-
2
-
-
0033952703
-
Tlr4: Central component of the sole mammalian LPS sensor
-
B. Beutler, Tlr4: central component of the sole mammalian LPS sensor, Curr. Opin. Immunol. 12 (2000) 20-26.
-
(2000)
Curr. Opin. Immunol.
, vol.12
, pp. 20-26
-
-
Beutler, B.1
-
3
-
-
0036301797
-
Essential role of MD-2 in LPS responsiveness and TLR4 distribution
-
Y. Nagai, S. Akashi, M. Nagafuku, M. Ogata, Y. Iwakura, S. Akira, T. Kitamura, A. Kosugi, M. Kimoto, K. Miyake, Essential role of MD-2 in LPS responsiveness and TLR4 distribution, Nat. Immunol. 3 (2002) 667-672.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 667-672
-
-
Nagai, Y.1
Akashi, S.2
Nagafuku, M.3
Ogata, M.4
Iwakura, Y.5
Akira, S.6
Kitamura, T.7
Kosugi, A.8
Kimoto, M.9
Miyake, K.10
-
4
-
-
0034610291
-
The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors
-
A. Ozinsky, D.M. Underhill, J.D. Fontenot, A.M. Hajjar, K.D. Smith, C.B. Wilson, et al., The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors, Proc. Natl. Acad. Sci. USA 97 (2000) 13766-13771.
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 13766-13771
-
-
Ozinsky, A.1
Underhill, D.M.2
Fontenot, J.D.3
Hajjar, A.M.4
Smith, K.D.5
Wilson, C.B.6
-
5
-
-
0034922923
-
Discrimination of bacterial lipoproteins by Toll-like receptor 6
-
O. Takeuchi, T. Kawai, P.F. Muhlradt, M. Morr, J.D. Radolf, A. Zychlinsky, K. Takeda, S. Akira, Discrimination of bacterial lipoproteins by Toll-like receptor 6, Int. Immunol. 13 (2001) 933-940.
-
(2001)
Int. Immunol.
, vol.13
, pp. 933-940
-
-
Takeuchi, O.1
Kawai, T.2
Muhlradt, P.F.3
Morr, M.4
Radolf, J.D.5
Zychlinsky, A.6
Takeda, K.7
Akira, S.8
-
6
-
-
0021256125
-
Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity
-
T. Tokunaga, H. Yamamoto, S. Shimada, H. Abe, T. Fukuda, Y. Fujisawa, et al., Antitumor activity of deoxyribonucleic acid fraction from Mycobacterium bovis BCG. I. Isolation, physicochemical characterization, and antitumor activity, J. Natl. Cancer Inst. 72 (1984) 955-962.
-
(1984)
J. Natl. Cancer Inst.
, vol.72
, pp. 955-962
-
-
Tokunaga, T.1
Yamamoto, H.2
Shimada, S.3
Abe, H.4
Fukuda, T.5
Fujisawa, Y.6
-
7
-
-
0034619794
-
A Toll-like receptor recognizes bacterial DNA
-
H. Hemmi, O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, H. Sanjo, et al., A Toll-like receptor recognizes bacterial DNA, Nature 408 (2000) 740-745.
-
(2000)
Nature
, vol.408
, pp. 740-745
-
-
Hemmi, H.1
Takeuchi, O.2
Kawai, T.3
Kaisho, T.4
Sato, S.5
Sanjo, H.6
-
8
-
-
0036008014
-
Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
-
H. Hemmi, T. Kaisho, O. Takeuchi, S. Sato, H. Sanjo, K. Hoshino, T. Horiuchi, H. Tomizawa, K. Takeda, S. Akira, Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway, Nat. Immunol. 3 (2002) 196-200.
-
(2002)
Nat. Immunol.
