Long-acting forms of sonic hedgehog with improved pharmacokinetic and pharmacodynamic properties are efficacious in a nerve injury model

Journal of Pharmaceutical Sciences

Volumn 91, Issue 2, 2002, Pages 371-387

  Pepinsky, R Blake ^a   Shapiro, Renee I ^a   Wang, Shaoshan ^a   Chakraborty, Abhijit ^a,c   Gill, Alan ^a   Lepage, Doreen J ^a   Wen, Dingyi ^a   Rayhorn, Paul ^a   Horan, Gerald S B ^b   Taylor, Frederick R ^a   Garber, Ellen A ^a   Galdes, Alphonse ^a   Engber, Thomas M ^a  

^a BIOGEN   (United States)

^b CURIS INC   (United States)

^c R W JOHNSON PHARMACEUTICAL RES I   (United States)

Author keywords

Nerve injury model; PEGylation; Pharmacokinetics; Polyethylene glycol modified; Sonic hedgehog

Indexed keywords

MACROGOL; SONIC HEDGEHOG PROTEIN;

ANIMAL MODEL; ARTICLE; DRUG CLEARANCE; DRUG EFFECT; DRUG EFFICACY; DRUG FORMULATION; DRUG HALF LIFE; DRUG POTENCY; MALE; NERVE INJURY; NERVE REGENERATION; NONHUMAN; RAT; SCIATIC NERVE; SITE DIRECTED MUTAGENESIS;

EID: 0036167305     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.10052     Document Type: Article

References (30)

1. The world according to Hedgehog
2. Transducing hedgehog: The story so far
3. Comparative biological responses to human Sonic, Indian, and Desert hedgehog
4. Recent advances in hedgehog signaling
5. Ptch2, a second mouse Patched gene is co-expressed with Sonic hedgehog
6. Vertebrate Hedgehog signaling modulated by induction of a Hedgehog-binding protein
7. Proteolytic processing yields two secreted forms of Sonic hedgehog
8. Hedgehog patterning activity: Role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain
9. Identification of a palmitic acid-modified form of human Sonic hedgehog
10. Cholesterol modification of hedgehog signaling proteins in animal development
11. Enhanced potency of human sonic hedgehog by hydrophobic modifications
12. Relationship of effective molecular size to systemic clearance in rats of recombinant interleukin-2 chemically modified with water-soluble polymers
13. Polymer-derivatized proteins: Analytical and preparative problems
14. Polyethylene glycol modification: Applications in tumour targeting and cytokine therapy
15. A dose finding study of pegylated interferon-alfa-2b and ribavirin in chronic hepatitis C
16. Improved pharmacokinetic properties of a polyethylene glycol-modified form of interferon-beta-1a with preserved in vitro bioactivity
17. The uses and properties of PEG-linked proteins
18. PEGylation of cytokines and other therpeutic proteins and peptides: The importance of biological optimisation of coupling techniques
19. A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog
20. Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched
21. Mapping sonic hedgehog-receptor interactions by steric interference
22. Functional antagonists of sonic hedgehog reveal the importance of the N terminus for activity
23. Two critical periods of Sonic Hedgehog signaling required for the specification of motor neuron identity
24. Conservation of the hedgehog/patched signaling pathway from flies to mice: Induction of a mouse patched gene by Hedgehog
25. The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors
26. Systemic administration of rhIGF-1 enhanced regeneration following sciatic nerve crush in rats and mice
27. Identification of insulin-like growth factor binding protein-2 as a biochemical surrogate marker for the in vivo effects of recombinant human insulin-like growth factor-1 in mice
28. Existence of two nonlinear elimination mechanisms for hepatocyte growth factor in rats
29. Two receptor systems are involved in the plasma clearance of tissue factor pathway inhibitor in vivo
30. Heparin decreases the blood clearance of interferon-gamma and increases its activity by limiting the processing of its carboxyl-terminal sequence