Elevated levels of the angiogenic cytokines basic fibroblast growth factor and vascular endothelial growth factor in sera of cancer patients

British Journal of Cancer

Volumn 76, Issue 2, 1997, Pages 238-243

  Dirix, L Y ^a,b,d   Vermeulen, P B ^a   Pawinski, A ^a   Prove A ^c   Benoy, I ^c   De Pooter, C ^b,c   Martin, M ^a,d   Van Oosterom, A T ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b SINT AUGUSTINUS HOSPITAL   (Belgium)

^c UNIVERSITY OF ANTWERP   (Belgium)

^d ANTWERP UNIVERSITY HOSPITAL   (Belgium)

Author keywords

Angiogenesis; Basic fibroblast growth factor; Enzyme linked immunosorbent assay; Solid tumours; Vascular endothelial cell growth factor

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; VASCULOTROPIN;

ARTICLE; BLOOD LEVEL; BREAST CANCER; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; KIDNEY CARCINOMA; MAJOR CLINICAL STUDY; METASTASIS; OVARY CANCER; PRIORITY JOURNAL;

EID: 0030997316     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.368     Document Type: Article

References (29)

1. Asahara T, Bauters C, Zheng LP, Takeshita S, Bunting S, Ferrara N, Symes JF and Isner JM (1995) Synergistic effect of vascular endothelial growth factor and basic fibroblast factor on angiogenesis in vivo. Circulation 92: 365-371
2. Berger DP, Herbstritt L, Dengler WA, Marme D, Mertelsmann R and Fiebig HH (1995) Vascular endothelial growth factor (VEGF) mRNA expression in human tumor models of different histologies. Ann Oncol 6: 817-825
3. Chodak GW, Scheiner CJ and Zetter BR (1981) Urine from patients with transitional cell carcinoma stimulates migration of capillary endothelial cells. N Engl J Med 305: 869-874
4. Chodak GW, Hospelhorn V, Judge SM, Mayforth R, Koeppen H and Sasse J (1988) Increased levels of fibroblast growth factor-like activity in urine from patients with bladder or kidney cancer. Cancer Res 48: 2083-2088
5. Dirix LY, Vermeulen PB, Hubens G, Benoy I, Martin M, De Pooter C and Van Oosterom (1996) Serum basic fibroblast growth factor and vascular endothelial growth factor and tumour growth kinetics in advanced colorectal cancer. Ann Oncol 7: 843-848
6. Folknian J (1990) What is the evidence that tumors are angiogenesis dependent?1 J Natl Cancer Inst 82: 4-6
7. Fox SB, Gatter KC, Bicknell R, Going JJ, Stanton P, Cooke TG and Harris AL (1993) Relationship of endothelial cell proliferation to tumor vascularity in human breast cancer. Cancer Res. 53: 4161-4163
8. Gasparini G and Harris AL (1995) Clinical importance of the determination of tumor angiogenesis in breast carcinoma: much more than a new prognostic tool. J Clin Oncol 13: 765-782
9. Goto F, Goto K, Weindel K and Folkman J (1993) Synergistic effects of vascular endothelial growth factor and basic fibroblast growth factor on the proliferation and cord formation of bovine capillary endothelial cells within collagen gels. Lab Invest 69: 508-517
10. Kondo S, Asano M, Matsuo K, Ohmori I and Suzuki H (1994) Vascular endothelial growth factor/vascular permeability factor is detectable in the sera of tumor-bearing mice and cancer patients. Biochem Biophys Acta 1221: 211-214
11. Kuwabara K, Ogawa S, Matsumoto M, Koga S, Clauss M, Pinsky DJ, Lyn P, Leavy J, Witte L, Joseph-Silverstein J, Furie MB, Torcia G, Cozzolino F, Kamada T and Stern DM (1995) Hypoxia-mediated induction of acidic/basic fibroblast growth factor and platelet-derived growth factor in mononuclear phagocytes stimulates growth of hypoxic endothelial cells. Proc Natl Acad Sci 92: 4606-4610
12. Keck PJ, Hauser SD, Krivi G , Sanzo K, Warren T, Feder J and Connolly DT (1989) Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246: 1309-1312
