-
4
-
-
0030274647
-
Genomic sciences and the medicine of tomorrow
-
Drews J. Genomic sciences and the medicine of tomorrow. Nat Biotechnol. 1996;14:1516-1518.
-
(1996)
Nat Biotechnol
, vol.14
, pp. 1516-1518
-
-
Drews, J.1
-
7
-
-
1842616433
-
The Genome Project and the pharmaceutical industry
-
Mansfield BK. The Genome Project and the pharmaceutical industry. Hum Genome News. 1990:10-11.
-
(1990)
Hum Genome News
, pp. 10-11
-
-
Mansfield, B.K.1
-
9
-
-
0033759620
-
Drug-metabolizing enzymes, polymorphisms and interindividual response to environmental toxicants
-
Nebert DW. Drug-metabolizing enzymes, polymorphisms and interindividual response to environmental toxicants. Clin Chem Lab Med. 2000;38:857-861.
-
(2000)
Clin Chem Lab Med
, vol.38
, pp. 857-861
-
-
Nebert, D.W.1
-
10
-
-
0030078281
-
Is there a paradigm shift in genetics? Lessons from the study of human diseases
-
Weiss KM. Is there a paradigm shift in genetics? Lessons from the study of human diseases. Mol Phylogenet Evol. 1996;5:259-265.
-
(1996)
Mol Phylogenet Evol
, vol.5
, pp. 259-265
-
-
Weiss, K.M.1
-
11
-
-
0031019954
-
Developing prescriptions with a personal touch
-
Cohen J. Developing prescriptions with a personal touch. Science. 1997;275:776.
-
(1997)
Science
, vol.275
, pp. 776
-
-
Cohen, J.1
-
12
-
-
0030770412
-
Laying the foundations for personalized medicines
-
Marshall A. Laying the foundations for personalized medicines. Nat Biotechnol. 1997;15:954-957.
-
(1997)
Nat Biotechnol
, vol.15
, pp. 954-957
-
-
Marshall, A.1
-
13
-
-
0030690262
-
Getting the right drug into the right patient
-
Marshall A. Getting the right drug into the right patient. Nat Biotechnol. 1997;15:1249-1252.
-
(1997)
Nat Biotechnol
, vol.15
, pp. 1249-1252
-
-
Marshall, A.1
-
14
-
-
0034660560
-
Pharmacogenetics and the practice of medicine
-
Roses AD. Pharmacogenetics and the practice of medicine. Nature. 2000;405:857-865.
-
(2000)
Nature
, vol.405
, pp. 857-865
-
-
Roses, A.D.1
-
15
-
-
0028907339
-
Positional cloning moves from perditional to traditional
-
Collins FS. Positional cloning moves from perditional to traditional. Nat Genet. 1995;9:347-350.
-
(1995)
Nat Genet
, vol.9
, pp. 347-350
-
-
Collins, F.S.1
-
16
-
-
0035895505
-
The sequence of the human genome
-
Venter JC, Adams MD, Myers EW, et al. The sequence of the human genome. Science. 2001;291:1304-1351.
-
(2001)
Science
, vol.291
, pp. 1304-1351
-
-
Venter, J.C.1
Adams, M.D.2
Myers, E.W.3
-
17
-
-
2042437650
-
Initial sequencing and analysis of the human genome
-
Lander ES, Linton LM, Birren B, et al. Initial sequencing and analysis of the human genome. Nature. 2001;409:860-921.
-
(2001)
Nature
, vol.409
, pp. 860-921
-
-
Lander, E.S.1
Linton, L.M.2
Birren, B.3
-
18
-
-
0030688004
-
Variations on a theme: Cataloging human DNA sequence variation
-
Collins FS, Guyer MS, Charkravarti A. Variations on a theme: cataloging human DNA sequence variation. Science. 1997;278:1580-1581.
-
(1997)
Science
, vol.278
, pp. 1580-1581
-
-
Collins, F.S.1
Guyer, M.S.2
Charkravarti, A.3
-
19
-
-
0035865322
-
A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms
-
Sachidanandam R, Weissman D, Schmidt SC, et al. A map of human genome sequence variation containing 1.42 million single nucleotide polymorphisms. Nature. 2001;409:928-933.
