Estradiol protects against injury-induced cell death in cortical explant cultures: A role for estrogen receptors

Brain Research

Volumn 873, Issue 2, 2000, Pages 235-242

  Wilson, Melinda E ^a   Dubal, Dena B ^a   Wise, Phyllis M ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

Cell death; Cortex; Estradiol; Explants; In vitro; Ischemia; Neuroprotection

Indexed keywords

ESTRADIOL; ESTROGEN RECEPTOR; LACTATE DEHYDROGENASE;

ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN CORTEX; BRAIN ISCHEMIA; CELL DEATH; CONTROLLED STUDY; ESTROGEN ACTIVITY; FEMALE; IN VITRO STUDY; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR INTRINSIC ACTIVITY;

ANIMALS; ANIMALS, NEWBORN; BIOLOGICAL MARKERS; CELL DEATH; CEREBRAL CORTEX; DEOXYGLUCOSE; DRUG COMBINATIONS; ESTRADIOL; FEMALE; KAINIC ACID; NEUROPROTECTIVE AGENTS; NEUROTOXINS; ORGAN CULTURE TECHNIQUES; POTASSIUM CYANIDE; PREGNANCY; PROPIDIUM; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ESTROGEN;

EID: 0034637265     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(00)02479-3     Document Type: Article

References (38)

