Estradiol protects against oxygen and glucose deprivation in rat hippocampal organotypic cultures and activates Akt and Inactivates GSK-3β

Neurochemical Research

Volumn 30, Issue 2, 2005, Pages 191-199

  Cimarosti, Helena ^a   Zamin, Lauren L ^a   Frozza, Rudimar ^a   Nassif, Melissa ^a   Horn, Ana Paula ^a   Tavares, Alexandre ^a   Netto, Carlos Alexandre ^a   Salbego, Christianne ^a  

^a FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

17 estradiol; Akt; Cerebral ischemia; GSK 3 ; Neuroprotection; Organotypic hippocampal culture

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ESTRADIOL; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3BETA; OXYGEN; PROPIDIUM IODIDE; PROTEIN KINASE B;

ANIMAL TISSUE; ARTICLE; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVATION; HIPPOCAMPUS; IMMUNOBLOTTING; ISCHEMIA; MALE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; ANOXIA; BIOTRANSFORMATION; BLOTTING, WESTERN; CELL DEATH; ENZYME ACTIVATION; ESTRADIOL; GLUCOSE; GLYCOGEN SYNTHASE KINASE 3; HIPPOCAMPUS; NEURONS; NEUROPROTECTIVE AGENTS; ORGAN CULTURE TECHNIQUES; PHOSPHORYLATION; PROPIDIUM; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; SIGNAL TRANSDUCTION;

EID: 17644423497     PISSN: 03643190     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11064-004-2441-y     Document Type: Article

References (48)