, vol.3
, pp. 196-200
-
-
Hemmi, H.1
Kaisho, T.2
Takeuchi, O.3
Sato, S.4
Sanjo, H.5
Hoshino, K.6
Horiuchi, T.7
Tomizawa, H.8
Takeda, K.9
Akira, S.10
-
9
-
-
1542317550
-
Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
-
S.S. Diebold, T. Kaisho, H. Hemmi, S. Akira, E.S.C. Reis, Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA, Science 303 (2004) 1529-1531.
-
(2004)
Science
, vol.303
, pp. 1529-1531
-
-
Diebold, S.S.1
Kaisho, T.2
Hemmi, H.3
Akira, S.4
Reis, E.S.C.5
-
10
-
-
1542317578
-
Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
-
F. Heil, H. Hemmi, H. Hochrein, F. Ampenberger, C. Kirschning, S. Akira, G. Lipford, H. Wagner, S. Bauer, Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8, Science 303 (2004) 1526-1529.
-
(2004)
Science
, vol.303
, pp. 1526-1529
-
-
Heil, F.1
Hemmi, H.2
Hochrein, H.3
Ampenberger, F.4
Kirschning, C.5
Akira, S.6
Lipford, G.7
Wagner, H.8
Bauer, S.9
-
11
-
-
0035909372
-
Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
-
L. Alexopoulou, A.C. Holt, R. Medzhitov, R.A. Flavell, Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3, Nature 413 (2001) 732-738.
-
(2001)
Nature
, vol.413
, pp. 732-738
-
-
Alexopoulou, L.1
Holt, A.C.2
Medzhitov, R.3
Flavell, R.A.4
-
12
-
-
0347146027
-
Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways
-
K. Hoebe, E.M. Janssen, S.O. Kim, L. Alexopoulou, R.A. Flavell, J. Han, B. Beutler, Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways, Nat. Immunol. 4 (2003) 1223-1229.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 1223-1229
-
-
Hoebe, K.1
Janssen, E.M.2
Kim, S.O.3
Alexopoulou, L.4
Flavell, R.A.5
Han, J.6
Beutler, B.7
-
13
-
-
0035953543
-
The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5
-
F. Hayashi, K.D. Smith, A. Ozinsky, T.R. Hawn, E.G. Yi, D.R. Goodlett, J.K. Eng, S. Akira, D.M. Underhill, A. Aderem, The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5, Nature 410 (2001) 1099-1103.
-
(2001)
Nature
, vol.410
, pp. 1099-1103
-
-
Hayashi, F.1
Smith, K.D.2
Ozinsky, A.3
Hawn, T.R.4
Yi, E.G.5
Goodlett, D.R.6
Eng, J.K.7
Akira, S.8
Underhill, D.M.9
Aderem, A.10
-
14
-
-
1542377424
-
A toll-like receptor that prevents infection by uropathogenic bacteria
-
D. Zhang, G. Zhang, M.S. Hayden, M.B. Greenblatt, C. Bussey, R.A. Flavell, S. Ghosh, A toll-like receptor that prevents infection by uropathogenic bacteria, Science 303 (2004) 1522-1526.
-
(2004)
Science
, vol.303
, pp. 1522-1526
-
-
Zhang, D.1
Zhang, G.2
Hayden, M.S.3
Greenblatt, M.B.4
Bussey, C.5
Flavell, R.A.6
Ghosh, S.7
-
15
-
-
0036518287
-
Mouse and human dendritic cell subtypes
-
K. Shortman, Y.J. Liu, Mouse and human dendritic cell subtypes, Nat. Rev. Immunol. 2 (2002) 151-161.
-
(2002)
Nat. Rev. Immunol.
, vol.2
, pp. 151-161
-
-
Shortman, K.1
Liu, Y.J.2
-
16
-
-
0036775463
-
IRAK-4 as the central TIR signaling mediator in innate immunity
-
[ 16] N. Suzuki, S. Suzuki, W.C. Yeh, IRAK-4 as the central TIR signaling mediator in innate immunity, Trends Immunol. 23 (2002) 503-506.
-
(2002)
Trends Immunol.
, vol.23
, pp. 503-506
-
-
Suzuki, N.1
Suzuki, S.2
Yeh, W.C.3
-
17
-
-
0037471003
-
Pyogenic bacterial infections in humans with IRAK-4 deficiency
-
C. Picard, A. Puel, M. Bonnet, C.L. Ku, J. Bustamante, K. Yang, C. Soudais, S. Dupuis, J. Feinberg, C. Fieschi, C. Elbim, R. Hitchcock, D. Lammas, G. Davies, A. Al-Ghonaium, H. Al-Rayes, S. Al-Jumaah, S. Al-Hajjar, I.Z. Al-Mohsen, H.H. Frayha, R. Rucker, T.R. Hawn, A. Aderem, H. Tufenkeji, S. Haraguchi, N.K. Day, R.A. Good, M.A. Gougerot-Pocidalo, A. Ozinsky, J.L. Casanova, Pyogenic bacterial infections in humans with IRAK-4 deficiency, Science 299 (2003) 2076-2079.
-
(2003)
Science
, vol.299
, pp. 2076-2079
-
-
Picard, C.1
Puel, A.2
Bonnet, M.3
Ku, C.L.4
Bustamante, J.5
Yang, K.6
Soudais, C.7
Dupuis, S.8
Feinberg, J.9
Fieschi, C.10
Elbim, C.11
Hitchcock, R.12
Lammas, D.13
Davies, G.14
Al-Ghonaium, A.15
Al-Rayes, H.16
Al-Jumaah, S.17
Al-Hajjar, S.18
Al-Mohsen, I.Z.19
Frayha, H.H.20
Rucker, R.21
Hawn, T.R.22
Aderem, A.23
Tufenkeji, H.24
Haraguchi, S.25
Day, N.K.26
Good, R.A.27
Gougerot-Pocidalo, M.A.28
Ozinsky, A.29
Casanova, J.L.30
more..
-
18
-
-
0033166472
-
Unresponsiveness of MyD88-deficient mice to endotoxin
-
T. Kawai, O. Adachi, T. Ogawa, K. Takeda, S. Akira, Unresponsiveness of MyD88-deficient mice to endotoxin, Immunity 11 (1999) 115-122.
-
(1999)
Immunity
, vol.11
, pp. 115-122
-
-
Kawai, T.1
Adachi, O.2
Ogawa, T.3
Takeda, K.4
Akira, S.5
-
19
-
-
0035339861
-
Endotoxin-induced maturation of MyD88-deficient dendritic cells
-
T. Kaisho, O. Takeuchi, T. Kawai, K. Hoshino, S. Akira, Endotoxin-induced maturation of MyD88-deficient dendritic cells, J. Immunol. 166 (2001) 5688-5694.
-
(2001)
J. Immunol.
, vol.166
, pp. 5688-5694
-
-
Kaisho, T.1
Takeuchi, O.2
Kawai, T.3
Hoshino, K.4
Akira, S.5
-
20
-
-
0036312668
-
Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation
-
T. Kaisho, K. Hoshino, T. Iwabe, O. Takeuchi, T. Yasui, S. Akira, Endotoxin can induce MyD88-deficient dendritic cells to support T(h)2 cell differentiation, Int. Immunol. 14 (2002) 695-700.
-
(2002)
Int. Immunol.
, vol.14
, pp. 695-700
-
-
Kaisho, T.1
Hoshino, K.2
Iwabe, T.3
Takeuchi, O.4
Yasui, T.5
Akira, S.6
-
21
-
-
0037121946
-
Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen
-
S.C. Eisenbarth, D.A. Piggott, J.W. Huleatt, I. Visintin, C.A. Herrick, K. Bottomly, Lipopolysaccharide-enhanced, toll-like receptor 4-dependent T helper cell type 2 responses to inhaled antigen, J. Exp. Med. 196 (2002) 1645-1651.
