Apoptosis signaling by the novel compound 3-Cl-AHPC involves increased EGFR proteolysis and accompanying decreased phosphatidylinositol 3-kinase and AKT kinase activities

Oncogene

Volumn 23, Issue 10, 2004, Pages 1874-1884

  Farhana, Lulu ^a   Dawson, Marcia I ^b   Huang, Ying ^c   Zhang, Yuxiang ^a   Rishi, Arun K ^a   Reddy, Kaladhar B ^a   Freeman, Robert S ^d   Fontana, Joseph A ^a,e  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BURNHAM INSTITUTE   (United States)

^c State University of New York Upstate Medical University: College of Medicine   (United States)

^d UNIVERSITY OF ROCHESTER   (United States)

^e VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

3 Cl AHPC; AKT; CD437 AHPN; EGFR; PI3 K

Indexed keywords

4 [3 (1 ADAMANTYL) 4 HYDROXYPHENYL] 3 CHLOROCINNAMIC ACID; AMINO ACID; CINNAMIC ACID DERIVATIVE; EPIDERMAL GROWTH FACTOR RECEPTOR; INTEGRIN LINKED KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4 BISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN KINASE B; PROTEIN P85; PROTEIN SERINE THREONINE KINASE; PROTEIN SUBUNIT; SERINE; THREONINE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BIOSYNTHESIS; BREAST CARCINOMA; CANCER CELL; CELL MEMBRANE; CELL SURVIVAL; CELL TYPE; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INACTIVATION; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROSTATE CARCINOMA; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; SIGNAL TRANSDUCTION; UBIQUITINATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADAMANTANE; APOPTOSIS; BREAST NEOPLASMS; CELL LINE, TUMOR; CINNAMATES; FEMALE; HUMANS; MALE; PHOSPHORYLATION; PROSTATIC NEOPLASMS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 1842586806     PISSN: 09509232     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.onc.1207311     Document Type: Article

References (70)

