Degradation of Drosophila PIM regulates sister chromatid separation during mitosis

Genes and Development

Volumn 14, Issue 17, 2000, Pages 2192-2205

  Leismann, O ^a   Herzig, A ^a   Heidmann, S ^a   Lehner, C F ^a  

^a UNIVERSITY OF BAYREUTH   (Germany)

Author keywords

Mitosis; Pimples; Securin; Separin; Sister chromatid separation; Three rows

Indexed keywords

COMPLEMENTARY DNA;

ARTICLE; CHROMATID; CONTROLLED STUDY; DROSOPHILA; EMBRYO; GENE MUTATION; GENE OVEREXPRESSION; MITOSIS; NONHUMAN; PRIORITY JOURNAL; SISTER CHROMATID;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; ANTINEOPLASTIC AGENTS, PHYTOGENIC; CELL CYCLE PROTEINS; CHROMATIDS; CYCLIN B; DEMECOLCINE; DROSOPHILA; DROSOPHILA PROTEINS; EPITOPES; FUNGAL PROTEINS; IMMUNOBLOTTING; INSECT PROTEINS; MITOSIS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-MYC; SACCHAROMYCES CEREVISIAE PROTEINS; TRANSCRIPTION FACTORS;

EID: 0033863619     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.176700     Document Type: Article

References (68)

1. Sister chromatid separation and chromosome re-duplication are regulated by different mechanisms in response to spindle damage
2. Cohesins bind to preferential sites along yeast chromosome III, with differential regulation along arms versus the centric region
3. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
4. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores
5. An ESP1/PDS1 complex regulates loss of sister chromatid cohesion at the metaphase to anaphase transition in yeast
6. The anaphase inhibitor of Saccharomyces cerevisiae pdslp is a target of the DNA damage checkpoint pathway
7. Pdslp of budding yeast has dual roles: Inhibition of anaphase initiation and regulation of mitotic exit
8. Anaphase initiation in Saccharomyces cerevisiae is controlled by the APC-dependent degradation of the anaphase inhibitor Pdslp
9. The three rows gene of Drosophila melanogaster encodes a novel protein that is required for chromosome disjunction during mitosis
10. Characterization of the components of the putative mammalian sister chromatid cohesion complex
11. Mutations of the fizzy locus cause metaphase arrest in Drosophila melanogaster embryos
12. The Drosophila cell cycle gene fizzy is required for normal degradation of cyclins A and B during mitosis and has homology to the CDC20 gene of Saccharomyces cerevisiae
13. Distinct molecular mechanisms regulate cell cycle timing at successive stages of Drosophila embryogenesis
14. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product
15. The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation
16. Mitosis and morphogenesis in the Drosophila embryo: Point and counter-point
17. Fission yeast cut1 and cut2 are essential for sister separation, concentrate along the metaphase spindle and form large complexes
18. Cut2 proteolysis required for sister-chromatid separation in fission yeast
19. Fission yeast cut2 required for anaphase has two destruction boxes
20. A direct link between sister chromatid cohesion and chromosome condensation revealed through the analysis of MCD1 in S. cerevisiae
21. Budding yeast cdc20: A target of the spindle checkpoint
22. Drosophila cyclin B3 is required for female fertility and is dispensable for mitosis like cyclin B
23. Mammalian p55CDC mediates association of the spindle checkpoint protein mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events
24. Fission yeast slpl: An effector of the mad2-dependent spindle checkpoint
25. Mutagenic analysis of the destruction signal of mitotic cyclins and structural characterization of ubiquitinated intermediates
26. Synergistic action of Drosophila cyclin A and cyclin B during the G2-M transition
27. Cut1 is loaded onto the spindle by binding to cut2 and promotes anaphase spindle movement upon cut2 proteolysis
28. Expression and function of Drosophila cyclin A during embryonic cell cycle progression
29. The roles of Drosophila cyclin A and cyclin B in mitotic control
30. Exploring the role of Drosophila cyclin A in the regulation of S-phase
31. Cdc20 is essential for the cyclosome-mediated proteolysis of both pds1 and clb2 during M phase in budding yeast
32. Identification of xenopus SMC protein complexes required for sister chromatid cohesion
33. Drosophila cdk4 is required for normal growth and dispensable for cell cycle progression
34. Cohesins: Chromosomal proteins that prevent premature separation of sister chromatids
35. Splitting the chromosomes: Cutting the ties that bind sister chromatids
36. Mutations affecting the pattern of the larval cuticle in Drosophila melanogaster. I. Zygotic loci on the second chromosome
37. Isolation and characterization of a pituitary tumor-transforming gene (PTTG)
38. Cell cycle control by ubiquitin-dependent proteolysis
39. Vectors for P-element transformation in Drosophila
40. Expression of N-terminally truncated cyclin-B in the Drosophila larval brain leads to mitotic delay at late anaphase
41. Uncoupling cadherin-based adhesion from wingless signalling in Drosophila
42. APC(Cdc20) promotes exit from mitosis by destroying the anaphase inhibitor pds1 and cyclin clb5
43. Drosophila fizzy-related down-regulates mitotic cyclins and is required for cell proliferation arrest and entry into endocycles
44. Exit from mitosis is regulated by Drosophila fizzy and the sequential destruction of cyclins A, B and B3
45. S phase function of Drosophila cyclin A and its downregulation in G1 phase
46. Separation of sister chromatids in mitosis requires the Drosophila pimples product, a protein degraded after the metaphase anaphase transition
47. Identification of cohesin association sites at centromeres and along chromosome arms
48. Maintenance of sister-chromatid cohesion at the centromere by the Drosophila MEI-S332 protein
49. Pds1 and esp1 control both anaphase and mitotic exit in normal cells and after DNA damage
50. Yeast cohesin complex requires a conserved protein, eco1p(ctf7), to establish cohesion between sister chromatids during DNA replication
51. Cohesion between sister chromatids must be established during DNA replication
52. Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit sccl
53. The fission yeast cut1 + gene regulates spindle pole body duplication and has homology to the budding yeast esp1 gene
54. CDC20 and CDH1: A family of substrate-specific activators of APC-dependent proteolysis
55. Cohesin rec8 is required for reductional chromosome segregation at meiosis
56. Mad2 binding by phosphorylated kinetochores links error detection and checkpoint action in mitosis
57. Continuous cyclin E expression inhibits progression through endoreduplication cycles in Drosophila
58. The A-type and B-type cyclins of Drosophila are accumulated and destroyed in temporally distinct events that define separable phases of the G2-M transition
59. Expression of crumbs confers apical character on plasma membrane domains of ectodermal epithelia of Drosophila
60. Pds1p, an inhibitor for faithful execution of anaphase in the yeast Saccharomyces cerevisiae
61. Pds1p, an inhibitor of anaphase in budding yeast, plays a critical role in the APC and checkpoint pathway(s)
62. A monoclonal antibody against the PSTAIR sequence of p34cdc2, catalytic subunit of maturation-promoting factor and key regulator of the cell cycle
63. Cell cycle mechanisms of sister chromatid separation; roles of cut1/separin and cut2/securin
64. Whose end is destruction: Cell division and the anaphase-promoting complex
65. Mass spectrometric analysis of the anaphase-promoting complex from yeast: Identification of a subunit related to cullins
66. Pituitary tumor transforming gene (PTTG) expression in pituitary adenomas
67. Identification of a vertebrate sister-chromatid separation inhibitor involved in transformation and tumorigenesis