B cells capturing antigen conjugated with CpG oligodeoxynucleotides induce Th1 cells by elaborating IL-12

Journal of Immunology

Volumn 169, Issue 2, 2002, Pages 787-794

  Shirota, Hidekazu ^a   Sano, Kunio ^a   Hirasawa, Noriyasu ^a   Terui, Tadashi ^a   Ohuchi, Kazuo ^a   Hattori, Toshio ^a   Tamura, Gen ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CD40 ANTIGEN; CD86 ANTIGEN; GAMMA INTERFERON; HLA ANTIGEN CLASS 2; INTERLEUKIN 12; LYMPHOCYTE ANTIGEN; OLIGODEOXYNUCLEOTIDE;

ANIMAL CELL; ANTIGEN EXPRESSION; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; B LYMPHOCYTE DIFFERENTIATION; CONJUGATION; CONTROLLED STUDY; CPG ISLAND; DENDRITIC CELL; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL;

EID: 0037100526     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.169.2.787     Document Type: Article

References (67)

1. Presentation of exogenous protein antigens by dendritic cells to T cell clones: Intact protein is presented best by immature, epidermal Langerhans cells
2. Dendritic cell progenitors phagocytose particulates, including bacillus Calmette-Guérin organisms, and sensitize mice to mycobacterial antigens in vivo
3. Phagocytosis of antigens by Langerhans cells in vitro
4. Activation of human dendritic cells through CD40 cross-linking
5. Protein-specific helper T-lymphocyte formation initiated by dendritic cells
6. Dendritic cells pulsed with protein antigens in vitro can prime antigen-specific, MHC-restricted T cells in situ
7. Augmentation of guinea pig T lymphocyte proliferative response to antigens in the presence of purified B cells
8. Accessory cell requirement in the proliferative response of T lymphocytes to hemocyanin
9. Studies on the capacity of B cells to serve as antigen-presenting cells
10. B cells as antigen-presenting cells: The requirement for B cell activation
11. Antigen presentation by splenic B cells: Resting B cells are ineffective, whereas activated B cells are effective accessory cells for T cell responses
12. Can B cells turn on virgin T cells?
13. B cells turn off virgin but not memory T cells
14. Small B cells as antigen-presenting cells in the induction of tolerance to soluble protein antigens
15. + T cells
16. Differential up-regulation of the B7-1 and B7-2 costimulatory molecules after Ig receptor engagement by antigen
17. A quantitative analysis of antigen-presenting cell function: Activated B cells stimulate naive CD4 T cells but are inferior to dendritic cells in providing costimulation
18. Antigen presentation by haptenspecific B lymphocytes. I. Role of surface immunoglobulin receptors
19. Antigen-specific interaction between T and B cells
20. B lymphocytes in vivo fail to prime naive T cells but can stimulate antigen-experienced T lymphocytes
21. Regulation of T-cell activation: Differences among T-cell subsets
22. Prevention of experimental allergic encephalomyelitis in rats by targeting autoantigen to B cells: Evidence that the protective mechanism depends on changes in the cytokine response and migratory properties of the autoantigen-specific T cells
23. B cells solicit their own help from T cells
24. The role of B cells in the programming of T cells for IL-4 synthesis
25. + T cells to produce IL-4
26. + T cells, but fail to produce IL-12: Selective APC for Th2 cell development?
27. B lymphocytes regulate dendritic cell (DC) function in vivo: Increased interleukin 12 production by DCs from B cell-deficient mice results in T helper cell type 1 deviation
28. T cell development in B cell-deficient mice. IV. The role of B cells as antigen-presenting cells in vivo
29. T cell priming in vivo: A major role for B cells in presenting antigen to T cells in lymph nodes
30. The B cell is the initiating antigen-presenting cell in peripheral lymph nodes
31. B lymphocytes in vivo fail to prime naive T cells but can stimulate antigen-experienced T lymphocytes
32. Successful T cell priming in B cell-deficient mice
33. + T cells to protein antigens in vivo
34. + T cell priming in vivo
35. + T cells to produce IL-4
36. GIF inhibits Th effector generation by acting on antigen-presenting B cells
37. CpG motifs in bacterial DNA trigger direct B-cell activation
38. Immunostimulatory DNA sequences necessary for effective intradermal gene immunization
39. Macrophages ingest and are activated by bacterial DNA
40. Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA
41. Bacterial DNA-induced NK cell IFN-γ production is dependent on macrophage secretion of IL-12
42. CpG oligodeoxynucleotides act as adjuvants that switch on T helper 1 (Th1) immunity
43. Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells
44. Activation of cutaneous dendritic cells by CpG-containing oligodeoxynucleotides: A role for dendritic cells in the augmentation of Th1 responses by immunostimulatory DNA
45. CpG DNA: A potent signal for growth, activation, and maturation of human dendritic cells
46. Regulation of murine airway eosinophilia and Th2 cells by antigen-conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator
47. Novel roles of CpG oligodeoxynucleotides as a leader for the sampling and presentation of CpG-Tagged Ag by dendritic cells
48. The role of cell surface receptors in the activation of human B cells by phosphorothioate oligonucleotides
49. Naive T cells can mediate delayed-type hypersensitivity response in T cell receptor transgenic mice
50. Regulation of T-helper cell type 2 and airway eosinophilia by transmucosal coadministration of antigen and oligodeoxynucleotides containing CpG motifs
51. Immunobiology of a spontaneous murine B cell leukemia (BCL1)
52. Ovalbumin (OVA) and Mycobacterium tuberculosis bacilli cooperatively polarize anti-OVA T-helper (Th) cells toward a Th1-dominant phenotype and ameliorate murine tracheal eosinophilia
53. Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas: Lack of independent antigen and H-2 recognition
54. Normal B cells fail to secrete interleukin-12
55. Bacterial LPS stimulates the production of cytokines and the expression of costimulatory molecules by human peripheral blood dendritic cells: Evidence for a soluble CD14-dependent pathway
56. Activation of human dendritic cells following infection with Mycobacterium tuberculosis
57. In vivo microbial stimulation induces rapid CD40 ligand-independent production of IL-12 by dendritic cells and their redistribution to T cell areas
58. Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection
59. The role of cell surface receptors in the activation of human B cells by phosphorothioate oligonucleotides
60. CpG motifs present in bacterial DNA rapidly induce lymphocytes to secrete interleukin 6, interleukin 12, and interferon
61. Reciprocal regulation of polarized cytokine production by effector B and T cells
62. Covalent binding of C3b to tetanus toxin: Influence on uptake/internalization of antigen by antigen-specific and non-specific B cell
63. Antigen-bound C3b and C4b enhance antigen-presenting cell function in activation of human T-cell clones
64. Tracing uptake of C3dg-conjugated antigen into B cells via complement receptor type 2 (CR2, CD21)
65. Natural antibody and complement-mediated antigen processing and presentation by B lymphocytes
66. Complement opsonization is required for presentation of immune complexes by resting peripheral blood B cells
67. DNA uptake in bacteria