Cellular distribution of platelet-derived growth factor, transforming growth factor-β, basic fibroblast growth factor, and their receptors in normal bone marrow

Acta Haematologica

Volumn 104, Issue 4, 2000, Pages 151-157

  Yoon, Soo Young ^a   Tefferi, Ayalew ^a   Li, Chin Yang ^a  

^a MAYO CLINIC   (United States)

Author keywords

Basic fibroblast growth factor; Bone marrow; Cytokine; Immunohistochemistry; Isotype; Myelofibrosis; Platelet derived growth factor; Receptors; Transforming growth factor

Indexed keywords

BASIC FIBROBLAST GROWTH FACTOR; CYTOKINE; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR RECEPTOR; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR B; PLATELET DERIVED GROWTH FACTOR RECEPTOR; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ARTICLE; BONE MARROW; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOKINE RELEASE; ENDOTHELIUM CELL; FIBROBLAST; HEMATOPOIETIC STEM CELL; HISTIOCYTE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MEGAKARYOCYTE; MYELOFIBROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

BONE MARROW CELLS; FIBROBLAST GROWTH FACTOR 2; GROWTH SUBSTANCES; HUMANS; IMMUNOHISTOCHEMISTRY; MYELOFIBROSIS; PLATELET-DERIVED GROWTH FACTOR; PROTEIN ISOFORMS; RECEPTORS, GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA;

EID: 0034463083     PISSN: 00015792     EISSN: None     Source Type: Journal    
DOI: 10.1159/000046507     Document Type: Article

References (52)

1. Idiopathic myelofibrosis: Pathogenesis, natural history and management
2. Differential effects of the various isoforms of platelet-derived growth factor on chemotaxis of fibroblasts, monocytes, and granulocytes
3. Effects of platelet derived growth factor, epidermal growth factor and transforming growth factor-beta on the growth of human marrow fibroblasts
4. Differential proliferation of rat lung fibroblasts induced by the platelet-derived growth factor -AA, -AB, and -BB isoforms secreted by rat alveolar macrophages
5. Platelet-derived growth factor (PDGF)-AA, -AB, and -BB induce differential chemotaxis of early-passage rat lung fibroblasts in vitro
6. Platelet-derived growth factor: Mechanism of action and possible in vivo function
7. Synthesis of transforming growth factor-beta 1 by megakaryocytes and its localization to megakaryocyte and platelet alpha-granules
8. Transforming growth factor-beta regulates growth as well as collagen and fibronectin synthesis of human marrow fibroblasts
9. The transforming growth factor-beta family
10. Neutralisation of TGF-beta 1 and TGF-beta 2 or exogenous addition of TGF-beta 3 to cutaneous rat wounds reduces scarring
11. Betaglycan presents ligand to the TGF beta signaling receptor
12. Mechanism of activation of the TGF-beta receptor
13. Expression cloning of the TGF-beta type II receptor, a functional transmembrane serine/threonine kinase
14. Fibroblast growth factors and early hemopoietic cell development
15. Basic fibroblast growth factor expression in human bone marrow and peripheral blood cells
16. Structural characterization and biological functions of fibroblast growth factor
17. Receptor specificity of the fibroblast growth factor family
18. Angiogenic factors are hematopoietic growth factors and vice versa
19. Angiogenesis: Mechanistic insights, neovascular diseases, and therapeutic prospects
20. Effects of type beta transforming growth factors on hematopoietic progenitor cells
21. Basic fibroblast growth factor and hematopoiesis
22. The role of transforming growth factor-beta in PEG-rHuMGDF-induced reversible myelofibrosis in rats
23. A model of myelofibrosis and osteosclerosis in mice induced by overexpressing thrombopoietin (mpl ligand): Reversal of disease by bone marrow transplantation
24. Human megakaryocyte stimulation of proliferation of bone marrow fibroblasts
25. Megakaryocytes and fibroblasts - Interactions as determined in normal human bone marrow specimens
26. Increased intraplatelet levels of platelet-derived growth factor and transforming growth factor-beta in patients with myelofibrosis with myeloid metaplasia
27. Elevated levels of basic fibroblast growth factor in megakaryocytes and platelets from patients with idiopathic myelofibrosis
28. Investigation of calmodulin and basic fibroblast growth factor (bFGF) in idiopathic myelofibrosis: Evidence for a role of extracellular calmodulin in fibroblast proliferation
29. Systemic transforming growth factor-beta in patients with bone marrow fibrosis - Pathophysiological implications
30. Differential expression of transforming growth factor-beta, basic fibroblast growth factor, and their receptors in CD34+ hematopoietic progenitor cells from patients with myelofibrosis and myeloid metaplasia
31. Reduced responsiveness of bone marrow megakaryocyte progenitors to platelet-derived transforming growth factor beta 1, produced in normal amount in patients with essential thrombocythaemia
32. Human bone marrow fibroblast - An overview of their characterization, proliferation and inflammatory mediator production
33. Regulated production of a pleiotropic cytokine-platelet-derived growth factor - By differentiating erythroid cells in vitro and in vivo
34. Recombinant PDGF enhances megakaryocytopoiesis in vitro
35. Comparison of the inhibitory effect of AcSDKP, TNF-alpha, TGF-beta, and MIP-1 alpha on marrow-purified CD34+ progenitors
36. Characterization of biologically active, platelet-derived growth factor-like molecules produced by murine erythroid cells in vitro and in vivo
37. Platelet-derived growth factor promotes proliferation of erythropoietic progenitor cells in vitro
38. Platelet-derived growth factor enhances in vitro erythropoiesis via stimulation of mesenchymal cells
39. Pathogenetic mechanisms in chronic myeloproliferative disorders: Polycythemia vera, essential thrombocythemia, agnogenic myeloid metaplasia, and chronic myelogenous leukemia
40. Deposition of transforming growth factor-beta in the marrow in myelofibrosis, and the intracellular localization and secretion of TGF-beta by leukemic cells
41. A major part of platelet-derived growth factor purified from human platelets is a heterodimer of one A and one B chain
42. Platelet derived growth factor messenger RNA is increased in bone marrow megakaryocytes in patients with myeloproliferative disorders
43. Identification of mRNA for PDGF B-chain in human megakaryocytes isolated using a novel immunomagnetic separation method
44. Expression of the platelet-derived growth factor 1 and 2 genes in human myeloid cell lines and monocytes
45. The influence of oxidatively modified low density lipoproteins on expression of platelet-derived growth factor by human monocyte-derived macrophages
46. Localization of PDGF-B protein in macrophages in all phases of atherogenesis
47. Platelet-derived growth factor expression in accelerated and blastic phase of chronic myelogenous leukaemia with myelofibrosis
48. Cultured human endothelial cells express platelet-derived growth factor B chain: cDNA cloning and structural analysis
49. Transforming growth factors-beta 1, -beta 2, and -beta 3 stimulate fibroblast procollagen production in vitro but are differentially expressed during bleomycin-induced lung fibrosis
50. Human transforming growth factor-beta 3: Recombinant expression, purification, and biological activities in comparison with transforming growth factors-beta 1 and -beta 2
51. Differential motogenic and biosynthetic response of fetal and adult skin fibroblasts to TGF-beta isoforms
52. Macrophages in normal human bone marrow and in chronic myeloproliferative disorders: An immunohistochemical and morphometric study by a new monoclonal antibody (PG-M1) on trephine biopsies