Regulation of human separase by securin binding and autocleavage

Current Biology

Volumn 12, Issue 16, 2002, Pages 1368-1378

  Waizenegger, Irene C ^a,b   Giménez Abián, Juan F ^c   Wernic, Dominik ^d   Peters, Jan Michael ^a  

^a RESEARCH INSTITUTE OF MOLECULAR PATHOLOGY   (Austria)

^b BOEHRINGER INGELHEIM RCV GMBH AND CO KG   (Austria)

^c CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^d Boehringer Ingelheim   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID SEQUENCE; ANIMAL; CELL CYCLE PROTEINS; CELL NUCLEUS; CHROMOSOMES; ENZYME ACTIVATION; ENZYME INHIBITORS; FUNGAL PROTEINS; HELA CELLS; HUMAN; MITOSIS; MODELS, BIOLOGICAL; MOLECULAR STRUCTURE; NEOPLASM PROTEINS; PEPTIDES; POLYPLOIDY; PROTEIN BINDING; RNA INTERFERENCE; SEQUENCE ALIGNMENT; SUPPORT, NON-U.S. GOV'T; TRANS-ACTIVATORS; ANIMALS; ENDOPEPTIDASES; HUMANS; NUCLEAR PROTEINS; PHOSPHOPROTEINS; SACCHAROMYCES CEREVISIAE PROTEINS;

CELL CYCLE PROTEIN; ENZYME INHIBITOR; FUNGAL PROTEIN; MCD1 PROTEIN, S CEREVISIAE; NUCLEAR PROTEIN; PEPTIDE; PHOSPHOPROTEIN; PITUITARY TUMOR TRANSFORMING PROTEINS; PITUITARY TUMOR-TRANSFORMING PROTEINS; PROTEINASE; SACCHAROMYCES CEREVISIAE PROTEIN; SEPARASE; TRANSACTIVATOR PROTEIN; TUMOR PROTEIN;

AMINO ACID SEQUENCE; ANIMAL; ARTICLE; BIOLOGICAL MODEL; CELL NUCLEUS; CHEMICAL STRUCTURE; CHROMOSOME; DRUG ANTAGONISM; ENZYME ACTIVATION; GENETICS; HELA CELL; HUMAN; METABOLISM; MITOSIS; POLYPLOIDY; PROTEIN BINDING; RNA INTERFERENCE; SEQUENCE ALIGNMENT;

EID: 0037143442     PISSN: 09609822     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-9822(02)01073-4     Document Type: Article

References (35)

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2. Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1
3. Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast
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5. An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast
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7. The bimB3 mutation of Aspergillus nidulans uncouples DNA replication from the completion of mitosis
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14. Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase
15. Cut2 proteolysis required for sister-chromatid seperation in fission yeast
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