Induction of apoptosis and activation of the caspase cascade by anti-EGF receptor monoclonal antibodies in DiFi human colon cancer cells do not involve the c-jun N-terminal kinase activity

British Journal of Cancer

Volumn 82, Issue 12, 2000, Pages 1991-1999

  Liu, B ^a   Fang, M ^a   Schmidt, M ^a   Lu, Y ^a   Mendelsohn, J ^a   Fan, Z ^a  

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Apoptosis; C jun N terminal kinase 1; Caspase; Epidermal growth factor receptor; Monoclonal antibody

Indexed keywords

CASPASE; EPIDERMAL GROWTH FACTOR RECEPTOR; MONOCLONAL ANTIBODY; STRESS ACTIVATED PROTEIN KINASE;

ANTIGEN BINDING; APOPTOSIS; ARTICLE; CANCER CELL; COLON CANCER; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HUMAN; HUMAN CELL; IMMUNOBLOTTING; PRIORITY JOURNAL;

ADENOCARCINOMA; ANTIBODIES, MONOCLONAL; APOPTOSIS; CASPASE 3; CASPASE 8; CASPASE 9; CASPASES; COLONIC NEOPLASMS; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASES; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TUMOR CELLS, CULTURED;

EID: 0034038282     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (69)

1. Adachi S, Cross AR, Babior BM and Gottlieb RA (1907) Bcl-2 and the outer mitochondrial membrane in the inactivation of cytochrome e during Fasmediated apoptosis. J Biol Chem 272: 21878-21882
2. Ashkenazi A and Dixit VM (1998) Death receptors: signaling and modulation. Science 281: 1305-1308
3. Baselga J, Mendelsohn J, Kim YM and Pandiella A (1996) Autocrine regulation of membrane transforming growth factor-alpha cleavage. J Biol Chem 271: 3279-3284
4. Baselga J, Pfister D, Cooper MR, Cohen R, Burtness B, Bos M. D'Andrea G, Seidman A, Norton L, Gunnett K, Falcey J, Anderson V, Waksal H and Mendelsohn J (2000) J Phase I studies of anti-epidermal growth factor receptor chimeric antibody C225 alone and in combination with cisplatin. J Clin Oncol: In press
5. Boldin MF, Goncharov TM, Goltsev YV and Wallach D (1996) Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1 - and TNF receptor-induced cell death. Cell 85: 803-815
6. Bossy-Wetzel E, Newmeyer DD and Green DR (1998) Mitochondrial cytochrome c release in apoptosis occurs upstream of DEVD-specific caspase activation and independently of mitochondrial transmembrane depolarization. EMBO J 17: 37-49
7. Bump NJ, Hackett M, Hugunin M, Seshagiri S, Brady K, Chen P, Ferenz C, Franklin S, Ghayur T and Li P (1995) Inhibition of ICE family proteases by baculovirus antiapoptotic protein p35. Science 269: 1885-1888
8. Chen YR, Wang X, Templeton D, Davis RJ and Tan TH (1996) The role of c-Jun N-terminal kinase (JNK) in apoptosis induced by ultraviolet C and gamma radiation. Duration of JNK activation may determine cell death and proliferation. J Biol Chem 271: 31929-31936
9. Chou JL, Fan Z, DeBlasio T, Koff A, Rosen N and Mendelsohn J (1999) Constitutive overexpression of cyclin DI in human breast epithelial cells does not prevent G1 arrest induced by deprivation of epidermal growth factor, Breast Cancer Res Treat 55: 267-283
10. Cohen GM (1997) Caspases: the executioners of apoptosis. Biochem J 326 (Pt 1): 1-16
11. Cowley GP, Smith JA and Gusterson BA (1986) Increased EGF receptors on human squamous carcinoma cell lines. Br J Cancer 53: 223-229
12. Ellis HM and Horvitz HR (1986) Genetic control of programmed cell death in the nematode C. elegans. Cell 44: 817-829
13. Ennis BW, Valverius EM, Bates SF, Lippman ME, Bellot F, Kris R, Schlessinger J, Masui H, Goldenberg A, Mendelsohn J and Dickson RB (1989) Anti-epidermal growth factor receptor antibodies inhibit the autocrine-stimulated growth of MDA-468 human breast cancer cells. Mol Endocrinol 3: 1830-1838
14. Fan Z and Mendelsohn J (1998) Therapeutic application of anti-growth factor receptor antibodies. Curr Opin Oncol 10: 67-73
15. Fan Z, Baselga J, Masui H and Mendelsohn J (1993a) Antitumour effect of anti-epidermal growth factor receptor monoclonal antibodies plus cis-diamminedichloroplatinum on well established A431 cell xenografts. Cancer Res 53: 4637-4642
