Subcellular localisation of Cdc25A determines cell fate

Cell Death and Differentiation

Volumn 11, Issue 1, 2004, Pages 80-89

  Leisser, C ^a   Rosenberger, G ^a   Maier, S ^a   Fuhrmann, G ^a   Grusch, M ^a   Strasser, S ^a   Huettenbrenner, S ^a   Fassl, S ^a   Polgar, D ^a   Krieger, S ^a   Cerni, C ^b   Hofer Warbinek, R ^a   deMartin, R ^a   Krupitza, G ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Apoptosis; Cdc25A; FKHRL1; Subcellular distribution

Indexed keywords

BIM PROTEIN; CELL CYCLE PROTEIN; CELL CYCLE PROTEIN 25A; ESTROGEN RECEPTOR; FAS LIGAND; HYBRID PROTEIN; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL FATE; CELL SPECIFICITY; CELL TYPE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; ONCOGENE; OVARY CARCINOMA; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN TARGETING; PROTEIN TRANSPORT; RAT;

ANIMALS; APOPTOSIS; ARTIFICIAL GENE FUSION; CDC25 PHOSPHATASE; CELL COMPARTMENTATION; CELL LINE, TUMOR; CELL NUCLEUS; DNA-BINDING PROTEINS; FORKHEAD TRANSCRIPTION FACTORS; GENETIC VECTORS; HUMANS; RATS; RECEPTORS, ESTROGEN; RECOMBINANT PROTEINS; TRANSCRIPTION FACTORS; TRANSFORMATION, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA;

EID: 1642514762     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401318     Document Type: Article

References (44)

1. Hernandez S, Hernandez L, Bea S, Pinyol M, Nayach I, Bellosillo B, Nadal A, Ferrer A, Fernandez PL, Montserrat E, Cardesa A and Campo E (2000) cdc25a and the splicing variant cdc25b2, but not cdc25B1, -B3 or -C, are overexpressed in aggressive human non-Hodgkin's lymphomas. Int. J. Cancer 89: 148-152
2. Gasparotto D, Maestro R, Piccinin S, Vukosavljevic T, Barzan L, Sulfaro S and Boiocchi M (1997) Overexpression of CDC25A and CDC25B in head and neck cancers. Cancer Res. 57: 2366-2368
3. Cangi MG, Cukor B, Soung P, Signoretti S, Moreira Jr G, Ranashinge M, Cady B, Pagano M and Loda M (2000) Role of the Cdc25A phosphatase in human breast cancer. J. Clin. Invest. 106: 753-761
4. Galaktionov K, Lee AK, Eckstein J, Draetta G, Meckler J, Loda M and Beach D (1995) CDC25 phosphatases as potential human oncogenes. Science 269: 1575-1577
5. Nilsson I and Hoffmann I (2000) Cell cycle regulation by the Cdc25 phosphatase family. Prog. Cell Cycle Res. 4: 107-114
6. Draetta G and Eckstein J (1997) Cdc25 protein phosphatases in cell proliferation. Biochim. Biophys. Acta 1332: M53-M63
7. Takizawa CG and Morgan DO (2000) Control of mitosis by changes in the subcellular location of cyclin-B1-Cdk1 and Cdc25C. Curr. Opin. Cell Biol. 12: 658-665
8. Hoffmann I, Draetta G and Karsenti E (1994) Activation of the phosphatase activity of human cdc25A by a cdk2-cyclin E dependent phosphorylation at the G1/S transition. EMBO J. 13: 4302-4310
9. Sandhu C, Donovan J, Bhattacharya N, Stampfer M, Worland P and Slingerland J (2000) Reduction of Cdc25A contributes to cyclin E1-Cdk2 inhibition at senescence in human mammary epithelial cells. Oncogene 19: 5314-5323
10. Blomberg I and Hoffmann I (1999) Ectopic expression of Cdc25A accelerates the G(1)/S transition and leads to premature activation of cyclin E- and cyclin A-dependent kinases. Mol. Cell. Biol. 19: 6183-6194
11. Jinno S, Suto K, Nagata A, Igarashi M, Kanaoka Y, Nojima H and Okayama H (1994) Cdc25A is a novel phosphatase functioning early in the cell cycle. EMBO J. 13: 1549-1556
12. Sexl V, Diehl JA, Sherr CJ, Ashmun R, Beach D and Roussel MF (1999) A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2. Oncogene 18: 573-582
13. Gu Y, Rosenblatt J and Morgan DO (1992) Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. EMBO J. 11: 3995-4005
14. Saha P, Eichbaum Q, Silberman ED, Mayer BJ and Dutla A (1997) p21CIP1 and Cdc25A: competition between an inhibitor and an activator of cyclin-dependent kinases. Mol. Cell. Biol. 17: 4338-4345
15. Mailand N, Falck J, Lukas C, Syljuasen RG, Welcker M, Bartek J and Lukas J (2000) Rapid destruction of human Cdc25A in response to DNA damage. Science 288: 1425-1429
16. Conklin DS, Galaktionov K and Beach D (1995) 14-3-3 proteins associate with cdc25 phosphatases. Proc. Natl. Acad. Sci. USA 92: 7892-7896
17. Galaktionov K, Jessus C and Beach D (1995) Raf1 interaction with Cdc25 phosphatase ties mitogenic signal transduction to cell cycle activation. Genes Dev. 9: 1046-1058
18. Fuhrmann G, Leisser C, Rosenberger G, Grusch M, Huettenbrenner S, Halama T, Mosberger I, Sasgary S, Cerni C and Krupitza G (2001) Cdc25A phosphatase suppresses apoptosis induced by serum deprivation. Oncogene 20: 4542-4553
19. Zou X, Tsutsui T, Ray D, Blomquist JF, Ichijo H, Ucker DS and Kiyokawa H (2001) The cell cycle-regulatory CDC25A phosphatase inhibits apoptosis signal-regulating kinase 1. Mol. Cell. Biol. 21: 4818-4828
20. Rosenberger G (1999) The function of cdc25A in active cell death. Master Thesis, Institute of Clinical Pathology, University of Vienna, Vienna, pp. 1-94
21. Jackson JG, Kreisberg JI, Koterba AP, Yee D and Brattain MG (2000) Phosphorylation and nuclear exclusion of the forkhead transcription factor FKHR after epidermal growth factor treatment in human breast cancer cells. Oncogene 19: 4574-4581
22. Brunet A, Park J, Tran H, Hu LS, Hemmings BA and Greenberg ME (2001) Protein kinase SGK mediates survival signals by phosphorylating the forkhead transcription factor FKHRL1 (FOXO3a). Mol. Cell. Biol. 21: 952-965
23. Brunet A, Bonni A, Zigmond MJ, Lin MZ, Juo P, Hu LS, Anderson MJ, Arden KC, Blenis J and Greenberg ME (1999) Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96: 857-868
24. Rena G, Prescott AR, Guo S, Cohen P and Unterman TG (2001) Roles of the forkhead in rhabdomyosarcoma (FKHR) phosphorylation sites in regulating 14-3-3 binding, transactivation and nuclear targeting. Biochem. J. 354: 605-612
