-
1
-
-
0034857599
-
New drugs and combinations in the palliative treatment of colon and rectal cancer
-
Beretta GD, Pessi MA, Poletti P, Mosconi S, Labianca R. New drugs and combinations in the palliative treatment of colon and rectal cancer. Eur J Surg Oncol 2001; 27:595-600.
-
(2001)
Eur J Surg Oncol
, vol.27
, pp. 595-600
-
-
Beretta, G.D.1
Pessi, M.A.2
Poletti, P.3
Mosconi, S.4
Labianca, R.5
-
2
-
-
0036250933
-
Novel therapeutics for head and neck cancer
-
Kim ES, Kies M, Herbst RS. Novel therapeutics for head and neck cancer. Curr Opin Oncol 2002; 14:334-342.
-
(2002)
Curr Opin Oncol
, vol.14
, pp. 334-342
-
-
Kim, E.S.1
Kies, M.2
Herbst, R.S.3
-
4
-
-
0033663028
-
New therapeutic strategies for the treatment and prevention of head and neck cancer
-
Lingen MW, Emami B, Clark JI. New therapeutic strategies for the treatment and prevention of head and neck cancer. Expert Opin Invest Drugs 2000; 9:2855-2872.
-
(2000)
Expert Opin Invest Drugs
, vol.9
, pp. 2855-2872
-
-
Lingen, M.W.1
Emami, B.2
Clark, J.I.3
-
5
-
-
0034614637
-
The hallmarks of cancer
-
Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000; 100:57-70.
-
(2000)
Cell
, vol.100
, pp. 57-70
-
-
Hanahan, D.1
Weinberg, R.A.2
-
6
-
-
0034988184
-
The epidermal growth factor receptor as a target for cancer therapy
-
Mendelsohn J. The epidermal growth factor receptor as a target for cancer therapy. Endocr Relat Cancer 2001; 8:3-9.
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 3-9
-
-
Mendelsohn, J.1
-
7
-
-
0035479296
-
EGFR overexpression and radiation response in glioblastoma multiforme
-
Barker FG, Simmons ML, Chang SM, Prados MD, Larson DA, Sneed PK, et al. EGFR overexpression and radiation response in glioblastoma multiforme. Int J Radiat Oncol Biol Phys 2001; 51:410-418.
-
(2001)
Int J Radiat Oncol Biol Phys
, vol.51
, pp. 410-418
-
-
Barker, F.G.1
Simmons, M.L.2
Chang, S.M.3
Prados, M.D.4
Larson, D.A.5
Sneed, P.K.6
-
8
-
-
0031056372
-
EGFR and steroid receptors in ovarian carcinoma: Comparison with prognostic parameters and outcome of patients
-
Fischer-Colbrie J, Witt A, Heinzl H, Speiser P, Czerwenka K, Sevelda P, et al. EGFR and steroid receptors in ovarian carcinoma: comparison with prognostic parameters and outcome of patients. Anticancer Res 1997; 17:613-619.
-
(1997)
Anticancer Res
, vol.17
, pp. 613-619
-
-
Fischer-Colbrie, J.1
Witt, A.2
Heinzl, H.3
Speiser, P.4
Czerwenka, K.5
Sevelda, P.6
-
9
-
-
0036235654
-
The roles of JNK1 and Stat3 in the response of head and neck cancer cell lines to combined treatment with all-trans-retinoic acid and 5-fluorouracil
-
Masuda M, Toh S, Koike K, Kuratomi Y, Suzui M, Deguchi A, et al. The roles of JNK1 and Stat3 in the response of head and neck cancer cell lines to combined treatment with all-trans-retinoic acid and 5-fluorouracil. Jpn J Cancer Res 2002; 93:329-339.
-
(2002)
Jpn J Cancer Res
, vol.93
, pp. 329-339
-
-
Masuda, M.1
Toh, S.2
Koike, K.3
Kuratomi, Y.4
Suzui, M.5
Deguchi, A.6
-
10
-
-
0023082137
-
Receptors for epidermal growth factor and other polypeptide mitogens
-
Carpenter G. Receptors for epidermal growth factor and other polypeptide mitogens. Annu Rev Biochem 1987; 56:881-914.
-
(1987)
Annu Rev Biochem
, vol.56
, pp. 881-914
-
-
Carpenter, G.1
-
12
-
-
0034773992
-
The EGFR family and its ligands in human cancer: Signalling mechanisms and therapeutic opportunities
-
Yarden Y. The EGFR family and its ligands in human cancer: signalling mechanisms and therapeutic opportunities. Eur J Cancer 2001; 37(suppl 4):S3-S8.
-
(2001)
Eur J Cancer
, vol.37
, Issue.SUPPL. 4
-
-
Yarden, Y.1
-
13
-
-
0026077157
-
The EGF receptor system as a target for antitumor therapy
-
Ennis BW, Lippman ME, Dickson RB. The EGF receptor system as a target for antitumor therapy. Cancer Invest 1991; 9:553-562.
-
(1991)
Cancer Invest
, vol.9
, pp. 553-562
-
-
Ennis, B.W.1
Lippman, M.E.2
Dickson, R.B.3
-
14
-
-
0031961980
-
Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor
-
Moscatello DK, Holgado-Madruga M, Emlet DR, Montgomery RB, Wong AJ. Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor. J Biol Chem 1998; 273:200-206.
-
(1998)
J Biol Chem
, vol.273
, pp. 200-206
-
-
Moscatello, D.K.1
Holgado-Madruga, M.2
Emlet, D.R.3
Montgomery, R.B.4
Wong, A.J.5
-
15
-
-
0028955388
-
Epidermal growth factor-related peptides and their receptors in human malignancies
-
Salomon DS, Brandt R, Ciardiello F, Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 1995; 19:183-232.
-
(1995)
Crit Rev Oncol Hematol
, vol.19
, pp. 183-232
-
-
Salomon, D.S.1
Brandt, R.2
Ciardiello, F.3
Normanno, N.4
-
16
-
-
0029025332
-
Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas
-
Wikstrand CJ, Hale LP, Batra SK, Hill ML, Humphrey PA, Kurpad SN, et al. Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas. Cancer Res 1995; 55:3140-3148.
-
(1995)
Cancer Res
, vol.55
, pp. 3140-3148
-
-
Wikstrand, C.J.1
Hale, L.P.2
Batra, S.K.3
Hill, M.L.4
Humphrey, P.A.5
Kurpad, S.N.6
-
18
-
-
0032549570
-
Overexpression of EGFR and c-erbB2 causes enhanced cell migration in human breast cancer cells and NIH3T3 fibroblasts
-
Verbeek BS, Adriaansen-Slot SS, Vroom TM, Beckers T, Rijksen G. Overexpression of EGFR and c-erbB2 causes enhanced cell migration in human breast cancer cells and NIH3T3 fibroblasts. FEBS Lett 1998; 425:145-150.
-
(1998)
FEBS Lett
, vol.425
, pp. 145-150
-
-
Verbeek, B.S.1
Adriaansen-Slot, S.S.2
Vroom, T.M.3
Beckers, T.4
Rijksen, G.5
-
19
-
-
0032731892
-
Tumor invasion: Role of growth factor-induced cell motility
-
Wells A. Tumor invasion: role of growth factor-induced cell motility. Adv Cancer Res 2000; 78:31-101.
-
(2000)
Adv Cancer Res
, vol.78
, pp. 31-101
-
-
Wells, A.1
-
20
-
-
0028000069
-
Signal-transduction therapy. A novel approach to disease management
-
Levitzki A. Signal-transduction therapy. A novel approach to disease management. Eur J Biochem 1994; 226:1-13.
-
(1994)
Eur J Biochem
, vol.226
, pp. 1-13
-
-
Levitzki, A.1
-
21
-
-
0028696975
-
Signalling targets for the development of cancer drugs
-
Powis G, Workman P. Signalling targets for the development of cancer drugs. Anticancer Drug Des 1994; 9:555-568.
-
(1994)
Anticancer Drug Des
, vol.9
, pp. 555-568
-
-
Powis, G.1
Workman, P.2
-
22
-
-
0034992521
-
The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification
-
Prenzel N, Fischer OM, Streit S, Hart S, Ullrich A. The epidermal growth factor receptor family as a central element for cellular signal transduction and diversification. Endocr Relat Cancer 2001; 8:11-31.
-
(2001)
Endocr Relat Cancer
, vol.8
, pp. 11-31
-
-
Prenzel, N.1
Fischer, O.M.2
Streit, S.3
Hart, S.4
Ullrich, A.5
-
23
-
-
18644386251
-
Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains
-
Ogiso H, Ishitani R, Nureki O, Fukai S, Yamanaka M, Kim JH, et al. Crystal structure of the complex of human epidermal growth factor and receptor extracellular domains. Cell 2002; 110:775-787.
