Cytotoxic and mutagenic response of mismatch repair-defective human cancer cells exposed to a food-associated heterocyclic amine

Carcinogenesis

Volumn 20, Issue 3, 1999, Pages 391-394

  Glaab, Warren E ^a   Skopek, Thomas R ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HETEROCYCLIC AMINE;

ARTICLE; BASE MISPAIRING; CANCER CELL CULTURE; CARCINOGENESIS; DNA REPAIR; FOOD PROCESSING; HUMAN; HUMAN CELL; MUTAGENIC ACTIVITY; PRIORITY JOURNAL;

EID: 0033060682     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/20.3.391     Document Type: Article

References (30)

1. Modrich, P. (1997) Strand-specific mismatch repair in mammalian cells. J. Biol. Chem., 272, 24727-24730.
2. Marra, G. and Boland, C.R. (1996) DNA repair and colorectal cancer. Gastroenterol. Clin. N. Am., 25, 755-772.
3. Eshleman, J.R. and Markowitz, S.D. (1996) Mismatch repair defects in human carcinogenesis. Hum. Mol. Genet., 5, 1489-1494.
4. Papadopoulos, N., Nicolaides, N.C., Wei, Y.F. et al. (1994) Mutation of a mutL homolog in hereditary colon cancer. Science, 263, 1625-1629.
5. Nicolaides, N.C., Papadopoulos, N., Liu, B. et al. (1994) Mutations of two PMS homologues in hereditary nonpolyposis colon cancer. Nature, 371, 75-80.
6. Leach, F.S., Nicolaides, N.C., Papadopoulos, N. et al. (1993) Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer. Cell, 75, 1215-1225.
7. Boyer, J.C., Umar, A., Risinger, J.I., Lipford, J.R., Kane, M., Yin, S., Barrett, J.C., Kolodner, R.D. and Kunkel, T.A. (1995) Microsatellite instability, mismatch repair deficiency, and genetic defects in human cancer cell lines. Cancer Res., 55, 6063-6070.
8. Koi, M., Umar, A., Chauhan, D.P., Cherian, S.P., Carethers, J.M., Kunkel, T.A. and Boland, C.R. (1994) Human chromosome 3 corrects mismatch repair deficiency and microsatellite instability and reduces N-methyl-N'-nitro-N-nitrosoguanidine tolerance in colon tumor cells with homozygous hMLH1 mutation. Cancer Res., 54, 4308-4312.
9. Umar, A., Koi, M., Risinger, J.I., Glaab, W.E., Tindall, K.R., Kolodner, R.D., Boland, C.R., Barrett, J.C. and Kunkel, T.A. (1997) Correction of hypermutability. N-methyl-N'-nitro-N-nitrosoguanidine resistance, and defective DNA mismatch repair by introducing chromosome 2 into human tumor cells with mutations in MSH2 and MSH6. Cancer Res., 57, 3949-3955.
10. Umar, A., Risinger, J.I., Glaab, W.E., Tindall, K.R., Barrett, J.C. and Kunkel, T.A. (1998) Functional overlap in mismatch repair by human MSH3 and MSH6. Genetics, 148, 1637-1646.
11. Glaab, W.E., Risinger, J.I., Umar, A., Barrett, J.C., Kunkel, T.A. and Tindall, K.R. (1998) Cellular resistance and hypermutability in mismatch repair-deficient human cancer cell lines following treatment with methyl methanesulfonate. Mutat. Res., 398, 197-207.
12. Karran, P. and Bignami, M. (1994) DNA damage tolerance, mismatch repair and genome instability. Bioessays, 16, 833-839.
13. Branch, P., Hampson, R. and Karran, P. (1995) DNA mismatch binding defects, DNA damage tolerance, and mutator phenotypes in human colorectal carcinoma cell lines. Cancer Res., 55, 2304-2309.
14. Drummond, J.T., Anthony, A. Brown, R. and Modrich, P. (1996) Cisplatin and adriamycin resistance are associated with MutLα and mismatch repair deficiency in an ovarian tumor cell line. J. Biol. Chem., 271, 19645-19648.