1. P. Lipton 1999 Ischemic cell death in brain neurons Physiol. Rev. 79 1431 1568
2. A. Pringle R. Angunawela G. Wilde J. Mepham L. Sundstrom F. Lannotti 1997 Induction of 72 kDa heat-shock protein following sub-lethal oxygen deprivation in organotypic hippocampal slice cultures Neuropathol. Appl. Neurobiol. 23 289 298
3. T. Sakaguchi M. Okada M. Kuno K. Kawasaki 1997 Dual mode of N-methyl-D-aspartate-induced neuronal death in hippocampal slice cultures in relation to N-methyl-D-aspartate receptor properties Neuroscience 76 411 423
4. H. Cimarosti R. Rodnight A. Tavares R. Paiva L. Valentim E. Rocha C. Salbego 2001 An investigation of the neuroprotective effect of lithium in organotypic slice culture of rat hippocampus exposed to oxygen and glucose deprivation Neurosci. Lett. 315 33 36
5. A. Tavares H. Cimarosti L. Valentim C. Salbego 2001 Profile of phosphoprotein labelling in organotypic slice culture of rat hippocampus Neuroreport 12 2705 2709
6. T. Hawk Y. Q. Zhang G. Rajakumar A. L. Day J. W. Simpkins 1998 Testosterone increases and estradiol decreases middle cerebral artery occlusion lesion size in males rats Brain Res. 796 296 298
7. R. Rusa N. J. Alakyed B. J. Crain R. J. Traystman A. S. Kimes E. D. London J. Klaus P. D. Hurn 1999 17β-Estradiol reduces stroke injury in estrogen deficient female animals Stroke 30 1665 1670
8. Y. Goodman Y. A. J. Bruce B. Cheng M. P. Mattson 1996 Estrogen attenuates and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid β-peptide toxicity in hippocampal neurons J. Neurochem. 66 1836 1844
9. P. S. Green K. E. Gridley J. W. Simpkins 1996 Estradiol protects against β-amyloid (25-35)-induced toxicity in SK-N-SH human neuroblastoma cells Neurosci. Lett. 218 165 168
10. L. D. McCullough P. D. Hurn 2003 Estrogen and ischemic neuroprotection: An integrated view Trends Endocrinol. Metab. 14 5 228 235
11. C. A. Singer K. L. Rogers T. M. Strickland D. M. Dorsa 1996 Estrogen protects primary cortical neurons from glutamate toxicity Neurosci. Lett. 212 13 16
12. A. K. Pringle W. Schmidt J. K. Deans E. Wulfert K. G. Reymann L. E. Sundstrom 2003 7-Hydroxylated epiandrosterone (7-OH-EPIA) reduces ischaemia-induced neuronal damage both in vivo and in vitro Eur. J. Neurosci. 18 117 124
13. K. Sato N. Matsuki Y. Ohno K. Nakazawa 2002 Effects of 17beta-estradiol and xenoestrogens on the neuronal survival in an organotypic hippocampal culture Neuroendocrinology 76 223 234
14. M. E. Wilson D. B. Dubal P. M. Wise 2000 Estradiol protects against injury-induced cell death in cortical explant cultures: A role for estrogen receptors Brain Res. 873 235 242
15. P. M. Wise 2002 Estrogens and neuroprotection Trends Endocrinol. Metab. 13 229 230
16. A. H. Gazzaley N. G. Weiland B. S. McEwen J. H. Morrison 1996 Differential regulation of NMDA R1 mRNA and protein by estradiol in the rat hippocampus J. Neurosci. 16 6830 6838
17. C. J. Pike 1999 Estrogen modulates neuronal Bcl-xl expression and β-amyloid-induced apoptosis: Relevance to Alzheimer's disease J. Neurochem. 72 1552 1563
18. C. A. Singer K. L. Rogers D. M. Dorsa 1998 Modulation of Bcl-2 expression: A potential component of estrogen protection in NT2 neurons Neuroreport 9 2565 2568
19. B. Moosman C. Behl 1999 The antioxidant neuroprotective effect of estrogens and phenolic compounds are independent from their estrogenic properties Proc. Natl. Acad. Sci. USA 96 8867 8872
20. J. Segars P. Driggers 2002 Estrogen action and signaling cascades. Part I: Membrane-associated signaling complexes Trends Endocrinol. Metab. 13 349 354
21. M. Wilson Y. Liu P.M Wise 2002 Estradiol enhances Akt activation in cortical explant cultures following neuronal injury Mol. Brain Res. 102 48 54
22. S. Goodenough M. Schafer C. Behl 2003 Estrogen-induced cell signaling in a model of Alzheimer's disease J. Steroid Metab. 84 301 305
23. L. Stoppini P. Buchs D. A. Muller 1991 Simple method for organotypic cultures of nervous tissue J. Neurosci. Methods 37 173 182
24. U. Strasser G. Fischer 1995 Quantitative measurement of neuronal degeneration in organotypic hippocampal cultures after combined oxygen/glucose deprivation J. Neurosci. Methods 57 177 186