-
(2002)
Cell
, vol.110
, pp. 775-787
-
-
Ogiso, H.1
Ishitani, R.2
Nureki, O.3
Fukai, S.4
Yamanaka, M.5
Kim, J.H.6
-
24
-
-
0013689209
-
Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro
-
Rubin Grandis J, Drenning SD, Chakraborty A, Zhou MY, Zeng Q, Pitt AS, et al. Requirement of Stat3 but not Stat1 activation for epidermal growth factor receptor-mediated cell growth in vitro. J Clin Invest 1998; 102:1385-1392.
-
(1998)
J Clin Invest
, vol.102
, pp. 1385-1392
-
-
Rubin Grandis, J.1
Drenning, S.D.2
Chakraborty, A.3
Zhou, M.Y.4
Zeng, Q.5
Pitt, A.S.6
-
25
-
-
0034021563
-
Epidermal growth factor receptor-mediated stat3 signaling blocks apoptosis in head and neck cancer
-
Rubin Grandis J, Zeng Q, Drenning SD. Epidermal growth factor receptor-mediated stat3 signaling blocks apoptosis in head and neck cancer. Laryngoscope 2000; 110:868-874.
-
(2000)
Laryngoscope
, vol.110
, pp. 868-874
-
-
Rubin Grandis, J.1
Zeng, Q.2
Drenning, S.D.3
-
26
-
-
0035018353
-
Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase
-
Lu Z, Jiang G, Blume-Jensen P, Hunter T. Epidermal growth factor-induced tumor cell invasion and metastasis initiated by dephosphorylation and downregulation of focal adhesion kinase. Mol Cell Biol 2001; 21: 4016-4031.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 4016-4031
-
-
Lu, Z.1
Jiang, G.2
Blume-Jensen, P.3
Hunter, T.4
-
27
-
-
85047695527
-
Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
-
Niu G, Wright KL, Huang M, Song L, Haura E, Turkson J, et al. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 2002; 21:2000-2008.
-
(2002)
Oncogene
, vol.21
, pp. 2000-2008
-
-
Niu, G.1
Wright, K.L.2
Huang, M.3
Song, L.4
Haura, E.5
Turkson, J.6
-
28
-
-
0036605053
-
Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappa;B and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines
-
Bancroft CC, Chen Z, Yeh J, Sunwoo JB, Yeh NT, Jackson S, et al. Effects of pharmacologic antagonists of epidermal growth factor receptor, PI3K and MEK signal kinases on NF-kappa;B and AP-1 activation and IL-8 and VEGF expression in human head and neck squamous cell carcinoma lines. Int J Cancer 2002; 99:538-548.
-
(2002)
Int J Cancer
, vol.99
, pp. 538-548
-
-
Bancroft, C.C.1
Chen, Z.2
Yeh, J.3
Sunwoo, J.B.4
Yeh, N.T.5
Jackson, S.6
-
29
-
-
0037374686
-
Critical role of both p27KIP1 and p21CIP1/WAF1 in the antiproliferative effect of ZD1839 ('Iressa'), an epidermal growth factor receptor tyrosine kinase inhibitor, in head and neck squamous carcinoma cells
-
Di Gennaro E, Barbarino M, Bruzzese F, De Lorenzo S, Caraglia M, Abbruzzese A, et al. Critical role of both p27KIP1 and p21CIP1/WAF1 in the antiproliferative effect of ZD1839 ('Iressa'), an epidermal growth factor receptor tyrosine kinase inhibitor, in head and neck squamous carcinoma cells. J Cell Physiol 2003; 195:139-150.
-
(2003)
J Cell Physiol
, vol.195
, pp. 139-150
-
-
Di Gennaro, E.1
Barbarino, M.2
Bruzzese, F.3
De Lorenzo, S.4
Caraglia, M.5
Abbruzzese, A.6
-
30
-
-
0030693984
-
Cip1 in growth inhibition mediated by blockade or overstimulation of epidermal growth factor receptors
-
Cip1 in growth inhibition mediated by blockade or overstimulation of epidermal growth factor receptors. Clin Cancer Res 1997; 3:1943-1948.
-
(1997)
Clin Cancer Res
, vol.3
, pp. 1943-1948
-
-
Fan, Z.1
Shang, B.Y.2
Lu, Y.3
Chou, J.L.4
Mendelsohn, J.5
-
31
-
-
0030774045
-
Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase
-
Moyer JD, Barbacci EG, Iwata KK, Arnold L, Boman B, Cunningham A, et al. Induction of apoptosis and cell cycle arrest by CP-358,774, an inhibitor of epidermal growth factor receptor tyrosine kinase. Cancer Res 1997; 57:4838-4848.
-
(1997)
Cancer Res
, vol.57
, pp. 4838-4848
-
-
Moyer, J.D.1
Barbacci, E.G.2
Iwata, K.K.3
Arnold, L.4
Boman, B.5
Cunningham, A.6
-
34
-
-
0035418622
-
Activated extracellular signal-regulated kinases: Association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments
-
Albanell J, Codony-Servat J, Rojo F, Del Campo JM, Sauleda S, Anido J, et al. Activated extracellular signal-regulated kinases: association with epidermal growth factor receptor/transforming growth factor alpha expression in head and neck squamous carcinoma and inhibition by anti-epidermal growth factor receptor treatments. Cancer Res 2001; 61: 6500-6510.
-
(2001)
Cancer Res
, vol.61
, pp. 6500-6510
-
-
Albanell, J.1
Codony-Servat, J.2
Rojo, F.3
Del Campo, J.M.4
Sauleda, S.5
Anido, J.6
-
35
-
-
0035863208
-
Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF
-
Lo RS, Wotton D, Massague J. Epidermal growth factor signaling via Ras controls the Smad transcriptional co-repressor TGIF. EMBO J 2001; 20:128-136.
-
(2001)
EMBO J
, vol.20
, pp. 128-136
-
-
Lo, R.S.1
Wotton, D.2
Massague, J.3
-
36
-
-
0034489116
-
Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma
-
Inoue K, Slaton JW, Perrotte P, Davis DW, Bruns CJ, Hicklin DJ, et al. Paclitaxel enhances the effects of the anti-epidermal growth factor receptor monoclonal antibody ImClone C225 in mice with metastatic human bladder transitional cell carcinoma. Clin Cancer Res 2000; 6:4874-4884.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 4874-4884
-
-
Inoue, K.1
Slaton, J.W.2
Perrotte, P.3
Davis, D.W.4
Bruns, C.J.5
Hicklin, D.J.6
-
37
-
-
0032972944
-
Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice
-
Perrotte P, Matsumoto T, Inoue K, Kuniyasu H, Eve BY, Hicklin DJ, et al. Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin Cancer Res 1999; 5:257-265.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 257-265
-
-
Perrotte, P.1
Matsumoto, T.2
Inoue, K.3
Kuniyasu, H.4
Eve, B.Y.5
Hicklin, D.J.6
-
38
-
-
0034896362
-
Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor
-
Ciardiello F, Caputo R, Bianco R, Damiano V, Fontanini G, Cuccato S, et al. Inhibition of growth factor production and angiogenesis in human cancer cells by ZD1839 (Iressa), a selective epidermal growth factor receptor tyrosine kinase inhibitor. Clin Cancer Res 2001; 7:1459-1465.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1459-1465
-
-
Ciardiello, F.1
Caputo, R.2
Bianco, R.3
Damiano, V.4
Fontanini, G.5
Cuccato, S.6
-
39
-
-
0035116241
-
Vascular endothelial growth factor family members are differentially regulated by c-erbB signaling in head and neck squamous carcinoma cells
-
O-charoenrat P, Rhys-Evans P, Modjtahedi H, Eccles SA. Vascular endothelial growth factor family members are differentially regulated by c-erbB signaling in head and neck squamous carcinoma cells. Clin Exp Metastasis 2000; 18:155-161.
-
(2000)
Clin Exp Metastasis
, vol.18
, pp. 155-161
-
-
O-Charoenrat, P.1
Rhys-Evans, P.2
Modjtahedi, H.3
Eccles, S.A.4
-
40
-
-
0242293804
-
ABX-EGF, a fully human anti-EGF receptor monoclonal antibody: Inhibition of prostate cancer in vitro and in vivo
-
abstr 2454
-
Yang XD, Wang P, Fredlin P, Davis CG. ABX-EGF, a fully human anti-EGF receptor monoclonal antibody: inhibition of prostate cancer in vitro and in vivo. Proc Am Soc Clin Oncol 2002; abstr 2454.
-
(2002)
Proc Am Soc Clin Oncol
-
-
Yang, X.D.1
Wang, P.2
Fredlin, P.3
Davis, C.G.4
-
41
-
-
0034212763
-
Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma
-
Bruns CJ, Solorzano CC, Harbison MT, Ozawa S, Tsan R, Fan D, et al. Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res 2000; 60:2926-2935.
