Neuroprotection by both NMDA and non-NMDA receptor antagonists in in vitro ischemia

Brain Research

Volumn 755, Issue 1, 1997, Pages 36-46

  Pringle, A K ^a   Iannotti, F ^a,c   Wilde, G J C ^a   Chad, J E ^a   Seeley, P J ^b   Sundstrom, L E ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b UNIVERSITY OF WINCHESTER   (United Kingdom)

^c SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

glutamate; hippocampus; hypoxia; ischaemia; organotypic slice culture

Indexed keywords

6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; DIZOCILPINE; GLUTAMATE RECEPTOR ANTAGONIST; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NEUROPROTECTIVE AGENT; TETRODOTOXIN;

ADOLESCENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN ISCHEMIA; BRAIN SLICE; CONTROLLED STUDY; HIPPOCAMPUS; NONHUMAN; PRIORITY JOURNAL; RAT; TISSUE CULTURE;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ANIMALS; BRAIN ISCHEMIA; CELL DEATH; EXCITATORY AMINO ACID ANTAGONISTS; HIPPOCAMPUS; HYPOGLYCEMIA; HYPOXIA, BRAIN; NEURONS; NEUROPROTECTIVE AGENTS; ORGAN CULTURE TECHNIQUES; RATS; RATS, WISTAR; RECEPTORS, AMPA; RECEPTORS, N-METHYL-D-ASPARTATE; SODIUM CHANNELS;

EID: 0030932741     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(97)00089-9     Document Type: Article

References (68)