1. Alkayed N.J., Harukuni I., Kimes A.S., London E.D., Traystman R.J., Hurn P.D. Gender-linked brain injury in experimental stroke. Stroke. 29:1998;159-166.
2. Azcoitia I., Sierra A., Garcia-Segura L.M. Localization of estrogen receptor beta immunoreactivity in astrocytes of the adult rat brain. Glia. 26:1999;260-267.
3. Barrett-Connor E., Kritz-Silverstein D. Estrogen replacement therapy and cognitive function in older women. J. Am. Med. Assoc. 269:1993;2637-2641.
4. Behl C., Widmann M., Trapp T., Holsboer F. 17-β Estradiol protects neurons from oxidative stress-induced cell death in vitro. Biochem. Biophys. Res. Commun. 216:1998;473-482.
5. Brawer J., Schipper H., Robaire B. Effects of long term androgen and estradiol exposure on the hypothalamus. Endocrinology. 112:1983;194-199.
6. Clark R.S.B., Chen J., Watkins S.C., Kochanek P.M., Chen M., Stetler R.A., Loeffert J.E., Graham S.H. Apoptosis-suppressor gene bcl-2 expression after traumatic brain injury in rats. J. Neurosci. 17:1997;9172-9182.
7. Dubal D.B., Kashon M.L., Pettigrew L.C., Ren J.M., Finklestein S.P., Rau S.W., Wise P.M. Estradiol protects against ischemic injury. J. Cereb. Blood Flow Metab. 18:1998;1253-1258.
8. Dubal D.B., Shughrue P.J., Wilson M.E., Merchenthaler I., Wise P.M. Estradiol modulates Bcl-2 in cerebral ischemia: a potential role for estrogen receptors. J. Neurosci. 19:1999;6385-6393.
9. Fillit H., Weinreb H., Cholst I., Luine V., McEwen B., Amador R., Zabriskie J. Observations in a preliminary open trial of estradiol therapy for senile dementia-Alzheimer's type. Psychoneuroendocrinology. 11:1986;337-345.
10. Garcia-Segura L.M., Cardona-Gomez P., Naftolin F., Chowen J.A. Estradiol upregulates Bcl-2 expression in adult brain neurons. NeuroReport. 9:1998;593-597.
11. Gibbs R.B., Hashash A., Johnson D.A. Effects of estrogen on potassium-stimulated acetylcholine release in the hippocampus and overlying cortex of adult rats. Brain Res. 749:1997;143-146.
12. Goodman Y., Bruce A.J., Cheng B., Mattson M.P. Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid B-peptide toxicity in hippocampal neurons. J. Neurochem. 66:1996;1836-1844.
13. Green P.S., Gridley K.E., Simpkins J.W. Estradiol protects against β-amyloid (25-35)-induced toxicity in SK-N-SH human neuroblastoma cells. Neurosci. Lett. 218:1996;165-168.
14. Green P.S., Gordon K., Simpkins J.W. Phenolic A ring requirement for the neuroprotective effects of steroids. J. Steroid Biochem. Mol. Biol. 63:1997;229-235.
15. Gridley K.E., Green P.S., Simpkins J.W. A novel, synergistic interaction between 17β-estradiol and glutathione in the protection of neurons against β-amyloid 25-35-induced toxicity in vitro. Mol. Pharmacol. 54:1998;874-880.
16. Gu Q., Korach K.S., Moss R.L. Rapid action of 17β-estradiol on kainate-induced currents in hippocampal neurons lacking intracellular estrogen receptors. Endocrinology. 140:1999;660-666.
17. Hayes C.L., Spink D.C., Spink B.C., Cao J.Q., Walker N.J., Sutter T.R. 17β-Estradiol hydroxylation catalyzed by human cytochrome P450 1B1. Proc. Natl. Acad. Sci. USA. 93:1996;9776-9781.
18. Henderson V.W., Watt L., Buckwalter J.G. Cognitive skills associated with estrogen replacement in women with Alzheimer's disease. Psychoneuroendocrinology. 21:1996;421-430.
19. Kawas C., Resnick S., Morrison A., Brookmeyer R., Corrada M., Zonderman A., Bacal C., Lingle D., Metter E. A prospective study of estrogen replacement therapy and the risk of developing Alzheimer's disease: the Baltimore Longitudinal Study of Aging. Neurology. 48:1997;1517-1521.
20. Liehr J.G., Ricci M.J., Jeffcoate C.R., Hannigan E.V., Hokanson J.A., Zhu B.T. 4-Hydroxylation of estradiol by human uterine myometrium and myoma microsomes: implications for the mechanism of uterine tumorigenesis. Proc. Natl. Acad. Sci. USA. 92:1995;9220-9224.
21. Luquin S., Naftolin F., Garcia-Segura L.M. Natural fluctuation and gonadal hormone regulation of astrocyte immunoreactivity in dentate gyrus. J. Neurobiol. 24:1993;913-924.
22. Miranda R.C., Sohrabji F., Toran-Allerand C.D. Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions. Proc. Natl. Acad. Sci. USA. 90:1993;6439-6443.
23. Miranda R.C., Sohrabji F., Singh M., Toran-Allerand C.D. Nerve growth factor (NGF) regulation of estrogen receptors in explant cultures of the developing forebrain. J. Neurobiol. 31:1996;77-87.
24. Noraberg J., Kristensen B.W., Zimmer J. Markers for neuronal degeneration in organotypic slice cultures. Brain Res. Protocols. 3:1999;278-290.
25. Pagnini-Hill A. Estrogen replacement therapy and stroke. Prog. Cardiovasc. Dis. 38:1995;223-242.
26. L expression and β-amyloid-induced apoptosis: relevance to Alzheimer's disease. J. Neurochem. 72:1999;1552-1563.
27. Shughrue P.J., Lane M.V., Merchenthaler I. Comparative distribution of estrogen receptor-α and -β mRNA in the rat central nervous system. J. Comp. Neurol. 388:1997;507-525.
28. Simpkins J.W., Rajakumar G., Zhang Y.-Q., Simpkins C.E., Greenwald D., Yu C.J., Bodor N., Day A.L. Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat. J. Neurosurg. 87:1997;724-730.
29. Singer C.A., Rogers K.L., Strickland T.M., Dorsa D.M. Estrogen protects primary cortical neurons from glutamate toxicity. Neurosci. Lett. 212:1996;13-16.
30. Singer C.A., Rogers K.L., Dorsa D.M. Modulation of Bcl-2 expression: a potential component of estrogen protection in NT2 neurons. NeuroReport. 9:1998;5-8.
31. Singh M., Setalo G. Jr., Guan X., Warren M., Toran-Allerand C.D. Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: convergence of estrogen and neurotrophin signaling pathways. J. Neurosci. 19:1999;1179-1188.
32. Sohrabji F., Greene L.A., Miranda R.C., Toran-Allerand C.D. Reciprocal regulation of estrogen and NGF receptors by their ligands in PC12 cells. J. Neurobiol. 25:1997;974-988.
33. Stone D.J., Song Y., Anderson C.P., Krohn K.K., Finch C.E., Rozovsky I. Bidirectional transcriptional regulation of glial fibrillary acidic protein by estradiol in vivo and in vitro. Endocrinology. 139:1998;3202-3209.
34. Toran-Allerand C.D. Organotypic culture of the developing cerebral cortex and hypothalamus relevance to sexual differentiation. Psychoneuroendocrinology. 16:1991;7-24.
35. Vornov J.J., Tasker R.C., Coyle J.T. Direct observation of the agonist-specific regional vulnerability to glutamate, NMDA, and kainate neurotoxicity in organotypic hippocampal cultures, Exp. Neurol. 114:1991;11-22.
36. Vornov J.J., Tasker R.C., Coyle J.T. Delayed protection by MK-801 and tetrodotoxin in a rat organotypic hippocampal culture model of ischemia. Stroke. 25:1994;457-465.
37. Wisden W., Seeburg P.H. A complex mosaic of high-affinity kainate receptors in rat brain. J. Neurosci. 13:1993;3582-3598.
38. Woolley C.S., McEwen B.S. Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat. J. Comp. Neurol. 336:1993;293-306.