1. Agarwal R. (2000). Biochem. Pharmacol., 60, 1051-1059.
2. Alessi DR, Deak M, Casamayor A, Caudwell FB, Morice N, Norman DG, Gaffney P, Reese CB, MacDougall CN, Harbison D, Ashworth A and Bownes M. (1997a). Curr. Biol., 7, 776-789.
3. Alessi DR, James SR, Downes CP, Holmes AB, Gaffney PRJ, Reese CB and Cohen P. (1997b). Curr. Biol., 7, 261-269.
4. Andjelkovic M, Alessi DR, Meier R, Fernandez A, Lamb NJC, Frech M, Cron P, Cohen P, Lucocq JM and Hemmings BA. (1997). J. Biol. Chem., 272, 31515-31524.
5. Auger KR, Serunian LA and Cantley LC. (1990). Methods in Inositide Research, Irvine RP (ed). Raven Press: New York.
6. Balendran AAM, Casamayor A, Deak M, Paterson A, Gaffney P, Currie R, Donnes CP and Alessi DR. (1999). Curr. Biol., 9, 393-404.
7. Balmer LA, Beveridge DJ, Jazayeri JA, Thompson AM, Walker CE and Leedman PJ. (2001). Mol. Cell. Biol., 21, 2070-2084.
8. Brognard J, Clark AS, Ni Y and Dennis PA. (2001). Cancer Res., 61, 3986-3992.
9. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J and Greenberg ME. (1999). Cell, 96, 857-868.
10. Cardone MH, Roy N, Stennicke HR, Salvesen GS, Franke TF, Stanbridge E, Frisch S and Reed JC. (1998). Science, 282, 1318-1321.
11. Carpentier CL, Duckworth BC, Auger KR, Cohen B, Schaffhausen BS and Cantley LC. (1990). J. Biol. Chem., 265, 19704-19711.
12. Chan TO, Rittenhouse SE and Tsichlis PN. (1999). Annu. Rev. Biochem., 68, 965-1014.
13. Charpenter B, Barnardon JM, Eustache J, Millois C, Martin B, Michel S and Shroot B. (1995). J. Med. Chem., 38, 4993-5001.
14. Chen R-H, Su Y-H, Chuang RLC and Chang T-Y. (1998). Oncogene, 17, 1959-1968.
15. Crowder RJ and Freeman RS. (1998). J. Neurosci., 18, 2933-2943.
16. Datta SR, Brunet A and Greenberg ME. (1999). Genes Dev., 13, 2905-2927.
17. Datta SR, Dudek HX, Masters S, Fu H, Gotoh Y and Greenberg ME. (1997). Cell, 91, 231-241.
18. Davies MA, Koul D, Dhesi H, Berman R, McDonnel TJ, McConkey D, Yung WK and Steck PA. (1999). Cancer Res., 59, 2551-2556
19. Delcommenne M, Tan C, Gray V, Rue L and Dedhor S. (1998). Proc. Natl. Acad. Sci. USA, 95, 11211-11216.
20. Domain J and Waterfield MD. (1997). FEBS Lett., 410, 91-95.
21. Dudek H, Datta SR, Franke TF, Birnbaum MJ, Yao R, Cooper GM, Segal RS, Kaplen DR and Greenberg ME. (1997). Science, 275, 661-665.
22. Ettenberg SA, Rubinstein YR, Banergee P, Nau MM, Keane MM and Lipkowitz S. (1999). Mol. Cell Res. Commun., 2, 111-118.
23. Farhana L, Dawson M, Rishi AK, Zhang Y, Van Buren E, Trivedi C, Reichert U, Fang G, Kirschner M and Fontana JA. (2002). Cancer Res., 62, 3842-3849.
24. Gil-Diez de Medina S, Salomon L, Colombel M, Abbou CC, Bellot J, Thiery JP, Radvanyi F, Van der Kwast TH and Chopin DK. (1998). Hum. Pathol., 29, 1005-1112.
25. Ghosh AK, Grigorieva I, Steele R, Hoover RG and Ray RB. (1999). Gene, 23, 85-91.
26. Hannigan GE, Hagesteijn CL, Gibbon LF, Coppolino MG, Radeva G, Filmus J, Bell JC and Dedhar S. (1996). Nature, 397, 91-96.
27. Hausler P, Papoff G, Eramo A, Reif K, Cantrell DA and Ruberti G. (1998). Eur. J. Immunol., 28, 57-69.
28. Holmes WF, Dawson MI, Soprano RD and Soprano KJ. (2000). J. Cell Physiol., 183, 61-67.
29. Hsu AL, Ching TT, Wang DS, Song X, Rangnekar VM and Chen CS. (2000). J. Biol. Chem., 275, 11397-11403.
30. Imukai K, Funaki M, Anai M, Ogihara T, Katagiri H, Fukushima Y, Sakoda H, Onishi Y, Fujishiro M, Abe M, Oka Y, Kikuchi M and Asano T. (2001). FEBS Lett., 490, 32-38.
31. Joly M, Kazlaukaus A, Fay FS and Corvera S. (1994). Science, 263, 684-687.
32. Kapeller R, Prasad KVS, Janssen O, Hou W, Schaffhausen BS, Rudd CE and Cantley LC. (1994). J. Biol. Chem., 269, 1927-1933.
33. Kennedy SG, Wagner AJ, Conzen SD, Jordan J, Bellacosa A, Tsichlis PN and Hay N. (1997). Genes Dev., 11, 701-713.
