Tissue inhibitor of metalloproteinases-2 gene polymorphisms in chronic obstructive pulmonary disease

European Respiratory Journal

Volumn 18, Issue 5, 2001, Pages 748-752

  Hirano, K ^a   Sakamoto, T ^a   Uchida, Y ^a   Morishima, Y ^a   Masuyama, K ^a   Ishii, Y ^a   Nomura, A ^a   Ohtsuka, M ^a   Sekizawa, K ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

Chronic obsructive; Polymorphism; Pulmonary disease; Tissue inhibitors of metalloproteinases

Indexed keywords

MATRIX METALLOPROTEINASE; MESSENGER RNA; NUCLEOTIDE; PROTEINASE; PROTEINASE INHIBITOR; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSCRIPTION FACTOR SP1;

AGED; ARTICLE; BINDING SITE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE PREDISPOSITION; DNA POLYMORPHISM; FEMALE; FREQUENCY ANALYSIS; GENE ACTIVITY; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; GENETIC MARKER; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN DEGRADATION; REGULATORY MECHANISM; RNA STABILITY; RNA TRANSCRIPTION; SEQUENCE ANALYSIS; SINGLE STRAND CONFORMATION POLYMORPHISM; THEORY;

AGED; DNA PRIMERS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); PROTEASE INHIBITORS; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASE-2; TRANSCRIPTION, GENETIC;

EID: 0035164768     PISSN: 09031936     EISSN: None     Source Type: Journal    
DOI: 10.1183/09031936.01.00102101     Document Type: Article

References (21)

1. Chronic obstructive pulmonary disease: Risk factors, pathophysiology and pathogenesis
2. Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha-1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase
3. Role of antileukoprotease in the human lung
4. Oxidation of the mesangial matrix metalloproteinase-2 impairs gelatinolytic activity
5. Oxidants, antioxidants and the pathogenesis of emphysema
6. Correlates of FEV1 and prevalence of pulmonary conditions in Japanese-American men
7. Matrix metalloproteinase expression and production by alveolar macrophages in emphysema
8. Matrix metalloproteinase-mediated extracellular matrix protein degradation in human pulmonary emphysema
9. Neutrophil granule proteins in bronchoalveolar lavage fluid from subjects with subclinical emphysema
10. Upregulation of gelatinases A and B, collagenases 1 and 2, and increased parenchymal cell death in COPD
11. Molecular cloning and characterization of human tissue inhibitor of metalloproteinase 4
12. Structure and characterization of the human tissue inhibitor of metalloproteinases-2 gene
13. Analysis of coding sequences for tissue inhibitor of metalloproteinases 1 (TIMP1) and 2 (TIMP2) in patients with aneurysms
14. Chronic obstructive pulmonary disease and abdominal aortic aneurysms
15. SSCP analysis: A blind sensitivity trial
16. Compilation of vertebrate-encoded transcription factors
17. Characterization of the promoter of the gene encoding human tissue inhibitor of metalloproteinases-2 (TIMP-2)
18. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice
19. Preferential inhibition of 72- and 92-kDa gelatinases by tissue inhibitor of metalloproteinases-2
20. Cell-matrix interactions in gland development in the lung
21. Role of matrix metalloproteinases in models of macrophage-dependent acute lung injury. Evidence for alveolar macrophage as source of proteinases