1. Bahr, B.A., Kessler, M., Rivera, S., Vanderklish, P.W., Hall, R.A., Mutneja, M.S., Gall, C. and Hoffman, K.B., Stable maintenance of glutamate receptors and other synaptic components in long-term hippocampal slices, Hippocampus, 5 (1995) 425-439.
2. 2+ antagonist is neuroprotective in two models of cerebral ischemia, Neuropharmacology, 32 (1993) 1249-1257.
3. Boast, C.A., Gerhardt, S.C., Pastor, G., Lehmann, J., Etienne, P.E. and Liebman, J.M., The N-methyl-D-aspartate antagonists CGS19755 and CPP reduce ischaemic brain damage in gerbils, Brain Res., 442 (1988) 345-348.
4. Boening, J.A., Kass, I.S., Cottrell, J.E. and Chambers, G., The effect of blocking sodium influx on anoxic damage in the rat hippocampal slice, Neuroscience, 33 (1991) 263-268.
5. Bullock, R., Graham, D.I., Chen, M.H., Lowe, D. and McCulloch, J., Focal cerebral ischaemia in the cat: pretreatment with a competitive NMDA receptor antagonist D-CPP-ene, J. Cereb. Blood Flow Metab., 10 (1990) 668-674.
6. Cheng, B., Christakos, S. and Mattson, M.P., Tumour necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintainence of calcium homeostasis, Neuron, 12 (1994) 139-155.
7. Cheng, B. and Mattson, M.P., NT-3 and BDNF protect CNS neurons against metabolic/excitotoxic insults, Brain Res., 640 (1994) 56-67.
8. Choi, D.W., Ionic dependence of glutamate neurotoxicity, J. Neurosci., 7 (1987) 369-379.
9. Choi, D.W., Cerebral hypoxia: Some new approaches and unanswered questions, J. Neurosci., 10 (1990) 2493-2501.
10. Choi, D.W., NMDA receptors and AMPA/kainate receptors mediate parallel injury in cerebral cortical cultures subjected to oxygen-glucose deprivation, Prog. Brain Res., 96 (1993) 137-143.
11. Choi, D.W, Maulucci-Gedde, M. and Kriegstein, A.R., Glutamate neurotoxicity in cortical cell culture, J. Neurosci., 7 (1987) 357-368.
12. Collingridge, G.L. and Lester, R.A., Excitatory amino acid receptors in the vertebrate central nervous system, Pharmacol. Rev., 41 (1989) 143-210.
13. Dessi, F., Charriaut-Marlangue, C. and Ben-Ari, Y., Glutamate-induced neuronal death in cerebellar cultures mediated by two distinct components: a sodium-chloride component and a calcium component, Brain Res., 650 (1994) 49-55.
14. Facci, L., Leon, A. and Skaper, S.D., Hypoglycaemic neurotoxicity in vitro: involvement of excitatory amino acid receptors and attenuation by monosialoganglioside GM1, Neuroscience, 37 (1990) 709-716.
15. Foster, A.C. and Wong, E.H.F., The novel anticonvulsant MK-801 binds to the activated state of the N-methy-D-aspartate receptor in rat brain, Br. J. Pharmacol., 91 (1987) 403-409.
16. o, J. Neurosci., 13 (1994) 63-72.
17. Gahwiler, B.H., Development of the hippocampus in vitro: Cell types, synapses and receptors, Neuroscience, 11 (1984) 751-760.
18. Gibson, D.D., Bracket, D.J., Squires, R.A., Balla, A.K., Lerner, M.R., McCay, P.B. and Pennington, C.R., Evidence that the large loss of glutathione observed in ischaemia/reperfusion of the small intestine is not due to oxidation to glutathione disulfide, Free Radic. Biol. Med., 14 (1993) 427-433.
19. Gill, R., The pharmacology of alpha-amino-3-hydroxy-5-methyl-4-isoxazole proprionate (AMPA)/kainate antagonists and their role in cerebral ischaemia, Cerebrovasc. Brain Metab. Rev., 6 (1994) 225-256.
20. Goldberg, M.P., Weiss, J.H., Pham, P.-C. and Choi, D.W., N-Methyl-D-aspartate receptors mediate hypoxic neuronal injury in cortical culture, J. Pharm. Exp. Ther., 243 (1987) 784-791.
21. Gozlan, H., Diabira, D., Chinestra, P. and Ben-Ari, Y., Anoxic LTP is mediated by the redox site of the NMDA receptor, J. Neurophysiol., 72 (1994) 3017-3022.
22. Hammond, C., Crepel, H. and Ben-Ari, Y., Anoxic LTP sheds light on the multiple facets of NMDA receptors, Trends Neurosci., 17 (1994) 497-503.
23. Hertz, L., Drejer, J. and Schousboe, A., Energy metabolism in glutamatergic neurons, GABAergic neurons and astrocytes in primary cultures, Neurochem. Res., 13 (1988) 605-610.
24. Huettner, J.E. and Bean, B.P., Block of the N-methyl-D-aspartate-activated current by the anticonvulsant MK-801: Selective binding to open channels, Proc. Natl. Acad. Sci. USA, 85 (1988) 1307-1311.
