Genetic interactions between Cdk1-CyclinB and the separase complex in Drosophila

Development

Volumn 132, Issue 8, 2005, Pages 1875-1884

  Ji, Jun Yuan ^a,b   Crest, Justin ^a   Schubiger, Gerold ^a  

^a UNIVERSITY OF WASHINGTON   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL CANCER CENTER   (United States)

Author keywords

Anaphase; Cdk1 CycB; Drosophila; Separase; Three rows

Indexed keywords

COHESIN; CYCLIN B; CYCLIN DEPENDENT KINASE 1; DROSOPHILA PROTEIN; PIMPLES PROTEIN; SEPARASE; THREE ROWS PROTEIN; UNCLASSIFIED DRUG;

ANAPHASE; ARTICLE; BLASTODERM; CELL MIGRATION; CELL NUCLEUS; COMPLEX FORMATION; CONTROLLED STUDY; DROSOPHILA; EMBRYO DEVELOPMENT; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE DOSAGE; GENE IDENTIFICATION; GENE INTERACTION; GENE MUTATION; GENETIC SCREENING; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SISTER CHROMATID;

ANAPHASE; ANIMALS; CDC2 PROTEIN KINASE; CELL CYCLE PROTEINS; CHROMATIDS; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOME MAPPING; CYCLIN B; DROSOPHILA; DROSOPHILA PROTEINS; ENDOPEPTIDASES; FUNGAL PROTEINS; MUTATION; NUCLEAR PROTEINS; PHENOTYPE; RNA INTERFERENCE; RNA, DOUBLE-STRANDED;

EID: 18844430786     PISSN: 09501991     EISSN: None     Source Type: Journal    
DOI: 10.1242/dev.01780     Document Type: Article

References (53)