-
(2000)
Cancer Res
, vol.60
, pp. 2926-2935
-
-
Bruns, C.J.1
Solorzano, C.C.2
Harbison, M.T.3
Ozawa, S.4
Tsan, R.5
Fan, D.6
-
42
-
-
18844473781
-
Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms
-
Bruns CJ, Harbison MT, Davis DW, Portera CA, Tsan R, McConkey DJ, et al. Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms. Clin Cancer Res 2000; 6:1936-1948.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 1936-1948
-
-
Bruns, C.J.1
Harbison, M.T.2
Davis, D.W.3
Portera, C.A.4
Tsan, R.5
McConkey, D.J.6
-
43
-
-
10444220480
-
Cetuximab prolongs survival in patients with locoregionally advanced squamous cell carinoma of head and neck: A phase III study of high dose radiation therapy with or without cetuximab
-
abstr 5507
-
Bonner JA, Giralt J, Harari PM, Cohen R, Jones C, Sur RK, et al. Cetuximab prolongs survival in patients with locoregionally advanced squamous cell carinoma of head and neck: a phase III study of high dose radiation therapy with or without cetuximab. Proc Am Soc Clin Oncol 2004; abstr 5507.
-
(2004)
Proc Am Soc Clin Oncol
-
-
Bonner, J.A.1
Giralt, J.2
Harari, P.M.3
Cohen, R.4
Jones, C.5
Sur, R.K.6
-
44
-
-
0034068319
-
Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor
-
Ciardiello F, Caputo R, Bianco R, Damiano V, Pomatico G, De Placido S, et al. Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor. Clin Cancer Res 2000; 6:2053-2063.
-
(2000)
Clin Cancer Res
, vol.6
, pp. 2053-2063
-
-
Ciardiello, F.1
Caputo, R.2
Bianco, R.3
Damiano, V.4
Pomatico, G.5
De Placido, S.6
-
45
-
-
0035879822
-
Antisense oligonucleotides targeting the epidermal growth factor receptor inhibit proliferation, induce apoptosis, and cooperate with cytotoxic drugs in human cancer cell lines
-
Ciardiello F, Caputo R, Troiani T, Borriello G, Kandimalla ER, Agrawal S, et al. Antisense oligonucleotides targeting the epidermal growth factor receptor inhibit proliferation, induce apoptosis, and cooperate with cytotoxic drugs in human cancer cell lines. Int J Cancer 2001; 93: 172-178.
-
(2001)
Int J Cancer
, vol.93
, pp. 172-178
-
-
Ciardiello, F.1
Caputo, R.2
Troiani, T.3
Borriello, G.4
Kandimalla, E.R.5
Agrawal, S.6
-
46
-
-
0031957897
-
Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells
-
Karnes WEJ, Weller SG, Adjei PN, Kottke TJ, Glenn KS, Gores GJ, et al. Inhibition of epidermal growth factor receptor kinase induces protease-dependent apoptosis in human colon cancer cells. Gastroenterology 1998; 114:930-939.
-
(1998)
Gastroenterology
, vol.114
, pp. 930-939
-
-
Karnes, W.E.J.1
Weller, S.G.2
Adjei, P.N.3
Kottke, T.J.4
Glenn, K.S.5
Gores, G.J.6
-
47
-
-
0028969852
-
Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin
-
Wu X, Fan Z, Masui H, Rosen N, Mendelsohn J. Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin. J Clin Invest 1995; 95:1897-1905.
-
(1995)
J Clin Invest
, vol.95
, pp. 1897-1905
-
-
Wu, X.1
Fan, Z.2
Masui, H.3
Rosen, N.4
Mendelsohn, J.5
-
48
-
-
0033561522
-
Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck
-
Huang SM, Bock JM, Harari PM. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res 1999; 59:1935-1940.
-
(1999)
Cancer Res
, vol.59
, pp. 1935-1940
-
-
Huang, S.M.1
Bock, J.M.2
Harari, P.M.3
-
49
-
-
0034038282
-
Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity
-
Liu B, Fang M, Schmidt M, Lu Y, Mendelsohn J, Fan Z. Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity. Br J Cancer 2000; 82:1991-1999.
-
(2000)
Br J Cancer
, vol.82
, pp. 1991-1999
-
-
Liu, B.1
Fang, M.2
Schmidt, M.3
Lu, Y.4
Mendelsohn, J.5
Fan, Z.6
-
50
-
-
0036096775
-
Inhibition of angiogenesis by the antiepidermal growth factor receptor antibody ImClone C225 in androgen-independent prostate cancer growing orthotopically in nude mice
-
Karashima T, Sweeney P, Slaton JW, Kim SJ, Kedar D, Izawa JI, et al. Inhibition of angiogenesis by the antiepidermal growth factor receptor antibody ImClone C225 in androgen-independent prostate cancer growing orthotopically in nude mice. Clin Cancer Res 2002; 8:1253-1264.
-
(2002)
Clin Cancer Res
, vol.8
, pp. 1253-1264
-
-
Karashima, T.1
Sweeney, P.2
Slaton, J.W.3
Kim, S.J.4
Kedar, D.5
Izawa, J.I.6
-
51
-
-
0024261027
-
Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice
-
Aboud-Pirak E, Hurwitz E, Pirak ME, Bellot F, Schlessinger J, Sela M. Efficacy of antibodies to epidermal growth factor receptor against KB carcinoma in vitro and in nude mice. J Natl Cancer Inst 1988; 80: 1605-1611.
-
(1988)
J Natl Cancer Inst
, vol.80
, pp. 1605-1611
-
-
Aboud-Pirak, E.1
Hurwitz, E.2
Pirak, M.E.3
Bellot, F.4
Schlessinger, J.5
Sela, M.6
-
52
-
-
0033763084
-
ZD1839 ('Iressa') as an anticancer agent
-
Baselga J, Averbuch SD. ZD1839 ('Iressa') as an anticancer agent. Drugs 2000; 60(suppl 1):33-40.
-
(2000)
Drugs
, vol.60
, Issue.SUPPL. 1
, pp. 33-40
-
-
Baselga, J.1
Averbuch, S.D.2
-
53
-
-
0035863314
-
The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux
-
Erlichman C, Boerner SA, Hallgren CG, Spieker R, Wang XY, James CD, et al. The HER tyrosine kinase inhibitor CI1033 enhances cytotoxicity of 7-ethyl-10-hydroxycamptothecin and topotecan by inhibiting breast cancer resistance protein-mediated drug efflux. Cancer Res 2001; 61:739-748.
-
(2001)
Cancer Res
, vol.61
, pp. 739-748
-
-
Erlichman, C.1
Boerner, S.A.2
Hallgren, C.G.3
Spieker, R.4
Wang, X.Y.5
James, C.D.6
-
54
-
-
0031427295
-
Antitumor activity of anti-epidermal growth factor receptor monoclonal antibodies and cisplatin in ten human head and neck squamous cell carcinoma lines
-
Hoffmann T, Hafner D, Ballo H, Haas I, Bier H. Antitumor activity of anti-epidermal growth factor receptor monoclonal antibodies and cisplatin in ten human head and neck squamous cell carcinoma lines. Anticancer Res 1997; 17:4419-4425.
-
(1997)
Anticancer Res
, vol.17
, pp. 4419-4425
-
-
Hoffmann, T.1
Hafner, D.2
Ballo, H.3
Haas, I.4
Bier, H.5
-
55
-
-
0032695910
-
Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: Dynamics of receptor inhibition in situ and antitumor effects in athymic mice
-
Pollack VA, Savage DM, Baker DA, Tsaparikos KE, Sloan DE, Moyer JD, et al. Inhibition of epidermal growth factor receptor-associated tyrosine phosphorylation in human carcinomas with CP-358,774: dynamics of receptor inhibition in situ and antitumor effects in athymic mice. J Pharmacol Exp Ther 1999; 291:739-748.
-
(1999)
J Pharmacol Exp Ther
, vol.291
, pp. 739-748
-
-
Pollack, V.A.1
Savage, D.M.2
Baker, D.A.3
Tsaparikos, K.E.4
Sloan, D.E.5
Moyer, J.D.6
-
56
-
-
0034565927
-
Radiosensitization of human breast cancer cells by a novel ErbB family receptor tyrosine kinase inhibitor
-
Rao GS, Murray S, Ethier SP. Radiosensitization of human breast cancer cells by a novel ErbB family receptor tyrosine kinase inhibitor. Int J Radiat Oncol Biol Phys 2000; 48:1519-1528.
-
(2000)
Int J Radiat Oncol Biol Phys
, vol.48
, pp. 1519-1528
-
-
Rao, G.S.1
Murray, S.2
Ethier, S.P.3
-
57
-
-
85047696958
-
ZD1839 ('Iressa'), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model
-
Williams KJ, Telfer BA, Stratford IJ, Wedge SR. ZD1839 ('Iressa'), a specific oral epidermal growth factor receptor-tyrosine kinase inhibitor, potentiates radiotherapy in a human colorectal cancer xenograft model. Br J Cancer 2002; 86:1157-1161.