16. Fan Z, Masui H, Altas I and Mendelsohn J (1993b) Blockade of epidermal growth factor receptor function by bivalent and monovalent fragments of 225 anti-epidermal growth factor receptor monoclonal antibodies. Cancer Res 53: 4322-4328
17. Fan Z, Mendelsohn J, Masui H and Kumar R (1993c) Regulation of epidermal growth factor receptor in NIH3T3/HER14 cells by antireceptor monoclonal antibodies. J Biol Chem 268: 21073-21079
18. Fan Z, Lu Y, Wu X and Mendelsohn J (1994) Antibody-induced epidermal growth factor receptor dimerization mediates inhibition of autocrine proliferation of A431 squamus carcinoma cells. J Biol Chem 269: 27595-27602
19. Cap1 in growth inhibition mediated by blockade or overstimulation of epidermal growth factor receptors. Clin Cancer Res 3: 1943-1948
20. Gill GN, Kawamoto T, Cochet C, Le A, Sato JD, Masui H, McLeod C and Mendelsohn J (1984) Monoclonal anti-epidermal growth factor receptor antibodies which are inhibitors of epidermal growth factor binding and antagonists of epidermal growth factor binding and antagonists of epidermal growth factor-stimulated tyrosine protein kinase activity. J Biol Chem 259: 7755-7760
21. Green DR (1998) Apoptotic pathways: the roads to ruin. Cell 94: 695-698
22. Green DR and Reed JC (1998) Mitochondria and apoptosis. Science 281: 1309-1312
23. Gross ME, Zorbas MA, Danels YJ, Garcia R, Gallick GE, Olive M, Brattain MG, Boman BM and Yeoman LC (1991) Cellular growth response to epidermal growth factor in colon carcinoma cells with an amplified epidermal growth factor receptor derived from a familial adenomatous polyposis patient. Cancer Res 51: 1452-1459
24. Hendler FJ and Ozanne BW (1984) Human squamous cell lung cancers express increased epidermal growth factor receptors. J Clin Invent 74: 647-651
25. Hofer DR, Sherwood ER, Bromberg WD, Mendelsohn J, Lee C and Kozlowski JM (1991) Autonomous growth of androgen-independent human prostatic carcinoma cells: role of transforming growth factor alpha. Cancer Res 51: 2780-2785
26. Ishitoya J, Toriyama M, Oguchi N, Kitamura K, Ohshima M, Asano K and Yamamoto T (1989) Gene amplification and overexpression of EGF receptor in squamous cell carcinomas of the head and neck. Br J Cancer 59: 559-562
27. Itoh N, Yonehara S, Ishii A, Yonehara M, Mizushima S, Sameshima M, Hase A, Seto Y and Nagata S(1991) The polypeptide encoded by the cDNA for humar cell surface antigen Fas can mediate apoptosis. Cell 66: 233-243
28. Janicke RU, Sprengart ML, Wati MR and Porter AG (1998a) Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis. J Biol Chem 273: 9357-9360
29. Janicke RU, Ng P, Sprengart ML and Porter AG (1998b) Caspase-3 is required for alpha-fodrin cleavage but dispensable for cleavage of other death substrates in apoptosis. J Biol Chem 273: 15540-15545
30. Karnes WJ, Walsh JH, Wu SV, Kim RS, Martin MG, Wong HC, Mendelsohn J, Park JG and Cuttitta F (1992) Autonomous proliferation of colon cancer cells that coexpress transforming growth factor alpha and its receptor. Variable effects of receptor-blocking antibody. Gastroenterology 102: 474-485
31. Kharbanda S, Pandey P, Schofield L, Israels S, Roncinske R, Yoshida K, Bharti A, Yuan ZM, Saxena S, Weichselbaum R, Nalin C and Kufe D (1997) Role for Bcl-xL as an inhibitor of cytosolic cytochrome C accumulation in DNA damage-induced apoptosis. Proc Natl Acad Sci USA 94: 6939-6942
32. Kim CN, Wang X, Huang Y, Ibrado AM, Liu L, Fang G and Bhalla K (1997) Overexpression of Bcl-X(L) inhibits Ara-C-induced mitochondrial loss of cytochrome c and other perturbations that activate the molecular cascade of apoptosis. Cancer Res 57: 3115-3120
33. Kluck RM, Bossy-Wetzel E, Green DR and Newmeyer DD (1997) The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science 275: 1132-1136