1. Agarwal, R. and Cohen-Fix, O. (2002). Phosphorylation of the mitotic regulator Pds1/securin by Cdc28 is required for efficient nuclear localization of Esp1/Separase. Genes Dev. 16, 1371-1382.
2. Baker, J., Theurkauf, W. E. and Schubiger, G. (1993). Dynamic changes in microtubule configuration correlate with nuclear migration in the preblastoderm Drosophila embryo. J. Cell Biol. 122, 113-121.
3. Bharadwaj, R. and Yu, H. (2004). The spindle checkpoint, aneuploidy, and cancer. Oncogene 23, 2016-2027.
4. D'Andrea, R., Stratmann, R., Lehner, C. F., John, U. P. and Saint, R. (1993). The three rows gene of Drosophila melanogaster encodes a novel protein that is required for chromosome disjunction during mitosis. Mol. Biol. Cell 4, 1161-1174.
5. Foe, V. E. and Alberts, B. M. (1983). Studies of nuclear and cytoplasmic behaviour during the five mitotic cycles that precede gastrulation in Drosophila embryogenesis. J. Cell Sci. 61, 31-70.
6. Follette, P. J. and O'Farrell, P. H. (1997). Cdks and the Drosophila cell cycle. Curr. Opin. Genet. Dev. 7, 17-22.
7. Funabiki, H., Kumada, K. and Yanagida, M. (1996). Fission yeast Cut1 and Cut2 are essential for sister chromatid separation, concentrate along the metaphase spindle and form large complexes. EMBO J. 15, 6617-6628.
8. Haering, C. H. and Nasmyth, K. (2003). Building and breaking bridges between sister chromatids. BioEssays 25, 1178-1191.
9. Hagting, A., Den Elzen, N., Vodermaier, H. C., Waizenegger, I. C., Peters, J.-M. and Pines, J. (2002). Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. J. Cell Biol. 157, 1125-1137.
10. Harper, J. W., Burton, J. L. and Solomon, M. J. (2002). The anapbase-promoting complex: it's not just for mitosis any more. Genes Dev. 16, 2179-2206.
11. Herzig, A., Lehner, C. F. and Heidmann, S. (2002). Proteolytic cleavage of the THR subunit during anaphase limits Drosophila Separase function. Genes Dev. 16, 2443-2454.
12. Huang, J. Y. and Raff, J. W. (1999). The disappearance of cyclin B at the end of mitosis is regulated spatially in Drosophila cells. EMBO J. 18, 2184-2195.
13. Ito, Y., Takeda, T., Sakon, M., Monden, M., Tsujimoto, M. and Matsuura, N. (2000). Expression and prognostic role of cyclin-dependent kinase 1 (cdc2) in hepatocellular carcinoma. Oncology 59, 68-74.
14. Jacobs, H. W., Knoblich, J. A. and Lehner, C. F. (1998). Drosophila Cyclin B3 is required for female fertility and is dispensable for mitosis like Cyclin B. Genes Dev. 12, 3741-3751.
15. Jäger, H., Herzig, A., Lehner, C. F. and Heidmann, S. (2001). Drosophila Separase is required for sister chromatid separation and binds to PIM and THR. Genes Dev. 15, 2572-2584.
16. Jäger, H., Herzig, B., Herzig, A., Sticht, H., Lehner, C. F. and Heidmann, S. (2004). Structure predications and interaction studies indicate homology of separase N-terminal regulatory domains and Drosophila THR. Cell Cycle 3, 182-188.
17. Jallepalli, P. V. and Lengauer, C. (2001). Chromosome segregation and cancer: cutting through the mystery. Nat. Rev. Cancer 1, 109-117.
18. Ji, J. Y., Haghnia, M., Trusty, C., Goldstein, L. S. B. and Schubiger, G. (2002). A genetic screen for suppressors and enhancers of the Drosophila Cdk1-Cyclin B identifies maternal factors that regulate microtubule and microfilament stability. Genetics 162, 1179-1195.
19. Ji, J. Y., Squrriell, J. M. and Schubiger, G. (2004). Both Cyclin B levels and DNA-replication checkpoint regulate the early embryonic mitoses in Drosophila. Development 131, 401-411.
20. Kennerdell, J. R. and Carthew, R. W. (1998). Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. Cell 95, 1017-1026.
21. Kennerdell, J. R., Yamaguchi, S. and Carthew, R. W. (2002). RNAi is activated during Drosophila oocyte maturation in a manner dependent on aubergine and spindle-E. Genes Dev. 16, 1884-1889.
22. Lehner, C. F. and O'Farrell, P. H. (1989). Expression and function of Drosophila cyclin A during embryonic cell cycle progression. Cell 56, 957-968.
23. Leismann, O. and Lehner, C. F. (2003). Drosophila securin destruction involves a D-box and a KEN-box and promotes anaphase in parallel with Cyclin A degradation. J. Cell Sci. 116, 2453-2460.
24. Leismann, O., Herzig, A., Heidmann, S. and Lehner, C. F. (2000). Degradation of Drosophila PIM regulates sister chromatid separation during mitosis. Genes Dev. 14, 2192-2205.
25. Maddox, P., Desai, A., Oegema, K., Mitchison, T. J. and Salmon, E. D. (2002). Poleward microtubule flux is a major component of spindle dynamics and anaphase A in mitotic Drosophila embryos. Curr. Biol. 12, 1670-1674.
26. Murray, A. W. (2004). Recycling the cell cycle: cyclins revisited. Cell 116, 221-234.