-
(2002)
Br J Cancer
, vol.86
, pp. 1157-1161
-
-
Williams, K.J.1
Telfer, B.A.2
Stratford, I.J.3
Wedge, S.R.4
-
58
-
-
0036500831
-
Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: A new paradigm for cancer therapy
-
Herbst RS, Shin DM. Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: a new paradigm for cancer therapy. Cancer 2002; 94:1593-1611.
-
(2002)
Cancer
, vol.94
, pp. 1593-1611
-
-
Herbst, R.S.1
Shin, D.M.2
-
59
-
-
0034754136
-
Epidermal growth factor receptor biology (IMC-C225)
-
Kim ES, Khuri FR, Herbst RS. Epidermal growth factor receptor biology (IMC-C225). Curr Opin Oncol 2001; 13:506-513.
-
(2001)
Curr Opin Oncol
, vol.13
, pp. 506-513
-
-
Kim, E.S.1
Khuri, F.R.2
Herbst, R.S.3
-
60
-
-
0034329308
-
Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck cancers
-
Bonner JA, Raisch KP, Trummell HQ, Robert F, Meredith RF, Spencer SA, et al. Enhanced apoptosis with combination C225/radiation treatment serves as the impetus for clinical investigation in head and neck cancers. J Clin Oncol 2000; 18:47S-53S.
-
(2000)
J Clin Oncol
, vol.18
-
-
Bonner, J.A.1
Raisch, K.P.2
Trummell, H.Q.3
Robert, F.4
Meredith, R.F.5
Spencer, S.A.6
-
61
-
-
0027290650
-
Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies
-
Baselga J, Norton L, Masui H, Pandiella A, Coplan K, Miller WHJ, et al. Antitumor effects of doxorubicin in combination with anti-epidermal growth factor receptor monoclonal antibodies. J Natl Cancer Inst 1993; 85: 1327-1333.
-
(1993)
J Natl Cancer Inst
, vol.85
, pp. 1327-1333
-
-
Baselga, J.1
Norton, L.2
Masui, H.3
Pandiella, A.4
Coplan, K.5
Miller, W.H.J.6
-
62
-
-
0032904485
-
Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225
-
Ciardiello F, Bianco R, Damiano V, De Lorsnzo S, Pepe S, De Placido S, et al. Antitumor activity of sequential treatment with topotecan and anti-epidermal growth factor receptor monoclonal antibody C225. Clin Cancer Res 1999; 5:909-916.
-
(1999)
Clin Cancer Res
, vol.5
, pp. 909-916
-
-
Ciardiello, F.1
Bianco, R.2
Damiano, V.3
De Lorsnzo, S.4
Pepe, S.5
De Placido, S.6
-
63
-
-
0027428571
-
Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts
-
Fan Z, Baselga J, Masui H, Mendelsohn J. Antitumor effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts. Cancer Res 1993; 53:4637-4642.
-
(1993)
Cancer Res
, vol.53
, pp. 4637-4642
-
-
Fan, Z.1
Baselga, J.2
Masui, H.3
Mendelsohn, J.4
-
64
-
-
0035479052
-
C225 antiepidermal growth factor receptor antibody enhances tumor radiocurability
-
Nasu S, Ang KK, Fan Z, Milas L. C225 antiepidermal growth factor receptor antibody enhances tumor radiocurability. Int J Radiat Oncol Biol Phys 2001; 51:474-477.
-
(2001)
Int J Radiat Oncol Biol Phys
, vol.51
, pp. 474-477
-
-
Nasu, S.1
Ang, K.K.2
Fan, Z.3
Milas, L.4
-
65
-
-
16244365228
-
Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody ERBITUX™ (IMC-C225) in combination with irinotecan (CPT-11), 5-FU, and leucovorin against human colorectal carcinoma xenografts
-
abstr
-
Prewett MC, Hooper AT, Bassi R, Waksal HW, Hicklin DJ. Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody ERBITUX™ (IMC-C225) in combination with irinotecan (CPT-11), 5-FU, and leucovorin against human colorectal carcinoma xenografts. Proc Am Ass Cancer Res 2002; abstr.
-
(2002)
Proc Am Ass Cancer Res
-
-
Prewett, M.C.1
Hooper, A.T.2
Bassi, R.3
Waksal, H.W.4
Hicklin, D.J.5
-
66
-
-
4444334483
-
Bevacizumab (BV) plus 5-FU/leucovorin (FU/LV) for advanced colorectal cancer (CRC) that progressed after standard chemotherapies: An NCI Treatment Referral Center trial (TRC-0301)
-
abstr 3515
-
Chen HX, Mooney M, Boron M, Grochow L, Zwiebel J, Vena D, et al. Bevacizumab (BV) plus 5-FU/leucovorin (FU/LV) for advanced colorectal cancer (CRC) that progressed after standard chemotherapies: an NCI Treatment Referral Center trial (TRC-0301). Proc Am Soc Clin Oncol 2004; abstr 3515.
-
(2004)
Proc Am Soc Clin Oncol
-
-
Chen, H.X.1
Mooney, M.2
Boron, M.3
Grochow, L.4
Zwiebel, J.5
Vena, D.6
-
67
-
-
11344281454
-
Cetuximab plus FOLFOX for colorectal cancer (EXPLORE): Preliminary safety analysis of a randomized phase III trial
-
abstr 3531
-
Badarinath S, Mitchell EP, Jennis A, Graham CD, Hansen VL, Henderson CA, et al. Cetuximab plus FOLFOX for colorectal cancer (EXPLORE): Preliminary safety analysis of a randomized phase III trial. Proc Am Soc Clin Oncol 2004; abstr 3531.
-
(2004)
Proc Am Soc Clin Oncol
-
-
Badarinath, S.1
Mitchell, E.P.2
Jennis, A.3
Graham, C.D.4
Hansen, V.L.5
Henderson, C.A.6
-
68
-
-
16244372110
-
Cetuximab + FOLFIRI as first-line treatment for metastatic colorectal CA
-
abstr 3513
-
Rougier P, Raoul JL, Van Laethem JL, Peeters M, Husseini F, Brezault C, et al. Cetuximab + FOLFIRI as first-line treatment for metastatic colorectal CA. Proc Am Soc Clin Oncol 2004; abstr 3513.
-
(2004)
Proc Am Soc Clin Oncol
-
-
Rougier, P.1
Raoul, J.L.2
Van Laethem, J.L.3
Peeters, M.4
Husseini, F.5
Brezault, C.6
-
69
-
-
6444243519
-
An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (S-FU)/folinic acid (FA) (FOLFOX-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing epidermal growth factor receptor (EGFR). Preliminary results
-
abstr 3512
-
Tabernero JM, Van Cutsem E, Sastre J, Cervantes A, Van Laethem JL, Humblet Y, et al. An international phase II study of cetuximab in combination with oxaliplatin/5-fluorouracil (S-FU)/folinic acid (FA) (FOLFOX-4) in the first-line treatment of patients with metastatic colorectal cancer (CRC) expressing epidermal growth factor receptor (EGFR). Preliminary results. Proc Am Soc Clin Oncol 2004; abstr 3512.
-
(2004)
Proc Am Soc Clin Oncol
-
-
Tabernero, J.M.1
Van Cutsem, E.2
Sastre, J.3
Cervantes, A.4
Van Laethem, J.L.5
Humblet, Y.6
-
70
-
-
3242720345
-
Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan-refractory metastatic colorectal cancer
-
Cunningham D, Humblet Y, Siena S, Khayat D, Bleiberg H, Santoro A, et al. Cetuximab Monotherapy and Cetuximab plus Irinotecan in Irinotecan-Refractory Metastatic Colorectal Cancer. N Engl J Med 2004; 351: 337-345.
-
(2004)
N Engl J Med
, vol.351
, pp. 337-345
-
-
Cunningham, D.1
Humblet, Y.2
Siena, S.3
Khayat, D.4
Bleiberg, H.5
Santoro, A.6
-
71
-
-
2142641698
-
Phase II trial of cetuximab in patients with refractory coforectal cancer that expresses the epidermal growth factor receptor
-
Saltz LB, Meropol NJ, Loehrer Sr PJ, Needle MN, Kopit J, Mayer RJ. Phase II trial of cetuximab in patients with refractory coforectal cancer that expresses the epidermal growth factor receptor. J Clin Oncol 2004; 22:1201-1208.
-
(2004)
J Clin Oncol
, vol.22
, pp. 1201-1208
-
-
Saltz, L.B.1
Meropol, N.J.2
Loehrer Sr., P.J.3
Needle, M.N.4
Kopit, J.5
Mayer, R.J.6
-
72
-
-
4344590997
-
Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II trial
-
Xiong HQ, Rosenberg A, LoBuglio A, Schmidt W, Wolff RA, Deutsch J, et al. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II trial. J Clin Oncol 2004; 22:2610-2616.
