Fission yeast ch-TOG/XMAP215 homologue Alp14 connects mitotic spindles with the kinetochore and is a component of the Mad2-dependent spindle checkpoint

EMBO Journal

Volumn 20, Issue 13, 2001, Pages 3389-3401

  Garcia, M A ^a   Vardy, L ^a   Koonrugsa, N ^a   Toda, T ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Fission yeast; Kinetochore; Spindle checkpoint; TOG XMAP 215

Indexed keywords

DNA; GREEN FLUORESCENT PROTEIN; MICROTUBULE ASSOCIATED PROTEIN; PROTAMINE KINASE; PROTEIN ALP14; PROTEIN MAD2; PROTEIN TOG XMAP215; TUBULIN; UNCLASSIFIED DRUG;

ARTICLE; CAENORHABDITIS ELEGANS; CENTROMERE; CHROMOSOME SEGREGATION; IMMUNOPRECIPITATION; MICROTUBULE; MITOSIS SPINDLE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES POMBE; YEAST;

ANIMALS; CAENORHABDITIS ELEGANS; CELL CYCLE; CHROMOSOMES, FUNGAL; FUNGAL PROTEINS; GENOTYPE; HUMANS; KINETICS; KINETOCHORES; MICROTUBULE-ASSOCIATED PROTEINS; MITOTIC SPINDLE APPARATUS; PHYLOGENY; SACCHAROMYCES CEREVISIAE; SCHIZOSACCHAROMYCES; SCHIZOSACCHAROMYCES POMBE PROTEINS; XENOPUS PROTEINS;

EID: 0035796586     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.13.3389     Document Type: Article

References (64)