-
(2001)
Nature
, vol.409
, pp. 928-933
-
-
Sachidanandam, R.1
Weissman, D.2
Schmidt, S.C.3
-
20
-
-
0034791035
-
High-resolution haplotype structure in the human genome
-
Daly MJ, Rioux JD, Schaffner SF, Hudson TJ, Lander ES. High-resolution haplotype structure in the human genome. Nat Genet. 2001;29:229-232.
-
(2001)
Nat Genet
, vol.29
, pp. 229-232
-
-
Daly, M.J.1
Rioux, J.D.2
Schaffner, S.F.3
Hudson, T.J.4
Lander, E.S.5
-
21
-
-
18444369013
-
The structure of haplotype blocks in the human genome
-
Gabriel SB, Schaffner SF, Nguyen H, et al. The structure of haplotype blocks in the human genome. Science. 2002;296:2225-2229.
-
(2002)
Science
, vol.296
, pp. 2225-2229
-
-
Gabriel, S.B.1
Schaffner, S.F.2
Nguyen, H.3
-
22
-
-
0035941029
-
Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21
-
Patil N, Berno AJ, Hinds DA, et al. Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science. 2001;294:1719-1723.
-
(2001)
Science
, vol.294
, pp. 1719-1723
-
-
Patil, N.1
Berno, A.J.2
Hinds, D.A.3
-
23
-
-
0035837267
-
Linkage disequilibrium in the human genome
-
Reich DE, Cargill M, Bolk S, et al. Linkage disequilibrium in the human genome. Nature. 2001;411:199-204.
-
(2001)
Nature
, vol.411
, pp. 199-204
-
-
Reich, D.E.1
Cargill, M.2
Bolk, S.3
-
24
-
-
0034641736
-
2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness
-
2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci U S A. 2000;97:10483-10488.
-
(2000)
Proc Natl Acad Sci U S A
, vol.97
, pp. 10483-10488
-
-
Drysdale, C.M.1
McGraw, D.W.2
Stack, C.B.3
-
25
-
-
0033799573
-
Apolipoprotein E variation at the sequence haplotype level: Implications for the origin and maintenance of a major human polymorphism
-
Fullerton SM, Clark AG, Weiss KM, et al. Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphism. Am J Hum Genet. 2000;67:881-900.
-
(2000)
Am J Hum Genet
, vol.67
, pp. 881-900
-
-
Fullerton, S.M.1
Clark, A.G.2
Weiss, K.M.3
-
26
-
-
0037154208
-
Evidence for positive selection and population structure at the human MAO-A gene
-
Gilad Y, Rosenberg S, Przeworski M, Lancet D, Skorecki K. Evidence for positive selection and population structure at the human MAO-A gene. Proc Natl Acad Sci U S A. 2002;99:862-867.
-
(2002)
Proc Natl Acad Sci U S A
, vol.99
, pp. 862-867
-
-
Gilad, Y.1
Rosenberg, S.2
Przeworski, M.3
Lancet, D.4
Skorecki, K.5
-
27
-
-
0030949513
-
Archaic African and Asian lineages in the genetic ancestry of modern humans
-
Harding RM, Fullerton SM, Griffiths RC, et al. Archaic African and Asian lineages in the genetic ancestry of modern humans. Am J Hum Genet. 1997;60:772-789.
-
(1997)
Am J Hum Genet
, vol.60
, pp. 772-789
-
-
Harding, R.M.1
Fullerton, S.M.2
Griffiths, R.C.3
-
28
-
-
0033057484
-
X chromosome evidence for ancient human histories
-
Harris EE, Hey J. X chromosome evidence for ancient human histories. Proc Natl Acad Sci U S A. 1999;96:3320-3324.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 3320-3324
-
-
Harris, E.E.1
Hey, J.2
-
29
-
-
0034703870
-
Sequence variability and candidate gene analysis in complex disease: Association of μ opioid receptor gene variation with substance dependence
-
Hoehe MR, Kopke K, Wendel B, et al. Sequence variability and candidate gene analysis in complex disease: association of μ opioid receptor gene variation with substance dependence. Hum Mol Genet. 2000;9:2895-2908.
