Inhibition of FGF-2-mediated chemotaxis of murine brain capillary endothelial cells by cyclic RGDfV peptide through blocking the redistribution of c-Src into focal adhesions

Experimental Cell Research

Volumn 268, Issue 2, 2001, Pages 169-178

  Shono, Takefumi ^a   Mochizuki, Yasushi ^a   Kanetake, Hiroshi ^a   Kanda, Shigeru ^a  

^a NAGASAKI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

c Src; CRGDfV peptide; Endothelial cells; FGF 2; Motility; v 3 integrin

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; CYCLIC RGDFV PEPTIDE; CYCLOPEPTIDE; FIBROBLAST GROWTH FACTOR 2; FIBRONECTIN; INTEGRIN; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN KINASE P60; UNCLASSIFIED DRUG; VITRONECTIN;

ANGIOGENESIS; ANIMAL CELL; ARTICLE; BRAIN CAPILLARY; CELL ADHESION; CELL IMMORTALIZATION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CELL SPREADING; CHEMOTAXIS; CONTROLLED STUDY; DEPHOSPHORYLATION; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LOCALIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION;

MURINAE;

EID: 0035881886     PISSN: 00144827     EISSN: None     Source Type: Journal    
DOI: 10.1006/excr.2001.5276     Document Type: Article

References (46)

1. 3 integrin during angiogenesis
2. 3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels
3. v integrins
4. 3 blocks human breast cancer growth and angiogenesis in human skin
5. 3 for angiogenesis
6. Motility of fibronectin receptor-deficient cells on fibronectin and vitronectin: Collaborative interactions among integrins
7. 3 binding to vitronectin
8. 3
9. 1 integrins
10. 3 inhibits micro-vascular endothelial cell capillary tube formation in fibrin
11. 1 and protein kinase A
12. Molecular mechanisms of angiogenesis: Fibroblast growth factor signal transduction
13. Biological roles of fibroblast growth factor-2
14. Divergent receptors for fibroblast growth factors
15. Signal transduction by fibroblast growth factor receptors
16. A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway
17. Contribution of Src and Ras pathways in FGF-2-induced endothelial differentiation
18. Roles of extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase in the signal transduction of basic fibroblast growth factor in endothelial cells during angiogenesis
19. Role of endothelial cell extracellular signal-regulated kinase 1/2 in urokinase-type plasminogen activator upregulation and in vitro angiogenesis by fibroblast growth factor-2
20. Adhesion in cell migration
21. Integrin transmembrane signaling and cytoskeletal control
22. Cell adhesion: The molecular basis of tissue architecture and morphogenesis
23. Integrins and signal transduction pathways: The road taken
24. Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: Roles of integrin aggregation and occupancy of receptors
25. Integrin signaling
26. SRC
27. FAK
28. Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases
29. Focal adhesion kinase overexpression enhances fas-dependent integrin signaling to ERK2/mitogen-activated protein kinase through interaction with and activation of c-Src
30. Fibroblast growth factor receptor 1-induced differentiation of an endothelial cell line established from tsA58 large T transgenic mice
31. The role of mitogen-activated protein kinase activation within focal adhesions in chemotaxis toward FGF-2 by murine brain capillary endothelial cells
32. Signaling via fibroblast growth factor receptor-1 is dependent on extracellular matrix in capillary endothelial cell differentiation
33. 1 in promoting cellular attachment and spreading on fibronectin
34. 3 contribute to cell attachment to vitronectin but differentially distribute on the cell surface
35. Role of thrombospondin-1-derived peptide, 4N1K, in FGF-2-induced angiogenesis
36. 3 function through integrin-associated protein
37. Selective recognition of cyclic RGD peptides of NMR defined conformation by αIIbβ3, αVβ3, and α5β1 integrins
38. The nonreceptor protein-tyrosine kinase c-Fes is involved in fibroblast growth factor-2-induced chemotaxis of murine brain capillary endothelial cells
39. Integrin and ECM functions
40. αVβ3 integrin mediates the cell-adhesive capacity and biological activity of basic fibroblast growth factor (FGF-2) in cultured endothelial cell
41. c-Src enhances the spreading of src-/- fibroblasts on fibronectin by a kinase-independent mechanism
42. Subcutaneous injection of a cyclic peptide antagonist of vitronectin receptor-type integrins inhibits retinal neovascularization
43. The extracellular matrix as a cell survival factor
44. Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase
45. Matrix survival signaling: From fibronectin via focal adhesion kinase to c-Jun-NH2-terminal kinase