-
2
-
-
0035936764
-
Obesity and the regulation of energy balance
-
Spiegelman BM, Flier JS. Obesity and the regulation of energy balance. Cell 2001; 104: 531-543.
-
(2001)
Cell
, vol.104
, pp. 531-543
-
-
Spiegelman, B.M.1
Flier, J.S.2
-
3
-
-
0034611791
-
Obesity as a medical problem
-
Kopelman PG. Obesity as a medical problem. Nature 2000; 404: 635-643.
-
(2000)
Nature
, vol.404
, pp. 635-643
-
-
Kopelman, P.G.1
-
4
-
-
0037423243
-
Obesity - What is to be done?
-
Kelner K, Helmuth L. Obesity - what is to be done? Science 2003; 299: 845.
-
(2003)
Science
, vol.299
, pp. 845
-
-
Kelner, K.1
Helmuth, L.2
-
5
-
-
0000067107
-
Genetics and pathophysiology of human obesity
-
Cummings DE, Schwartz MW. Genetics and pathophysiology of human obesity. Annu Rev Med 2003; 54: 453-471.
-
(2003)
Annu. Rev. Med.
, vol.54
, pp. 453-471
-
-
Cummings, D.E.1
Schwartz, M.W.2
-
6
-
-
0035709038
-
The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis
-
Cone RD, Cowley MA, Butler AA, Fan W, Marks DL, Low MJ. The arcuate nucleus as a conduit for diverse signals relevant to energy homeostasis. Int J Obes Relat Metab Disord 2001; 25: S63-S67.
-
(2001)
Int. J. Obes. Relat. Metab. Disord.
, vol.25
-
-
Cone, R.D.1
Cowley, M.A.2
Butler, A.A.3
Fan, W.4
Marks, D.L.5
Low, M.J.6
-
8
-
-
0032558725
-
Leptin and the regulation of body weight in mammals
-
Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998; 395: 763-770.
-
(1998)
Nature
, vol.395
, pp. 763-770
-
-
Friedman, J.M.1
Halaas, J.L.2
-
9
-
-
0031440266
-
Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
-
Spanswick D, Smith MA, Groppi VE, Logan SD, Ashford MLJ. Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 1997; 390: 521-525.
-
(1997)
Nature
, vol.390
, pp. 521-525
-
-
Spanswick, D.1
Smith, M.A.2
Groppi, V.E.3
Logan, S.D.4
Ashford, M.L.J.5
-
11
-
-
0035942777
-
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
-
Cowley M, Smart JL, Rubenstein M, Cerdan MG, Diano S, Horvath TL, Cone RD, Low MJ. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 2001; 411: 480-484.
-
(2001)
Nature
, vol.411
, pp. 480-484
-
-
Cowley, M.1
Smart, J.L.2
Rubenstein, M.3
Cerdan, M.G.4
Diano, S.5
Horvath, T.L.6
Cone, R.D.7
Low, M.J.8
-
12
-
-
2142758640
-
Orexigen-sensitive NPY/AgRP pacemeaker neurons in the hypothalamic arcuate nucleus
-
Van den Top M, Lee K, Whyment AD, Blanks AM, Spanswick D. Orexigen-sensitive NPY/AgRP pacemeaker neurons in the hypothalamic arcuate nucleus. Nature Neurosci 2004; 7: 493-494.
-
(2004)
Nature Neurosci.
, vol.7
, pp. 493-494
-
-
Van den Top, M.1
Lee, K.2
Whyment, A.D.3
Blanks, A.M.4
Spanswick, D.5
-
14
-
-
0035950093
-
Intracellular signalling. Key enzyme in leptin-induced anorexia
-
Niswender KD, Morton GJ, Stearns WH, Rhodes CJ, Myers MG Jr, Schwartz MW. Intracellular signalling. Key enzyme in leptin-induced anorexia. Nature 2001; 413: 794-795.
-
(2001)
Nature
, vol.413
, pp. 794-795
-
-
Niswender, K.D.1
Morton, G.J.2
Stearns, W.H.3
Rhodes, C.J.4
Myers Jr., M.G.5
Schwartz, M.W.6
-
15
-
-
0027847677
-
Antihyperglycemic action of guanidinoalkanoic acids: 3-guanidinopropionic acid ameliorates hyperglycemia in diabetic kkay and c57bl6job/ob mice and increases glucose disappearance in rhesus monkeys
-
Meglasson MD, Wilson JM, Yu JH, Robinson DD, Wyse BM, De Souza CJ. Antihyperglycemic action of guanidinoalkanoic acids: 3-guanidinopropionic acid ameliorates hyperglycemia in diabetic kkay and c57bl6job/ob mice and increases glucose disappearance in rhesus monkeys. J Pharmacol Exp Ther 1993; 266: 1454-1462.