-
(2002)
J. Exp. Med.
, vol.196
, pp. 1645-1651
-
-
Eisenbarth, S.C.1
Piggott, D.A.2
Huleatt, J.W.3
Visintin, I.4
Herrick, C.A.5
Bottomly, K.6
-
22
-
-
0035889228
-
Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes
-
T. Kawai, O. Takeuchi, T. Fujita, J. Inoue, P.P. Muhlradt, S. Sato, K. Hoshino, S. Akira, Lipopolysaccharide stimulates the MyD88-independent pathway and results in activation of IFN-regulatory factor 3 and the expression of a subset of lipopolysaccharide-inducible genes, J. Immunol. 167 (2001) 5887-5894.
-
(2001)
J. Immunol.
, vol.167
, pp. 5887-5894
-
-
Kawai, T.1
Takeuchi, O.2
Fujita, T.3
Inoue, J.4
Muhlradt, P.P.5
Sato, S.6
Hoshino, K.7
Akira, S.8
-
23
-
-
0037153191
-
Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4
-
M. Yamamoto, S. Sato, H. Hemmi, H. Sanjo, S. Uematsu, T. Kaisho, K. Hoshino, O. Takeuchi, M. Kobayashi, T. Fujita, K. Takeda, S. Akira, Essential role for TIRAP in activation of the signalling cascade shared by TLR2 and TLR4, Nature 420 (2002) 324-329.
-
(2002)
Nature
, vol.420
, pp. 324-329
-
-
Yamamoto, M.1
Sato, S.2
Hemmi, H.3
Sanjo, H.4
Uematsu, S.5
Kaisho, T.6
Hoshino, K.7
Takeuchi, O.8
Kobayashi, M.9
Fujita, T.10
Takeda, K.11
Akira, S.12
-
24
-
-
0043176281
-
Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway
-
M. Yamamoto, S. Sato, H. Hemmi, K. Hoshino, T. Kaisho, H. Sanjo, O. Takeuchi, M. Sugiyama, M. Okabe, K. Takeda, S. Akira, Role of adaptor TRIF in the MyD88-independent toll-like receptor signaling pathway, Science 301 (2003) 640-643.
-
(2003)
Science 301
, pp. 640-643
-
-
Yamamoto, M.1
Sato, S.2
Hemmi, H.3
Hoshino, K.4
Kaisho, T.5
Sanjo, H.6
Takeuchi, O.7
Sugiyama, M.8
Okabe, M.9
Takeda, K.10
Akira, S.11
-
25
-
-
0042679529
-
Identification of Lps2 as a key transducer of MyD88-independent TIR signalling
-
K. Hoebe, X. Du, P. Georgel, E. Janssen, K. Tabeta, S.O. Kim, J. Goode, P. Lin, N. Mann, S. Mudd, K. Crozat, S. Sovath, J. Han, B. Beutler, Identification of Lps2 as a key transducer of MyD88-independent TIR signalling, Nature 424 (2003) 743-748.
-
(2003)
Nature
, vol.424
, pp. 743-748
-
-
Hoebe, K.1
Du, X.2
Georgel, P.3
Janssen, E.4
Tabeta, K.5
Kim, S.O.6
Goode, J.7
Lin, P.8
Mann, N.9
Mudd, S.10
Crozat, K.11
Sovath, S.12
Han, J.13
Beutler, B.14
-
26
-
-
0038393016
-
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway
-
K.A. Fitzgerald, S.M. McWhirter, K.L. Faia, D.C. Rowe, E. Latz, D.T. Golenbock, A.J. Coyle, S.M. Liao, T. Maniatis, IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway, Nat. Immunol. 4 (2003) 491-496.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 491-496
-
-
Fitzgerald, K.A.1
McWhirter, S.M.2
Faia, K.L.3
Rowe, D.C.4
Latz, E.5
Golenbock, D.T.6
Coyle, A.J.7
Liao, S.M.8
Maniatis, T.9
-
27
-
-
0038363463
-
Triggering the interferon antiviral response through an IKK-related pathway
-
S. Sharma, B.R. TenOever, N. Grandvaux, O.P. Zhou, R. Lin, J. Hiscott, Triggering the interferon antiviral response through an IKK-related pathway, Science 300 (2003) 1148-1151.