25. Kaku, D.A., Goldberg, M.P. and Choi, D.W., Antagonists of non-NMDA receptors augments the neuroprotective effect of NMDA receptor blockade in cortical cultures subjected to prolonged deprivation of oxygen and glucose, Brain Res., 554 (1991) 344-347.
26. Koh, J.Y. and Choi, D.W., Selective blockade of non-NMDA receptors does not block rapidly triggered glutamate-induced neuronal death, Brain Res., 548 (1991) 318-321.
27. Koretz, B., Ahern, K., Wang, N., Lustig, H.S. and Greenberg, D.A., Pre-and post-synaptic modulators of excitatory neurotransmission: comparative effects on hypoxia/hypoglycaemia in cortical cultures, Brain Res., 643 (1994) 334-337.
28. Le Peillet, E., Arvin, B., Moncada, C. and Meldrum, B.S., The non-NMDA antagonists NBQX and GYKI 52466 protect against cortical and striatal cell loss following transient global ischaemia in the rat, Brain Res., 571 (1992) 115-120.
29. Lester, R.A., Quaram, M.L., Parker, J.D., Weber, E. and Jahr, C.E., Interaction of 6-cyano-7-nitroquinoxaline-2,3-dione with the N-methyl-D-aspartate receptor associated glycine binding site, Mol. Pharmacol., 35 (1989) 565-570.
30. Martin, R.J., Lloyd, H.G.E. and Cowan, A.T., The early events of oxygen and glucose deprivation: setting the scene for neuronal death, Trends Neurosci., 17 (1994) 251-257.
31. Michaels, R.L. and Rothman, S.M., Glutamate neurotoxicity in vitro: Antagonist pharmacology and intracellular calcium concentrations, J. Neurosci., 10 (1990) 283-392.
32. Monyer, H., Goldberg, M.P. and Choi, D.W., Glucose deprivation neuronal injury in cortical culture, Brain Res., 483 (1989) 347-354.
33. Monyer, H., Hartley, D.M. and Choi, D.W., 21-Aminosteroids attenuate excitotoxic neuronal injury in cortical cell cultures, Neuron, 5 (1990) 121-126.
34. Nakao, N., Kokaia, Z., Odin, P. and Lindvall, O., Protective effects of BDNF and NT-3 but not PDGF against hypoglycaemic injury to cultured striatal neurons, Exp. Neurol., 131 (1995) 1-10.
35. Newell, D.W., Barth, A. and Malouf, A.T., Glycine site NMDA receptor antagonists provide protection against ischemia-induced neuronal damage in hippocampal slice cultures, Brain Res., 675 (1995) 38-44.
36. Newell, D.W., Barth, A., Papermaster, V. and Malouf, A.T., Glutamate and non-glutamate receptor-mediated toxicity caused by oxygen and glucose deprivation in organotypic hippocampal cultures, J. Neurosci., 15 (1995) 7702-7711.
37. Newell, D.W., Malouf, A.T. and Franck, J.E., Glutamate mediated selective vulnerability to ischaemia is present in organotypic cultures of hippocampus, Neurosci. Lett., 116 (1990) 325-330.
38. Novelli, A., Reilly, J.A., Lysko, P.G. and Henneberry, R.C., Glutamate becomes neurotoxic via the N-methyl-D-aspartate receptor when intracellular energy levels are reduced, Brain Res., 451 (1988) 205-212.
39. 3H]-D-APV binding sites in rat brain membranes, Nature, 307 (1984) 460-462.
40. Omerovic, A., Leonard, J.P. and Kelso, S.R., Effects of nitroprusside and redox reagents on NMDA receptors expressed in xenopus oocytes, Mol. Brain Res., 22 (1994) 89-96.
41. Orkand, R.K. and Marrero, H., Calcium dependence of the facilitation of glial voltage-gated sodium channels by impulses in isolated frog optic nerve, J. Physiol. (Lond.), 473 (1993) 38P.
42. Park, C.K., McCulloch, J., Kang, J.K. and Choi, C.R., Efficacy of CPP-ene a competitive N-methyl-D-aspartate antagonist in focal cerebral ischaemia in the rat, Neurosci. Lett., 147 (1992) 41-44.
43. Pringle, A.K., Benham, C.D., Sim, L., Kennedy, J., Iannotti and Sundstrom, L.E., Selective N-type calcium channel antagonist omega conotoxin MVIIA is neuroprotective against hypoxic neurodegeneration in organotypic hippocampal slice cultures, Stroke, 27 (1996) 2124-2130.
44. Pringle, A.K., Sundstrom, L.E., Wilde, G.J.C., Williams, L.R. and Iannotti, F., Brain-derived neurotrophic factor, but not neurotrophin-3, prevents ischaemia-induced neuronal cell death in organotypic hippocampal cultures, Neurosci. Lett., 211 (1996) 203-206.
45. Pulsinelli, W.A., Brierly, J.B. and Plum, F., Temporal profile of neuronal damage in a model of transient forebrain ischaemia, Ann. Neurol., 11 (1982) 491-498.
46. Rothman, S., Non-competitive N-methyl-D-aspartate antagonists affect multiple ionic currents, J. Pharmac. Exp. Ther., 246 (1988) 137-142.
