메뉴 건너뛰기




Volumn 331, Issue 1, 2005, Pages 303-308

Wortmannin induces zebrafish cardia bifida through a mechanism independent of phosphoinositide 3-kinase and myosin light chain kinase

Author keywords

Cardia bifida; Chemical genetics; Wortmannin; Zebrafish

Indexed keywords

1 (5 CHLORO 1 NAPHTHALENESULFONYL)HEXAHYDRO 1H 1,4 DIAZEPINE; 1 (5 IODO 1 NAPHTHALENESULFONYL)HEXAHYDRO 1H 1,4 DIAZEPINE; 2 MORPHOLINO 8 PHENYLCHROMONE; MYOSIN LIGHT CHAIN KINASE; MYOSIN LIGHT CHAIN KINASE INHIBITOR; PHOSPHATIDYLINOSITOL 3 KINASE; UNCLASSIFIED DRUG; WORTMANNIN;

EID: 17444387756     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.03.145     Document Type: Article
Times cited : (7)

References (41)
  • 2
    • 0033634827 scopus 로고    scopus 로고
    • Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine
    • E.H. Walker, M.E. Pacold, O. Perisic, L. Stephens, P.T. Hawkins, M.P. Wymann, and R.L. Williams Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine Mol. Cell 6 2000 909 919
    • (2000) Mol. Cell , vol.6 , pp. 909-919
    • Walker, E.H.1    Pacold, M.E.2    Perisic, O.3    Stephens, L.4    Hawkins, P.T.5    Wymann, M.P.6    Williams, R.L.7
  • 3
    • 0037452981 scopus 로고    scopus 로고
    • Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin
    • A. Zewail, M.W. Xie, Y. Xing, L. Lin, P.F. Zhang, W. Zou, J.P. Saxe, and J. Huang Novel functions of the phosphatidylinositol metabolic pathway discovered by a chemical genomics screen with wortmannin Proc. Natl. Acad. Sci. USA 100 2003 3345 3350
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 3345-3350
    • Zewail, A.1    Xie, M.W.2    Xing, Y.3    Lin, L.4    Zhang, P.F.5    Zou, W.6    Saxe, J.P.7    Huang, J.8
  • 4
    • 0029831167 scopus 로고    scopus 로고
    • Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002
    • G.J. Brunn, J. Williams, C. Sabers, G. Wiederrecht, J.C. Lawrence Jr., and R.T. Abraham Direct inhibition of the signaling functions of the mammalian target of rapamycin by the phosphoinositide 3-kinase inhibitors, wortmannin and LY294002 EMBO J. 15 1996 5256 5267
    • (1996) EMBO J. , vol.15 , pp. 5256-5267
    • Brunn, G.J.1    Williams, J.2    Sabers, C.3    Wiederrecht, G.4    Lawrence Jr., J.C.5    Abraham, R.T.6
  • 5
    • 0029118603 scopus 로고
    • Wortmannin as a unique probe for an intracellular signaling protein, phosphoinositide-3-kinase
    • M. Ui, T. Okada, K. Hazeki, and O. Hazeki Wortmannin as a unique probe for an intracellular signaling protein, phosphoinositide-3-kinase Trends Biochem. Sci. 20 1995 303 307
    • (1995) Trends Biochem. Sci. , vol.20 , pp. 303-307
    • Ui, M.1    Okada, T.2    Hazeki, K.3    Hazeki, O.4
  • 6
    • 0029965452 scopus 로고    scopus 로고
    • Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction
    • M.P. Wymann, G. Bulgarelli-Leva, M.J. Zvelebil, L. Pirola, B. Vanhaesebroeck, M.D. Waterfield, and G. Panayotou Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction Mol. Cell. Biol. 16 1996 1722 1733
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 1722-1733
    • Wymann, M.P.1    Bulgarelli-Leva, G.2    Zvelebil, M.J.3    Pirola, L.4    Vanhaesebroeck, B.5    Waterfield, M.D.6    Panayotou, G.7
  • 7
    • 0027374488 scopus 로고
    • Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells
    • H. Yano, S. Nakanishi, K. Kimura, N. Hanai, Y. Saitoh, Y. Fukui, Y. Nonomura, and Y. Matsuda Inhibition of histamine secretion by wortmannin through the blockade of phosphatidylinositol 3-kinase in RBL-2H3 cells J. Biol. Chem. 268 1993 25846 25856
    • (1993) J. Biol. Chem. , vol.268 , pp. 25846-25856
    • Yano, H.1    Nakanishi, S.2    Kimura, K.3    Hanai, N.4    Saitoh, Y.5    Fukui, Y.6    Nonomura, Y.7    Matsuda, Y.8
  • 8
    • 0027432424 scopus 로고
    • Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: The role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses
    • A. Arcaro, and M.P. Wymann Wortmannin is a potent phosphatidylinositol 3-kinase inhibitor: the role of phosphatidylinositol 3,4,5-trisphosphate in neutrophil responses Biochem. J. 296 1993 297 301
    • (1993) Biochem. J. , vol.296 , pp. 297-301
    • Arcaro, A.1    Wymann, M.P.2
  • 9
    • 0029067502 scopus 로고
    • Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of phosphatidylinositol 3-kinase in insulin-induced Xenopus oocyte maturation
    • X.J. Liu, A. Sorisky, L. Zhu, and T. Pawson Molecular cloning of an amphibian insulin receptor substrate 1-like cDNA and involvement of phosphatidylinositol 3-kinase in insulin-induced Xenopus oocyte maturation Mol. Cell. Biol. 15 1995 3563 3570
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3563-3570
    • Liu, X.J.1    Sorisky, A.2    Zhu, L.3    Pawson, T.4
  • 10
    • 2442653876 scopus 로고    scopus 로고
    • Neomycin prevents the wortmannin inhibition of insulin-stimulated Glut4 translocation and glucose transport in 3T3-L1 adipocytes
    • D.J. James, C. Salaun, F.M. Brandie, J.M. Connell, and L.H. Chamberlain Neomycin prevents the wortmannin inhibition of insulin-stimulated Glut4 translocation and glucose transport in 3T3-L1 adipocytes J. Biol. Chem. 279 2004 20567 20570
    • (2004) J. Biol. Chem. , vol.279 , pp. 20567-20570
    • James, D.J.1    Salaun, C.2    Brandie, F.M.3    Connell, J.M.4    Chamberlain, L.H.5
  • 11
    • 0037127066 scopus 로고    scopus 로고
    • Organogenesis-heart and blood formation from the zebrafish point of view
    • C. Thisse, and L.I. Zon Organogenesis-heart and blood formation from the zebrafish point of view Science 295 2003 457 462
    • (2003) Science , vol.295 , pp. 457-462
    • Thisse, C.1    Zon, L.I.2
  • 12
    • 0035834358 scopus 로고    scopus 로고
    • Zebrafish-the canonical vertebrate
    • M.C. Fishman Zebrafish-the canonical vertebrate Science 294 2001 1290 1291
    • (2001) Science , vol.294 , pp. 1290-1291
    • Fishman, M.C.1
  • 17
    • 1642318780 scopus 로고    scopus 로고
    • Fibronectin regulates epithelial organization during myocardial migration in zebrafish
    • L.A. Trinh, and D.Y. Stainier Fibronectin regulates epithelial organization during myocardial migration in zebrafish Dev. Cell 6 2004 371 382
    • (2004) Dev. Cell , vol.6 , pp. 371-382
    • Trinh, L.A.1    Stainier, D.Y.2
  • 18
    • 0035221107 scopus 로고    scopus 로고
    • Zebrafish genetics and vertebrate heart formation
    • D.Y. Stainier Zebrafish genetics and vertebrate heart formation Nat. Rev. Genet. 2 2001 39 48
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 39-48
    • Stainier, D.Y.1
  • 22
    • 0033215267 scopus 로고    scopus 로고
    • Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish
    • D. Yelon, S.A. Home, and D.Y. Stainier Restricted expression of cardiac myosin genes reveals regulated aspects of heart tube assembly in zebrafish Dev. Biol. 214 1999 23 37
    • (1999) Dev. Biol. , vol.214 , pp. 23-37
    • Yelon, D.1    Home, S.A.2    Stainier, D.Y.3
  • 23
    • 0346602694 scopus 로고    scopus 로고
    • Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish
    • E. Berdougo, H. Coleman, D.H. Lee, D.Y. Stainier, and D. Yelon Mutation of weak atrium/atrial myosin heavy chain disrupts atrial function and influences ventricular morphogenesis in zebrafish Development 130 2003 6121 6129
    • (2003) Development , vol.130 , pp. 6121-6129
    • Berdougo, E.1    Coleman, H.2    Lee, D.H.3    Stainier, D.Y.4    Yelon, D.5
  • 24
    • 0029924872 scopus 로고    scopus 로고
    • Lysophosphatidic acid stimulates glucose transport in Xenopus oocytes via a phosphatidylinositol 3′-kinase with distinct properties
    • F.J. Thomson, C. Moyes, P.H. Scott, R. Plevin, and G.W. Gould Lysophosphatidic acid stimulates glucose transport in Xenopus oocytes via a phosphatidylinositol 3′-kinase with distinct properties Biochem. J. 316 1996 161 166
    • (1996) Biochem. J. , vol.316 , pp. 161-166
    • Thomson, F.J.1    Moyes, C.2    Scott, P.H.3    Plevin, R.4    Gould, G.W.5
  • 26
    • 0036527350 scopus 로고    scopus 로고
    • Dissection of angiogenic signaling in zebrafish using a chemical genetic approach
    • J. Chan, P.E. Bayliss, J.M. Wood, and T.M. Roberts Dissection of angiogenic signaling in zebrafish using a chemical genetic approach Cancer Cell 1 2002 257 267
    • (2002) Cancer Cell , vol.1 , pp. 257-267
    • Chan, J.1    Bayliss, P.E.2    Wood, J.M.3    Roberts, T.M.4
  • 27
    • 12144273121 scopus 로고    scopus 로고
    • In vivo drug discovery in the zebrafish
    • L.I. Zon, and R.T. Peterson In vivo drug discovery in the zebrafish Nat. Rev. Drug Discov. 4 2005 35 44
    • (2005) Nat. Rev. Drug Discov. , vol.4 , pp. 35-44
    • Zon, L.I.1    Peterson, R.T.2
  • 28
    • 0034700166 scopus 로고    scopus 로고
    • Small molecule developmental screens reveal the logic and timing of vertebrate development
    • R.T. Peterson, B.A. Link, J.E. Dowling, and S.L. Schreiber Small molecule developmental screens reveal the logic and timing of vertebrate development Proc. Natl. Acad. Sci. USA 97 2000 12965 12969
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 12965-12969
    • Peterson, R.T.1    Link, B.A.2    Dowling, J.E.3    Schreiber, S.L.4
  • 29
    • 0038010068 scopus 로고    scopus 로고
    • Chemical genetics: Adding to the developmental biology toolbox
    • J.R. Yeh, and C.M. Crews Chemical genetics: adding to the developmental biology toolbox Dev. Cell 5 2003 11 19
    • (2003) Dev. Cell , vol.5 , pp. 11-19
    • Yeh, J.R.1    Crews, C.M.2
  • 30
    • 0033780376 scopus 로고    scopus 로고
    • Effective targeted gene "knockdown" in zebrafish
    • A. Nasevicius, and S.C. Ekker Effective targeted gene "knockdown" in zebrafish Nat. Genet. 26 2000 216 220
    • (2000) Nat. Genet. , vol.26 , pp. 216-220
    • Nasevicius, A.1    Ekker, S.C.2
  • 32
    • 0041817808 scopus 로고    scopus 로고
    • Zebrafish: A new model on the pharmaceutical catwalk
    • U. Langheinrich Zebrafish: a new model on the pharmaceutical catwalk Bioessays 25 2003 904 912