34. Khwaja A. (1999). Nature, 401, 33-34.
35. Kohn AD, Summers SA, Birnbaum MJ and Roth RA. (1996). J. Biol. Chem., 271, 31372-31378.
36. Kulik G, Kleppel A and Weber MJ. (1997). Mol. Cell. Biol., 17, 1595-1606.
37. Lazebnik Y. (2000). Science, 287, 1363a.
38. Levkowitz G, Waterman H, Ettenberg SA, Katz M, Tsygankov AY, Alroy I, Lavi S, Iwal K, Reiss Y, Clechanover A and Yarden Y. (1999). Mol. Cell, 4, 1029-1040.
39. Levy-Toledano R, Taouis M, Blaettler DH, Gorden P and Taylor SI. (1994). J. Biol. Chem., 269, 31178-31182.
40. Li XS, Rishi AK, Shao Z-M, Dawson MI, Jong L, Shroot B, Reichert U, Ordenez J and Fontana JA. (1996). Cancer Res., 56, 5055-5062.
41. Liang J-Y, Fontana JA, Rao JN, Ordonez JV, Dawson MI, Shroot B, Wilber JF and Feng P. (1999). Prostate, 38, 228-236.
42. Lin J, Adam RM, Santiestevan E and Freeman MR. (1999). Cancer Res., 59, 2891-2897.
43. Pacold ME, Suire S, Perisic O, Lara-Gonzalez S, Davis CT, Walker EH, Hawkins PT, Stephens L, Eccleston JF and Williams RL. (2000). Cell, 103, 931-943.
44. Persad S, Attwell S, Gray V, Delcommenne M, Troussard A, Sanghera J and Dedhar S. (2000). Proc. Natl. Acad Sci. USA, 97, 3207-3212.
45. Philpott KL, McCarthy MJ, Klippel A and Rubin LL. (1997). J. Cell. Biol., 139, 809-815.
46. Ponzanelli I, Gianni M, Giavazzi R, Garofalo A, Nicoletti I, Reichert U, Erba E, Rambaldi A, Terao M and Garattini E. (2000). Blood, 95, 2672-2682.
47. Rameh LE, Chen C-S and Cantley LC. (1995). Cell, 83, 821-830.
48. Rebello A and Ayllon V. (2000). Mol. Membrane Biol., 17, 65-73.
49. Rodriquez-Viciana P, Wayne PH, Khwaja A, Marte BM, Pappin D, Das P, Waterfield MD, Ridley A and Downward J. (1997). Cell, 89, 457-467.
50. Romashkova JA and Makarov SS. (1999). Nature, 401, 86-88.
51. Rong R, He Q, Liu Y, Sheikh MS and Huang Y. (2002). Oncogene, 21, 1062-1070.
52. Rubio I, Wittig U, Meyer C, Heinze R, Kadereit D, Waldman H, Downward J and Wetzke R. (1999). Eur. J. Biochem., 266, 70-82.
53. Schwartz S, Caceres C, Morote J, De Torres I, Rodriquez JM, Gonzalez J and Reventos J. (1999). Int. J. Oncol., 14, 367-371.
54. Shao Z-M, Dawson MI, Li X-S, Rishi AK, Sheikh MS, Han Q-X, Ordonez JV, Shroot B and Fontana JA. (1995). Oncogene, 11, 493-505.
55. Sjolander A, Yamamoto K, Huber BE and Lapetina EG. (1991). Proc. Natl. Acad. Sci. USA, 88, 7908-7912.
56. Soler C, Berquinot L and Carpenter G. (1994). J. Biol. Chem., 269, 12320-12324.
57. Sook E, Wong M, Fong CW, Lim J, Yusoff P, Low BC, Langdon WY and Guy GR. (2002). EMBO J., 21, 4796-4808.
58. Sun SY, Yue P, Chandraratna RA, Tesfaigzi Y, Hong WK and Lotan R. (2000b). Mol. Pharmacol., 58, 508-514.
59. Sun SY, Yue P and Lotan R. (2000a). Oncogene, 19, 4513-4522.
60. Tang D, Okada H, Ruland J, Liu L, Stambolic V, Mak TW and Ingram AJ. (2001). J. Biol. Chem., 276, 30461-30466.
61. Tiganis T, Kemp BE and Tonks NK. (1999). J. Biol. Chem., 274, 27768-27775.
62. Toker A. (2000). Mol. Pharmacol., 57, 652-658.
63. Wan X, Nass P, Duncan MD and Harmon JW. (2001). J. Mol. Med., 79, 143-148.
64. Yamamoto K, Lapetina EG and Moxham CP. (1992). Endocrinology, 130, 1490-1498.
65. Yang E, Zha J, Boise LH, Thompson CB and Korsmeyer SJ. (1995). Cell, 80, 285-291.
66. Yokouch M, Kondo T, Houghton A, Bartkiewicz M, Horne WC, Zhang H, Yoshimura A and Baron RL. (1999). J. Biol. Chem., 274, 31707-31712.
67. Zha J, Harada H, Yang E and Korsmeyer S. (1996). Cell, 87, 619-628.
68. Zhang Y, Dawson MI, Mohammad R, Rishi AK, Farhana L, Feng K-C, Leid M, Peterson V, Zhang X-k, Edelstein M, Eilander D, Biggar S, Wall N, Reichert U and Fontana JA. (2002). Blood, 100, 2911-2918.
69. Zheng N, Wang P, Jeffrey PD and Pavletich NP. (2000). Cell, 102, 533-539.
70. Zheng Y, Bagrodia S and Cerione RA. (1994). J. Biol. Chem., 269, 18727-18730.