34. Lee M, Draoui M, Zia H, Gazdar A, Oie H, Bepler G, Bellot F, Tarr C, Kris R and Moody TW (1992) Epidermal growth factor receptor monoclonal antibodies inhibit the growth of lung cancer cell lines. J Natl Cancer Inst Monogr 13: 117-123
35. Lei W, Yu R, Mandlekar S and Kong AN (1998) Induction of apoptosis and activation of interleukin 1beta-converting enzyme/Ced-3 protease (caspase 3) and c-Jun NH2-terminal kinase I by benzo(a)pyrene. Cancer Res 58: 2102-2106
36. Li H, Zhu H, Xu CJ and Yuan J (1998) Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell 94: 491-501
37. Masui H, Boman HM, Hyman J, Castro L and Mendelsohn J (1991) Treatment with anti-EGF receptor monoclonal antibody causes regression of DiFi human colorectal carcinoma xenografts. Proc Am Assoc Cancer Res 32: 394
38. Mendelsohn J, Shin DM, Donato N, Khuri F, Radinsky R, Glisson BS, Shin HJ, Metz E, Pfister D, Perez-Soler R, Lawhorn K, Matsumoto T, Gunnett K, Falcey J, Waksal H and Hong WK (1999) A phase I study of chimerized anti-epidermal growth factor receptor (EGFR) monoclonal antibody, C225, in combination with cisplatin (CDDP) in patients (pts) with recurrent head and neck squamous cell carcinoma (SCC). Proc Am Soc Clin Oncol 18: 389a (abstract 1502)
39. Modjtahedi H, Eccles S, Box G, Styles J and Dean C (1993) Immunotherapy of human tumour xenografts overexpressing the EGF receptor with rat antibodies that block growth factor-receptor interaction. Br J Cancer 67: 254-261
40. Muhlenbeck F, Haas E, Schwenzer R, Schubert G, Grell M, Smith C, Scheurich P and Wajant H (1998) TRAIL/Apo2L activates c-Jun NH2-terminal kinase (JNK) via caspase-dependent and caspase-independent pathways. J Biol Chem 273: 33091-33098
41. Muzio M, Chinnaiyan AM, Kischkel FC, O'Rourke K, Shevehenko A, Ni J, Scaffidi C, Bretz JD, Zhang M, Gentz R, Mann M, Krammer PH, Peter ME and Dixit VM (1996) FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex. Cell 85: 817-827
42. Muzio M, Stockwell BR, Stennicke HR, Salvesen GS and Dixit VM (1998) An induced proximity model for caspase-8 activation. J Biol Chem 273: 2926-2930
43. Neal DEF, Marsh C, Bennett MK, Abel PD, Hall RR, Sainsbury JR and Harris AL (1985) Epidermal-growth-factor receptors in human bladder cancer: comparison of invasive and superficial tumours. Lancet 1: 366-368
44. Ozanne B, Richards CS, Hendler F, Burns D and Gusterson B (1986) Over-expression of the EGF receptor is a hallmark of squamous cell carcinomas. J Pathol 149: 9-14
45. KIP1 and induces G1 arrest in prostatic cancer cell line DU145. Cancer Res 56: 3666-3669
46. Perez-Soler R. Shin D, Donato N, Radinsky R, Khuri F, Glisson BS, Shin H, Matsumoto T, Lawhorn K, Hong WK and Mendelsohn J (1998) Tumour studies in patients wilh head and neck cancer treated with humanized anti-epidermal growth factor receptor (EGFR) monoclonal antibody C225 in combination with cisplatin. Proc Am Soc Clin Oncol 17: 393a (abstract 1514)
47. Perrotte P, Matsumoto T, Inoue K, Kuniyasu H, Eve BY, Hicklin DJ, Radinsky R and Dinney CT (1999) Anti-epidermal growth factor receptor antibody C225 inhibits angiogenesis in human transitional cell carcinoma growing orthotopically in nude mice. Clin Cancer Res 5: 257-265
48. Prewett M, Rothman M, Waksal H, Feldman M, Bander NH and Hicklin DJ (1998) Mouse-human chimeric anti-epidermal growth factor receptor antibody C225 inhibits the growth of human renal cell carcinoma xenografls in nude mice. Clin Cancer Ko 4: 2957-2966
49. Sainsbury JR, Malcolm AJ, Appleton DR, Farndon JR and Harris AL (1985) Presence of epidermal growth factor receptor as an indicator of poor prognosis in patients with breast cancer. J Clin Pathol 38: 1225-1228
50. Sato JD, Kawamoto T, Le AD, Mendelsohn J, Polikoff J and Sato GH (1983) Biological effects in vitro of monoclonal antibodies to human epidermal growth factor receptors. Mol Biol Med 1:511-529