-
(2000)
Hum Mol Genet
, vol.9
, pp. 2895-2908
-
-
Hoehe, M.R.1
Kopke, K.2
Wendel, B.3
-
30
-
-
0033787023
-
Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene
-
Nickerson DA, Taylor SL, Fullerton SM, et al. Sequence diversity and large-scale typing of SNPs in the human apolipoprotein E gene. Genome Res. 2000;10:1532-1545.
-
(2000)
Genome Res
, vol.10
, pp. 1532-1545
-
-
Nickerson, D.A.1
Taylor, S.L.2
Fullerton, S.M.3
-
31
-
-
17344364213
-
DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene
-
Nickerson DA, Taylor SL, Weiss KM, et al. DNA sequence diversity in a 9.7-kb region of the human lipoprotein lipase gene. Nat Genet. 1998;19:233-240.
-
(1998)
Nat Genet
, vol.19
, pp. 233-240
-
-
Nickerson, D.A.1
Taylor, S.L.2
Weiss, K.M.3
-
33
-
-
0035919656
-
Haplotype variation and linkage disequilibrium in 313 human genes
-
Stephens JC, Schneider JA, Tanguay DA, et al. Haplotype variation and linkage disequilibrium in 313 human genes. Science. 2001;293:489-493.
-
(2001)
Science
, vol.293
, pp. 489-493
-
-
Stephens, J.C.1
Schneider, J.A.2
Tanguay, D.A.3
-
34
-
-
0036671928
-
Sequence variation and haplotype structure at the human HFE locus
-
Toomajian C, Kreitman M. Sequence variation and haplotype structure at the human HFE locus. Genetics. 2002;161:1609-1623.
-
(2002)
Genetics
, vol.161
, pp. 1609-1623
-
-
Toomajian, C.1
Kreitman, M.2
-
35
-
-
0031834225
-
It's raining SNPs, hallelujah?
-
Chakravarti A. It's raining SNPs, hallelujah? Nat Genet. 1998;19:216-217.
-
(1998)
Nat Genet
, vol.19
, pp. 216-217
-
-
Chakravarti, A.1
-
36
-
-
0032990407
-
Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis
-
Halushka MK, Fan JB, Bentley K, et al. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nat Genet. 1999;22:239-247.
-
(1999)
Nat Genet
, vol.22
, pp. 239-247
-
-
Halushka, M.K.1
Fan, J.B.2
Bentley, K.3
-
37
-
-
0032991552
-
Characterization of single-nucleotide polymorphisms in coding regions of human genes
-
Cargill M, Altshuler D, Ireland J, et al. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nat Genet. 1999;22:231-238.
-
(1999)
Nat Genet
, vol.22
, pp. 231-238
-
-
Cargill, M.1
Altshuler, D.2
Ireland, J.3
-
38
-
-
0032231888
-
Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase
-
Clark AG, Weiss KM, Nickerson DA, et al. Haplotype structure and population genetic inferences from nucleotide-sequence variation in human lipoprotein lipase. Am J Hum Genet. 1998;63:595-612.
-
(1998)
Am J Hum Genet
, vol.63
, pp. 595-612
-
-
Clark, A.G.1
Weiss, K.M.2
Nickerson, D.A.3
-
39
-
-
0141739796
-
Haplotypes and the systematic analysis of genetic variation in genes and genomes
-
Hoehe MR. Haplotypes and the systematic analysis of genetic variation in genes and genomes. Pharmacogenomics. 2003;4:547-570.
-
(2003)
Pharmacogenomics
, vol.4
, pp. 547-570
-
-
Hoehe, M.R.1
-
40
-
-
1842563106
-
Differing response to antipsychotic therapy in schizophrenia: Pharmacogenomic aspects
-
Ackenheil M, Weber K. Differing response to antipsychotic therapy in schizophrenia: pharmacogenomic aspects. Dialogues Clin Neurosci. 2004;6:71-77.
-
(2004)
Dialogues Clin Neurosci
, vol.6
, pp. 71-77
-
-
Ackenheil, M.1
Weber, K.2
-
42
-
-
0034727107
-
An SNP map of the human genome generated by reduced representation shotgun sequencing
-
Altshuler D, Pollara VJ, Cowles CR, et al. An SNP map of the human genome generated by reduced representation shotgun sequencing. Nature. 2000;407:513-516.