-
(2004)
J Clin Oncol
, vol.22
, pp. 2610-2616
-
-
Xiong, H.Q.1
Rosenberg, A.2
LoBuglio, A.3
Schmidt, W.4
Wolff, R.A.5
Deutsch, J.6
-
73
-
-
4444325685
-
A phase II trial of cetuximab as therapy for recurrent non-small cell lung cancer (NSCLC)
-
abstr 7084
-
Lynch TJ, Lilenbaum R, Bonomi P, Ansari R, Govindan R, Janne PA, et al. A phase II trial of cetuximab as therapy for recurrent non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2004; abstr 7084.
-
(2004)
Proc Am Soc Clin Oncol
-
-
Lynch, T.J.1
Lilenbaum, R.2
Bonomi, P.3
Ansari, R.4
Govindan, R.5
Janne, P.A.6
-
74
-
-
4444377694
-
Randomized phase II study of cetuximab in combination with cisplatin (C) and vinorelbine (V) vs. CV alone in the first-line treatment of patients with epidermal growth factor receptor (EGFR)-expressing advanced non-small-cell lung cancer (NSCLC)
-
abstr 7012
-
Resell R, Daniel C, Ramlau R, Szczesna A, Constenla M, Mennecier B, et al. Randomized phase II study of cetuximab in combination with cisplatin (C) and vinorelbine (V) vs. CV alone in the first-line treatment of patients with epidermal growth factor receptor (EGFR)-expressing advanced non-small-cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2004; abstr 7012.
-
(2004)
Proc Am Soc Clin Oncol
-
-
Resell, R.1
Daniel, C.2
Ramlau, R.3
Szczesna, A.4
Constenla, M.5
Mennecier, B.6
-
75
-
-
0028819660
-
Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model
-
Goldstein NI, Prewett M, Zuklys K, Rockwell P, Mendelsohn J. Biological efficacy of a chimeric antibody to the epidermal growth factor receptor in a human tumor xenograft model. Clin Cancer Res 1995; 1:1311-1318.
-
(1995)
Clin Cancer Res
, vol.1
, pp. 1311-1318
-
-
Goldstein, N.I.1
Prewett, M.2
Zuklys, K.3
Rockwell, P.4
Mendelsohn, J.5
-
76
-
-
0035398021
-
Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer
-
Robert F, Ezekiel MP, Spencer SA, Meredith RF, Bonner JA, Khazaeli MB, et al. Phase I study of anti-epidermal growth factor receptor antibody cetuximab in combination with radiation therapy in patients with advanced head and neck cancer. J Clin Oncol 2001; 19:3234-3243.
-
(2001)
J Clin Oncol
, vol.19
, pp. 3234-3243
-
-
Robert, F.1
Ezekiel, M.P.2
Spencer, S.A.3
Meredith, R.F.4
Bonner, J.A.5
Khazaeli, M.B.6
-
77
-
-
0001355931
-
Low immunogenicity of a chimeric monoclonal antibody (MoAb), IMC-C225, used to treat epidermal growth factor receptor-positive tumors
-
abstr 808
-
Khazaeli MB, LoBuglio AF, Falcey JW, Paulter VJ, Fetzer MK, Waksal HW. Low immunogenicity of a chimeric monoclonal antibody (MoAb), IMC-C225, used to treat epidermal growth factor receptor-positive tumors. Proc Am Soc Clin Oncol 2000; 207a (abstr 808).
-
(2000)
Proc Am Soc Clin Oncol
-
-
Khazaeli, M.B.1
LoBuglio, A.F.2
Falcey, J.W.3
Paulter, V.J.4
Fetzer, M.K.5
Waksal, H.W.6
-
78
-
-
8944263458
-
Phase I trial and tumour localisation of the anti-EGFR monoclonal antibody ICR62 in head and neck or lung cancer
-
Modjtahedi H, Hickish T, Nicolson M, Moore J, Styles J, Eccles S, et al. Phase I trial and tumour localisation of the anti-EGFR monoclonal antibody ICR62 in head and neck or lung cancer. Br J Cancer 1996; 73:228-235.
-
(1996)
Br J Cancer
, vol.73
, pp. 228-235
-
-
Modjtahedi, H.1
Hickish, T.2
Nicolson, M.3
Moore, J.4
Styles, J.5
Eccles, S.6
-
79
-
-
0030324626
-
The biologic effects of C225, a chimeric monoclonal antibody to the EGFR, on human prostate carcinoma
-
Prewett M, Rockwell P, Rockwell RF, Giorgio NA, Mendelsohn J, Scher HI, et al. The biologic effects of C225, a chimeric monoclonal antibody to the EGFR, on human prostate carcinoma. J Immunother Emphasis Tumor Immunol 1996; 19:419-427.
-
(1996)
J Immunother Emphasis Tumor Immunol
, vol.19
, pp. 419-427
-
-
Prewett, M.1
Rockwell, P.2
Rockwell, R.F.3
Giorgio, N.A.4
Mendelsohn, J.5
Scher, H.I.6
-
80
-
-
0032407024
-
Mouse-human chimeric anti-epidermal growth factor receptor antibody C225 inhibits the growth of human renal cell carcinoma xenografts in nude mice
-
Prewett M, Rothman M, Waksal H, Feldman M, Bander NH, Hicklin DJ. Mouse-human chimeric anti-epidermal growth factor receptor antibody C225 inhibits the growth of human renal cell carcinoma xenografts in nude mice. Clin Cancer Res 1998; 4:2957-2966.
-
(1998)
Clin Cancer Res
, vol.4
, pp. 2957-2966
-
-
Prewett, M.1
Rothman, M.2
Waksal, H.3
Feldman, M.4
Bander, N.H.5
Hicklin, D.J.6
-
81
-
-
0008486660
-
Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation
-
Sunada H, Magun BE, Mendelsohn J, MacLeod CL. Monoclonal antibody against epidermal growth factor receptor is internalized without stimulating receptor phosphorylation. Proc Natl Acad Sci USA 1986; 83:3825-3829.
-
(1986)
Proc Natl Acad Sci USA
, vol.83
, pp. 3825-3829
-
-
Sunada, H.1
Magun, B.E.2
Mendelsohn, J.3
MacLeod, C.L.4
-
82
-
-
0025056525
-
Modulation of tyrosine, serine, and threonine phosphorylation and intracellular processing of the epidermal growth factor receptor by antireceptor monoclonal antibody
-
Sunada H, Yu P, Peacock JS, Mendelsohn J. Modulation of tyrosine, serine, and threonine phosphorylation and intracellular processing of the epidermal growth factor receptor by antireceptor monoclonal antibody. J Cell Physiol 1990; 142:284-292.
-
(1990)
J Cell Physiol
, vol.142
, pp. 284-292
-
-
Sunada, H.1
Yu, P.2
Peacock, J.S.3
Mendelsohn, J.4
-
83
-
-
33845370537
-
The IgG1 monoclonal antibody cetuximab induces degradation of the epidermal growth factor receptor
-
abstr 234
-
Hadari YR, Doody JF, Wang Y, Patel SN, Apblett RL, Loizos N, et al. The IgG1 monoclonal antibody cetuximab induces degradation of the epidermal growth factor receptor. Proc Am Soc Clin Oncol 2004; abstr 234.
-
(2004)
Proc Am Soc Clin Oncol
-
-
Hadari, Y.R.1
Doody, J.F.2
Wang, Y.3
Patel, S.N.4
Apblett, R.L.5
Loizos, N.6
-
84
-
-
0035524114
-
Improving the efficacy of antibody-based cancer therapies
-
Carter P. Improving the efficacy of antibody-based cancer therapies. Nat Rev Cancer 2001; 1:118-129.
-
(2001)
Nat Rev Cancer
, vol.1
, pp. 118-129
-
-
Carter, P.1
-
85
-
-
0026657624
-
Human antibody effector function
-
Burton DR, Woof JM. Human antibody effector function. Adv Immunol 1992; 51:1-84.
-
(1992)
Adv Immunol
, vol.51
, pp. 1-84
-
-
Burton, D.R.1
Woof, J.M.2
-
86
-
-
0027818836
-
Blockade of epidermal growth factor receptor function by bivalent and monovalent fragments of 225 anti-epidermal growth factor receptor monoclonal antibodies
-
Fan Z, Masui H, Altas I, Mendelsohn J. Blockade of epidermal growth factor receptor function by bivalent and monovalent fragments of 225 anti-epidermal growth factor receptor monoclonal antibodies. Cancer Res 1993; 53:4322-4328.
-
(1993)
Cancer Res
, vol.53
, pp. 4322-4328
-
-
Fan, Z.1
Masui, H.2
Altas, I.3
Mendelsohn, J.4
-
87
-
-
0027442527
-
Therapeutic potential of chimeric and murine anti-(epidermal growth factor receptor) antibodies in a metastasis model for human melanoma
-
Naramura M, Gillies SD, Mendelsohn J, Reisfeld RA, Mueller BM. Therapeutic potential of chimeric and murine anti-(epidermal growth factor receptor) antibodies in a metastasis model for human melanoma. Cancer Immunol Immunother 1993; 37:343-349.
