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Volumn 21, Issue 4, 2005, Pages 587-593

Therapeutic inhibition of matrix metalloproteinases for the treatment of chronic obstructive pulmonary disease (COPD)

Author keywords

COPD; Inhibitor; Lung inflammation; Matrix metalloproteinases; Selectivity

Indexed keywords

BATIMASTAT; CGS 27023A; MARIMASTAT; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE INHIBITOR; PRINOMASTAT; TISSUE INHIBITOR OF METALLOPROTEINASE; TOXIC GAS;

EID: 18744384999     PISSN: 03007995     EISSN: None     Source Type: Journal    
DOI: 10.1185/030079905X41417     Document Type: Review
Times cited : (27)

References (56)
  • 1
    • 2942729608 scopus 로고    scopus 로고
    • Management of chronic obstructive pulmonary disease
    • Sutherland ER, Cherniack RM. Management of chronic obstructive pulmonary disease. N Engl J Med 2004;350(26):2689-97
    • (2004) N Engl J Med , vol.350 , Issue.26 , pp. 2689-2697
    • Sutherland, E.R.1    Cherniack, R.M.2
  • 2
    • 0041810589 scopus 로고    scopus 로고
    • Global strategy for the diagnosis, management and prevention of COPD: 2003 Update
    • Fabbri LM, Hurd SS, GOLD Scientific Committee. Global Strategy for the Diagnosis, Management and Prevention of COPD: 2003 update. Eur Respir J 2003;22(1):1-2
    • (2003) Eur Respir J , vol.22 , Issue.1 , pp. 1-2
    • Fabbri, L.M.1    Hurd, S.S.2
  • 3
    • 0036598241 scopus 로고    scopus 로고
    • New treatments for COPD
    • Barnes PJ. New treatments for COPD. Nat Rev Drug Discov 2002;1(6):437-46
    • (2002) Nat Rev Drug Discov , vol.1 , Issue.6 , pp. 437-446
    • Barnes, P.J.1
  • 4
    • 16544379971 scopus 로고    scopus 로고
    • The worldwide burden of COPD is on the increase
    • Cross S. The worldwide burden of COPD is on the increase. Br J Nurs 2004;13(18):1066
    • (2004) Br J Nurs , vol.13 , Issue.18 , pp. 1066
    • Cross, S.1
  • 5
    • 0033190781 scopus 로고    scopus 로고
    • Genetics and pulmonary medicine. 10: Genetic epidemiology of pulmonary function
    • Chen Y. Genetics and pulmonary medicine. 10: Genetic epidemiology of pulmonary function. Thorax 1999;54(9):818-24
    • (1999) Thorax , vol.54 , Issue.9 , pp. 818-824
    • Chen, Y.1
  • 6
    • 0024470262 scopus 로고
    • Chronic obstructive pulmonary disease: A definition and implications of structural determinants of airflow obstruction for epidemiology
    • Snider GL. Chronic obstructive pulmonary disease: a definition and implications of structural determinants of airflow obstruction for epidemiology. Am Rev Respir Dis 1989;140(3 Pt 2):S3-8
    • (1989) Am Rev Respir Dis , vol.140 , Issue.3 PART 2
    • Snider, G.L.1
  • 7
    • 0035035768 scopus 로고    scopus 로고
    • Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary
    • Pauwels RA, Buist AS, Calverley PM, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med 2001;163(5):1256-76
    • (2001) Am J Respir Crit Care Med , vol.163 , Issue.5 , pp. 1256-1276
    • Pauwels, R.A.1    Buist, A.S.2    Calverley, P.M.3
  • 8
    • 0036545472 scopus 로고    scopus 로고
    • Proteinases in chronic obstructive pulmonary disease
    • Shapiro SD. Proteinases in chronic obstructive pulmonary disease. Biochem Soc Trans 2002;30(2):98-102
    • (2002) Biochem Soc Trans , vol.30 , Issue.2 , pp. 98-102
    • Shapiro, S.D.1
  • 9
