A direct comparison of two nonviral gene therapy vectors for somatic integration: In vivo evaluation of the bacteriophage integrase φC31 and the Sleeping Beauty transposase

Molecular Therapy

Volumn 11, Issue 5, 2005, Pages 695-706

  Ehrhardt, Anja ^a   Xu, Hui ^a   Huang, Zan ^a   Engler, Jeffrey A ^b   Kay, Mark A ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

C31; Bacteriophage integrase; Gene therapy; Hemophilia; Nonviral; Sleeping Beauty

Indexed keywords

BACTERIAL DNA; BLOOD CLOTTING FACTOR 9; GENOMIC DNA; INTEGRASE; TRANSPOSASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BACTERIOPHAGE; CELL CYCLE; CHROMOSOME DELETION; COMPARATIVE STUDY; CONTROLLED STUDY; DNA INTEGRATION; DNA SEQUENCE; ENZYME ACTIVE SITE; GENE CASSETTE; GENE EXPRESSION; GENE TARGETING; IN VIVO STUDY; LIVER CELL; MOLECULAR CLONING; MOUSE; MOUSE STRAIN; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; NONVIRAL GENE THERAPY; NUCLEOTIDE SEQUENCE; PLASMID; PROTEIN EXPRESSION; STREPTOMYCES; TRANSGENE;

ANIMALS; BACTERIOPHAGES; BASE SEQUENCE; GENE THERAPY; GENETIC VECTORS; HELA CELLS; HUMANS; INTEGRASES; LIVER; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; PLASMIDS; TRANSPOSASES;

STREPTOMYCES;

EID: 17644425657     PISSN: 15250016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ymthe.2005.01.010     Document Type: Article

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