25. L. M. Valentim R. Rodnight A. B. Geyer A. P. Horn A. Tavares H. Cimarosti C. A. Netto C. G. Salbego 2003 Changes in heat shock protein 27 phosphorylation and immunocontent in response to preconditioning to oxygen and glucose deprivation in organotypic hippocampal cultures Neuroscience 118 379 386
26. L. A. Mise R. A. Shapiro D. A. Dorsa 2003 Estrogen receptor-mediated neuroprotection from oxidative stress requires activation of the mitogen-activated protein kinase pathway Endocrinology 144 306 312
27. K. L. Philpott M. J. McCarthy A. Klippel L. L. Rubin 1997 Activated phosphatidylinositol-3-kinase and AKT kinase promote survival of superior cervical neurons J. Cell. Biol. 139 809 815
28. R. L. Moss Q. Gu M. Wong 1997 Estrogen: Nontranscriptional signaling pathway Recent Prog. Horm. Res. 52 33 68
29. P. M. Wise D. B. Dubal M. E. Wilson S. W. Rau M. Böttner K. L. K. L. Rosewell 2001 Estradiol is a protective factor in the adult and aging brain: Understanding of mechanisms derived from in vivo and in vitro studies Brain Res. Rev. 37 313 319
30. K. Dhandapani D. W. Brann 2002 Protective effects of estrogens and SERMs in the brain Biol. Reprod. 67 1379 1385
31. I. Azcoitia A. Sierra L. M. Garcia-Segura 1999 Localization of estrogen receptor beta immunoreactivity in astrocytes of the adult rat brain Glia 26 260 267
32. D. J. Stone Y. Song C. P. Anderson K. K. Krohn C. E. Finch I. Rozovsky 1998 Bidirectional transcriptional regulation of glial fibrillary acidic protein by estradiol in vivo and in vitro Endocrinology 139 3202 3209
33. J. Noraberg B. W. Kristensen J. Zimmer 1999 Markers for neuronal degeneration in organotypic slice cultures Brain Res. Protocols 3 278 290
34. A. Barth L. Barth D. W. Newell 1996 Combination therapy with MK-801 and alpha-phenyl-tert-butyl-nitrone enhances protection against ischemic neuronal damage in organotypic hippocampal slice cultures Exp. Neurol. 141 330 336
35. A. K. Pringle F. Iannotti G. J. C. Wilde J. C. Chad P. J. Seeley L. E. Sundstrom 1997 Neuroprotection by both NMDA and non-NMDA receptor antagonists in in vitro ischaemia Brain Res. 755 36 46
36. R. J. Pietras C. M. Szego 1980 Partial purification and characterization of oestrogen receptors in subfractions of hepatocyte plasma membranes Biochem. J. 191 743 760
37. S. M. Belcher A. Zsarnovsky 2001 Estrogenic actions in the brain: Estrogens, phytoestrogens, and rapid intracellular signaling mechanisms J. Pharmacol. Exp. Ther. 299 408 414
38. C. L. Smith O. M. Conneely B. W. O'Malley 1993 Modulation of the ligand-independent activation of the human estrogen receptor by hormone and antihormone Proc. Natl. Acad. Sci. USA 90 6120 6124
39. C. A. Singer X. A. Figueroa-Masot R. H. Batchelor D. M. Dorsa 1999 The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons J. Neurosci. 19 2455 2463
40. K. Honda H. Sawada T. Kihara M. Urushitani T. Nakamizo A. Akaike S. Shimohama 2000 Phosphatidylinositol-3-kinase mediates neuroprotection by estrogen in cultured cortical neurons J. Neurosci. Res. 60 321 327
41. M. P. Wymann L. Pirola 1998 Structure and function of phosphoinositide-3-kinases Biochim. Biophys. Acta 1436 127 150
42. L. Xue H. Murray A. M. Tolkovsky 2000 The Ras/Phosphatidylinositol-3- Kinase and Ras/ERK pathways function in sympathetic neurons J. Biol. Chem. 275 12 8817 8824
43. Z. Songyang D. Baltimore L. C. Cantley D. R. Kaplan T. F. Franke 1997 Interleukin-3-dependent survival by the Akt protein kinase Proc. Natl. Acad. Sci. USA 94 11345 11350
44. R. J. Crowder R. S. Freeman 1998 Phosphatidylinositol-3-kinase and AKT protein kinase are necessary and sufficient for the survival of nerve growth factor sympathetic neurons J. Neurosci. 18 2933 2943
45. D. A. Cross D. R. Alessi P. Cohen M. Andjelkovich B. A. Hemmings 1995 Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B Nature 378 785 789
46. M. Li X. Wang M. K. Meintzer T. Laessig M. J. Birnbaum K. A. Heidereich 2000 Cyclic AMP promotes neuronal survival by phosphorylation of glycogen synthase kinase 3beta Mol. Cell. Biol. 20 9356 9363
47. M. Pap G. M. Cooper 1998 Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-kinase/AKT cell survival pathway J. Biol. Chem. 273 19929 19932
48. P. S. Green J. W. Simpkins 2000 Neuroprotective effects of estrogens: Potential mechanisms of action Int. J. Dev. Neurosci. 18 347 358