Crystal structure of the E166A mutant of extended-spectrum β-lactamase Toho-1 at 1.8 Å resolution

Journal of Molecular Biology

Volumn 285, Issue 5, 1999, Pages 2079-2087

  Ibuka, Akiko ^a,b   Taguchi, Ayako ^a   Ishiguro, Masaji ^c   Fushinobu, Shinya ^a   Ishii, Yoshikazu ^d   Kamitori, Shigehiro ^e   Okuyama, Kenji ^e   Yamaguchi, Keizo ^d   Konno, Michiko ^f   Matsuzawa, Hiroshi ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

^c SUNTORY INSTITUTE FOR BIOORGANIC RESEARCH   (Japan)

^d TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^e TOKYO UNIVERSITY OF AGRICULTURE AND TECHNOLOGY   (Japan)

^f OCHANOMIZU UNIVERSITY   (Japan)

Author keywords

Expanded cephems; Molecular replacement; Toho 1; X ray structure; lactamase

Indexed keywords

ALANINE; ARGININE; BETA LACTAMASE; GLUTAMIC ACID; MUTANT PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME SPECIFICITY; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL;

EID: 0033525223     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.1998.2432     Document Type: Article

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