-
(2000)
Nature
, vol.407
, pp. 513-516
-
-
Altshuler, D.1
Pollara, V.J.2
Cowles, C.R.3
-
43
-
-
17344380534
-
An SNP map of human chromosome 22
-
Mullikin JC, Hunt SE, Cole CG, et al. An SNP map of human chromosome 22. Nature. 2000;407:516-520.
-
(2000)
Nature
, vol.407
, pp. 516-520
-
-
Mullikin, J.C.1
Hunt, S.E.2
Cole, C.G.3
-
44
-
-
0032524383
-
Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome
-
Wang DG, Fan JB, Siao CJ, et al. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science. 1998;280:1077-1082.
-
(1998)
Science
, vol.280
, pp. 1077-1082
-
-
Wang, D.G.1
Fan, J.B.2
Siao, C.J.3
-
45
-
-
0032706623
-
A general approach to single-nucleotide polymorphism discovery
-
Marth GT, Korf I, Yandell MD, et al. A general approach to single-nucleotide polymorphism discovery. Nat Genet. 1999;23:452-456.
-
(1999)
Nat Genet
, vol.23
, pp. 452-456
-
-
Marth, G.T.1
Korf, I.2
Yandell, M.D.3
-
46
-
-
0034789532
-
Haplotype tagging for the identification of common disease genes
-
Johnson GC, Esposito L, Barratt BJ, et al. Haplotype tagging for the identification of common disease genes. Nat Genet. 2001;29:233-237.
-
(2001)
Nat Genet
, vol.29
, pp. 233-237
-
-
Johnson, G.C.1
Esposito, L.2
Barratt, B.J.3
-
49
-
-
0029937381
-
DRD2 haplotypes containing the Taql A1 allele: Implications for alcoholism research
-
Kidd KK, Pakstis AJ, Castiglione CM, et al. DRD2 haplotypes containing the Taql A1 allele: implications for alcoholism research. Alcohol Clin Exp Res. 1996;20:697-705.
-
(1996)
Alcohol Clin Exp Res
, vol.20
, pp. 697-705
-
-
Kidd, K.K.1
Pakstis, A.J.2
Castiglione, C.M.3
-
50
-
-
0033940849
-
Recombinational and mutational hotspots within the human lipoprotein lipase gene
-
Templeton AR, Clark AG, Weiss KM, Nickerson DA, Boerwinkle E, Sing CF. Recombinational and mutational hotspots within the human lipoprotein lipase gene. Am J Hum Genet. 2000;66:69-83.
-
(2000)
Am J Hum Genet
, vol.66
, pp. 69-83
-
-
Templeton, A.R.1
Clark, A.G.2
Weiss, K.M.3
Nickerson, D.A.4
Boerwinkle, E.5
Sing, C.F.6
-
51
-
-
84984760488
-
Research suggests importance of haplotypes over SNPs
-
Davidson S. Research suggests importance of haplotypes over SNPs. Nat Biotechnol. 2000;18:1134-1135.
-
(2000)
Nat Biotechnol
, vol.18
, pp. 1134-1135
-
-
Davidson, S.1
-
52
-
-
0035136746
-
Promoter haplotype combinations of the platelet-derived growth factor alpha-receptor gene predispose to human neural tube defects
-
Joosten PH, Toepoel M, Mariman EC, Van Zoelen EJ. Promoter haplotype combinations of the platelet-derived growth factor alpha-receptor gene predispose to human neural tube defects. Nat Genet. 2001;27:215-217.
-
(2001)
Nat Genet
, vol.27
, pp. 215-217
-
-
Joosten, P.H.1
Toepoel, M.2
Mariman, E.C.3
Van Zoelen, E.J.4
-
54
-
-
0035282836
-
Determination of cytokine regulatory haplotypes by induced heteroduplex analysis of DNA
-
Wood NA, Keen LJ, Tilley LA, Bidwell JL. Determination of cytokine regulatory haplotypes by induced heteroduplex analysis of DNA. J Immunol Methods. 2001;249:191-198.
-
(2001)
J Immunol Methods
, vol.249
, pp. 191-198
-
-
Wood, N.A.1
Keen, L.J.2
Tilley, L.A.3
Bidwell, J.L.4
-
55
-
-
0345978368
-
Haplotypes and the systematic analysis of genetic variation: Disease genes, drug targets and pharmacogenomics
-
Hoehe MR, Timmermann B, Lehrach H. Haplotypes and the systematic analysis of genetic variation: disease genes, drug targets and pharmacogenomics [in German]. Biospektrum. 2002;8:478-485.