-
(1993)
J. Pharmacol. Exp. Ther.
, vol.266
, pp. 1454-1462
-
-
Meglasson, M.D.1
Wilson, J.M.2
Yu, J.H.3
Robinson, D.D.4
Wyse, B.M.5
De Souza, C.J.6
-
16
-
-
0035848573
-
Synthesis and biological activity of aminoguanidine and diaminoguanidine analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid
-
Vaillancourt VA, Larsen SD, Tanis SP, Burr JE, Conell MA, Cuahy MM, Evans BR, Fisher PV, May PD, Meglasson MD, Robinson DD, Stevens FC, Tucker JA, Vidmar TJ, Yu JH. Synthesis and biological activity of aminoguanidine and diaminoguanidine analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid. J Med Chem 2001; 44: 1231-1248.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 1231-1248
-
-
Vaillancourt, V.A.1
Larsen, S.D.2
Tanis, S.P.3
Burr, J.E.4
Conell, M.A.5
Cuahy, M.M.6
Evans, B.R.7
Fisher, P.V.8
May, P.D.9
Meglasson, M.D.10
Robinson, D.D.11
Stevens, F.C.12
Tucker, J.A.13
Vidmar, T.J.14
Yu, J.H.15
-
17
-
-
12944257117
-
+ channels in the rat insulinoma cell line, CRI-G1
-
+ channels in the rat insulinoma cell line, CRI-G1. BMC Pharmacology 2004; 4: 17.
-
(2004)
BMC Pharmacology
, vol.4
, pp. 17
-
-
Kinsella, J.K.1
Laidlaw, H.A.2
Tang, T.3
Harvey, J.4
Sutherland, C.5
Ashford, M.L.J.6
-
18
-
-
0030729888
-
Leptin activates ATP sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1
-
Harvey J, Mckenna F, Herson PS, Spanswick D, Ashford MLJ. Leptin activates ATP sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1. J Physiol 1997; 504: 527-535.
-
(1997)
J. Physiol.
, vol.504
, pp. 527-535
-
-
Harvey, J.1
Mckenna, F.2
Herson, P.S.3
Spanswick, D.4
Ashford, M.L.J.5
-
19
-
-
0017184389
-
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
-
Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976; 72: 248-254.
-
(1976)
Anal. Biochem.
, vol.72
, pp. 248-254
-
-
Bradford, M.M.1
-
21
-
-
0029048408
-
Recombinant mouse ob protein: Evidence for a peripheral signal linking adiposity and central neural networks
-
Camptield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995; 269: 546-548.
-
(1995)
Science
, vol.269
, pp. 546-548
-
-
Camptield, L.A.1
Smith, F.J.2
Guisez, Y.3
Devos, R.4
Burn, P.5
-
22
-
-
0029098589
-
The role of neuropeptide Y in the antiobesity action of the obese gene product
-
Stephans TW, Basinski M, Bristow PK, Bue-valleskey JM, Burgett SG, Craft L, Hale J, Hoffman J, Hsuing HM, Kriauciunas A, Macfellar W, Rosteck PR, Schoner B, Smith D, Tinsley FC, Zhang X-Y, Helman M. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995; 377: 530-532.
-
(1995)
Nature
, vol.377
, pp. 530-532
-
-
Stephans, T.W.1
Basinski, M.2
Bristow, P.K.3
Bue-Valleskey, J.M.4
Burgett, S.G.5
Craft, L.6
Hale, J.7
Hoffman, J.8
Hsuing, H.M.9
Kriauciunas, A.10
Macfellar, W.11
Rosteck, P.R.12
Schoner, B.13
Smith, D.14
Tinsley, F.C.15
Zhang, X.-Y.16
Helman, M.17
-
23
-
-
0036000280
-
Leptin signalling
-
Sweeney G. Leptin signalling. Cell Signal 2002; 14: 655-663.
-
(2002)
Cell Signal
, vol.14
, pp. 655-663
-
-
Sweeney, G.1
-
24
-
-
0347320633
-
Leptin signaling in the hypothalamus: Emphasis on energy homeostasis and leptin resistance
-
Sahu A. Leptin signaling in the hypothalamus: emphasis on energy homeostasis and leptin resistance. Front Neuroendocrinol 2003; 24: 225-253.
-
(2003)
Front Neuroendocrinol.
, vol.24
, pp. 225-253
-
-
Sahu, A.1
-
25
-
-
12944261926
-
Stimulation of PI3K by leptin and insulin leads to actin reorganization and KATP activation of arcuate nucleus neurons
-
Mirshamsi S, Laidlaw HA, Ning K, Anderson E, Burgess LA, Gray A, Sutherland C, Ashford MLJ. Stimulation of PI3K by leptin and insulin leads to actin reorganization and KATP activation of arcuate nucleus neurons. BMC Neurosci 2004; 5: 54.
