K. N. Frayn, G. F. Gibbons, S. M. Humphreys, M. L. Kirk, J. L. Potts, and T. D. R. Hockaday. Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal. Metab. Clin. Exp. 41: 264-272, 1992.
6. Elia, M. General integration and regulation of metabolism at the organ level Proc. Nutr. Soc. 54: 213-232, 1995.
7. Elia, M., A. Kurpad, I. Macdonald, S. W. Coppack, and K. N. Frayn. Effect of noradrenaline infusion on the net exchange of noradrenaline across human adipose tissue and muscle in vivo. Endocrinol. Metab. 3: 31-35, 1996.
8. Fielding, B. A., S. M. Humphreys, S. Shadid, and K. N. Frayn. Arterio-venous differences across adipose tissue for mono-, di- and triacylglycerols before and after a high-fat meal. Endocrinol. Metab. 2: 13-17, 1995.
9. Frayn, K. N., S. W. Coppack, B. A. Fielding, and S. M. Humphreys. Coordinated regulation of hormone-sensitive lipase and lipoprotein lipase in human adipose tissue in vivo: implications for the control of fat storage and fat mobilization. Adv. Enzyme Regul. 35: 163-178, 1995.
10. Frayn, K. N., S. W. Coppack, and S. M. Humphreys. Subcutaneous adipose tissue metabolism studied by local catheterization. Int. J. Obes. Suppl. 3 17: S18-S21, 1993.
11. Frayn, K. N., S. W. Coppack, S. M. Humphreys, and P. L. Whyte. Metabolic characteristics of human adipose tissue in vivo. Clin. Sci. Lond. 76: 509-516, 1989.
12. Frayn, K. N., and I. A. Macdonald. Adipose tissue circulation. In: Nervous Control of Blood Vessels, edited by T. Bennett and S. M. Gardiner. Amsterdam: Harwood Academic, 1996, p. 505-540.
13. Frayn, K. N., S. Shadid, R. Hamlani, S. M. Humphreys, M. L. Clark, B. A. Fielding, O. Boland, and S. W. Coppack. Regulation of fatty acid movement in human adipose tissue in the postabsorptive-to-postprandial transition. Am. J. Physiol. 266 (Endocrinol. Metab. 29): E308-E317, 1994.
14. Freyschuss, U., P. Hjemdahl, A. Juhlin-Dannfelt, and B. Linde. Cardiovascular and metabolic responses to low dose adrenaline infusion: an invasive study in humans. Clin. Sci. Lond. 70: 199-206, 1986.
15. Galbo, H., J. J. Holst, and N. J. Christensen. Glucagon and plasma catecholamine responses to graded and prolonged exercise in man. J. Appl. Physiol 38: 70-76, 1975.
16. Hjemdahl, P., and B. Linde. Influence of circulating NE and Epi on adipose tissue vascular resistance and lipolysis in humans. Am. J. Physiol. 245 (Heart Circ. Physiol. 14): H447-H452, 1983.
17. Jensen, M. D., M. W. Raymond, J. E. Gerich, P. E. Cryer, and J. M. Miles. Lipolysis during fasting. Decreased suppression by insulin and increased stimulation by epinephrine. J. Clin. Invest. 79: 207-213, 1987.
18. Kurpad, A., K. Khan, A. G. Calder, S. W. Coppack, K. Frayn, I. Macdonald, and M. Elia. Effect of noradrenaline on glycerol turnover and lipolysis in the whole body and subcutaneous adipose tissue in humans in vivo. Clin. Sci. Lond. 86: 177-184, 1994.
19. Larsen, A. O., N. A. Lassen, and F. Quaade. Blood flow through human adipose tissue determined with radioactive xenon. Acta Physiol. Scand. 66: 337-345, 1966.
20. Lillioja, S., J. Foley, C. Bogardus, D. Mott, and B. V. Howard. Free fatty acid metabolism and obesity in man: in vivo in vitro comparisons. Metab. Clin. Exp. 6: 505-514, 1986.
21. Macdonald, I, A., and D. M. Lake. An improved technique for extracting catecholamines from body fluids. J. Neurosci. Methods 13: 239-248, 1985.
22. Martin, S. E., and E. L. Bookman. Adenosine regulates blood flow and glucose uptake in adipose tissue of dogs. Am. J. Physiol. 250 (Heart Circ. Physiol. 19): H1127-H1135, 1986.
23. Ong, J. M., B. Saffari, R, B. Simsolo, and P. A. Kern. Epinephrine inhibits lipoprotein lipase gene expression in rat adipocytes through multiple steps in posttranscriptional processing. Mol. Endocrinol. 6: 61-69, 1992.
24. Östman, J., P. Arner, P. Engfeldt, and L. Kager. Regional differences in the control of lipolysis in human adipose tissue. Metab. Clin. Exp. 28: 1198-1205, 1979.
25. Pizzinat, N., L. Marti, C. Carpene, I. Couprey, M. Lafontan, D. Langin, and A. Parini. Expression of monoamine oxydases A and B in human subcutaneous adipocytes (Abstract). Int. J. Obesity 19, Suppl. 2: 69, 1995.
26. Samra, J. S., K. N. Frayn, J. A. Giddings, M. L. Clark, and I. A. Macdonald. Modification and validation of a commercially available portable detector for measurement of adipose tissue blood flow. Clin. Physiol. Oxf. 15: 241-248, 1995.
27. Symonds, M. E., M. J. Bryant, and M. A. Lomax. Lipid metabolism in shorn and unshorn pregnant sheep. Br. J. Nutr. 62: 35-49, 1989.
28. Vaughan, M. The metabolism of adipose tissue in vitro. J. Lipid Res. 2: 293-316, 1961.
29. Vikman, H.-L., J. M. Kaartinen, R. K. Tuominen, and J. J. Ohisalo. A possible role for protein kinase C in the regulatory differences between intra-abdominal and subcutaneous human adipose tissue. Clin. Sci. Oxf. 85: 265-268, 1993.
30. Wolfe, R. R., E. J. Peters, S. Klein, O. B. Holland, J. Rosenblatt, and H. Gray, Jr. Effect of short-term fasting on lipolytic responsiveness in normal and obese human subjects. Am. J. Physiol. 252 (Endocrinol. Metab. 15): E189-E196, 1987.
31. Yeh, S.-Y., and R. E. Peterson. Solubility of krypton and xenon in blood, protein solutions, and tissue homogenates. J. Appl. Physiol. 20: 1041-1047, 1965.
32. Yukht, A., R. C. Davis, J. M. Ong, G. Ranganthan, and P. A. Kern. Regulation of lipoprotein lipase translation by epinephrine in 3T3-L1 cells. J. Clin. Invest. 96: 2438-2444, 1995.