-
(1993)
Cancer Immunol Immunother
, vol.37
, pp. 343-349
-
-
Naramura, M.1
Gillies, S.D.2
Mendelsohn, J.3
Reisfeld, R.A.4
Mueller, B.M.5
-
88
-
-
0031868728
-
Anti-(epidermal growth factor) receptor monoclonal antibodies for the induction of antibody-dependent cell-mediated cytotoxicity against squamous cell carcinoma lines of the head and neck
-
Bier H, Hoffmann T, Haas I, van Lierop A. Anti-(epidermal growth factor) receptor monoclonal antibodies for the induction of antibody-dependent cell-mediated cytotoxicity against squamous cell carcinoma lines of the head and neck. Cancer Immunol Immunother 1998; 46:167-173.
-
(1998)
Cancer Immunol Immunother
, vol.46
, pp. 167-173
-
-
Bier, H.1
Hoffmann, T.2
Haas, I.3
Van Lierop, A.4
-
89
-
-
19244366949
-
Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin
-
Baselga J, Pfister D, Cooper MR, Cohen R, Burtness B, Bos M, et al. Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin. J Clin Oncol 2000; 18: 904-914.
-
(2000)
J Clin Oncol
, vol.18
, pp. 904-914
-
-
Baselga, J.1
Pfister, D.2
Cooper, M.R.3
Cohen, R.4
Burtness, B.5
Bos, M.6
-
90
-
-
0034895886
-
Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer
-
Shin DM, Donate NJ, Perez-Soler R, Shin HJ, Wu JY, Zhang P, et al. Epidermal growth factor receptor-targeted therapy with C225 and cisplatin in patients with head and neck cancer. Clin Cancer Res 2001; 7: 1204-1213.
-
(2001)
Clin Cancer Res
, vol.7
, pp. 1204-1213
-
-
Shin, D.M.1
Donate, N.J.2
Perez-Soler, R.3
Shin, H.J.4
Wu, J.Y.5
Zhang, P.6
-
91
-
-
0001409147
-
Safety profile of the monoclonal antibody (MoAb) IMC-C225, an Anti-epidermal growth factor receptor (EGFr) used in the treatment of EGFr positive tumors
-
abstr 1862
-
Cohen RB, Falcey JW, Paulter VJ, Fetzer KM, Waksal HW. Safety profile of the monoclonal antibody (MoAb) IMC-C225, an Anti-epidermal growth factor receptor (EGFr) used in the treatment of EGFr positive tumors. Proc Am Soc Clin Oncol 2000; 474a (abstr 1862).
-
(2000)
Proc Am Soc Clin Oncol
-
-
Cohen, R.B.1
Falcey, J.W.2
Paulter, V.J.3
Fetzer, K.M.4
Waksal, H.W.5
-
92
-
-
0037010077
-
Safety experience with IMC-C225, an anti-epidermal growth factor receptor antibody
-
Needle MN. Safety experience with IMC-C225, an anti-epidermal growth factor receptor antibody. Semin Oncol 2002; 29:55-60.
-
(2002)
Semin Oncol
, vol.29
, pp. 55-60
-
-
Needle, M.N.1
-
93
-
-
0001407134
-
Cetuximab (C225) plus cisplatin/carboplatin is active in patients (pts) with recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) progressing on a same dose and schedule platinum-based regimen
-
abstr 900
-
Baselga J, Trigo JM, Bourhis J, Tortochaux J, Cortes-Funes H, Hitt R, et al. Cetuximab (C225) plus cisplatin/carboplatin is active in patients (pts) with recurrent/metastatic squamous cell carcinoma of the head and neck (SCCHN) progressing on a same dose and schedule platinum-based regimen. Proc Am Soc Clin Oncol 2002; 226a (abstr 900).
-
(2002)
Proc Am Soc Clin Oncol
-
-
Baselga, J.1
Trigo, J.M.2
Bourhis, J.3
Tortochaux, J.4
Cortes-Funes, H.5
Hitt, R.6
-
94
-
-
33751580192
-
A phase II study of cetuximab, an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small cell lung cancer: Final report
-
abstr 2581
-
Kim ES, Mauer AM, Tran HT, Liu D, Gladish G, Dicke K, et al. A phase II study of cetuximab, an epidermal growth factor receptor (EGFR) blocking antibody, in combination with docetaxel in chemotherapy refractory/resistant patients with advanced non-small cell lung cancer: final report. Proc Am Soc Clin Oncol 2003; 642 (abstr 2581).
-
(2003)
Proc Am Soc Clin Oncol
, pp. 642
-
-
Kim, E.S.1
Mauer, A.M.2
Tran, H.T.3
Liu, D.4
Gladish, G.5
Dicke, K.6
-
95
-
-
0001407137
-
Erbitux (IMC-C225) plus weekly irinotecan (CPT-11), fluorouracil (5FU) and leucovorin (LV) in colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFR)
-
abstr 536
-
Rosenberg AH, Loehrer PJ, Needle MN, Waksal H, Hollywood E, Ramos L, et al. Erbitux (IMC-C225) plus weekly irinotecan (CPT-11), fluorouracil (5FU) and leucovorin (LV) in colorectal cancer (CRC) that expresses the epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 2002; 135a (abstr 536).
-
(2002)
Proc Am Soc Clin Oncol
-
-
Rosenberg, A.H.1
Loehrer, P.J.2
Needle, M.N.3
Waksal, H.4
Hollywood, E.5
Ramos, L.6
-
96
-
-
17644389416
-
Cetuximab/irinotecan/high-dose-5-fluorouracil/leucovorin (HD-5-FU/LV) in the first-line therapy of metastatic colorecial cancer (CRC)
-
abstr 283
-
Folprecht G, Lutz M, Schoeffski P, Seufferlein T, Haag C, Beutel G, et al. Cetuximab/irinotecan/high-dose-5-fluorouracil/leucovorin (HD-5-FU/LV) in the first-line therapy of metastatic colorecial cancer (CRC). Presented at Am Soc Clin Oncol Gastrointestinal Cancers Symp 2004; abstr 283.
-
(2004)
Am Soc Clin Oncol Gastrointestinal Cancers Symp
-
-
Folprecht, G.1
Lutz, M.2
Schoeffski, P.3
Seufferlein, T.4
Haag, C.5
Beutel, G.6
-
97
-
-
0002823211
-
Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR)
-
abstr 7
-
Saltz L, Rubin M, Hochster H, Tchekmeydian NS, Waksal H, Needle M, et al. Cetuximab (IMC-C225) plus irinotecan (CPT-11) is active in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR). Proc Am Soc Clin Oncol 2001; 3a (abstr 7).
-
(2001)
Proc Am Soc Clin Oncol
-
-
Saltz, L.1
Rubin, M.2
Hochster, H.3
Tchekmeydian, N.S.4
Waksal, H.5
Needle, M.6
-
98
-
-
0009350583
-
Acne-like rash predicts response in patients treated with cetuximab (IMC-C225) plus irinotecan (CPT-11) in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR)
-
abstr 559
-
Saltz L, Rubin MS, Hochster HS, Tchekmeydian NS, Waksal HW, Needle MN, et al. Acne-like rash predicts response in patients treated with cetuximab (IMC-C225) plus irinotecan (CPT-11) in CPT-11-refractory colorectal cancer (CRC) that expresses epidermal growth factor receptor (EGFR). Presented at AACR-NCI-EORTC Int Conf 2001; abstr 559.
-
(2001)
AACR-NCI-EORTC Int Conf
-
-
Saltz, L.1
Rubin, M.S.2
Hochster, H.S.3
Tchekmeydian, N.S.4
Waksal, H.W.5
Needle, M.N.6
-
99
-
-
32244438689
-
Erbitux™ (Cetuximab)
-
Princeton, NJ: ImClone Systems
-
ImClone Systems. Erbitux™ (Cetuximab). US Prescribing Information. Princeton, NJ: ImClone Systems; 2004.
-
(2004)
US Prescribing Information
-
-
-
100
-
-
0036569870
-
2D1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: Results of a phase I trial
-
Ranson M, Hammond LA, Ferry D, Kris M, Tullo A, Murray PI, et al. 2D1839, a selective oral epidermal growth factor receptor-tyrosine kinase inhibitor, is well tolerated and active in patients with solid, malignant tumors: results of a phase I trial. J Clin Oncol 2002; 20:2240-2250.
-
(2002)
J Clin Oncol
, vol.20
, pp. 2240-2250
-
-
Ranson, M.1
Hammond, L.A.2
Ferry, D.3
Kris, M.4
Tullo, A.5
Murray, P.I.6
-
101
-
-
0037674062
-
Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck
-
Cohen EE, Rosen F, Stadler WM, Recant W, Stenson K, Huo D, et al. Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol 2003; 21:1980-1987.