    • 4644248792 scopus 로고    scopus 로고
    • Recent advances in the design of matrix metalloprotease inhibitors
    • Matter H, Schudok M. Recent advances in the design of matrix metalloprotease inhibitors. Curr Opin Drug Discov Devel 2004;7(4):513-35
    • (2004) Curr Opin Drug Discov Devel , vol.7 , Issue.4 , pp. 513-535
    • Matter, H.1    Schudok, M.2
  • 10
    • 3543134126 scopus 로고    scopus 로고
    • Matrix metalloproteinases as modulators of inflammation and innate immunity
    • Aug
    • Parks WC, Wilson CL, Lopez-Boado YS. Matrix metalloproteinases as modulators of inflammation and innate immunity. Nat Rev Immunol 2004 Aug;4(8):617-29
    • (2004) Nat Rev Immunol , vol.4 , Issue.8 , pp. 617-629
    • Parks, W.C.1    Wilson, C.L.2    Lopez-Boado, Y.S.3
  • 11
    • 0028907318 scopus 로고
    • Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease
    • Strongin AY, Collier I, Bannikov G, et al. Mechanism of cell surface activation of 72-kDa type IV collagenase. Isolation of the activated form of the membrane metalloprotease. J Biol Chem 1995;270(10):5331-8
    • (1995) J Biol Chem , vol.270 , Issue.10 , pp. 5331-5338
    • Strongin, A.Y.1    Collier, I.2    Bannikov, G.3
  • 12
    • 4043161974 scopus 로고    scopus 로고
    • Mitochondrial redox control of matrix metalloproteinases
    • Nelson KK, Melendez JA. Mitochondrial redox control of matrix metalloproteinases. Free Radic Biol Med 2004;37(6):768-84
    • (2004) Free Radic Biol Med , vol.37 , Issue.6 , pp. 768-784
    • Nelson, K.K.1    Melendez, J.A.2
  • 13
    • 0034915250 scopus 로고    scopus 로고
    • Matrilysin in epithelial repair and defense
    • Parks WC, Lopez-Boado YS, Wilson CL. Matrilysin in epithelial repair and defense. Chest 2001;120(1 Suppl):36S-41S
    • (2001) Chest , vol.120 , Issue.1 SUPPL.
    • Parks, W.C.1    Lopez-Boado, Y.S.2    Wilson, C.L.3
  • 14
    • 0035129952 scopus 로고    scopus 로고
    • Role of human airway smooth muscle in altered extracellular matrix production in asthma
    • Johnson PR. Role of human airway smooth muscle in altered extracellular matrix production in asthma. Clin Exp Pharmacol Physiol 2001;28(3):233-6
    • (2001) Clin Exp Pharmacol Physiol , vol.28 , Issue.3 , pp. 233-236
    • Johnson, P.R.1
  • 15
    • 0032791025 scopus 로고    scopus 로고
    • Regulation of gelatinases in human airway smooth muscle cells: Mechanism of progelatinase A activation
    • Foda HD, George S, Rollo E, et al. Regulation of gelatinases in human airway smooth muscle cells: mechanism of progelatinase A activation. Am J Physiol 1999;277(1 Pt 1):L174-821
    • (1999) Am J Physiol , vol.277 , Issue.1 PART 1
    • Foda, H.D.1    George, S.2    Rollo, E.3
  • 16
    • 0034689027 scopus 로고    scopus 로고
    • Bacterial exposure induces and activates matrilysin in mucosal epithelial cells
    • Lopez-Boado YS, Wilson CL, Hooper LV, et al. Bacterial exposure induces and activates matrilysin in mucosal epithelial cells. J Cell Biol 2000;148(6):1305-15
    • (2000) J Cell Biol , vol.148 , Issue.6 , pp. 1305-1315
    • Lopez-Boado, Y.S.1    Wilson, C.L.2    Hooper, L.V.3
  • 17
    • 0035798708 scopus 로고    scopus 로고
    • Regulation of matrilysin expression in airway epithelial cells by Pseudomonas aeruginosa flagellin
    • Epub 2001 Aug 29