1. CENP-E as an essential component of the mitotic checkpoint in vitro
2. HEAT repeats in the Huntington's disease protein
3. Heterologous modules for efficient and versatile PCR-based gene targeting in Schizosaccharomyces pombe
4. The fission yeast SPB component Cut12 links bipolar spindle formation to mitotic control
5. CLIP170-like tip1p spatially organizes microtubular dynamics in fission yeast
6. Mutations of mitotic checkpoint genes in human cancers
7. Characterization of the cDNA and pattern of expression of a new gene over-expressed in human hepatomas and colonic tumors
8. The TOGp protein is a new human microtubule-associated protein homologous to the Xenopus XMAP215
9. Association of spindle assembly checkpoint component XMAD2 with unattached kinetochores
10. Spindle checkpoint protein Xmad1 recruits Xmad2 to unattached kinetochores
11. The yeast spindle pole body component Spc72p interacts with Stu2p and is required for proper microtubule assembly
12. Mini spindles: A gene encoding a conserved microtubule-associated protein required for the integrity of the mitotic spindle in Drosophila
13. The spindle pole body of Schizosaccharomyces pombe enters and leaves the nuclear envelope as the cell cycle proceeds
14. Fission yeast chromosome analysis: Fluorescence in situ hybridisation (FISH) and chromatin immunoprecipitation (CHIP)
15. Transient inhibition of histone deacetylation alters the structural and functional imprint at fission yeast centromeres
16. Cell cycle-dependent specific positioning and clustering of centromeres and telomeres in fission yeast
17. Cut2 proteolysis required for sister-chromatid separation in fission yeast
18. A microtubule-associated protein from Xenopus eggs that specifically promotes assembly at the plus-end
19. The structure of the protein phosphatase 2A PR65/A subunit reveals the conformation of its 15 tandemly repeated HEAT motifs
20. + associates with the fission yeast spindle pole body and is essential for viability
21. The Schizosaccharomyces pombe spindle checkpoint protein mad2p blocks anaphase and genetically interacts with the anaphase-promoting complex
22. Spreading of transcriptional repressor SIR3 from telomeric heterochromatin
23. + that encodes a nuclear scaffold-like protein blocks spindle elongation in mitotic anaphase
24. The NDA3 gene of fission yeast encodes β-tubulin: A cold-sensitive nda3 mutation reversibly blocks spindle formation and chromosome movement in mitosis
25. Essential role of tubulin-folding cofactor D in microtubule assembly and its association with microtubules in fission yeast
26. Visualization of Mad2 dynamics at kinetochores, along spindle fibers and at spindle poles in living cells
27. S.cerevisiae genes required for cell cycle arrest in response to loss of microtubule function
28. Budding yeast Cdc20: A target of the spindle checkpoint
29. The budding yeast proteins Spc24p and Spc25p interact with Ndc80p and Nuf2p at the kinetochore and are important for kinetochore clustering and checkpoint control
30. Human T cell leukemia virus type 1 oncoprotein tax targets the human mitotic checkpoint protein MAD1
31. Fission yeast Slp1: An effector of the Mad2-dependent spindle checkpoint
32. A 20S complex containing CDC27 and CDC16 catalyzes the mitotic-specific conjugation of ubiquitin to cyclin B
33. How proteolysis drives the cell cycle
34. Genetic instabilities in human cancers
35. Feedback control of mitosis in budding yeast
36. Identification of a human mitotic checkpoint gene: hsMAD2
37. ZYG-9, a Caenorhabditis elegans protein required for microtubule organization and function, is a component of meiotic and mitotic spindle poles
38. Budding yeast centromere composition and assembly as revealed by in vivo cross-linking
39. Molecular genetic analyses of fission yeast Schizosaccharomyces pombe
40. p93dis1, which is required for sister chromatid separation, is a novel microtubule and spindle pole body-associating protein phosphorylated at the Cdc2 target sites
41. Dynamics of centromeres during metaphase-anaphase transition in fission yeast: Dis1 is implicated in force balance in metaphase bipolar spindle
42. Dissection of fission yeast microtubule associating protein p93dis1: Regions implicated in regulated localization and microtubule interaction
43. HEAT repeats associated with condensins, cohesins and other complexes involved in chromosome-related functions
44. Characterization of Schizosaccharomyces pombe minichromosome deletion derivatives and a functional allocation of their centromere
45. Cold sensitive and caffeine supersensitive mutants of the Schizosaccharomyces pombe dis genes implicated in sister chromatid separation during mitosis
46. Distinct protein interaction domains and protein spreading in a complex centromere
47. XMAP215 regulates microtubule dynamics through two distinct domains
48. Identification of novel temperature-sensitive lethal alleles in essential β-tubulin and nonessential α2-tubulin genes as fission yeast polarity mutants
49. Functional dissection and hierarchy of tubulin-folding cofactor homologues in fission yeast
50. 1/S and forms specialized chromatin required for equal segregation
51. GFP tagging of budding yeast chromosomes reveals that protein-protein interactions can mediate sister chromatid cohesion
52. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis
53. A low copy number central sequence with strict symmetry and unusual chromatin structure in fission yeast centromere
54. Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage
55. The human homologue of Bub3 is required for kinetochore localization of Bub1 and a Mad3/Bub1-related protein kinase
56. Control of microtubule dynamics by the antagonistic activities of XMAP215 and XKCM1 in Xenopus egg extracts
57. 1 phase and is a component of the spindle-assembly checkpoint
58. XMAP from Xenopus eggs promotes rapid plus end assembly of microtubules and rapid microtubule polymer turnover
59. Stu2p: A microtubule-binding protein that is an essential component of the yeast spindle pole body
60. Localization of Mad2 to kinetochores depends on microtubule attachment, not tension
61. The Saccharomyces cerevisiae spindle pole body duplication gene MPS1 is part of a mitotic checkpoint
62. The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation
63. Analysis of the Saccharomyces spindle pole by matrix-assisted laser desorption/ionization (MALDI) mass spectrometry
64. CENP-E forms a link between attachment of spindle microtubules to kinetochores and the mitotic checkpoint