-
(2003)
J Clin Oncol
, vol.21
, pp. 1980-1987
-
-
Cohen, E.E.1
Rosen, F.2
Stadler, W.M.3
Recant, W.4
Stenson, K.5
Huo, D.6
-
102
-
-
0345714775
-
Phase II trial of ZD1839 (IRESSA) in patients with advanced renal cell carcinoma
-
Drucker B, Bacik J, Ginsberg M, Marion S, Russo P, Mazumdar M, et al. Phase II trial of ZD1839 (IRESSA) in patients with advanced renal cell carcinoma. Invest New Drugs 2003; 21:341-345.
-
(2003)
Invest New Drugs
, vol.21
, pp. 341-345
-
-
Drucker, B.1
Bacik, J.2
Ginsberg, M.3
Marion, S.4
Russo, P.5
Mazumdar, M.6
-
103
-
-
1842500007
-
Phase II trial of gefitinib in recurrent glioblastoma
-
Rich JN, Reardon DA, Peery T, Dowell JM, Quinn JA, Penne KL, et al. Phase II trial of gefitinib in recurrent glioblastoma. J Clin Oncol 2004; 22:133-142.
-
(2004)
J Clin Oncol
, vol.22
, pp. 133-142
-
-
Rich, J.N.1
Reardon, D.A.2
Peery, T.3
Dowell, J.M.4
Quinn, J.A.5
Penne, K.L.6
-
104
-
-
0038599605
-
Initial results of part 2 of a phase I/II pharmacokinetics (PK), pharmacodynamic (PD) and biological activity study of ZD1839 (Iressa): NCIC CTG IND.122
-
abstr 59
-
Goss GD, Stewart DJ, Hirte H, Miller W, Major P, Batist G, et al. Initial results of part 2 of a phase I/II pharmacokinetics (PK), pharmacodynamic (PD) and biological activity study of ZD1839 (Iressa): NCIC CTG IND.122. Proc Am Soc Clin Oncol 2002; 16a (abstr 59).
-
(2002)
Proc Am Soc Clin Oncol
-
-
Goss, G.D.1
Stewart, D.J.2
Hirte, H.3
Miller, W.4
Major, P.5
Batist, G.6
-
105
-
-
0012381722
-
Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer
-
Fukuoka M, Yano S, Giaccone G, Tamura T, Nakagawa K, Douillard JY, et al. Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer. J Clin Oncol 2003; 12:2237-2246.
-
(2003)
J Clin Oncol
, vol.12
, pp. 2237-2246
-
-
Fukuoka, M.1
Yano, S.2
Giaccone, G.3
Tamura, T.4
Nakagawa, K.5
Douillard, J.Y.6
-
106
-
-
0142055937
-
Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial
-
Kris MG, Natale RB, Herbst RS, Lynch Jr TJ, Prager D, Belani CP, et al. Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: a randomized trial. J Am Med Ass 2003; 290:2149-2158.
-
(2003)
J Am Med Ass
, vol.290
, pp. 2149-2158
-
-
Kris, M.G.1
Natale, R.B.2
Herbst, R.S.3
Lynch Jr., T.J.4
Prager, D.5
Belani, C.P.6
-
108
-
-
0242668485
-
Tumor EGFR membrane staining is not clinically relevant for predicting response in patients receiving gefitinib ('Iressa', ZD1839) monotherapy for pre-treated advanced non-small-cell lung cancer: IDEAL 1 and 2
-
abstr LB-170
-
Bailey LR, Kris M, Wolf M, et al. Tumor EGFR membrane staining is not clinically relevant for predicting response in patients receiving gefitinib ('Iressa', ZD1839) monotherapy for pre-treated advanced non-small-cell lung cancer: IDEAL 1 and 2. Proc Am Ass Cancer Res 2003; 1362 (abstr LB-170).
-
(2003)
Proc Am Ass Cancer Res
, pp. 1362
-
-
Bailey, L.R.1
Kris, M.2
Wolf, M.3
-
109
-
-
2342471392
-
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
-
Lynch TJ, Bell DW, Sordella R, Gurubhagavatula S, Okimoto RA, Brannigan BW, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004; 21:2129-2139.
-
(2004)
N Engl J Med
, vol.21
, pp. 2129-2139
-
-
Lynch, T.J.1
Bell, D.W.2
Sordella, R.3
Gurubhagavatula, S.4
Okimoto, R.A.5
Brannigan, B.W.6
-
110
-
-
2342624080
-
EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy
-
Paez JG, Janne PA, Lee JC, Tracy S, Greulich H, Gabriel S, et al. EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy. Science 2004; 304:1497-1500.
-
(2004)
Science
, vol.304
, pp. 1497-1500
-
-
Paez, J.G.1
Janne, P.A.2
Lee, J.C.3
Tracy, S.4
Greulich, H.5
Gabriel, S.6
-
111
-
-
1542503746
-
Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: A phase III trial-INTACT 1
-
Giaccone G, Herbst RS, Manegold C, Scagliotti G, Resell R, Miller V, et al. Gefitinib in combination with gemcitabine and cisplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 1. J Clin Oncol 2004; 22:777-784.
-
(2004)
J Clin Oncol
, vol.22
, pp. 777-784
-
-
Giaccone, G.1
Herbst, R.S.2
Manegold, C.3
Scagliotti, G.4
Resell, R.5
Miller, V.6
-
112
-
-
1542713370
-
Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: A phase III trial-INTACT 2
-
Herbst RS, Giaccone G, Schiller JH, Natale RB, Miller V, Manegold C, et al. Gefitinib in combination with paclitaxel and carboplatin in advanced non-small-cell lung cancer: a phase III trial-INTACT 2. J Clin Oncol 2004; 22:785-794.
-
(2004)
J Clin Oncol
, vol.22
, pp. 785-794
-
-
Herbst, R.S.1
Giaccone, G.2
Schiller, J.H.3
Natale, R.B.4
Miller, V.5
Manegold, C.6
-
113
-
-
0036731698
-
Treatment of advanced non-small-cell lung cancer with two-drug combinations
-
Bunn PA Jr. Treatment of advanced non-small-cell lung cancer with two-drug combinations. J Clin Oncol 2002; 20:3565-3567.
-
(2002)
J Clin Oncol
, vol.20
, pp. 3565-3567
-
-
Bunn Jr., P.A.1
-
114
-
-
18844386944
-
Pulsatile administration of the EGF receptor inhibitor (Iressa, ZD1839) is significantly more effective than continuous dosing for sensitizing tumors to Taxol
-
abstr A83
-
Solit DB, She Y, Moasser M, Hudis C, Kris M, Scher H, et al. Pulsatile administration of the EGF receptor inhibitor (Iressa, ZD1839) is significantly more effective than continuous dosing for sensitizing tumors to Taxol. Presented at AACR-NCI-EORTC Int Conf on Molecular Targets and Cancer Therapeutics 2003; abstr A83.
-
(2003)
AACR-NCI-EORTC Int Conf on Molecular Targets and Cancer Therapeutics
-
-
Solit, D.B.1
She, Y.2
Moasser, M.3
Hudis, C.4
Kris, M.5
Scher, H.6
-
115
-
-
0345375552
-
The effect of gefitinib (Iressa, ZD1839) in combination with oxaliplatin is schedule-dependent in colon cancer cell lines
-
Xu JM, Azzariti A, Colucci G, Paradiso A. The effect of gefitinib (Iressa, ZD1839) in combination with oxaliplatin is schedule-dependent in colon cancer cell lines. Cancer Chemother Pharmacol 2003; 52:442-448.
-
(2003)
Cancer Chemother Pharmacol
, vol.52
, pp. 442-448
-
-
Xu, J.M.1
Azzariti, A.2
Colucci, G.3
Paradiso, A.4
-
116
-
-
0035398631
-
Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies
-
Hidalgo M, Siu LL, Nemunaitis J, Rizzo J, Hammond LA, Takimoto C, et al. Phase I and pharmacologic study of OSI-774, an epidermal growth factor receptor tyrosine kinase inhibitor, in patients with advanced solid malignancies. J Clin Oncol 2001; 19:3267-3279.
-
(2001)
J Clin Oncol
, vol.19
, pp. 3267-3279
-
-
Hidalgo, M.1
Siu, L.L.2
Nemunaitis, J.3
Rizzo, J.4
Hammond, L.A.5
Takimoto, C.6
-
117
-
-
0003282151
-
Phase I trial of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor (EGFR), in patients with advanced solid tumors
-
abstr 65
-
Hidalgo M, Erlichman C, Rowinsky EK, Keopp-Norris J, Jensen K, Boni J, et al. Phase I trial of EKB-569, an irreversible inhibitor of the epidermal growth factor receptor (EGFR), in patients with advanced solid tumors. Proc Am Soc Clin Oncol 2002; 17a (abstr 65).
-
(2002)
Proc Am Soc Clin Oncol
-
-
Hidalgo, M.1
Erlichman, C.2
Rowinsky, E.K.3
Keopp-Norris, J.4
Jensen, K.5
Boni, J.6
-
118
-
-
0001100596
-
A phase I dose-escalating study to evaluate the biological activity and pharmacokinetics of PKI166, a novel tyrosine kinase inhibitor, in patients with advanced cancers
-
abstr 377
-
Murren JR, Papadimitrakopoulou VA, Sizer KC, Vaidyanathan S, Ravera C, Abbruzzese JL. A phase I dose-escalating study to evaluate the biological activity and pharmacokinetics of PKI166, a novel tyrosine kinase inhibitor, in patients with advanced cancers. Proc Am Soc Clin Oncol 2002; 95a (abstr 377).
-
(2002)
Proc Am Soc Clin Oncol
-
-
Murren, J.R.1
Papadimitrakopoulou, V.A.2
Sizer, K.C.3
Vaidyanathan, S.4
Ravera, C.5
Abbruzzese, J.L.6
-
119
-
-
0000329007
-
A phase II trial of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy, in patients (pts) with advanced, EGFR-expressing, non-small cell lung cancer (NSCLC)
-
abstr 1235
-
Perez-Soler R, Chachoua A, Huberman M, Karp D, Rigas J, Hammond L, et al. A phase II trial of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor OSI-774, following platinum-based chemotherapy, in patients (pts) with advanced, EGFR-expressing, non-small cell lung cancer (NSCLC). Proc Am Soc Clin Oncol 2001; 310a (abstr 1235).
-
(2001)
Proc Am Soc Clin Oncol
-
-
Perez-Soler, R.1
Chachoua, A.2
Huberman, M.3
Karp, D.4
Rigas, J.5
Hammond, L.6
-
120
-
-
0002114422
-
Dose-schedule-finding, pharmacokinetic (PK) biologic, and functional imaging studies of OSI-774, a selective epidermal growth factor receptor (EGFR) tyrosine kinase (TK) inhibitor
-
abstr 5
-
Rowinsky EK, Hammond L, Siu P, Jerabek J, Rizzo J. Dose-schedule-finding, pharmacokinetic (PK) biologic, and functional imaging studies of OSI-774, a selective epidermal growth factor receptor (EGFR) tyrosine kinase (TK) inhibitor. Proc Am Soc Clin Oncol 2001; 2a (abstr 5).
-
(2001)
Proc Am Soc Clin Oncol
-
-
Rowinsky, E.K.1
Hammond, L.2
Siu, P.3
Jerabek, J.4
Rizzo, J.5
-
121
-
-
1842772526
-
Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
-
Soulieres D, Senzer NN, Vokes EE, Hidalgo M, Agarwala SS, Siu LL. Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J Clin Oncol 2004; 22: 77-85.
-
(2004)
J Clin Oncol
, vol.22
, pp. 77-85
-
-
Soulieres, D.1
Senzer, N.N.2
Vokes, E.E.3
Hidalgo, M.4
Agarwala, S.S.5
Siu, L.L.6
-
122
-
-
0035117355
-
Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy
-
Yang XD, Jia XC, Corvalan JR, Wang P, Davis CG. Development of ABX-EGF, a fully human anti-EGF receptor monoclonal antibody, for cancer therapy. Crit Rev Oncol Hematol 2001; 38:17-23.
-
(2001)
Crit Rev Oncol Hematol
, vol.38
, pp. 17-23
-
-
Yang, X.D.1
Jia, X.C.2
Corvalan, J.R.3
Wang, P.4
Davis, C.G.5
-
123
-
-
0035116907
-
Tumor necrosis factor alpha sensitizes low epidermal growth factor receptor (EGFR)-expressing carcinomas for anti-EGFR therapy
-
Hambek M, Solbach C, Schnuerch HG, Roller M, Stegmueller M, Sterner-Kock A, et al. Tumor necrosis factor alpha sensitizes low epidermal growth factor receptor (EGFR)-expressing carcinomas for anti-EGFR therapy. Cancer Res 2001; 61:1045-1049.
-
(2001)
Cancer Res
, vol.61
, pp. 1045-1049
-
-
Hambek, M.1
Solbach, C.2
Schnuerch, H.G.3
Roller, M.4
Stegmueller, M.5
Sterner-Kock, A.6
-
124
-
-
18844434541
-
-
Carpinteria, CA: Dako
-
Dako Cytomation. EGFR pharmDx™ Package Insert. Carpinteria, CA: Dako; 2004.
-
(2004)
EGFR PharmDx™ Package Insert
-
-
-
125
-
-
0036467826
-
Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer
-
5 Vogel CL, Cobleigh MA, Tripathy D, Gutheil JC, Harris LN, Fehrenbacher L, et al. Efficacy and safety of trastuzumab as a single agent in first-line treatment of HER2-overexpressing metastatic breast cancer. J Clin Oncol 2002; 20:719-726.
-
(2002)
J Clin Oncol
, vol.20
, pp. 719-726
-
-
Vogel, C.L.1
Cobleigh, M.A.2
Tripathy, D.3
Gutheil, J.C.4
Harris, L.N.5
Fehrenbacher, L.6
-
126
-
-
0842264243
-
Cutaneous side effects in non-small cell lung cancer patients treated with Iressa (ZD1839), an inhibitor of epidermal growth factor
-
Lee MW, Seo CW, Kim SW, Yang HJ, Lee HW, Choi JH, et al. Cutaneous side effects in non-small cell lung cancer patients treated with Iressa (ZD1839), an inhibitor of epidermal growth factor. Acta Derm Venereol 2004; 84:23-26.
-
(2004)
Acta Derm Venereol
, vol.84
, pp. 23-26
-
-
Lee, M.W.1
Seo, C.W.2
Kim, S.W.3
Yang, H.J.4
Lee, H.W.5
Choi, J.H.6
-
127
-
-
1542438546
-
Can rash associated with HER1/EGFR inhibition be used as a marker of treatment outcome?
-
Perez-Soler R. Can rash associated with HER1/EGFR inhibition be used as a marker of treatment outcome? Oncology (Huntingt) 2003; 17:23-28.
-
(2003)
Oncology (Huntingt)
, vol.17
, pp. 23-28
-
-
Perez-Soler, R.1
-
128
-
-
0035174127
-
Pharmacodynamic studies with the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839
-
Albanell J, Rojo F, Baselga J. Pharmacodynamic studies with the epidermal growth factor receptor tyrosine kinase inhibitor ZD1839. Semin Oncol 2001; 28:56-66.
-
(2001)
Semin Oncol
, vol.28
, pp. 56-66
-
-
Albanell, J.1
Rojo, F.2
Baselga, J.3
-
129
-
-
0035724536
-
Cutaneous side-effects in cancer patients treated with the antiepidermal growth factor receptor antibody C225
-
Busam KJ, Capodieci P, Motzer R, Kiehn T, Phelan D, Halpern AC. Cutaneous side-effects in cancer patients treated with the antiepidermal growth factor receptor antibody C225. Br J Dermatol 2001; 144: 1169-1176.
-
(2001)
Br J Dermatol
, vol.144
, pp. 1169-1176
-
-
Busam, K.J.1
Capodieci, P.2
Motzer, R.3
Kiehn, T.4
Phelan, D.5
Halpern, A.C.6
-
130
-
-
12444259660
-
Pharmacodynamic evaluation of the epidermal growth factor receptor inhibitor OSI-774 in human epidermis of cancer patients
-
Malik SN, Siu LL, Rowinsky EK, deGraffenried L, Hammond LA, Rizzo J, et al. Pharmacodynamic evaluation of the epidermal growth factor receptor inhibitor OSI-774 in human epidermis of cancer patients. Clin Cancer Res 2003; 9:2478-2486.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 2478-2486
-
-
Malik, S.N.1
Siu, L.L.2
Rowinsky, E.K.3
DeGraffenried, L.4
Hammond, L.A.5
Rizzo, J.6
-
131
-
-
18844377568
-
Correlation of acne rash and tumor response with cetuximab monotherapy in patients with colorectal cancer refractory to both irinotecan and oxaliplatin
-
abstr 279
-
Van Cutsem E, Mayer RJ, Gold P, Stella PJ, Cohn A, Pippas AW, et al. Correlation of acne rash and tumor response with cetuximab monotherapy in patients with colorectal cancer refractory to both irinotecan and oxaliplatin. Presented at EORTC-NCI-AACR Symp on Molecular Targets and Cancer Therapeutics 2004; abstr 279.
-
(2004)
EORTC-NCI-AACR Symp on Molecular Targets and Cancer Therapeutics
-
-
Van Cutsem, E.1
Mayer, R.J.2
Gold, P.3
Stella, P.J.4
Cohn, A.5
Pippas, A.W.6
-
132
-
-
13844317894
-
EGFR mutation and resistance of non-small-cell lung cancer to gefitinib
-
Kobayashi S, Boggon TJ, Dayaram T, Janne PA, Kocher O, Meyerson M. et al. EGFR mutation and resistance of non-small-cell lung cancer to gefitinib. N Engl J Med 2005; 352:786-792.
-
(2005)
N Engl J Med
, vol.352
, pp. 786-792
-
-
Kobayashi, S.1
Boggon, T.J.2
Dayaram, T.3
Janne, P.A.4
Kocher, O.5
Meyerson, M.6
|