    • Lopez-Boado YS, Wilson CL, Parks WC. Regulation of matrilysin expression in airway epithelial cells by Pseudomonas aeruginosa flagellin. J Biol Chem 2001;276(44):41417-23. Epub 2001 Aug 29
    • (2001) J Biol Chem , vol.276 , Issue.44 , pp. 41417-41423
    • Lopez-Boado, Y.S.1    Wilson, C.L.2    Parks, W.C.3
  • 18
    • 0032091787 scopus 로고    scopus 로고
    • Cell-matrix interactions modulate 92-kD gelatinase expression by human bronchial epithelial cells
    • Yao PM, Delclaux C, d'Ortho MP et al. Cell-matrix interactions modulate 92-kD gelatinase expression by human bronchial epithelial cells. Am J Respir Cell Mol Biol 1998;18(6):813-22
    • (1998) Am J Respir Cell Mol Biol , vol.18 , Issue.6 , pp. 813-822
    • Yao, P.M.1    Delclaux, C.2    D'Ortho, M.P.3
  • 19
    • 0033773688 scopus 로고    scopus 로고
    • Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers. Regulation by interleukin-10
    • Lim S, Roche N, Oliver BG, et al. Balance of matrix metalloprotease-9 and tissue inhibitor of metalloprotease-1 from alveolar macrophages in cigarette smokers. Regulation by interleukin-10. Am J Respir Crit Care Med 2000;162(4 Pt 1):1355-60
    • (2000) Am J Respir Crit Care Med , vol.162 , Issue.4 PART 1 , pp. 1355-1360
    • Lim, S.1    Roche, N.2    Oliver, B.G.3
  • 20
    • 0033049944 scopus 로고    scopus 로고
    • Immunohistochemical localisation of the matrix metalloproteinases MMP-3 and MMP-9 within the airways in asthma
    • Dahlen B, Shute J, Howarth P. Immunohistochemical localisation of the matrix metalloproteinases MMP-3 and MMP-9 within the airways in asthma. Thorax 1999;54(7):590-6
    • (1999) Thorax , vol.54 , Issue.7 , pp. 590-596
    • Dahlen, B.1    Shute, J.2    Howarth, P.3
  • 22
    • 0035077465 scopus 로고    scopus 로고
    • Human collagenase (matrix metalloproteinase-1) expression in the lungs of patients with emphysema
    • Imai K, Dalal SS, Chen ES, et al. Human collagenase (matrix metalloproteinase-1) expression in the lungs of patients with emphysema. Am J Respir Crit Care Med 2001;163(3 Pt 1): 786-91
    • (2001) Am J Respir Crit Care Med , vol.163 , Issue.3 PART 1 , pp. 786-791
    • Imai, K.1    Dalal, S.S.2    Chen, E.S.3
  • 23
    • 0031710577 scopus 로고    scopus 로고
    • Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema
    • Ohnishi K, Takagi M, Kurokawa Y, et al. Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema. Lab Invest 1998;78(9):1077-87
    • (1998) Lab Invest , vol.78 , Issue.9 , pp. 1077-1087
    • Ohnishi, K.1    Takagi, M.2    Kurokawa, Y.3
  • 24
    • 0032989453 scopus 로고    scopus 로고
    • Neutrophil granule proteins in bronchoalveolar lavage fluid from subjects with subclinical emphysema
    • Betsuyaku T, Nishimura M, Takeyabu K, et al. Neutrophil granule proteins in bronchoalveolar lavage fluid from subjects with subclinical emphysema. Am J Respir Crit Care Med 1999;159(6):1985-91
    • (1999) Am J Respir Crit Care Med , vol.159 , Issue.6 , pp. 1985-1991
    • Betsuyaku, T.1    Nishimura, M.2    Takeyabu, K.3
  • 25
    • 0030811545 scopus 로고    scopus 로고
    • Elevated levels of matrix metalloproteinases in bronchoalveolar lavage fluid of emphysematous patients
    • Finlay GA, Russell KJ, McMahon KJ, et al. Elevated levels of matrix metalloproteinases in bronchoalveolar lavage fluid of emphysematous patients. Thorax 1997;52(6):502-6
    • (1997) Thorax , vol.52 , Issue.6 , pp. 502-506