-
(2002)
Biospektrum
, vol.8
, pp. 478-485
-
-
Hoehe, M.R.1
Timmermann, B.2
Lehrach, H.3
-
56
-
-
7144261714
-
Beta adrenoceptor genetic variation is associated with genetic predisposition to essential hypertension: The Bergen Blood Pressure Study
-
Timmermann B, Mo R, Luft FC, et al. Beta adrenoceptor genetic variation is associated with genetic predisposition to essential hypertension: The Bergen Blood Pressure Study. Kidney Int. 1998;53:1455-1460.
-
(1998)
Kidney Int
, vol.53
, pp. 1455-1460
-
-
Timmermann, B.1
Mo, R.2
Luft, F.C.3
-
57
-
-
0028068550
-
2-adrenergic receptor impart distinct agonist-promoted regulatory properties
-
2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry. 1994;33:9414-9419.
-
(1994)
Biochemistry
, vol.33
, pp. 9414-9419
-
-
Green, S.A.1
Turki, J.2
Innis, M.3
Liggett, S.B.4
-
58
-
-
0027519404
-
2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor
-
2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. J Biol Chem. 1993;268:23116-23121.
-
(1993)
J Biol Chem
, vol.268
, pp. 23116-23121
-
-
Green, S.A.1
Cole, G.2
Jacinto, M.3
Innis, M.4
Liggett, S.B.5
-
59
-
-
0028145741
-
2 adrenergic receptor mRNA inhibits receptor synthesis
-
2 adrenergic receptor mRNA inhibits receptor synthesis. J Biol Chem. 1994;269:4497-4505.
-
(1994)
J Biol Chem
, vol.269
, pp. 4497-4505
-
-
Parola, A.L.1
Kobilka, B.K.2
-
62
-
-
0034458325
-
Comparative sequencing of the human CB1 cannabinoid receptor gene coding exon: No structural mutations in individuals exhibiting extreme responses to cannabis
-
Hoehe MR, Rinn T, Flachmeier C, et al. Comparative sequencing of the human CB1 cannabinoid receptor gene coding exon: no structural mutations in individuals exhibiting extreme responses to cannabis. Psychiatr Genet. 2000;10:173-177.
-
(2000)
Psychiatr Genet
, vol.10
, pp. 173-177
-
-
Hoehe, M.R.1
Rinn, T.2
Flachmeier, C.3
-
63
-
-
0034785352
-
Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease
-
Rioux JD, Daly MJ, Silverberg MS, et al. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nat Genet. 2001;29:223-228.
-
(2001)
Nat Genet
, vol.29
, pp. 223-228
-
-
Rioux, J.D.1
Daly, M.J.2
Silverberg, M.S.3
-
64
-
-
0032918729
-
High polymorphism at the human melanocortin 1 receptor locus
-
Rana BK, Hewett-Emmett D, Jin L, et al. High polymorphism at the human melanocortin 1 receptor locus. Genetics. 1999;151:1547-1557.
-
(1999)
Genetics
, vol.151
, pp. 1547-1557
-
-
Rana, B.K.1
Hewett-Emmett, D.2
Jin, L.3
-
65
-
-
0035978651
-
Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease
-
Hugot JP, Chamaillard M, Zouali H, et al. Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. Nature. 2001;411:599-603.
-
(2001)
Nature
, vol.411
, pp. 599-603
-
-
Hugot, J.P.1
Chamaillard, M.2
Zouali, H.3
-
66
-
-
0036201577
-
CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease
-
Lesage S, Zouali H, Cezard JP, et al. CARD15/NOD2 mutational analysis and genotype-phenotype correlation in 612 patients with inflammatory bowel disease. Am J Hum Genet. 2002;70:845-857.
-
(2002)
Am J Hum Genet
, vol.70
, pp. 845-857
-
-
Lesage, S.1
Zouali, H.2
Cezard, J.P.3
-
67
-
-
0035978533
-
A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease
-
Ogura Y, Bonen DK, Inohara N, et al. A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. Nature. 2001;411:603-606.
