Molecular and genetic basis of β2adrenergic receptor function

Journal of Allergy and Clinical Immunology

Volumn 104, Issue 2 SUPPL., 1999, Pages

  Liggett, Stephen B ^a,b  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b Pulmonary and Critical Care Medicine   (United States)

Author keywords

Adenylyl cyclase; Agonist; Allele; Desensitization; G protein; Isomers; Polymorphism

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN KINASE;

ARTICLE; DNA POLYMORPHISM; DRUG RECEPTOR BINDING; GENETIC VARIABILITY; HUMAN; NONHUMAN; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RECEPTOR DOWN REGULATION; STEREOCHEMISTRY;

EID: 0032888049     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/s0091-6749(99)70272-1     Document Type: Article

References (24)

1. Liggett SB. Molecular basis of G-protein coupled receptor signalling. In: Crystal R, West JB, Weibel ER, Barnes PJ, editors. The lung: scientific foundations. New York: Raven Press; 1997. p. 19-36.
2. Tota MR, Strader CD. Characterization of the binding domain of the β-adrenergic receptor with the fluorescent antagonist carazolol. J Biol Chem 1995;265:16891-7.
3. Strader CD, Sigal IS, Candelore MR, Rands E, Hill WS, Dixon RAF. Conserved aspartic acid residues 79 and 113 of the β-adrenergic receptor have different roles in receptor function. J Biol Chem 1988;263:10267-71.
4. Strader CD, Gaffney T, Sugg EE, Candelore MR, Keys R, Patchett AA, et al. Allele-specific activation of genetically engineered receptors. J Biol Chem 1995;266:5-8.
5. Strader CD, Candelore MR, Hill WS, Dixon RAF, Sigal IS. A single amino acid substitution in the β-adrenergic receptor promotes partial agonist activity from antagonists. J Biol Chem 1989;264:16470-7.
6. 2-adrenergic receptor. Proc Natl Acad Sci USA 1996;93:9276-81.
7. Liggett SB, Lefkowitz RJ. Adrenergic receptor-coupled adenylyl cyclase systems: regulation of receptor function by phosphorylation, sequestration and downregulation. In: Sibley D, Houslay M, editors. Regulation of cellular signal transduction pathways by desensitization and amplification. London: John Wiley & Sons; 1993. p. 71-97.
8. Green SA, Liggett SB. Molecular basis of G-protein coupled receptor signalling. In: Liggett SB, Meyers D, editors. The genetics of asthma. New York: Marcel Dekker, Inc, 1996. p. 67-90.
9. 2-adrenergic receptor function and regulation. In: Barnes P, Grunstein M, Leff A, Woolcock A, editors. Asthma. New York: Lippincott-Raven, Inc; 1996. p. 299-311.
10. Carman CV, Benovic JL. G-protein-coupled receptors: turn-ons and turn-offs. Curr Opin Cardiol 1998;8:335-44.
11. 2-adrenergic receptor. Cell Signal 1998;10:197-204.
12. 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor. J Biol Chem 1993;268:23116-21.
13. 2-adrenergic receptor in normal and asthmatic subjects. Am J Resp Cell Mol Biol 1993;8:334-9.
14. McGraw DW, Forbes SL, Kramer LA, Liggett SB. Polymorphisms of the 5' leader cistron of the human beta2-adrenergic receptor regulate receptor expression. J Clin Invest 1998;102:1927-32.
15. 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochem 1994;33:9414-9.
16. 2-adrenergic receptor: a protein with multiple membrane spanning domains and a chromosomal location shared with PDGF receptor gene. Proc Natl Acad Sci USA 1987;84:46-50.
17. 2-adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am J Resp Cell Mol Biol 1995;13:25-33.
18. 2 adrenoceptor with reported childhood asthma: population based study. Br Med J 1998;316:664.
19. Martinez FD, Graves PE, Baldini M, Solomon S, Erickson R. Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest 1997;100:3184-8.
20. Tan S, Hall IP, Dewar J, Dow E, Lipworth B. Association between beta 2-adrenoceptor polymorphism and susceptibility to bronchodilator desensitisation in moderately severe stable asthmatics. Lancet 1997;350:995-9.
21. 2 adrenergic receptor haplotypes in mild, moderate and fatal/near fatal asthma. Am J Respir Crit Care Med 1998;158:787-91.
22. 2-adrenoceptor polymorphism with lower airway reactivity in asthmatic subjects. Lancet 1995;345:1213-4.
23. 2 adrenoceptor polymorphism is associated with elevated immunoglobulin E levels in asthmatic families. J Allergy Clin Immunol 1997;100:261-5.
24. 2-adrenergic receptor in nocturnal and non-nocturnal asthma: evidence that Glylo correlates with the nocturnal phenotype. J Clin Invest 1995;95:1635-41.