    • Finlay, G.A.1    Russell, K.J.2    McMahon, K.J.3
  • 26
    • 0027971976 scopus 로고
    • Elastolytic metalloproteinases produced by human mononuclear phagocytes. Potential roles in destructive lung disease
    • Shapiro SD. Elastolytic metalloproteinases produced by human mononuclear phagocytes. Potential roles in destructive lung disease. Am J Respir Crit Care Med 1994;150(6 Pt 2):S160-4
    • (1994) Am J Respir Crit Care Med , vol.150 , Issue.6 PART 2
    • Shapiro, S.D.1
  • 27
    • 0034101866 scopus 로고    scopus 로고
    • Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD
    • Segura-Valdez L, Pardo A, Gaxiola M, et al. Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD. Chest 2000;117(3):684-94
    • (2000) Chest , vol.117 , Issue.3 , pp. 684-694
    • Segura-Valdez, L.1    Pardo, A.2    Gaxiola, M.3
  • 28
    • 0037407465 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases MMP-9 within the airways in asthma
    • Han Z, Junxu, Zhong N. Expression of matrix metalloproteinases MMP-9 within the airways in asthma. Respir Med 2003;97(5): 563-7
    • (2003) Respir Med , vol.97 , Issue.5 , pp. 563-567
    • Han, Z.1    Junxu2    Zhong, N.3
  • 29
    • 0042165852 scopus 로고    scopus 로고
    • Extracellular matrix metalloproteinase inducer is increased in smokers' bronchoalveolar lavage fluid
    • Jul 15. Epub 2003 Apr 24
    • Betsuyaku T, Tanino M, Nagai K, et al. Extracellular matrix metalloproteinase inducer is increased in smokers' bronchoalveolar lavage fluid. Am J Respir Crit Care Med 2003;Jul 15;168(2):222-7. Epub 2003 Apr 24
    • (2003) Am J Respir Crit Care Med , vol.168 , Issue.2 , pp. 222-227
    • Betsuyaku, T.1    Tanino, M.2    Nagai, K.3
  • 30
    • 0032417102 scopus 로고    scopus 로고
    • Sputum metalloproteinase-9/tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis
    • Vignola AM, Riccobono L, Mirabella A, et al. Sputum metalloproteinase-9/ tissue inhibitor of metalloproteinase-1 ratio correlates with airflow obstruction in asthma and chronic bronchitis. Am J Respir Crit Care Med 1998;158(6):1945-50
    • (1998) Am J Respir Crit Care Med , vol.158 , Issue.6 , pp. 1945-1950
    • Vignola, A.M.1    Riccobono, L.2    Mirabella, A.3
  • 31
    • 13544262442 scopus 로고    scopus 로고
    • Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation
    • Hitesh S, Deshmukh LM, Case SC, et al. Metalloproteinases mediate mucin 5AC expression by epidermal growth factor receptor activation. Am J Respir Crit Care Med 2005;171:305-14
    • (2005) Am J Respir Crit Care Med , vol.171 , pp. 305-314
    • Hitesh, S.1    Deshmukh, L.M.2    Case, S.C.3
  • 32
    • 14444279391 scopus 로고    scopus 로고
    • Severity of airflow limitation is associated with severity of airway inflammation in smokers
    • Di Stefano A, Capelli A, Lusuardi M, et al. Severity of airflow limitation is associated with severity of airway inflammation in smokers. Am J Respir Crit Care Med 1998;158(4):1277-85
    • (1998) Am J Respir Crit Care Med , vol.158 , Issue.4 , pp. 1277-1285
    • Di Stefano, A.1    Capelli, A.2    Lusuardi, M.3
  • 33
    • 0036257599 scopus 로고    scopus 로고
    • Macrophages and the pathogenesis of COPD
    • Tetley TD. Macrophages and the pathogenesis of COPD. Chest 2002;121(5 Suppl):156S-159S
    • (2002) Chest , vol.121 , Issue.5 SUPPL.