-
(2004)
BMC Neurosci.
, vol.5
, pp. 54
-
-
Mirshamsi, S.1
Laidlaw, H.A.2
Ning, K.3
Anderson, E.4
Burgess, L.A.5
Gray, A.6
Sutherland, C.7
Ashford, M.L.J.8
-
26
-
-
0032143284
-
Phosphoinositide 3-kinase: The key switch in insulin signalling
-
Shepherd PR, Withers DJ, Siddle K. Phosphoinositide 3-kinase: the key switch in insulin signalling. Biochem J 1998; 333: 471-490.
-
(1998)
Biochem. J.
, vol.333
, pp. 471-490
-
-
Shepherd, P.R.1
Withers, D.J.2
Siddle, K.3
-
27
-
-
0033104765
-
Glucose-receptive neurones in the rat ventromedial hypothalamus express KATP channels composed of Kir6.1 and SUR1 subunits
-
Lee K, Dixon AK, Richardson PJ, Pinnock RD. Glucose-receptive neurones in the rat ventromedial hypothalamus express KATP channels composed of Kir6.1 and SUR1 subunits. J Physiol 1999; 515: 439-452.
-
(1999)
J. Physiol.
, vol.515
, pp. 439-452
-
-
Lee, K.1
Dixon, A.K.2
Richardson, P.J.3
Pinnock, R.D.4
-
29
-
-
0032788372
-
Molecular biology of adenosine triphosphate-sensitive potassium channels
-
Aguilar-Bryan L, Bryan J. Molecular biology of adenosine triphosphate-sensitive potassium channels. Endocrinol Rev 1999; 20: 101-135.
-
(1999)
Endocrinol. Rev.
, vol.20
, pp. 101-135
-
-
Aguilar-Bryan, L.1
Bryan, J.2
-
30
-
-
0031850240
-
The cytoskeleton and cell signalling: Component localisation and mechanical coupling
-
Janmey PA. The cytoskeleton and cell signalling: component localisation and mechanical coupling. Physiol Rev 1998; 78: 763-781.
-
(1998)
Physiol. Rev.
, vol.78
, pp. 763-781
-
-
Janmey, P.A.1
-
31
-
-
0028244823
-
Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin
-
Bubb MR, Senderowicz AM, Sausville EA, Duncan KL, Korn ED. Jasplakinolide, a cytotoxic natural product, induces actin polymerization and competitively inhibits the binding of phalloidin to F-actin. J Biol Chem 1994; 269: 14869-14871.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 14869-14871
-
-
Bubb, M.R.1
Senderowicz, A.M.2
Sausville, E.A.3
Duncan, K.L.4
Korn, E.D.5
-
32
-
-
0034681423
-
Effects of jasplakinolide on the kinetics of actin polymerization. An explanation for certain in vivo observations
-
Bubb MR, Spector I, Beyer BB, Fosen KM. Effects of jasplakinolide on the kinetics of actin polymerization. An explanation for certain in vivo observations. J Biol Chem 2000; 275: 5163-5170.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 5163-5170
-
-
Bubb, M.R.1
Spector, I.2
Beyer, B.B.3
Fosen, K.M.4
-
33
-
-
0018127874
-
Cytoplasmic streaming in amoeba proteus is inhibited by the actin-specific drug phalloidin
-
Wehland J, Stockem W, Weber K. Cytoplasmic streaming in amoeba proteus is inhibited by the actin-specific drug phalloidin. Exp Cell Res 1978; 115: 451-454.
-
(1978)
Exp. Cell Res.
, vol.115
, pp. 451-454
-
-
Wehland, J.1
Stockem, W.2
Weber, K.3
-
34
-
-
0023427610
-
Effects of cytochalasin and phalloidin on actin
-
Cooper JA. Effects of cytochalasin and phalloidin on actin. J Cell Biol 1987; 105: 1473-1478.
-
(1987)
J. Cell Biol.
, vol.105
, pp. 1473-1478
-
-
Cooper, J.A.1
-
35
-
-
0037456304
-
Stat3 signalling is required for leptin regulation of energy balance but not reproduction
-
Bates SH, Stearns WH, Dundon TA, Schubert M, Tso AW, Wang Y, Banks AS, Lavery HJ, Haq AK, Maratos-Flier E, Neel BG, Schwartz MW, Myers MG Jr. Stat3 signalling is required for leptin regulation of energy balance but not reproduction. Nature 2003; 421: 856-859.
