Spindle-kinetochore attachment requires the combined action of Kin I-like Klp5/6 and Alp14/Dis1-MAPs in fission yeast

EMBO Journal

Volumn 21, Issue 22, 2002, Pages 6015-6024

  Garcia, Miguel Angel ^b   Koonrugsa, Nirada ^a   Toda, Takashi ^a  

^a THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^b UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

Author keywords

Kin I XKCM; Kinetochore; Metaphase; Spindle checkpoint; TOG XMAP215

Indexed keywords

PROTEIN MAD2;

ANAPHASE; ANIMAL CELL; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL INTERACTION; CENTROMERE; CONTROLLED STUDY; MICROTUBULE; MITOSIS SPINDLE; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN STABILITY;

CHROMOSOMES, FUNGAL; KINESIN; KINETOCHORES; MACROMOLECULAR SUBSTANCES; METAPHASE; MICROTUBULE-ASSOCIATED PROTEINS; MICROTUBULES; MITOTIC SPINDLE APPARATUS; PHENOTYPE; PROTEIN INTERACTION MAPPING; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS;

ANIMALIA; SCHIZOSACCHAROMYCES POMBE;

EID: 18744393712     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/cdf611     Document Type: Article

References (54)

1. Amon, A. (1999) The spindle checkpoint. Curr. Opin. Genet. Dev., 9, 69-75.
2. Bernard, P., Hardwick, K. and Javerzat, J.-P. (1998) Fission yeast Bubl is a mitotic centromere protein essential for the spindle checkpoint and the preservation of correct ploidy through mitosis. J. Cell Biol., 143, 1775-1787.
3. Bridge, A.J., Morphew, M., Bartlett, R. and Hagan, I.M. (1998) The fission yeast SPB component Cut12 links bipolar spindle formation to mitotic control. Genes Dev., 12, 927-942.
4. Cahill, D.P., Lengauer, C., Yu, J., Riggins, G.J., Willson, J.K.V., Markowitz, S.D., Kinzler, K.W. and Vogelstein, B. (1998) Mutations of mitotic checkpoint genes in human cancers. Nature, 392, 300-303.
5. Chen, R.-H., Waters, J.C., Salmon, E.D. and Murray, A.W. (1996) Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores. Science, 274, 242-246.
6. Chikashige, Y., Ding, D.-Q., Imai, Y., Yamamoto, M., Haraguchi, T. and Hiraoka, Y. (1997) Meiotic nuclear reorganization: Switching the position of centromeres and telomeres in the fission yeast Schizosaccharomyces pombe. EMBO J., 16, 193-202.
7. Desai, A., Verma, S., Mitchison, T.J. and Walczak, C.E. (1999) Kin I kinesins are microtubule-destabilizing enzymes. Cell, 96, 69-78.
8. Garcia, M.A., Vardy, L., Koonrugsa, N. and Toda, T. (2001) Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint. EMBO J., 20, 3389-3401.
9. Garcia, M.A., Koonrugsa, N. and Toda, T. (2002) Two kinesin-like Kin I family proteins in fission yeast regulate the establishment of metaphase and the onset of anaphase A. Curr. Biol., 12, 610-621.
10. Guacci, V., Hogan, E. and Koshland, D. (1997) Centromere position in budding yeast: Evidence for anaphase A. Mol. Biol. Cell, 8, 957-972.
11. + associates with the fission yeast spindle pole body and is essential for viability. J. Cell Biol., 129, 1033-1047.
12. Ikui, A.E., Furuya, K., Yanagida, M. and Matsumoto, T. (2002) Control of localization of a spindle checkpoint protein, Mad2, in fission yeast. J. Cell Sci., 115, 1603-1610.
13. Kinoshita, K., Arnal, I., Desai, A., Drechsel, D.N. and Hyman, A.A. (2001) Reconstitution of physiological microtubule dynamics using purified components. Science, 294, 1340-1343.
14. Kinoshita, K., Habermann, B. and Hyman, A.A. (2002) XMAP215: A key component of the dynamic microtubule cytoskeleton. Trends Cell Biol., 6, 267-273.
15. Kline-Smith, S.L. and Walczak, C.E. (2002) The microtubule-destabilizing kinesin XKCM1 regulates microtubule dynamic instability in cells. Mol. Biol. Cell, 13, 2718-2731.
