Interleukin 7 receptor control of T cell receptor γ gene rearrangement: Role of receptor-associated chains and locus accessibility

Journal of Experimental Medicine

Volumn 188, Issue 12, 1998, Pages 2233-2241

  Durum, Scott K ^a   Candèias, Serge ^a   Nakajima, Hiroshi ^b   Leonard, Warren J ^b   Baird, Allison M ^c   Berg, Leslie J ^c   Muegge, Kathrin ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^c UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

T cells; Interleukin 7; T cell receptor; T cell receptor locus; Thymus; VDJ recombination

Indexed keywords

INTERLEUKIN 7 RECEPTOR; T LYMPHOCYTE RECEPTOR;

ANIMAL TISSUE; ARTICLE; DNA CLEAVAGE; GENE EXPRESSION REGULATION; GENE LOCUS; GENE MUTATION; GENE REARRANGEMENT; GENE TARGETING; GENETIC RECOMBINATION; IMMUNOREGULATION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; THYMOCYTE;

ANIMALS; BONE MARROW CELLS; CHROMATIN; DNA; DNA METHYLATION; ENHANCER ELEMENTS (GENETICS); ENZYME INHIBITORS; GENE REARRANGEMENT, GAMMA-CHAIN T-CELL ANTIGEN RECEPTOR; GENES, RAG-1; HEMATOPOIETIC STEM CELLS; HISTONE DEACETYLASES; HYDROXAMIC ACIDS; JANUS KINASE 3; MICE; MICE, INBRED C57BL; PROTEIN-TYROSINE KINASES; RECEPTORS, ANTIGEN, T-CELL, GAMMA-DELTA; RECEPTORS, INTERLEUKIN-7; RNA; T-LYMPHOCYTES; THYMUS GLAND; TRANSCRIPTION FACTORS;

EID: 0032441260     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.188.12.2233     Document Type: Article

References (14)

1. Peschon, J.J., P.J. Morrissey, K.H. Grabstein, F.J. Ramsdell, E. Maraskovsky, B.C. Gliniak, L.S. Park, S.F. Ziegler, D.E. Williams, C.B. Ware, et al. 1994. Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice J. Exp. Med. 180:1955-1960.
2. Peschon, J.J., B.C. Gliniak, P. Morrissey, and E. Maraskovsky. 1998. Lymphoid development and function in IL-7R deficient mice. In Cytokine Knockouts. S.K. Durum and K. Muegge, editors. Humana Press, Totowa, NJ. 37-52.
3. Maki, K., S. Sunaga, Y. Komagata, Y. Kodaira, A. Mabuchi, H. Karasuyama, K. Yokomuro, J. Miyazaki, and K. Ikuta. 1996. Interleukin 7 receptor-deficient mice lack 78 T cells. Proc. Natl. Acad. Sci. USA. 93:7172-7177.
4. + T cells, but not natural killer cells. J. Exp. Med. 184:289-293.
5. CandPias, S., K. Muegge, and S.K. Durum. 1997. IL-7 receptor and VDJ recombination: trophic versus mechanistic actions. Immunity. 6:501-508.
6. Kim, K., C.-K. Lee, T.J. Sayers, K. Muegge, and S.K. Durum. 1998. The trophic action of IL-7 on pro-T cells: inhibition of apoptosis of pro-T1, T2 and T3 cells correlates with Bcl-2 and Bax levels and is independent of Fas and p53 pathways. J Immunol. 160:5735-5741.
7. -/- mice. Cell. 89:1011-1019.
8. Akashi, K., M. Kondo, U. von Freeden-Jeffry, R. Murray, and I.L. Weissman. 1997. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell. 89:1033-1041.
9. Muegge, K., M.P. Vila, and S.K. Durum. 1993. Interleukin-7: a cofactor for V(D)J rearrangement of the T cell receptor β gene. Science. 261:93-95.
10. Crompton, T., S.V. Outram, J. Buckland, and M.J. Owen. 1997. A transgenic T cell receptor restores thymocyte differentiation in interleukin-7 receptor α chain-deficient mice. Eur. J. Immunol. 27:100-104.
11. Corcoran, A.E., F.M. Smart, R.J. Cowling, T. Crompton, M.J. Owen, and A.R. Venkitaraman. 1996. The interleukin-7 receptor a chain transmits distinct signals for proliferation and differentiation during B lymphopoiesis. EMBO (Eur. Mol. Biol. Organ.) J. 15:1924-1932.
12. Corcoran, A.E., A. Riddell, D. Krooshoop, and A.R. Venkitaraman. 1998. Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. Nature. 391:904-907.
13. Maki, K., S. Sunaga, and K. Ikuta. 1996. The V-J recombination of T cell receptor-γ genes is blocked in interleukin-7 receptor-deficient mice. J. Exp. Med. 184:2423-2427.
14. CandPias, S., J.J. Peschon, K. Muegge, and S.K. Durum. 1997. Defective T-cell receptor γ gene rearrangement in interleukin 7 receptor knockout mice. Immunol. Lett. 57:9-14.