Drosophila separase is required for sister chromatid separation and binds to PIM and THR

Genes and Development

Volumn 15, Issue 19, 2001, Pages 2572-2584

  Jager H ^a   Herzig, A ^a   Lehner, C F ^a   Heidmann, S ^a  

^a UNIVERSITY OF BAYREUTH   (Germany)

Author keywords

Mitosis; Pimples; Securin; Separase; Sister chromatid separation; Three rows

Indexed keywords

CYSTEINE PROTEINASE; INSECT PROTEIN; PROTEIN PIM; PROTEIN PIMPLE; PROTEIN THR; PROTEIN THREE ROW; REGULATOR PROTEIN; SECURIN; SEPARASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE PHASE; DROSOPHILA MELANOGASTER; ENZYME ACTIVATION; EUKARYOTE; GENE SEQUENCE; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; SISTER CHROMATID;

AMINO ACID SEQUENCE; ANIMALS; CELL CYCLE PROTEINS; CHROMATIDS; DROSOPHILA; DROSOPHILA PROTEINS; ENDOPEPTIDASES; INSECT PROTEINS; MOLECULAR SEQUENCE DATA; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

DROSOPHILA MELANOGASTER; EUKARYOTA; INSECTA; MELANOGASTER;

EID: 0035477669     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.207301     Document Type: Article

References (45)

1. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
2. Functional cDNA libraries from Drosophila embryos
3. An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast
4. Pds1p of budding yeast has dual roles: Inhibition of anaphase initiation and regulation of mitotic exit
5. The three rows gene of Drosophila melanogaster encodes a novel protein that is required for chromosome disjunction during mitosis
6. Separation anxiety at the centromere
7. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product
8. Fission yeast Cur1 and Cut2 are essential for sister separation, concentrate along the metaphase spindle and form large complexes
9. Genes controlling essential cell-cycle functions in Drosophila melanogaster
10. Techniques for studying mitosis in Drosophila
11. A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae
12. Chromosome cohesion, condensation, and separation
13. A versatile vector set for animal transgenesis
14. A novel role of the budding yeast separin Esp1 in anaphase spindle elongation: Evidence that proper spindle association of Esp1 is regulated by Pds1
15. Synergistic action of Drosophila cyclin A and cyclin B during the G2-M transition
16. Epitope tagging of yeast genes using a PCR-based strategy: More tags and improved practical routines
17. Sister chromatid cohesion: The beginning of a long and beautiful relationship
18. Cut1 is loaded onto the spindle by binding to Cut2 and promotes anaphase spindle movement upon Cut2 proteolysis
19. Degradation of Drosophila PIM regulates sister chromatid separation during mitosis
20. Identification of Xenopus SMC protein complexes required for sister chromatid cohesion
21. Cohesins: Chromosomal proteins that prevent premature separation of sister chromatids
22. Splitting the chromosome: Cutting the ties that bind sister chromatids
23. Generation of protein-reactive antibodies by short peptides is an event of high frequency: Implications for the structural basis of immune recognition
24. Mutations in the Drosophila melanogaster gene three rows permit aspects of mitosis to continue in the absence of chromatid segregation
25. Preparation and analysis of Drosophila mitotic chromosomes
26. P-element-induced male recombination and gene conversion in Drosophila
27. Flanking duplications and deletions associated with P-induced male recombination in Drosophila
28. Gal4 in the Drosophila female germline
29. Uncoupling cadherin-based adhesion from wingless signalling in Drosophila
30. Ctf7p is essential for sister chromatid cohesion and links mitotic chromosome structure to the DNA replication machinery
31. Synaptic development is controlled in the periactive zones of Drosophila synapses
32. Separation of sister chromatids in mitosis requires the Drosophila pimples product, a protein degraded after the metaphase anaphase transition
33. Characterization of vertebrate cohesin complexes and their regulation in prophase
34. Maintenance of sister-chromatid cohesion at the centromere by the Drosophila MEI-S332 protein
35. Pds1 and Esp1 control both anaphase and mitotic exit in normal cells and after DNA damage
36. Characterization of fission yeast cohesin: Essential anaphase proteolysis of Rad21 phosphorylated in the S phase
37. Cohesion between sister chromatids must be established during DNA replication
38. Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast
39. The fission yeast cut1+ gene regulates spindle pole body duplication and has homology to the budding yeast ESP1 gene
40. Two distinct pathways remove mammalian cohesin from chromosome arms in prophase and from centromeres in anaphase
41. The Drosophila RAD21 cohesin persists at the centromere region in mitosis
42. Expression of crumbs confers apical character on plasma-membrane domains of ectodermal epithelia of Drosophila
43. Cell cycle mechanisms of sister chromatid separation; roles of Cut1/separin and Cut2/securin
44. Whose end is destruction: Cell division and the anaphase-promoting complex
45. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis