Drosophila securin destruction involves a D-box and a KEN-box and promotes anaphase in parallel with Cyclin A degradation

Journal of Cell Science

Volumn 116, Issue 12, 2003, Pages 2453-2460

  Leismann, Oliver ^a   Lehner, Christian F ^a  

^a UNIVERSITY OF BAYREUTH   (Germany)

Author keywords

APC C; Cyclin A; Pimples; Polo; Separase; Sister chromatid separation

Indexed keywords

ANAPHASE PROMOTING COMPLEX; CYCLIN A; CYSTEINE PROTEINASE; PROTEIN KINASE; REGULATOR PROTEIN; SECURIN; SEPARASE; UNCLASSIFIED DRUG;

ANAPHASE; CONTROLLED STUDY; DROSOPHILA; EMBRYO; HOMEOBOX; IN VIVO STUDY; MALE; MITOSIS; MOLECULAR STABILITY; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; SISTER CHROMATID;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ANAPHASE; ANIMALS; CELL CYCLE PROTEINS; CYCLIN A; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; ENDOPEPTIDASES; GENE EXPRESSION REGULATION; MITOSIS; MOLECULAR SEQUENCE DATA; MUTATION; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; UBIQUITIN-PROTEIN LIGASE COMPLEXES;

VERTEBRATA;

EID: 0037821614     PISSN: 00219533     EISSN: None     Source Type: Journal    
DOI: 10.1242/jcs.00411     Document Type: Review

References (40)

1. Alexandru, G., Uhlmann, F., Mechtler, K., Poupart, M. A. and Nasmyth, K. (2001). Phosphorylation of the cohesin subunit Scc1 by Polo/Cdc5 kinase regulates sister chromatid separation in yeast. Cell 105, 459-472.
2. Brand, A. H. and Perrimon, N. (1993). Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118, 401-415.
3. Burton, J. L. and Solomon, M. J. (2001). D box and KEN box motifs in budding yeast Hs11p are required for APC-mediated degradation and direct binding to Cdc20p and Cdh1p. Genes Dev. 15, 2381-2395.
4. Ciosk, R., Zachariae, W., Michaelis, C., Shevchenko, A., Mann, M. and Nasmyth, K. (1998). An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast. Cell 93, 1067-1076.
5. Cohen-Fix, O., Peters, J. M., Kirschner, M. W. and Koshland, D. (1996). Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pds1p. Genes Dev. 10, 3081-3093.
6. Donaldson, M. M., Tavares, A. A., Ohkura, H., Deak, P. and Glover, D. M. (2001). Metaphase arrest with centromere separation in polo mutants of Drosophila. J. Cell Biol. 153, 663-676.
7. Funabiki, H., Kumada, K. and Yanagida, M. (1996a). Fission yeast Cut1 and Cut2 are essential for sister separation, concentrate along the metaphase spindle and form large complexes. EMBO J. 15, 6617-6628.
8. Funabiki, H., Yamano, H., Kumada, K., Nagao, K., Hunt, T. and Yanagida, M. (1996b). Cut2 proteolysis required for sister-chromatid separation in fission yeast. Nature 381, 438-441.
9. Funabiki, H., Yamano, H., Nagao, K., Tanaka, H., Yasuda, H., Hunt, T. and Yanagida, M. (1997). Fission yeast Cut2 required for anaphase has two destruction boxes. EMBO J. 16, 5977-5987.
10. Golic, M. M., Rong, Y. S., Petersen, R. B., Lindquist, S. L. and Golic, K. G. (1997). FLP-mediated DNA mobilization to specific target sites in Drosophila chromosomes. Nucleic Acids Res. 25, 3665-3671.
11. Hagting, A., den Elzen, N., Vodermaier, H. C., Waizenegger, I. C., Peters, J. M. and Pines, J. (2002). Human securin proteolysis is controlled by the spindle checkpoint and reveals when the APC/C switches from activation by Cdc20 to Cdh1. J. Cell Biol. 157, 1125-1137.
12. Hauf, S., Waizenegger, I. C. and Peters, J. M. (2001). Cohesin cleavage by separase required for anaphase and cytokinesis in human cells. Science 293, 1320-1323.
13. Jacobs, H. W., Keidel, E. and Lehner, C. F. (2001). A complex degradation signal in Cyclin A required for G1 arrest, and a C-terminal region for mitosis. EMBO J. 20, 2376-2386.
14. Jäger, H., Herzig, A., Lehner, C. F. and Heidmann, S. (2001). Drosophila separase is required for sister chromatid separation and binds to PIM and THR. Genes Dev. 15, 2572-2584.
15. Jallepalli, P. V., Waizenegger, I. C., Bunz, F., Langer, S., Speicher, M. R., Peters, J. M., Kinzler, K. W., Vogelstein, B. and Lengauer, C. (2001). Securin is required for chromosomal stability in human cells. Cell 105, 445-457.
16. Janody, F., Reischl, J. and Dostatni, N. (2000). Persistence of Hunchback in the terminal region of the Drosophila blastoderm embryo impairs anterior development. Development 127, 1573-1582.
17. Kaspar, M., Dienemann, A., Schulze, C. and Sprenger, F. (2001). Mitotic degradation of cyclin A is mediated by multiple and novel destruction signals. Curr. Biol. 11, 685-690.
18. Leismann, O., Herzig, A., Heidmann, S. and Lehner, C. F. (2000). Degradation of Drosophila PIM regulates sister chromatid separation during mitosis. Genes Dev. 14, 2192-2205.
19. Losada, A., Hirano, M. and Hirano, T. (2002). Cohesin release is required for sister chromatid resolution, but not for condensin-mediated compaction, at the onset of mitosis. Genes Dev. 16, 3004-3016.
20. Meyer, C. A., Jacobs, H. W., Datar, S. A., Du, W., Edgar, B. A. and Lehner, C. F. (2000). Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression. EMBO J. 19, 4533-4542.
21. Nasmyth, K. (2002). Segregating sister genomes: the molecular biology of chromosome separation. Science 297, 559-565.
22. Parry, D. H. and O'Farrell, P. H. (2001). The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis. Curr. Biol. 11, 671-683.
23. Peters, J. M. (1999). Subunits and substrates of the anaphase-promoting complex. Exp. Cell Res. 248, 339-349.
24. Peters, J. M. (2002). The anaphase-promoting complex: proteolysis in mitosis and beyond. Mol. Cell 9, 931-943.
25. Pfleger, C. M. and Kirschner, M. W. (2000). The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev. 14, 655-665.
26. Pfleger, C. M., Lee, E. and Kirschner, M. W. (2001). Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex. Genes Dev. 15, 2396-2407.
27. Pirrotta, V. (1988). Vectors for P-element transformation in Drosophila. In Vectors. A Survey of Cloning Vectors and Their Uses (eds R. L. Rodriguez and D. T. Denhardt), pp. 437-456. Boston and London: Butterworths.
28. Rupp, R. A., Snider, L. and Weintraub, H. (1994). Xenopus embryos regulate the nuclear localization of XMyoD. Genes Dev. 8, 1311-1323.
29. Sanson, B., White, P. and Vincent, J. P. (1996). Uncoupling cadherin-based adhesion from wingless signalling in Drosophila. Nature 383, 627-630.
30. Sigrist, S., Jacobs, H., Stratmann, R. and Lehner, C. F. (1995). Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3. EMBO J. 14, 4827-4838.
31. Stemmann, O., Zou, H., Gerber, S. A., Gygi, S. P. and Kirschner, M. W. (2001). Dual inhibition of sister chromatid separation at metaphase. Cell 107, 715-726.
32. Stratmann, R. and Lehner, C. F. (1996). Separation of sister chromatids in mitosis requires the Drosophila pimples product, a protein degraded after the metaphase anaphase transition. Cell 84, 25-35.
33. Struhl, G. and Basler, K. (1993). Organizing activity of wingless protein in Drosophila. Cell 72, 527-540.
34. Sumara, I., Vorlaufer, E., Stukenberg, P. T., Kelm, O., Redemann, N., Nigg, E. A. and Peters, J. M. (2002). The dissociation of cohesin from chromosomes in prophase is regulated by Polo-like kinase. Mol. Cell 9, 515-25.
35. Uhlmann, F., Wernic, D., Poupart, M. A., Koonin, E. V. and Nasmyth, K. (2000). Cleavage of cohesin by the CD clan protease separin triggers anaphase in yeast. Cell 103, 375-386.
36. Wang, Z., Yu, R. and Melmed, S. (2001). Mice lacking pituitary tumor transforming gene show testicular and splenic hypoplasia, thymic hyperplasia, thrombocytopenia, aberrant cell cycle progression, and premature centromere division. Mol. Endocrinol. 15, 1870-1879.
37. Wodarz, A., Hinz, U., Engelbert, M. and Knust, E. (1995). Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila. Cell 82, 67-76.
38. Yamamoto, A., Guacci, V. and Koshland, D. (1996). Pds1p is required for faithful execution of anaphase in the yeast Saccharomyces cerevisiae. J. Cell Biol. 133, 85-97.
39. Zou, H., McGarry, T. J., Bernal, T. and Kirschner, M. W. (1999). Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis. Science 285, 418-422.
40. Zur, A. and Brandeis, M. (2001). Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis. EMBO J. 20, 792-801.