-
(2001)
Nature
, vol.411
, pp. 603-606
-
-
Ogura, Y.1
Bonen, D.K.2
Inohara, N.3
-
68
-
-
0037456733
-
Binge eating as a major phenotype of melanocortin 4 receptor gene mutations
-
Branson R, Potoczna N, Kral JG, Lentes KU, Hoehe MR, Horber FF. Binge eating as a major phenotype of melanocortin 4 receptor gene mutations. N Engl J Med. 2003;348:1096-1103.
-
(2003)
N Engl J Med
, vol.348
, pp. 1096-1103
-
-
Branson, R.1
Potoczna, N.2
Kral, J.G.3
Lentes, K.U.4
Hoehe, M.R.5
Horber, F.F.6
-
69
-
-
0033772073
-
Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
-
Horikawa Y, Oda N, Cox NJ, et al. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat Genet. 2000;26:163-175.
-
(2000)
Nat Genet
, vol.26
, pp. 163-175
-
-
Horikawa, Y.1
Oda, N.2
Cox, N.J.3
-
70
-
-
0141487861
-
Haplotypes, in depth variation analysis, and the future of the analysis of genotype-phenotype relationships
-
Cold Spring Harbor, NY, February 26-March 2
-
Hoehe MR, Timmermann B, Reinhardt R, Ott J, Lehrach H, Church GM. Haplotypes, in depth variation analysis, and the future of the analysis of genotype-phenotype relationships. Cold Spring Harbor Meeting. The Biology of DNA. Cold Spring Harbor, NY, February 26-March 2;2003:45.
-
(2003)
Cold Spring Harbor Meeting. The Biology of DNA
, pp. 45
-
-
Hoehe, M.R.1
Timmermann, B.2
Reinhardt, R.3
Ott, J.4
Lehrach, H.5
Church, G.M.6
-
71
-
-
0026053092
-
Low nucleotide diversity in man
-
Li WH, Sadler LA. Low nucleotide diversity in man. Genetics. 1991;129:513-523.
-
(1991)
Genetics
, vol.129
, pp. 513-523
-
-
Li, W.H.1
Sadler, L.A.2
-
72
-
-
0034255419
-
SNP frequencies in human genes an excess of rare alleles and differing modes of selection
-
Sunyaev SR, Lathe WC III, Ramensky VE, Bork P. SNP frequencies in human genes an excess of rare alleles and differing modes of selection. Trends Genet. 2000;16:335-337.
-
(2000)
Trends Genet
, vol.16
, pp. 335-337
-
-
Sunyaev, S.R.1
Lathe III, W.C.2
Ramensky, V.E.3
Bork, P.4
-
73
-
-
0016197604
-
Amino acid difference formula to help explain protein evolution
-
Grantham R. Amino acid difference formula to help explain protein evolution. Science. 1974;185:862-864.
-
(1974)
Science
, vol.185
, pp. 862-864
-
-
Grantham, R.1
-
74
-
-
0015363126
-
Average heterozygosity per locus in man: An estimate based on the incidence of enzyme polymorphisms
-
Harris H, Hopkinson DA. Average heterozygosity per locus in man: an estimate based on the incidence of enzyme polymorphisms. Ann Hum Genet. 1972;36:9-20.
-
(1972)
Ann Hum Genet
, vol.36
, pp. 9-20
-
-
Harris, H.1
Hopkinson, D.A.2
-
75
-
-
0033611501
-
High genomic deleterious mutation rates in hominids
-
Eyre-Walker A, Keightley PD. High genomic deleterious mutation rates in hominids. Nature. 1999;397:344-347.
-
(1999)
Nature
, vol.397
, pp. 344-347
-
-
Eyre-Walker, A.1
Keightley, P.D.2
-
76
-
-
0003421005
-
-
Sunderland, Mass: Sinauer Associates
-
Li WH. Molecular Evolution. Sunderland, Mass: Sinauer Associates; 1997
-
(1997)
Molecular Evolution
-
-
Li, W.H.1
-
78
-
-
0036664926
-
Sequence polymorphism at the human apolipoprotein All gene (APOA2): Unexpected deficit of variation in an African-American sample
-
Fullerton SM, Clark AG, Weiss KM, et al. Sequence polymorphism at the human apolipoprotein All gene (APOA2): unexpected deficit of variation in an African-American sample. Hum Genet. 2002;111:75-87.