-
(2003)
Science
, vol.300
, pp. 1148-1151
-
-
Sharma, S.1
Tenoever, B.R.2
Grandvaux, N.3
Zhou, O.P.4
Lin, R.5
Hiscott, J.6
-
28
-
-
0345827590
-
From the cover: IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts
-
S.M. McWhirter, K.A. Fitzgerald, J. Rosains, D.C. Rowe, D.T. Golenbock, T. Maniatis, From the cover: IFN-regulatory factor 3-dependent gene expression is defective in Tbk1-deficient mouse embryonic fibroblasts, Proc. Natl. Acad. Sci. USA 101 (2004) 233-238.
-
(2004)
Proc. Natl. Acad. Sci. USA
, vol.101
, pp. 233-238
-
-
McWhirter, S.M.1
Fitzgerald, K.A.2
Rosains, J.3
Rowe, D.C.4
Golenbock, D.T.5
Maniatis, T.6
-
29
-
-
0242624622
-
TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway
-
M. Yamamoto, S. Sato, H. Hemmi, S. Uematsu, K. Hoshino, T. Kaisho, O. Takeuchi, K. Takeda, S. Akira, TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway, Nat. Immunol. 4 (2003) 1144-1150.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 1144-1150
-
-
Yamamoto, M.1
Sato, S.2
Hemmi, H.3
Uematsu, S.4
Hoshino, K.5
Kaisho, T.6
Takeuchi, O.7
Takeda, K.8
Akira, S.9
-
30
-
-
0034933019
-
Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells
-
A. Krug, S. Rothenfusser, V. Hornung, B. Jahrsdorfer, S. Blackwell, Z.K. Ballas, S. Endres, A.M. Krieg, G. Hartmann, Identification of CpG oligonucleotide sequences with high induction of IFN-alpha/beta in plasmacytoid dendritic cells, Eur. J. Immunol. 31 (2001) 2154-2163.
-
(2001)
Eur. J. Immunol.
, vol.31
, pp. 2154-2163
-
-
Krug, A.1
Rothenfusser, S.2
Hornung, V.3
Jahrsdorfer, B.4
Blackwell, S.5
Ballas, Z.K.6
Endres, S.7
Krieg, A.M.8
Hartmann, G.9
-
31
-
-
0035865054
-
Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs
-
D. Verthelyi, K.J. Ishii, M. Gursel, F. Takeshita, D.M. Klinman, Human peripheral blood cells differentially recognize and respond to two distinct CPG motifs, J. Immunol. 166 (2001) 2372-2377.
-
(2001)
J. Immunol.
, vol.166
, pp. 2372-2377
-
-
Verthelyi, D.1
Ishii, K.J.2
Gursel, M.3
Takeshita, F.4
Klinman, D.M.5
-
32
-
-
0037443644
-
The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets
-
H. Hemmi, T. Kaisho, K. Takeda, S. Akira, The roles of Toll-like receptor 9, MyD88, and DNA-dependent protein kinase catalytic subunit in the effects of two distinct CpG DNAs on dendritic cell subsets, J. Immunol. 170 (2003) 3059-3064.
-
(2003)
J. Immunol.
, vol.170
, pp. 3059-3064
-
-
Hemmi, H.1
Kaisho, T.2
Takeda, K.3
Akira, S.4
-
33
-
-
0038624558
-
NODs: Intracellular proteins involved in inflammation and apoptosis
-
N. Inohara, G. Nunez, NODs: intracellular proteins involved in inflammation and apoptosis, Nat. Rev. Immunol. 3 (2003) 371-382.
-
(2003)
Nat. Rev. Immunol.
, vol.3
, pp. 371-382
-
-
Inohara, N.1
Nunez, G.2
|