The aminoguanidine carboxylate BVT.12777 activities ATP-sensitive K+ channels in the rat insulinoma cell line, CRI-G1

BMC Pharmacology

Volumn 4, Issue , 2004, Pages

  Kinsella, Jackie M ^a   Laidlaw, Hilary A ^a   Tang, Teresa ^a   Harvey, Jenni Z ^a   Sutherland, Calum D ^a   Ashford, Michael L J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; [2 (HYDRAZINOIMINOMETHYL)HYDRAZINO]ACETIC ACID; ADENOSINE TRIPHOSPHATE; CYTOSKELETON PROTEIN; DIAZOXIDE; F ACTIN; GUANIDINOPROPIONIC ACID; LEPTIN; MITOGEN ACTIVATED PROTEIN KINASE 1; PHALLOIDIN; PHOSPHATIDYLINOSITOL 3 KINASE; POTASSIUM CHANNEL; STAT3 PROTEIN; TOLBUTAMIDE; UNCLASSIFIED DRUG; WORTMANNIN; ABC TRANSPORTER; ACTIN; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; BVT.12777; COMPLEMENTARY RNA; DRUG RECEPTOR; GUANIDINE DERIVATIVE; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.2; MULTIDRUG RESISTANCE PROTEIN; SULFONYLUREA RECEPTOR; UK ATP 1 POTASSIUM CHANNEL; UK-ATP-1 POTASSIUM CHANNEL;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DOWNSTREAM PROCESSING; DRUG MECHANISM; DRUG STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME SUBUNIT; FEMALE; HUMAN; HUMAN CELL; HYPERPOLARIZATION; IMAGE ANALYSIS; INSULINOMA; MOLECULAR DYNAMICS; NONHUMAN; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; RAT; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; TUMOR CELL LINE; ANIMAL; CHEMISTRY; CYTOSKELETON; ENZYMOLOGY; GENETICS; INJECTION; METABOLISM; METHODOLOGY; OOCYTE; PANCREAS TUMOR; PATHOLOGY; XENOPUS LAEVIS;

ACTINS; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELL LINE, TUMOR; CYTOSKELETON; FEMALE; GUANIDINES; INJECTIONS; INSULINOMA; KATP CHANNELS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; OOCYTES; PANCREATIC NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RATS; RECEPTORS, DRUG; RNA, COMPLEMENTARY; XENOPUS LAEVIS;

EID: 12944257117     PISSN: 14712210     EISSN: None     Source Type: Journal    
DOI: 10.1186/1471-2210-4-17     Document Type: Article

References (45)