-
(2003)
Nature
, vol.421
, pp. 856-859
-
-
Bates, S.H.1
Stearns, W.H.2
Dundon, T.A.3
Schubert, M.4
Tso, A.W.5
Wang, Y.6
Banks, A.S.7
Lavery, H.J.8
Haq, A.K.9
Maratos-Flier, E.10
Neel, B.G.11
Schwartz, M.W.12
Myers Jr., M.G.13
-
36
-
-
10744232925
-
Essential role of Stat3 in body weight and glucose homeostasis
-
Cui Y, Huang L, Elefteriou F, Yang G, Shelton JM, Giles JE, Oz OK, Pourbahrami T, Lu CY, Richardson JA, Karsenty G, Li C. Essential role of Stat3 in body weight and glucose homeostasis. Mol Cell Biol 2004; 24: 258-269.
-
(2004)
Mol. Cell Biol.
, vol.24
, pp. 258-269
-
-
Cui, Y.1
Huang, L.2
Elefteriou, F.3
Yang, G.4
Shelton, J.M.5
Giles, J.E.6
Oz, O.K.7
Pourbahrami, T.8
Lu, C.Y.9
Richardson, J.A.10
Karsenty, G.11
Li, C.12
-
37
-
-
0035313701
-
The Stat family in cytokine signaling
-
Ihle JN. The Stat family in cytokine signaling. Curr Opin Cell Biol 2001; 13: 211-217.
-
(2001)
Curr. Opin. Cell Biol.
, vol.13
, pp. 211-217
-
-
Ihle, J.N.1
-
38
-
-
0037315042
-
Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: A key mediator of insulin-induced anorexia
-
Niswender KD, Morrison CD, Clegg DJ, Olson R, Baskin DG, Myers MG Jr, Seeley RJ, Schwartz MW. Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: a key mediator of insulin-induced anorexia. Diabetes 2002; 52: 227-231.
-
(2002)
Diabetes
, vol.52
, pp. 227-231
-
-
Niswender, K.D.1
Morrison, C.D.2
Clegg, D.J.3
Olson, R.4
Baskin, D.G.5
Myers Jr., M.G.6
Seeley, R.J.7
Schwartz, M.W.8
-
39
-
-
0035851907
-
Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin
-
Elmquist JK. Hypothalamic pathways underlying the endocrine, autonomic, and behavioral effects of leptin. Physiol Behav 2001; 74: 703-708.
-
(2001)
Physiol. Behav.
, vol.74
, pp. 703-708
-
-
Elmquist, J.K.1
-
40
-
-
0033845529
-
Leptin activation of KATP channels in CRI-G1 insulinoma cells involves disruption of the actin cytoskeleton
-
Harvey J, Hardy SC, Ashford MLJ. Leptin activation of KATP channels in CRI-G1 insulinoma cells involves disruption of the actin cytoskeleton. J Physiol 2000; 527: 95-107.
-
(2000)
J. Physiol.
, vol.527
, pp. 95-107
-
-
Harvey, J.1
Hardy, S.C.2
Ashford, M.L.J.3
-
41
-
-
0034817058
-
Regions in the carboxy terminus of α-bENaC involved in gating and functional effects of actin
-
Copeland SJ, Berdiev BK, Ji H-L, Lockhart J, Parker S, Fuller CM, Benos DJ. Regions in the carboxy terminus of α-bENaC involved in gating and functional effects of actin. Am J Physiol Cell Physiol 2001; 281: C231-C240.
-
(2001)
Am. J. Physiol. Cell Physiol.
, vol.281
-
-
Copeland, S.J.1
Berdiev, B.K.2
Ji, H.-L.3
Lockhart, J.4
Parker, S.5
Fuller, C.M.6
Benos, D.J.7
-
42
-
-
0037064067
-
Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin
-
Hattan D, Nesti E, Cachero TG, Morielli AD. Tyrosine phosphorylation of Kv1.2 modulates its interaction with the actin-binding protein cortactin. J Biol Chem 2002; 277: 38596-38606.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 38596-38606
-
-
Hattan, D.1
Nesti, E.2
Cachero, T.G.3
Morielli, A.D.4
-
43
-
-
0346216155
-
Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats
-
Carvalheira JB, Ribeiro EB, Araujo EP, Guimaraes RB, Telles MM, Torsoni M, Gontijo JA, Velloso LA, Saad MJ. Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats. Diabetologia 2003; 46: 1629-1640.
-
(2003)
Diabetologia
, vol.46
, pp. 1629-1640
-
-
Carvalheira, J.B.1
Ribeiro, E.B.2
Araujo, E.P.3
Guimaraes, R.B.4
Telles, M.M.5
Torsoni, M.6
Gontijo, J.A.7
Velloso, L.A.8
Saad, M.J.9
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