27. Nüsslein-Volhard, C., Wieschaus, E. and Kluding, H. (1984). Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. I. Zygotic loci on the second chromosome. Roux's Arch Dev. Biol. 193, 267-282.
28. Parry, D. H. and O'Farrell, P. H. (2001). The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis. Curr. Biol. 11, 671-683.
29. Pellman, D. and Christman, M. F. (2001). Separase anxiety: dissolving the sister bond and more. Nat. Cell Biol. 3, E207-E209.
30. Peters, J.-M. (2002). The anaphase-promoting complex: proteolysis in mitosis and beyond. Mol. Cell. 9, 931-943.
31. Petronczki, M., Siomos, M. F. and Nasmyth, K. (2003). Un menage a quatre: the molecular biology of chromosome segregation in meiosis. Cell 112, 423-440.
32. Philp, A. V., Axton, J. M., Saunders, R. D. and Glover, D. M. (1993). Mutations in the Drosophila melanogaster gene three rows permit aspects of mitosis to continue in the absence of chromatid segregation. J. Cell Sci. 106, 87-98.
33. Pickart, C. M. (2001). Mechanisms underlying ubiquitination. Annu. Rev. Biochem. 70, 503-533.
34. Pihan, G. and Doxsey, S. J. (2003). Mutations and aneuploidy: co-conspirators in cancer? Cancer Cell 4, 89-94.
35. Rogers, G. C., Rogers, S. L., Schwimmer, T. A., Ems-McClung, S. C., Walczak, C. E., Vale, R. D., Scholey, J. M. and Sharp, D. J. (2004). Two mitotic kinesins cooperate to drive sister chromatid separation during anaphase. Nature 427, 364-370.
36. Sarafan-Vasseur, N., Lamy, A., Bourguignon, J., Pessot, F. L., Hieter, P., Sesboue, R., Bastard, C., Frebourg, T. and Flaman, J. M. (2002). Overexpression of B-type cyclins alters chromosomal segregation. Oncogene 21, 2051-2057.
37. Schüpbach, T. and Wieschaus, E. (1989). Female sterile mutations on the second chromosome of Drosophila melanogaster. I. Maternal effect mutations. Genetics 121, 101-117.
38. Shirayama, M., Toth, A., Galova, M. and Nasmyth, K. (1999). APC(CdC20) promotes exit from mitosis by destroying the anaphase inhibitor Pds1 and cyclin Clb5. Nature 402, 203-207.
39. Sigrist, S., Jacobs, H., Stratmann, R. and Lehner, C. F. (1995). Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3. EMBO J. 14, 4827-4838.
40. Soria, J. C., Jang, S. J., Khuri, F. R., Hassan, K., Liu, D., Hong, W. K. and Mao, L. (2000). Overexpression of cyclin B1 in early-stage non-small cell lung cancer and its clinical implication. Cancer Res. 60, 4000-4004.
41. Stemmann, O., Zou, H., Gerber, S. A., Gygi, S. P. and Kirschner, M. W. (2001). Dual inhibition of sister chromatid separation at metaphase. Cell 107, 715-726.
42. Stiffler, L. A., Ji, J. Y., Trautmann, S., Trusty, C. and Schubiger, G. (1999). Cyclin A and B functions in the early Drosophila embryo. Development 126, 5505-5513.
43. Stratmann, R. and Lehner, C. F. (1996). Separation of sister chromatids in mitosis requires the Drosophila pimples product, a protein degraded after the metaphase/anaphase transition. Cell 84, 25-35.
44. Su, T. T., Sprenger, F., DiGregorio, P. J., Campbell, S. D. and O'Farrell, P. H. (1998). Exit from mitosis in Drosophila syncytial embryos requires proteolysis and cyclin degradation, and is associated with localized dephosphorylation. Genes Dev. 12, 1495-1503.
45. Sullivan, M. and Uhlmann, F. (2003). A non-proteolytic function of separase links the onset of anaphase to mitotic exit. Nat. Cell Biol. 5, 249-254.
46. Sullivan, M., Lehane, C. and Uhlmann, F. (2001). Orchestrating anaphase and mitotic exit: separase cleavage and localization of Slk19. Nat. Cell Biol. 3, 771-777.
47. Vass, S., Cotterill, S., Valdeolmillos, A. M., Barbero, J. L., Lin, E., Warren, W. D. and Heck, M. M. (2003). Depletion of Drad21/Scc1 in Drosophila cells leads to instability of the cohesin complex and disruption of mitotic progression. Curr. Biol. 13, 208-218.
48. von Dassow, G. and Schubiger, G. (1994). How an actin network might cause fountain streaming and nuclear migration in the syncytial Drosophila embryo. J. Cell Biol. 127, 1637-1653.
49. Waizenegger, I., Gimenez-Abian, J. F., Wernic, D. and Peters, J.-M. (2002). Regulation of human separase by securin binding and autocleavage. Curr. Biol. 12, 1368-1378.
50. Warren, W. D., Steffensen, S., Lin, E., Coelho, P., Loupart, M., Cobbe, N., Lee, J. Y., McKay, M. J., Orr-Weaver, T., Heck, M. M. and Sunkel, C. E. (2000). The Drosophila RAD21 cohesin persists at the centromere region in mitosis. Curr. Biol. 10, 1463-1466.
51. Yamamoto, A., Guacci, V. and Koshland, D. (1996). Pds1 is required for faithful excution of anaphase in the yeast, Saccharomyces cerevisiae. J. Cell Biol. 133, 85-97.
52. Zachariae, W. and Nasmyth, K. (1999). Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev. 13, 2039-2058.
53. Zou, H., Stemmann, O., Anderson, J. S., Mann, M. and Kirschner, M. W. (2002). Anaphase specific auto-cleavage of separase. FEBS Lett. 528, 246-250.