-
(2002)
Hum Genet
, vol.111
, pp. 75-87
-
-
Fullerton, S.M.1
Clark, A.G.2
Weiss, K.M.3
-
79
-
-
0035873844
-
Human populations show reduced DNA sequence variation at the factor IX locus
-
Harris EE, Hey J. Human populations show reduced DNA sequence variation at the factor IX locus. Curr Biol. 2001;11:774-778.
-
(2001)
Curr Biol
, vol.11
, pp. 774-778
-
-
Harris, E.E.1
Hey, J.2
-
80
-
-
0347526061
-
Human inter-individual DNA sequence variation in candidate genes, drug targets, the importance of haplotypes and implications for pharmacogenomics
-
Hoehe MR, Timmermann B, Lehrach H. Human inter-individual DNA sequence variation in candidate genes, drug targets, the importance of haplotypes and implications for pharmacogenomics. Curr Pharm Biotechnol. 2003;4:351-378.
-
(2003)
Curr Pharm Biotechnol
, vol.4
, pp. 351-378
-
-
Hoehe, M.R.1
Timmermann, B.2
Lehrach, H.3
-
81
-
-
0033624744
-
1-adrenoceptor gene variations: A role in idiopathic dilated cardiomyopathy?
-
1-adrenoceptor gene variations: a role in idiopathic dilated cardiomyopathy? J Mol Med. 2000;78:87-93.
-
(2000)
J Mol Med
, vol.78
, pp. 87-93
-
-
Podlowski, S.1
Wenzel, K.2
Luther, H.P.3
-
82
-
-
0035793631
-
A single nucleotide polymorphic mutation in the human μ-opioid receptor severely impairs receptor signaling
-
Befort K, Filliol D, Decaillot FM, Gaveriaux-Ruff C, Hoehe MR, Kieffer BL. A single nucleotide polymorphic mutation in the human μ-opioid receptor severely impairs receptor signaling. J Biol Chem. 2001;276:3130-3137.
-
(2001)
J Biol Chem
, vol.276
, pp. 3130-3137
-
-
Befort, K.1
Filliol, D.2
Decaillot, F.M.3
Gaveriaux-Ruff, C.4
Hoehe, M.R.5
Kieffer, B.L.6
-
83
-
-
13144261678
-
Single-nucleotide polymorphism in the human μ-opioid receptor gene alters β-endorphin binding and activity: Possible implications for opiate addiction
-
Bond C, LaForge KS, Tian M, et al. Single-nucleotide polymorphism in the human μ-opioid receptor gene alters β-endorphin binding and activity: possible implications for opiate addiction. Proc Natl Acad Sci U S A. 1998;95:9608-9613.
-
(1998)
Proc Natl Acad Sci U S A
, vol.95
, pp. 9608-9613
-
-
Bond, C.1
LaForge, K.S.2
Tian, M.3
-
84
-
-
0035188058
-
Population genetic structure of variable drug response
-
Wilson JF, Weale ME, Smith AC, et al. Population genetic structure of variable drug response. Nat Genet. 2001;29:265-269.
-
(2001)
Nat Genet
, vol.29
, pp. 265-269
-
-
Wilson, J.F.1
Weale, M.E.2
Smith, A.C.3
-
85
-
-
0028827598
-
What's in a gene: Using genetic information for the design of clinical trials
-
Lichter J, McNamara D. What's in a gene: using genetic information for the design of clinical trials. Curr Opin Biotechnol. 1995;6:715-717.
-
(1995)
Curr Opin Biotechnol
, vol.6
, pp. 715-717
-
-
Lichter, J.1
McNamara, D.2
-
86
-
-
0034638766
-
Pharmacogenetics and adverse drug reactions
-
Meyer UA. Pharmacogenetics and adverse drug reactions. Lancet. 2000;356:1667-1671.
-
(2000)
Lancet
, vol.356
, pp. 1667-1671
-
-
Meyer, U.A.1
-
87
-
-
0031907535
-
Pharmacogenomics: A new approach to individual therapy of hypertension?
-
Ferrari P. Pharmacogenomics: a new approach to individual therapy of hypertension? Curr Opin Nephrol Hypertens. 1998;7:217-222.
