Structure-based design of a potent transition state analogue for TEM-1 β-lactamase

Nature Structural Biology

Volumn 3, Issue 8, 1996, Pages 688-695

  Strynadka, Natalie C J ^a   Martin, Richard ^b   Jensen, S E ^a   Gold, Marvin ^c   Jones, J Bryan ^b  

^a UNIVERSITY OF ALBERTA   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; BETA LACTAMASE INHIBITOR; BORONIC ACID DERIVATIVE; CEPHALOSPORIN DERIVATIVE; CLAVULANIC ACID; PENICILLIN DERIVATIVE; PENICILLIN G; TAZOBACTAM;

ANTIBIOTIC RESISTANCE; ARTICLE; CRYSTALLOGRAPHY; DEACYLATION; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITOR COMPLEX; ENZYME MECHANISM; ESCHERICHIA COLI; HYDROGEN BOND; NONHUMAN; PRIORITY JOURNAL;

ACETAMIDES; BETA-LACTAMASES; BINDING SITES; BORONIC ACIDS; CRYSTALLOGRAPHY; DRUG DESIGN; ENZYME INHIBITORS; HYDROGEN BONDING; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR MIMICRY; PENICILLIN G;

EID: 0029760859     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb0896-688     Document Type: Article

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