1. Seino S: ATP-sensitive potassium channels: a model of heteromultimeric potassium channel/receptor assemblies. Annu Rev Physiol 1999, 61:337-362.
2. ATP channels. Annu Rev Physiol 1998, 60: 67-687.
3. + channels and insulin secretion: their role in health and disease. Diabetologia 1999, 42:903-919.
4. Lawson K: Potassium channel openers as potential therapeutic weapons in ion channel disease. Kidney Int 2000, 5:838-845.
5. ATP channels. Biochem Soc Trans 2002, 30:333-339.
6. Rorsman P: The pancreatic beta-cell as a fuel sensor: an electrophysiologist's viewpoint. Diabetologia 1997, 40: 87-495.
7. Proks P, Reimann F, Green N, Gribble FM, Ashcroft FM: Sulfonylurea stimulation of insulin secretion. Diabetes 2002, 51:S368-S376.
8. Dunne MJ: Ions, genes and insulin release: from basic science to clinical disease. Diabetic Med 2000, 17:91-104.
9. + channel openers. J Biol Chem 2000, 275:717-720.
10. Dabrowski M, Ashcroft FM, Ashfield R, Lebrun P, Pirotte B, Egebjerg J, Bondo Hansen J, Wahl P: The novel diazoxide analog 3-isopropylamino-7-methoxy-4H-1,2,4-benzothiadiazine 1,1-dioxide is a selective Kir6.2/SUR1 channel opener. Diabetes 2002, 51: 896-1906.
11. Mannhold R: KATP channel openers: structure activity relationships and therapeutic potential. Med Res Rev 2004, 24:213-266.
12. + channels in pancreatic beta-cells. Diabetes 1997, 46:1087-1093.
13. Harvey J, Mckenna F, Herson PS, Spanswick D, Ashford MLJ: Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1. J Physiol 1997, 504: 27-535.
14. Kieffer TJ, Habener JF: The adipoinsular axis: the effects of leptin on pancreatic β-cells. Am J Physiol Endocrinol Metab 2000, 278:E1-E14.
15. Ahima RS, Flier JS: Leptin. Annu Rev Physiol 2000, 62:413-437.
16. Spanswick D, Smith MA, Groppi V, Logan SD, Ashford MLJ: Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 1997, 390:521-525.
17. ATP channels composed of Kir6.1 and SUR1 subunits. J Physiol 1999, 515:439-452.
18. + channels in the hypothalamus are essential for the maintenance of glucose homeostasis. Nature Neurosci 2001, 4:507-512.
19. y and C75BL6J ob/ob mice and increases glucose disappearance in rhesus monkeys. J Pharmacol Exp Ther 1993, 266:1454-1462.
20. Vaillancourt VA, Larsen SD, Tanis SP, Burr JE, Connell MA, Cudahy MM, Evans BR, Fisher PV, May PD, Meglasson MD, Robinson DD, Stevens FC, Tucker JA, Vidmar TJ, Yu JH: Synthesis and biological activity of aminoguanidine and diaminoguanidine analogues of the antidiabetic/antiobesity agent 3-guanidinopropionic acid. J Med Chem 2001, 44:1231-1248.
21. Carrington CA, Rubery ED, Pearson EC, Hales CN: Five new insulin-producing cell lines with differing secretory properties. J Endocrinol 1986, 109:193-200.
22. ATP channel activation in the rat CRI-G1 insulinoma cell line. J Biol Chem 2000, 275:4660-4669.
23. + channels in rat CRI-G1 insulin secreting cells. J Physiol 1998, 511:695-706.
24. + currents expressed in Xenopus oocytes. J Physiol 1997, 498:87-98.
25. ATP channel inhibitors, ciclazindol and englitazone. Br J Pharmacol 2000, 130:857-866.
26. Alessi DR, Cuendo A, Cohen P, Dudley DT, Saltiel AR: PD 98059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem 1995, 270:27489-27494.
27. Lazar DF, Wiese RJ, Brady MJ, Mastick CC, Waters SB, Yamauchi K, Pessin JE, Cuatrecasas P, Saltiel AR: Mitogen-activated protein kinase kinase inhibition does not block the stimulation of glucose utilization by insulin. J Biol Chem 1995, 270:20801-20807.
28. Takahashi Y, Okimura Y, Mizuno I, Takahashi T, Kaji H, Uchiyama T, Abe H, Chihara K: Leptin induces mitogen-activated protein kinase dependent proliferation of C1H10T1/2 cells. J Biol Chem 1997, 272:12897-12900.
29. Tanabe K, Okuya S, Tanizawa T, Matsutani A, Oka Y: Leptin induces proliferation of pancreatic beta cell line MIN6 through activation of mitogen-activated protein kinase. Biochem Bioph Res Com 1997, 241:765-768.
30. Davies SP, Reddy H, Caivano M, Cohen P: Specificity and mechanism of action of come commonly used protein kinase inhibitors. Biochem J 2000, 351:95-105.
31. ATP) channels in rat CRI-G1 insulinoma cells involves disruption of the actin cytoskeleton. J Physiol 2000, 527:95-107.
32. Wieland I, Faulstich H: Amatoxins, phallotoxins, phallolysin, and antamanide: the biologically active components of poisonous Amanita mushrooms. Crit Rev Biochem 1978, 5: 85-260.
33. Cooper JA: Effects of cytochalasin and phalloidin on actin. J Cell Biol 1987, 105:1473-1478.
34. + currents recorded from an insulin-secreting cell line. Br J Pharmacol 1989, 97:1039-1050.
35. ATP channel currents in the rat CRI-G1 insulinoma cell line. Br J Pharmacol 1999, 126: 1-60.
36. Sturgess NC, Kozlowski RZ, Carrington CA, Hales CN, Ashford MLJ: Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line. Br J Pharmacol 1988, 95:83-94.
37. Sweeney G: Leptin signalling. Cell Signal 2002, 14:655-663.
38. Niswender KD, Schwartz MW: Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular capabilities. Front Neuroendocrinol 2003, 24:1-10.
39. Gribble FM, Tucker SJ, Ashcroft FM: The essential role of the walker A motifs of SUR1 in K-ATP channel activation by Mg-ADP and diazoxide. EMBO J 1997, 16:1145-1152.
40. Janmey PA: The cytoskeleton and cell signalling: component localisation and mechanical coupling. Ann Rev Physiol 1994, 56:169-191.
41. A receptors and the cytoskeleton. Nature 1999, 397:69-72.
42. Terzic A, Kurachi Y: Actin microfilament disrupters enhance K (ATP) channel opening in patches from guinea-pig cardiomyocytes. J Physiol 1996, 492:395-404.
43. Pollard TD, Borisy GG: Cellular motility driven by assembly and disassembly of actin filaments. Cell 2003, 112: 53-465.
44. Schuppe-Koistinen I, Frisk AL, Janzon L: Molecular profiling of hepatotoxicity induced by a aminoguanidine carboxylate in the rat: gene expression profiling. Toxicology 2002, 179: 97-219.
45. + channel present in rat cortical neurones. J Physiol 1995, 488:319-337.