    • (2003) Bioessays , vol.25 , pp. 904-912
    • Langheinrich, U.1
  • 33
    • 0035876418 scopus 로고    scopus 로고
    • Bmp2b and Oep promote early myocardial differentiation through their regulation of gata5
    • J.F. Reiter, H. Verkade, and D.Y. Stainier Bmp2b and Oep promote early myocardial differentiation through their regulation of gata5 Dev. Biol. 234 2001 330 338
    • (2001) Dev. Biol. , vol.234 , pp. 330-338
    • Reiter, J.F.1    Verkade, H.2    Stainier, D.Y.3
  • 34
    • 0034657309 scopus 로고    scopus 로고
    • The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors
    • Y. Kikuchi, L.A. Trinh, J.F. Reiter, J. Alexander, D. Yelon, and D.Y. Stainier The zebrafish bonnie and clyde gene encodes a Mix family homeodomain protein that regulates the generation of endodermal precursors Genes Dev. 14 2000 1279 1289
    • (2000) Genes Dev. , vol.14 , pp. 1279-1289
    • Kikuchi, Y.1    Trinh, L.A.2    Reiter, J.F.3    Alexander, J.4    Yelon, D.5    Stainier, D.Y.6
  • 35
    • 14344254476 scopus 로고    scopus 로고
    • Inhibition of wortmannin activities by amino compounds
    • M. Isosaki Inhibition of wortmannin activities by amino compounds Biochem. Biophys. Res. Commun. 324 2004 1406 1412
    • (2004) Biochem. Biophys. Res. Commun. , vol.324 , pp. 1406-1412
    • Isosaki, M.1
  • 37
    • 0028287427 scopus 로고
    • Effect of myosin light chain kinase inhibitor wortmannin on the wound repair of cultured gastric mucosal cells
    • S. Watanabe, X.E. Wang, M. Hirose, and N. Sato Effect of myosin light chain kinase inhibitor wortmannin on the wound repair of cultured gastric mucosal cells Biochem. Biophys. Res. Commun. 199 1994 799 806
    • (1994) Biochem. Biophys. Res. Commun. , vol.199 , pp. 799-806
    • Watanabe, S.1    Wang, X.E.2    Hirose, M.3    Sato, N.4
  • 39
    • 0034532378 scopus 로고    scopus 로고
    • ML-7, chelerythrine and phorbol ester increase outflow facility in the monkey eye
    • B. Tian, L.C. Brumback, and P.L. Kaufman ML-7, chelerythrine and phorbol ester increase outflow facility in the monkey eye Exp. Eye Res. 71 2000 551 566
    • (2000) Exp. Eye Res. , vol.71 , pp. 551-566
    • Tian, B.1    Brumback, L.C.2    Kaufman, P.L.3
  • 40
    • 11144311152 scopus 로고    scopus 로고
    • Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium
    • M. Grimm, P. Haas, B. Willipinski-Stapelfeldt, W.H. Zimmermann, T. Rau, K. Pantel, M. Weyand, and T. Eschenhagen Key role of myosin light chain (MLC) kinase-mediated MLC2a phosphorylation in the alpha 1-adrenergic positive inotropic effect in human atrium Cardiovasc. Res. 65 2005 211 220
    • (2005) Cardiovasc. Res. , vol.65 , pp. 211-220
    • Grimm, M.1    Haas, P.2    Willipinski-Stapelfeldt, B.3    Zimmermann, W.H.4    Rau, T.5    Pantel, K.6    Weyand, M.7    Eschenhagen, T.8
  • 41
    • 12344256951 scopus 로고    scopus 로고
    • Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase
    • Y. Liu, K.R. Shreder, W. Gai, S. Corral, D.K. Ferris, and J.S. Rosenblum Wortmannin, a widely used phosphoinositide 3-kinase inhibitor, also potently inhibits mammalian polo-like kinase Chem. Biol. 12 2005 99 107
    • (2005) Chem. Biol. , vol.12 , pp. 99-107
    • Liu, Y.1    Shreder, K.R.2    Gai, W.3    Corral, S.4    Ferris, D.K.5    Rosenblum, J.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.