16. Leverson, J.D., Huang, H.-K., Forsburg, S.L. and Hunter, T. (2002) The Schizosaccharomyces pombe Aurora-related kinase Ark1 interacts with the inner centromere protein Picl and mediates chromosome segregation and cytokinesis. Mol. Biol. Cell, 13, 1132-1143.
17. Li, X. and Nicklas, R.B. (1995) Mitotic forces control a cell-cycle checkpoint. Nature, 373, 630-632.
18. Li, Y. and Benezra, R. (1996) Identification of a human mitotic checkpoint gene: hsMAD2. Science, 274, 246-248.
19. Mallavarapu, A., Sawin, K. and Mitchison, T. (1999) A switch in microtubule dynamics at the onset of anaphase B in the mitotic spindle of Schizosaccharomyces pombe. Curr. Biol., 9, 1423-1426.
20. Maney, T., Hunter, A.W., Wagenbach, M. and Wordeman, L. (1998) Mitotic centromere-associated kinesin is important for anaphase chromosome segregation. J. Cell Biol., 142, 787-801.
21. Millband, D.N. and Hardwick, K.G. (2002) Fission yeast Mad3p is required for Mad2p to inhibit the anaphase-promoting complex and localizes to kinetochores in a Bub1p-, Bub3p- and Mph1p-dependent manner. Mol. Cell. Biol., 22, 2728-2742.
22. Moores, C.A., Yu, M., Guo, J., Beraud, C., Sakowicz, R. and Milligan, R.A. (2002) A mechanism for microtubule depolymerization by KinI kinesins. Mol. Cell, 9, 903-909.
23. Morishita, J., Matsusaka, T., Goshima, G., Nakamura, T., Tatebe, H. and Yanagida, M. (2001) Bir1/Cut17 moving from chromosome to spindle upon the loss of cohesion is required for condensation, spindle elongation and repair. Genes Cells, 6, 743-763.
24. Nabeshima, K., Kurooka, H., Takeuchi, M., Kinoshita, K., Nakaseko, Y. and Yanagida, M. (1995) p93dis1, which is required for sister chromatid separation, is a novel microtubule and spindle pole body-associating protein phosphorylated at the Cdc2 target sites. Genes Dev., 9, 1572-1585.
25. Nabeshima, K., Nakagawa, T., Straight, A.F., Murray, A., Chikashige, Y., Yamashita, Y.M., Hiraoka, Y. and Yanagida, M. (1998) Dynamics of centromeres during metaphase-anaphase transition in fission yeast: Dis1 is implicated in force balance in metaphase bipolar spindle. Mol. Biol. Cell, 9, 3211-3225.
26. Nakaseko, Y., Goshima, G., Morishita, J. and Yanagida, M. (2001) M phase-specific kinetochore proteins in fission yeast microtubule-associating Dis1 and Mtc1 display rapid separation and segregation during anaphase. Curr. Biol., 11, 537-549.
27. Nicklas, R.B. (1997) How cells get the right chromosomes. Science, 275, 632-637.
28. Niederstrasser, H., Salehi-Had, H., Gan, E.C., Walczak, C. and Nogales, E. (2002) XKCM1 acts on a single protofilament and requires the C terminus of tubulin. J. Mol. Biol., 316, 817-828.
29. Niwa, O., Matsumoto, T., Chikashige, Y. and Yanagida, M. (1989) Characterization of Schizosaccharomyces pombe minichromosome deletion derivatives and a functional allocation of their centromere. EMBO J., 8, 3045-3052.
30. + essential for a mid-mitotic transition encodes a leucine-rich repeat protein that positively modulates protein phosphatase-I. Cell, 64, 149-157.
31. Ohkura, H., Adachi, Y., Kinoshita, N., Niwa, O., Toda, T. and Yanagida, M. (1988) Cold-sensitive and caffeine supersensitive mutants of the Schizosaccharomyces pombe dis genes implicated in sister chromatid separation during mitosis. EMBO J., 7, 1465-1473.
32. Ohkura, H., Garcia, M.A. and Toda, T. (2001) Dis1/TOG universal microtubule adaptors - One MAP for all? J. Cell Sci., 114, 3805-3812.
33. Petersen, J., Paris, J., Willer, M., Philippe, M. and Hagan, I.M. (2001) The S. pombe aurora-related kinase Ark1 associates with mitotic structures in a stage dependent manner and is required for chromosome segregation. J. Cell Sci., 114, 4371-4384.
34. Rajagopalan, S. and Balasubramanian, M.K. (2002) Schizosaccharomyces pombe Bir1p, a nuclear protein that localizes to kinetochores and the spindle midzone, is essential for chromosome condensation and spindle elongation during mitosis. Genetics, 160, 445-456.