-
(1998)
Curr Opin Nephrol Hypertens
, vol.7
, pp. 217-222
-
-
Ferrari, P.1
-
88
-
-
0035756143
-
Pharmacogenetics and the future of medical practice: Conceptual considerations
-
Lindpaintner K. Pharmacogenetics and the future of medical practice: conceptual considerations. Pharmacogenomics J. 2001;1:23-26.
-
(2001)
Pharmacogenomics J
, vol.1
, pp. 23-26
-
-
Lindpaintner, K.1
-
89
-
-
0036848039
-
The importance of being modest-reflections on the pharmacogenetics of abacavir
-
Lindpaintner K. The importance of being modest-reflections on the pharmacogenetics of abacavir. Pharmacogenomics. 2002;3:835-838.
-
(2002)
Pharmacogenomics
, vol.3
, pp. 835-838
-
-
Lindpaintner, K.1
-
90
-
-
0032403973
-
Linkage disequilibrium mapping of complex disease: Fantasy or reality?
-
Terwilliger JD, Weiss KM. Linkage disequilibrium mapping of complex disease: fantasy or reality? Curr Opin Biotechnol. 1998;9:578-594.
-
(1998)
Curr Opin Biotechnol
, vol.9
, pp. 578-594
-
-
Terwilliger, J.D.1
Weiss, K.M.2
-
91
-
-
0029741063
-
The future of genetic studies of complex human diseases
-
Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science. 1996;273:1516-1517.
-
(1996)
Science
, vol.273
, pp. 1516-1517
-
-
Risch, N.1
Merikangas, K.2
-
92
-
-
0029805706
-
The new genomics: Global views of biology
-
Lander ES. The new genomics: global views of biology. Science. 1996;274:536-539.
-
(1996)
Science
, vol.274
, pp. 536-539
-
-
Lander, E.S.1
-
93
-
-
0037340445
-
Haplotype analysis in population genetics and association studies
-
Zhao H, Pfeiffer R, Gail MH. Haplotype analysis in population genetics and association studies. Pharmacogenomics. 2003;4:171-178.
-
(2003)
Pharmacogenomics
, vol.4
, pp. 171-178
-
-
Zhao, H.1
Pfeiffer, R.2
Gail, M.H.3
-
94
-
-
0035451780
-
On the allelic spectrum of human disease
-
Reich DE, Lander ES. On the allelic spectrum of human disease. Trends Genet. 2001;17:502-510.
-
(2001)
Trends Genet
, vol.17
, pp. 502-510
-
-
Reich, D.E.1
Lander, E.S.2
-
95
-
-
0034969437
-
Are rare variants responsible for susceptibility to complex diseases?
-
Pritchard JK. Are rare variants responsible for susceptibility to complex diseases? Am J Hum Genet. 2001;69:124-137.
-
(2001)
Am J Hum Genet
, vol.69
, pp. 124-137
-
-
Pritchard, J.K.1
-
96
-
-
0036799545
-
The allelic architecture of human disease genes: Common disease-common variant ... or not?
-
Pritchard JK, Cox NJ. The allelic architecture of human disease genes: common disease-common variant ... or not? Hum Mol Genet. 2002;11:2417-2423.
-
(2002)
Hum Mol Genet
, vol.11
, pp. 2417-2423
-
-
Pritchard, J.K.1
Cox, N.J.2
-
97
-
-
0033780104
-
How many diseases does it take to map a gene with SNPs?
-
Weiss KM, Terwilliger JD. How many diseases does it take to map a gene with SNPs? Nat Genet. 2000;26:151-157.
-
(2000)
Nat Genet
, vol.26
, pp. 151-157
-
-
Weiss, K.M.1
Terwilliger, J.D.2
-
98
-
-
0028090414
-
Genetic dissection of complex traits
-
Lander ES, Schork NJ. Genetic dissection of complex traits. Science. 1994;265:2037-2048.
-
(1994)
Science
, vol.265
, pp. 2037-2048
-
-
Lander, E.S.1
Schork, N.J.2
-
99
-
-
0031886030
-
The business of pharmacogenomics
-
Persidis A. The business of pharmacogenomics. Nat Biotechnol. 1998;16:209-210.
-
(1998)
Nat Biotechnol
, vol.16
, pp. 209-210
-
-
Persidis, A.1
|