25. Dijkers PF, Medema RH, Pals C, Banerji L, Thomas NS, Lam EW, Burgering BM, Raaijmakers JA, Lammers JW, Koenderman L and Coffer PJ (2000) Forkhead transcription factor FKHR-L1 modulates cytokine-dependent transcriptional regulation of p27(KIP1). Mol. Cell. Biol. 20: 9138-9148
26. Dijkers PF, Medema RH, Lammers JW, Koenderman L and Coffer PJ (2000) Expression of the pro-apoptotic Bcl-2 family member Bim is regulated by the forkhead transcription factor FKHR-L1. Curr. Biol. 10: 1201-1204
27. Stahl M, Dijkers PF, Kops GJ, Lens SM, Coffer PJ, Burgering BM and Medema RH (2002) The forkhead transcription factor FoxO regulates transcription of p27Kip1 and Bim in response to IL-2. J. Immunol. 168: 5024-5031
28. Kops GJ and Burgering BM (1999) Forkhead transcription factors: new insights into protein kinase B (c-akt) signaling. J. Mol. Med. 77: 656-665
29. Dijkers PF, Birkenkamp KU, Lam EW, Thomas NS, Lammers JW, Koenderman L and Coffer PJ (2002) FKHR-L1 can act as a critical effector of cell death induced by cytokine withdrawal: protein kinase B-enhanced cell survival through maintenance of mitochondrial integrity. J. Cell Biol. 156: 531-542
30. Grusch M, Rosenberger G, Fuhrmann G, Braun K, Titscher B, Szekeres T, Fritzer-Skekeres M, Oberhuber G, Krohn K, Hengstschlaeger M, Krupitza G and Jayaram HN (1999) Benzamide riboside induces apoptosis independent of Cdc25A expression in human ovarian carcinoma N.1 cells. Cell Death Differ. 6: 736-744
31. Krupitza G, Grusch M, Braun K, Fuhrmann G, Steinbrugger R, Hulla W, Simonitsch I, Chott A and Hengstschlager M (1998) TNFalpha-mediated cell death is independent of cdc25A. Cell Death Differ. 5: 758-764
32. Fuhrmann G, Rosenberger G, Grusch M, Klein N, Hofmann J and Krupitza G (1999) The MYC dualism in growth and death. Mutat. Res. 437: 205-217
33. Galaktionov K, Chen X and Beach D (1996) Cdc25 cell-cycle phosphatase as a target of c-myc. Nature 382: 511-517
34. Macdonald K and Bennett MR (1999) cdc25A is necessary but not sufficient for optimal c-myc-induced apoptosis and cell proliferation of vascular smooth muscle cells. Circ. Res. 84: 820-830
35. Wijayaratne AL and McDonnell DP (2001) The human estrogen receptor-alpha is a ubiquitinated protein whose stability is affected differentially by agonists, antagonists, and selective estrogen receptor modulators. J. Biol. Chem. 276: 35684-35692
36. Brunet A, Kanai F, Stehn J, Xu J, Sarbassova D, Frangioni JV, Dalal SN, DeCaprio JA, Greenberg ME and Yaffe MB (2002) 14-3-3 transits to the nucleus and participates in dynamic nucleocytoplasmic transport. J. Cell Biol. 156:817-828
37. Nakae J, Barr V and Accili D (2000) Differential regulation of gene expression by insulin and IGF-1 receptors correlates with phosphorylation of a single amino acid residue in the forkhead transcription factor FKHR. EMBO J. 19: 989-996
38. Tang ED, Nunez G, Barr FG and Guan KL (1999) Negative regulation of the forkhead transcription factor FKHR by Akt. J. Biol. Chem. 274: 16741-16746
39. Shin I, Bakin AV, Rodeck U, Brunet A and Arteaga CL (2001) Transforming growth factor beta enhances epithelial cell survival via Akt-dependent regulation of FKHRL1. Mol. Biol. Cell 12: 3328-3339
40. Nakamura N, Ramaswamy S, Vazquez F, Signoretti S, Loda M and Sellers WR (2000) Forkhead transcription factors are critical effectors of cell death and cell cycle arrest downstream of PTEN. Mol. Cell. Biol. 20: 8969-8982
41. Littlewood TD, Hancock DC, Danielian PS, Parker MG and Evan GI (1995) A modified oestrogen receptor ligand-binding domain as an improved switch for the regulation of heterologous proteins. Nucleic Acids Res. 23: 1686-1690
42. Grusch M, Polgar D, Gfatter S, Leuhuber K, Huettenbrenner S, Leisser C, Fuhrmann G, Kassie F, Steinkellner H, Smid K, Peters GJ, Jayaram HN, Klepal W, Szekeres T, Knasmuller S and Krupitza G (2002) Maintenance of ATP favours apoptosis over necrosis triggered by benzamide riboside. Cell Death Differ. 9: 169-178
43. Grusch M, Fritzer-Szekeres M, Fuhrmann G, Rosenberger G, Luxbacher C, Elford HL, Smid K, Peters GJ, Szekeres T and Krupitza G (2001) Activation of caspases and induction of apoptosis by novel ribonucleotide reductase inhibitors amidox and didox. Exp. Hematol. 29: 623-632
44. Rosenberger G, Fuhrmann G, Grusch M, Fassl S, Efford HL, Smid K, Peters GJ, Szekeres T and Krupitza G (2000) The ribonucleotide reductase inhibitor trimidox induces c-myc and apoptosis of human ovarian carcinoma cells. Life Sci. 67: 3131-3142