    • Tetley, T.D.1
  • 34
    • 0030825320 scopus 로고    scopus 로고
    • Matrix metalloproteinase expression and production by alveolar macrophages in emphysema
    • Finlay GA, O'Driscoll LR, Russell KJ, et al. Matrix metalloproteinase expression and production by alveolar macrophages in emphysema. Am J Respir Crit Care Med 1997;156(1):240-7
    • (1997) Am J Respir Crit Care Med , vol.156 , Issue.1 , pp. 240-247
    • Finlay, G.A.1    O'Driscoll, L.R.2    Russell, K.J.3
  • 35
    • 0036010527 scopus 로고    scopus 로고
    • Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease
    • Russell RE, Culpitt SV, DeMatos C, et al. Release and activity of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 by alveolar macrophages from patients with chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol 2002;26(5):602-9
    • (2002) Am J Respir Cell Mol Biol , vol.26 , Issue.5 , pp. 602-609
    • Russell, R.E.1    Culpitt, S.V.2    DeMatos, C.3
  • 36
    • 0036783727 scopus 로고    scopus 로고
    • Alveolar macrophage-mediated elastolysis: Roles of matrix metalloproteinases, cysteine, and serine proteases
    • Russell RE, Thorley A, Culpitt SV, et al. Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases. Am J Physiol Lung Cell Mol Physiol 2002;283(4):L867-73
    • (2002) Am J Physiol Lung Cell Mol Physiol , vol.283 , Issue.4
    • Russell, R.E.1    Thorley, A.2    Culpitt, S.V.3
  • 37
    • 0035941048 scopus 로고    scopus 로고
    • Genetic polymorphism in matrix metalloproteinase-9 and pulmonary emphysema
    • Minematsu N, Nakamura H, Tateno H, et al. Genetic polymorphism in matrix metalloproteinase-9 and pulmonary emphysema. Biochem Biophys Res Commun 2001;289(1):116-9
    • (2001) Biochem Biophys Res Commun , vol.289 , Issue.1 , pp. 116-119
    • Minematsu, N.1    Nakamura, H.2    Tateno, H.3
  • 38
    • 8844250037 scopus 로고    scopus 로고
    • Genetic polymorphism in matrix metalloproteinase-9 and the susceptibility to chronic obstructive pulmonary disease in Han population of south China
    • Zhou M, Huang SG, Wan HY, et al. Genetic polymorphism in matrix metalloproteinase-9 and the susceptibility to chronic obstructive pulmonary disease in Han population of south China. Chin Med J (Engl) 2004;117(10):1481-4
    • (2004) Chin Med J (Engl) , vol.117 , Issue.10 , pp. 1481-1484
    • Zhou, M.1    Huang, S.G.2    Wan, H.Y.3
  • 39
    • 0036501372 scopus 로고    scopus 로고
    • The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function
    • Joos L, He JQ, Shepherdson MB, et al. The role of matrix metalloproteinase polymorphisms in the rate of decline in lung function. Hum Mol Genet 2002;11(5):569-76.