15. Andrew, S.E., McKinnon, M., Cheng, B.S., Francis, A., Penney, J., Reitmair, A.H., Mak, T.W. and Jirik, F.R. (1998) Tissues of MSH2-deficient mice demonstrate hypermutability on exposure to a DNA methylating agent. Proc. Natl Acad. Sci. USA, 95, 1126-1130.
16. Felton, J.S., Malfatti, M.A., Knize, M.H., Salmon, C.P., Hopmans, E.C. and Wu, R.W. (1997) Health risk of heterocyclic amines. Mutat. Res., 376, 37-41.
17. Gooderham, N.J., Murray, S., Lynch, A.M., Yadollahi-Farsani, M., Zhao, K., Rich, K., Boobis, A.R. and Davies, D.S. (1997) Assessing human risk to heterocyclic amines. Mutat. Res., 376, 53-60.
18. Lynch, A.M., Knize, M.G., Boobis, A.R., Gooderham, N.J., Davies, D.S. and Murray, S. (1993) Intra-and interindividual variability in systemic exposure in humans to 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine, carcinogens present in cooked beef. Cancer Res., 52, 6216-6223.
19. Ito, N., Hasegawa, R., Imaida, K., Tamano, S., Hagiwara, A., Hirose, M. and Shirai, T. (1997) Carcinogenicity of 2-amino-1-methyl-6-phenyl-imidazo-[4,5-b]-pyridine (PhIP) in the rat. Mutat. Res., 376, 107-114.
20. Potter, J.D., Slatery, M.L., Bostick, R.M. and Gapstur, S.M. (1993) Colon cancer: a review of the epidemiology. Epidemiol. Rev., 15, 499-545.
21. Glaab, W.E. and Tindall, K.R. (1997) Mutation rate at the hprt locus in human cancer cell lines with specific mismatch-repair gene defects. Carcinogenesis, 18, 1-8.
22. Buonarati, M.H. and Felton, J.S. (1990) Activation of 2-amino-1-methyl-6-phenylimidazo[4,5-f]pyridine (PhIP) to mutagenic metabolites. Carcinogenesis, 11, 1133-1138.
23. Buonarati, M.H., Turteltaub, K.W., Shen, N.H. and Felton, J.S. (1990) Role of sulfation and acetylation in the activation of 2-amino-1-methyl-6-phenylimidazo[4,5-f]pyridine (PhIP) to intermediates which bind DNA. Mutat. Res., 245, 185-190.
24. Lin, D., Kaderlik, K.R., Turesky, R.J., Miller, D.W., Lay, J.O. and Kadlubar, F.F. (1992) Identification of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo-[4,5-f]-pyridine as the major adduct formed by the food-borne carcinogen, 2-amino-1-methyl-6-phenylimidazo[4,5-f]pyridine, with DNA. Chem. Res. Toxicol., 5, 691-697.
25. Li, G.M., Wang, H. and Romano, L.J. (1996) Human MutSα specifically binds to DNA containing aminofluorene and acetylaminofluorene adducts. J. Biol. Chem., 271, 24084-24088.
26. Leong-Morgenthaler, P.M. and Holzhauser, D. (1995) Analysis of mutations induced by 2-amino-1-methyl-6-phenylimidazo-[4,5-b]-pyridine (PhIP) in human lymphoblastoid cells. Carcinogenesis, 16, 713-718.
27. Yadollahi-Farsani, M., Gooderham, N.J., Davies, D.S. and Boobis, A.R. (1996) Mutational spectra of the dietary carcinogen 2-amino-1-methyl-6-phenylimidazo-[4,5-b]-pyridine (PhIP) at the Chinese hamster hprt locus. Carcinogenesis, 17, 617-624.
28. Kakiuchi, H., Watanabe, M., Ushijima, T., Toyota, M., Imai, K., Weisburger, J.H., Sugimura, T. and Nagao, M. (1995) Specific GGGA to GGA mutation of the APC gene in rat colon tumors induced by 2-amino-1-methyl-6-phenylimindazo-[4,5-b]-pyridine. Proc. Natl Acad. Sci. USA, 92, 910-914.
29. Yamamoto, H., Sawai, H. and Perucho, M. (1997) Frameshift somatic mutations in gastrointestinal cancer of the microsatellite mutator phenotype. Cancer Res., 57, 4420-4426.
30. Fearon, E.R. and Vogelstein, B. (1990) A genetic model for colorectal tumorigenesis. Cell, 61, 759-767.