35. Severin, F., Habermann, B., Huffaker, T. and Hyman, T. (2001) Stu2 promotes mitotic spindle elongation in anaphase. J. Cell Biol., 153, 435-442.
36. Skoufias, D.A. andreassen, P.R., Lacroix, F.B., Wilson, L. and Margolis, R.L. (2001) Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints. Proc. Natl Acad. Sci. USA, 98, 4492-4497.
37. Sonoda, E. et al. (2001) Scc1/Rad21/Mcd1 is required for sister chromatid cohesion and kinetochore function in vertebrate cells. Dev. Cell, 1, 759-770.
38. Straight, A.F., Belmont, A.S., Robinett, C.C. and Murray, A.W. (1996) GFP tagging of budding yeast chromosomes reveals that protein-protein interactions can mediate sister chromatid cohesion. Curr. Biol., 6, 1599-1608.
39. ts mutant that is aberrant in chromosome segregation, microtubule function, DNA repair and sensitive to hydroxyurea: Possible involvement of Rad21 in ubiquitin-mediated proteolysis. Genetics, 148, 49-57.
40. Tanaka, T.U. (2002) Bi-orientating chromosomes on the mitotic spindles. Curr. Opin. Cell Biol., 14, 365-371.
41. Tanaka, T., Fuchs, J., Loidl, J. and Nasmyth, K. (2000) Cohesin ensures bipolar attachment of microtubules to sister centromeres and resists their precocious separation. Nature Cell Biol., 2, 492-499.
42. Tanaka, T.U., Rachidi, N., Janke, C., Pereira, G., Galova, M., Schiebel, E., Stark, M.J.R. and Nasmyth, K. (2002) Evidence that the Ip11-Sli15 (aurora kinase-INCENP) complex promotes chromosome biorientation by altering kinetochore-spindle pole connections. Cell, 108, 317-329.
43. Taylor, S.S. and McKeon, F. (1997) Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage. Cell, 89, 727-735.
44. Taylor, S.S., Hussein, D., Wang, Y., Elderkin, S. and Morrow, C.J. (2001) Kinetochore localisation and phosphorylation of the mitotic checkpoint components Bub1 and BubR1 are differentially regulated by spindle events in human cells. J. Cell Sci., 114, 4385-4395.
45. Tournebize, R. et al. (2000) Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts. Nat. Cell Biol., 2, 13-19.
46. Toyoda, Y., Furuya, K., Goshima, G., Nagao, K., Takahashi, K. and Yanagida, M. (2002) Requirement of chromatid cohesion proteins Rad21/Scc1 and Mis4/Scc2 for normal spindle-kinetochore interaction in fission yeast. Curr. Biol., 12, 347-358.
47. Vardy, L., Fujita, A. and Toda, T. (2002) The γ-tubulin complex protein Alp4 provides a link between the metaphase checkpoint and cytokinesis in fission yeast. Genes Cells, 7, 365-373.
48. Walczak, C.E., Mitchison, T.J. and Desai, A. (1996) XKCM1: A Xenopus kinesin-related protein that regulates microtubule dynamics during mitotic spindle assembly. Cell, 84, 37-47.
49. Waters, J.C., Chen, R.-H., Murray, A.W. and Salmon, E.D. (1998) Localization of Mad2 to kinetochores depends on microtubule attachment, not tension. J. Cell Biol., 141, 1181-1191.
50. +, foster microtubule disassembly and are required for meiosis in fission yeast. Mol. Biol. Cell, 12, 3919-3932.
51. + and klp6+ are required for normal chromosome movement in mitosis. J. Cell Sci., 115, 931-940.
52. Wordeman, L. and Mitchison, T.J. (1995) Identification and partial characterization of mitotic centromere-associated kinesin, a kinesin-related protein that associates with centromeres during mitosis. J. Cell Biol., 128, 95-104.
53. Zhou, J., Panda, D., Landen, J.W., Wilson, L. and Joshi, H.C. (2002a) Minor alteration of microtubule dynamics causes loss of tension across kinetochore pairs and activates the spindle checkpoint. J. Biol. Chem., 277, 17200-17208.
54. Zhou, J., Yao, J. and Joshi, H.C. (2002b) Attachment and tension in the spindle assembly checkpoint. J. Cell Sci., 115, 3547-3555.