51. Schmidt M, Vakalopoulou E, Schneider DW and Wels W (1997) Construction and functional characterization of scFv(14E1)-TA - a novel, highly potent antibody-toxin specific for the EGF receptor. Br J Cancer 75: 1575-1584
52. Seimiya H, Mashima T, Toho M and Tsuruo T (1997) c-Jun NH2-terminal kinase-mediated activation of interleukin-1β converting enzyme/CED-3-like protease during anticancer drug-induced apoptosis. J Biol Chem 272: 4631-4636
53. Shiah SG, Chuang SE, Chau YP, Shen SC and Kuo ML (1999) Activation of c-Jun NH2-terminal kinase and subsequent CPP32/Yama during topoisomerase inhibitor β-lapachone-induced apoptosis through an oxidation-dependent pathway. Cancer Res 59: 391-398
54. Stampfer MR, Pan CH, Hosoda J, Bartholomew J, Mendelsohn J and Yaswen P (1993) Blockage of EGF receptor signal transduction causes reversible arrest of normal and immortal human mammary epithelial cells with synchronous reentn into the cell cycle. Exp Cell Res 208: 175-188
55. Sun XM, MacFarlane M, Zhuang J, Wolf BB, Green DR and Cohen GM (1999) Distinct caspase cascades are initiated in receptor-mediated and chemical-induced apoptosis. J Biol Chem 274: 5053-5060
56. Susin SA, Lorenzo HK, Zamzami N, Marzo I, Snow BE, Brothers GM, Mangion J, Jacotot E, Costantini P, Loeffler M, Larochette N, Goodlett DR, Aebersold R, Siderovski DP, Penninger JM and Kroemer G (1999) Molecular characterization of mitochondrial apoptosis-inducing factor. Nature 397: 441-446
57. Tewari M, Quan LT, O'Rourke K, Desnoyers S, Zeng Z, Beidler DR, Poirier GG, Salvesen US and Dixit VM (1995) Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 81: 801-809
58. Thornberry NA and Lazebnik Y (1998) Caspases: enemies within. Science 281: 1312-1316
59. Ullrich A and Schlessinger J (1990) Signal transduction by receptors with tyrosine kinase activity. Cell 61: 203-212
60. Untawale S, Zorbas MA, Hodgson CP, Coffey RJ, Gallick GE, North SM, Wildrick DM, Olive M, Blick M, Yeoman LC and Boman BM (1993) Transforming growth factor alpha production and autoinduction in a colorectal carcinoma cell line (DiFi) with an amplified epidermal growth factor receptor gene. Cancer Res 53: 1630-1636
61. Van de Vijver MJ, Kumar R and Mendelsohn J (1991) Ligand-induced activation of A431 cell epidermal growth factor receptors occurs primarily by an autocrine pathway that acts upon receptors on the surface rather than intracellularly. J Biol Chem 266: 7503-7508
62. Veale D, Ashcroft T, Marsh C, Gibson GJ and Harris AL (1987) Epidermal growth factor receptors in non-small cell lung cancer. Br J Cancer 55: 513-516
63. Wersall P, Ohlsson I, Biberfeld P, Collins VP, von Krusenstjerna S, Larsson S, Mellstedt H and Boethius J (1997) Intratumoural infusion of the monoclonal antibody, mAb 425, against the epidermal-growth-factor receptor in patients with advanced malignant glioma. Cancer Immunol Immunother 44: 157-164
64. Woo M, Hakem R, Soengas MS, Duncan GS, Shahinian A, Kagi D, Hakem A, McCurrach M, Khoo W, Kaufman SA, Senaldi G, Howard T, Lowe SW and Mak TW (1998) Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev 12: 806-819
65. Wu X, Fan Z, Masui H, Rosen N and Mendelsohn J (1995) Apoptosis induced by an anti-epidermal growth factor receptor monoclonal antibody in a human colorectal carcinoma cell line and its delay by insulin. J Clin Invest 95: 1897-1905
66. KIP1 in G1 arrest mediated by an anti-epidermal growth factor receptor monoclonal antibody. Oncogene 12: 1397-1403
67. Xiang J, Chao DT and Korsmejer SJ (1996) BAX-induced cell death may not require interleukin 1β-converting enzyme-like proteases. Proc Natl Acad Sci U S A 93: 14559-14563
68. Yang X, Chang HY and Baltimore D (1998) Autoproteolytic activation of procaspases by oligomerization. Mol Cell 1: 319-325
69. Ye D, Mendelsohn J and Fan Z, (1999) Augmentation of a humanized anti-HER2 mAb 4D5 induced growth inhibition by a human-mouse chimeric anti-EGF receptor mAb C225. Oncogene 18: 731-738