Role of heparan sulfate in fibroblast growth factor signalling: A structural view

Current Opinion in Structural Biology

Volumn 11, Issue 5, 2001, Pages 629-634

  Pellegrini, Luca ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

FIBROBLAST GROWTH FACTOR; HEPARAN SULFATE; HEPARIN; PROTEIN TYROSINE KINASE; PROTEOHEPARAN SULFATE;

CRYSTAL STRUCTURE; DIMERIZATION; MOLECULAR INTERACTION; MOLECULAR MODEL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; REVIEW; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

EID: 0035443744     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(00)00258-X     Document Type: Review

References (35)

1. FGFs, heparan sulfate and FGFRs: Complex interactions essential for development
2. Three-dimensional structures of acidic and basic fibroblast growth factors
3. Heparin structure and interactions with basic fibroblast growth factor
4. Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization
5. Crystal structure of fibroblast growth factor receptor ectodomain bound to ligand and heparin
6. Structural basis for FGF receptor dimerization and activation
7. Importance of size, sulfation, and anticoagulant activity in the potentiation of acidic fibroblast growth factor by heparin
8. Heparin is required for cell-free binding of basic fibroblast growth factor to a soluble receptor and for mitogenesis in whole cells
9. Preparation of affinity-fractionated, heparin-derived oligosaccharides and their effects on selected biological activities mediated by basic fibroblast growth factor
10. Properly oriented heparin-decasaccharide-induced dimers are the biologically active form of basic fibroblast growth factor
11. Regulation of FGF-1 mitogenic activity by heparan sulfate oligosaccharides is dependent on specific structural features: Differential requirements for the modulation of FGF-1 and FGF-2
12. Selectively desulfated heparin inhibits fibroblast growth factor-induced mitogenicity and angiogenesis
13. Energetic characterization of the basic fibroblast growth factor-heparin interaction: Identification of the heparin binding domain
14. An essential heparin-binding domain in the fibroblast growth factor receptor kinase
15. Structure of a heparin-linked biologically active dimer of fibroblast growth factor
16. Effect of heparin on the binding affinity of acidic FGF for the cloned human FGF receptors, flg and bek
17. Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor
18. Multivalent ligand-receptor binding interactions in the fibroblast growth factor system produce a cooperative growth factor and heparin mechanism for receptor dimerization
19. Heparin increases the affinity of basic fibroblast growth factor for its receptor but is not required for binding
20. Identification and concerted function of two receptor binding surfaces on basic fibroblast growth factor required for mitogenesis
21. Structural interactions of fibroblast growth factor receptor with its ligands
22. Crystal structures of two FGF-FGFR complexes reveal the determinants of ligand-receptor specificity
23. Structural basis for fibroblast growth factor receptor 2 activation in Apert syndrome
24. Heparin-derived oligosaccharides: Affinity for acidic fibroblast growth factor and effect on its growth-promoting activity for human endothelial cells
25. Structural requirements in heparin for binding and activation of FGF-1 and FGF-4 are different from that for FGF-2
26. Heparan sulfate oligosaccharides require 6-O-sulfation for promotion of basic fibroblast growth factor mitogenic activity
27. Heparin-induced oligomerization of FGF molecules is responsible for FGF receptor dimerization, activation, and cell proliferation
28. Monomer complexes of basic fibroblast growth factor and heparan sulfate oligosaccharides are the minimal functional unit for cell activation
29. Activating and inhibitory heparan sequences for FGF-2 (basic FGF). Distinct requirements for FGF-1, FGF-2, and FGF-4
30. Distinct role of 2-O-, N-, and 6-O-sulfate groups of heparin in the formation of the ternary complex with basic fibroblast growth factor and soluble FGF receptor-1
31. Identification of the basic fibroblast growth factor binding sequence in fibroblast heparan sulfate
32. Importance of 2-O-sulfate groups of uronate residues in heparin for activation of FGF-1 and FGF-2
33. Characterization of fibroblast growth factor 1 binding heparan sulfate domain
34. Sequence analysis of heparan sulfate epitopes with graded affinities for fibroblast growth factors 1 and 2
35. Fibroblast growth factor receptor signalling is dictated by specific heparan sulphate saccharides