47. Schurr, A., Payne, R.S. and Rigor, B.M., Synergism between diltiazem and MK-801 but not APV in protecting hippocampal slices against hypoxic damage, Brain Res., 684 (1995) 233-236.
48. Schurr, A., Payne, R.S. and Rigor, B.M., Protection by MK-801 against hypoxia-, excitotoxin-and depolarization-induced neuronal damage in vitro, Neurochem. Int., 26 (1995) 519-525.
49. Siesjo, B.K., Pathophysiology and treatment of focal cerebral ischaemia. Part I: Pathophysiology, J. Neurosurg., 77 (1992) 169-184.
50. Siesjo, B.K., Pathophysiology and treatment of focal cerebral ischaemia. Part II: Mechanisms of damage and treatment, J. Neurosurg., 77 (1992) 337-354.
51. Sochoka, E., Juurlink, B.H.J., Code, W.E., Hertz, V., Peng, L. and Hertz, L., Cell death in primary cultures of mouse neurons and astrocytes during exposure to and recovery from hypoxia, substrate deprivation and simulated ischaemia, Brain Res., 638 (1994) 21-28.
52. Stoppini, L., Buchs, P.A. and Muller, D., A simple method for organotypic cultures of nervous tissue, J. Neurosci. Methods, 37 (1991) 173-182.
53. Strasser, U. and Fischer, G., Protection from neuronal damage induced by combined oxygen and glucose deprivation in organotypic hippocampal cultures by glutamate receptor antagonists, Brain Res., 687 (1995) 167-174.
54. 2+ influx during anoxia in mammalian central nervous system white matter, Ann. Neurol., 30 (1991) 375-380.
55. ++ exchanger, J. Neurosci., 12 (1992) 430-439.
56. Sugiyama, K., Brunori, A. and Mayer, M.L., Glial uptake of excitatory amino acids influences neuronal survival in cultures of mouse hippocampus, Neuroscience, 32 (1989) 779-791.
57. Swanson, R.A. and Choi, D.W., Glial glycogen stores affect neuronal survival during glucose deprivation in vitro, J. Cereb. Blood Flow Metab., 13 (1993) 162-169.
58. Tanaka, K., Dora, E., Greenberg, J.H. and Reivich, M., Cerebral glucose metabolism during the recovery period after ischaemia - its relationship to NADH-fluorescence, blood flow, EcoG and histology, Stroke, 17 (1986) 994-1004.
59. Tang, L.H. and Aizenman, E., The modulation of N-methyl-D-aspartate receptors by redox and alkylating reagents in rat cortical neurones in vitro, J. Physiol., 465 (1993) 303-323.
60. Tasker, R.C., Coyle, J.T. and Vornov, J.J., The regional vulnerability to hypoglycaemia-induced neurotoxicity in organotypic hippocampal culture: protection by early tetrodotoxin or delayed MK-801, J. Neurosci., 12 (1992) 4298-4308.
61. Valentino, K., Newcomb, R., Gadbois, T., Singh, T., Bowersox, S., Bitner, S., Justice, A., Yamashiro, D., Hoffman, B.B., Ciaranello, R., Miljanich, G. and Ramachandran, J., A selective N-type calcium channel antagonist protects against neuronal loss after global cerebral ischemia, Proc. Natl. Acad. Sci. USA., 90 (1993) 7894-7897.
62. Vibulsreth, S., Hefti, F., Ginsberg, M.D., Dietrich, W.D. and Busto, R., Astrocytes protect cultured neurons from degeneration induced by anoxia, Brain Res., 422 (1987) 303-311.
63. Vornov, J.J., Tasker, R. and Coyle, J.T., Direct observation of the agonist specific regional vulnerability to glutamate, NMDA and kainate neurotoxicity in organotypic hippocampal cultures, Exp. Neurol., 114 (1991) 11-22.
64. Vornov, J.J., Tasker, R.C., Coyle, J.T. and Koroshetz, W.J., Delayed protection by MK-801 and tetrodotoxin in a rat organotypic hippocampal culture model of ischemia, Stroke, 25 (1994) 457-465.
65. Vornov, J.J., Tasker, R.C. and Park, J., Neurotoxicity of acute glutamate transport blockade depends on coactivation of both NMDA and AMPA/kainate receptors in organotypic hippocampal cultures, Exp. Neurol., 133 (1995) 7-17.
66. Wong, E.H.F., Kemp, J.A., Priestly, T., Knight, A.R., Woodruff, G.N. and Iversen, L.L., The anticonvulsant MK-801 is a potent N-methyl-D-aspartate antagonist, Proc. Natl. Acad. Sci. USA., 83 (1986) 7104-7108.
67. Woodward, J.J. and Blair, R., Redox modulation of N-methyl-D-aspartate-stimulated neurotransmitter release from rat brain slices, J. Neurochem., 57 (1991) 2059-2064.
68. Yamasaki, Y., Kogure, K., Hara, H., Ban, H. and Akaike, N., The possible involvement of tetrodotoxin-sensitive ion channels in ischaemic neuronal damage in the rat hippocampus, Neurosci. Lett., 121 (1991) 251-254.