    • (2002) Hum Mol Genet , vol.11 , Issue.5 , pp. 569-576
    • Joos, L.1    He, J.Q.2    Shepherdson, M.B.3
  • 40
    • 0037388272 scopus 로고    scopus 로고
    • Erratum
    • Apr 1
    • Erratum in: Hum Mol Genet 2003 Apr 1;12(7):803-4
    • (2003) Hum Mol Genet , vol.12 , Issue.7 , pp. 803-804
  • 41
    • 0035164768 scopus 로고    scopus 로고
    • Tissue inhibitor of metalloproteinases-2 gene polymorphisms in chronic obstructive pulmonary disease
    • Hirano K, Sakamoto T, Uchida Y, et al. Tissue inhibitor of metalloproteinases-2 gene polymorphisms in chronic obstructive pulmonary disease. Eur Respir J 2001;18(5):748-52
    • (2001) Eur Respir J , vol.18 , Issue.5 , pp. 748-752
    • Hirano, K.1    Sakamoto, T.2    Uchida, Y.3
  • 42
    • 0026461115 scopus 로고
    • Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema
    • D'Armiento, Dalal SS, Okada Y, et al. Collagenase expression in the lungs of transgenic mice causes pulmonary emphysema. Cell 1992;71(6):955-61
    • (1992) Cell , vol.71 , Issue.6 , pp. 955-961
    • D'Armiento1    Dalal, S.S.2    Okada, Y.3
  • 43
    • 0344241478 scopus 로고    scopus 로고
    • Progressive adult-onset emphysema in transgenic mice expressing human MMP-1 in the lung
    • Epub 2003 Jan 10
    • Foronjy RF, Okada Y, Cole R, et al. Progressive adult-onset emphysema in transgenic mice expressing human MMP-1 in the lung. Am J Physiol Lung Cell Mol Physiol 2003;284(5):L727-37. Epub 2003 Jan 10
    • (2003) Am J Physiol Lung Cell Mol Physiol , vol.284 , Issue.5
    • Foronjy, R.F.1    Okada, Y.2    Cole, R.3
  • 44
    • 0036679426 scopus 로고    scopus 로고
    • Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling
    • Lanone S, Zheng T, Zhu Z, et al. Overlapping and enzyme-specific contributions of matrix metalloproteinases-9 and -12 in IL-13-induced inflammation and remodeling. J Clin Invest 2002;110(4):463-74
    • (2002) J Clin Invest , vol.110 , Issue.4 , pp. 463-474
    • Lanone, S.1    Zheng, T.2    Zhu, Z.3
  • 45
    • 0034606218 scopus 로고    scopus 로고
    • Interferon gamma induction of pulmonary emphysema in the adult murine lung
    • Wang Z, Zheng T, Zhu Z, et al. Interferon gamma induction of pulmonary emphysema in the adult murine lung. J Exp Med 2000;192(11):1587-600
    • (2000) J Exp Med , vol.192 , Issue.11 , pp. 1587-1600
    • Wang, Z.1    Zheng, T.2    Zhu, Z.3
  • 46
    • 0030823772 scopus 로고    scopus 로고
    • Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
    • Hautamaki RD, Kobayashi DK, Senior RM, et al. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 1997;277(5334):2002-4
    • (1997) Science , vol.277 , Issue.5334 , pp. 2002-2004
    • Hautamaki, R.D.1    Kobayashi, D.K.2    Senior, R.M.3
  • 47
    • 0037447184 scopus 로고    scopus 로고
    • Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release
    • Epub 2003 Jan 09
    • Churg A, Wang RD, Tai H, et al. Macrophage metalloelastase mediates acute cigarette smoke-induced inflammation via tumor necrosis factor-alpha release. Am J Respir Crit Care Med 2003;167(8):1083-9. Epub 2003 Jan 09
    • (2003) Am J Respir Crit Care Med , vol.167 , Issue.8 , pp. 1083-1089
    • Churg, A.1    Wang, R.D.2    Tai, H.3
  • 48
    • 0037435009 scopus 로고    scopus 로고
    • Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema
    • Morris DG, Huang X, Kaminski N, et al. Loss of integrin alpha(v)beta6-mediated TGF-beta activation causes Mmp12-dependent emphysema. Nature 2003;422(6928):169-73