13. Leek RD, Harris AL and Lewis CE (1994) Cytokine networks in solid human tumors: regulation of angiogenesis. J Leukoc Biol 56: 423-435
14. Li VW, Folkerth RD, Watanabe H, Yu C, Rupnick M, Barnes P, Scott RM, Black PM, Sallan SE and Folkman J (1994) Microvessel count and cerebrospinal fluid basic fibroblast growth factor in children with brain tumours. Lancet 344: 82-86
15. Liu Y, Cox SR, Morita T and Kourembanas S (1995) Hypoxia regulates vascular endothelial growth factor gene expression in endothelial cells. Identification of a 5′ enhancer. Circ Res 77: 638-643
16. Mattern J, Koomagi R and Volm M (1996) Association of vascular endothelial growth factor with intratumoral microvessel density and tumour cell proliferation in human epidermoid lung carcinoma. Br J Cancer 73: 931-934
17. McCarty LP, Karr SM, Harris BZ, Michelson SG and Leith JT (1995) Comparison of basic fibroblast growth factor levels in clone A human colon cancer cells in vitro with levels in xenografted tumours. Br J Cancer 72: 10-16
18. Nguyen M, Hiroyuki W, Budson AE, Richie JP and Folkman J (1993) Elevated levels of the angiogenic peptide basic fibroblast growth factor in urine of bladder cancer patients. J Natl Cancer Inst 85: 24-25
19. Schultz-Hector S and Haghayegh S (1993) β-fibroblast growth factor expression in human and murine squamous cell carcinomas and its relationship to regional endothelial cell proliferation. Cancer Res 53: 1444-1449
20. Schweigerer L, Neufeld G, Friedman J, Abraham JA, Fiddes JC and Gospodarowiz D (1987) Capillary endothelial cells express basic fibroblast growth factor, a mitogen that promotes their own growth. Nature 325: 257-259
21. Shweiki D, Itin A, Soffer D and Keshet E (1992) Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis. Nature 359: 843-845
22. Sliulz G, Tempfer C, Obermair A, Dadak CH and Kainz CH (1995) Serum evaluation of basic FGF in breast cancer patients. Anticancer Res 15: 2675-2678
23. Takahashi Y, Kitadai Y, Bucana CD, Cleary KR and Ellis LM (1995) Expression of vascular endothelial growth factor and its receptor, KDR, correlates with vascularity, metastasis, and proliferation of human colon cancer, Cancer Res 55: 3964-3968
24. Taniguchi T, Toi M, Inada K, Imazawa T, Yamamoto Y and Tominaga T (1995) Serum concentrations of hepatocyte growth factor in breast cancer patients. Clin Cancer Res 1: 1031-1034
25. Toi M, Kondo S, Suzuki H, Yamamoto Y, Inada K, Imazawa T, Taniguchi T and Tominaga T (1996) Quantitative analysis of vascular endothelial growth factor in primary breast cancer, Cancer 77: 1101-1106
26. Vermeulen PB, Verhoeven D, Hubens G, Van Marck E, Goovaerts G, Huyghe M, De Bruijn EA, Van Oosterom AT and Dirix LY (1995) Microvessel density, endothelial cell proliferation and tumour cell proliferation in human colorectal adenocarcinomas. Ann Oncol 6: 59-64
27. Watanabe H, Hori A, Seno M, Kozai Y, Igarashi K, Ichimori Y and Kondo K (1991) A sensitive enzyme immunoassay for human basic fibroblast growth factor. Biochem Biophys Res Comm 175: 229-235
28. Weidner N and Folkman J (1996) Tumoral vascularity as a prognostic factor in cancer. In Important Advances in Oncology DeVita VT, Hellman S and Rosen berg SA. (eds), pp. 167-190. Lippincott-Raven: Philadelphia
29. Yamamoto Y, Toi M, Kondo S, Matsumoto T, Suzuki H, Kitamura M, Tsuruta K, Taniguchi T, Okamoto A, Mon T, Yoshida M, Ikeda T and Tominaga T (1996) Concentrations of vascular endothelial growth factor in the sera of normal controls and cancer patients. Clin Cancer Res 2: 821-826