    • (2003) Nature , vol.422 , Issue.6928 , pp. 169-173
    • Morris, D.G.1    Huang, X.2    Kaminski, N.3
  • 49
    • 0034705208 scopus 로고    scopus 로고
    • Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice
    • Wert SE, Yoshida M, LeVine AM, et al. Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice. Proc Natl Acad Sci USA 2000;97(11):5972-7
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.11 , pp. 5972-5977
    • Wert, S.E.1    Yoshida, M.2    LeVine, A.M.3
  • 50
    • 0344413022 scopus 로고    scopus 로고
    • Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice
    • Shapiro SD, Goldstein NM, Houghton AM, et al. Neutrophil elastase contributes to cigarette smoke-induced emphysema in mice. Am J Pathol 2003;163(6):2329-35
    • (2003) Am J Pathol , vol.163 , Issue.6 , pp. 2329-2335
    • Shapiro, S.D.1    Goldstein, N.M.2    Houghton, A.M.3
  • 51
    • 3343006385 scopus 로고    scopus 로고
    • Metalloprotease inhibitors as anti-inflammatory agents: An evolving target?
    • Whelan CJ. Metalloprotease inhibitors as anti-inflammatory agents: an evolving target? Curr Opin Investig Drugs 2004;5(5):511-6
    • (2004) Curr Opin Investig Drugs , vol.5 , Issue.5 , pp. 511-516
    • Whelan, C.J.1
  • 52
    • 15644374838 scopus 로고    scopus 로고
    • Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits
    • MacPherson LJ, Bayburt EK, Capparelli MP, et al. Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. J Med Chem 1997;40(16):2525-32
    • (1997) J Med Chem , vol.40 , Issue.16 , pp. 2525-2532
    • MacPherson, L.J.1    Bayburt, E.K.2    Capparelli, M.P.3
  • 53
    • 0037192458 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors and cancer: Trials and tribulations
    • Coussens LM, Fingleton B, Matrisian LM. Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 2002;295(5564):2387-92
    • (2002) Science , vol.295 , Issue.5564 , pp. 2387-2392
    • Coussens, L.M.1    Fingleton, B.2    Matrisian, L.M.3
  • 54
    • 0036892178 scopus 로고    scopus 로고
    • The role of new agents in the treatment of non-small cell lung cancer
    • Broker LE, Giaccone G. The role of new agents in the treatment of non-small cell lung cancer. Eur J Cancer 2002;38(18):2347-61
    • (2002) Eur J Cancer , vol.38 , Issue.18 , pp. 2347-2361
    • Broker, L.E.1    Giaccone, G.2
  • 55
    • 0034751435 scopus 로고    scopus 로고
    • Matrix metalloproteinase inhibitors: Current developments and future perspectives
    • Hoekstra R, Eskens FA, Verweij J. Matrix metalloproteinase inhibitors: current developments and future perspectives. Oncologist 2001;6(5):415-27
    • (2001) Oncologist , vol.6 , Issue.5 , pp. 415-427
    • Hoekstra, R.1    Eskens, F.A.2    Verweij, J.3
  • 56
    • 0035318252 scopus 로고    scopus 로고
    • All trans-retinoic acid selectively down-regulates matrix metalloproteinase-9 (MMP-9) and up-regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) in human bronchoalveolar lavage cells
    • Frankenberger M, Hauck RW, Frankenberger B, et al. All trans-retinoic acid selectively down-regulates matrix metalloproteinase-9 (MMP-9) and up-regulates tissue inhibitor of metalloproteinase-1 (TIMP-1) in human bronchoalveolar lavage cells. Mo Med 2001;7(4):263-70
    • (2001) Mol Med , vol.7 , Issue.4 , pp. 263-270
    • Frankenberger, M.1    Hauck, R.W.2    Frankenberger, B.3


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