cdc25A is necessary but not sufficient for optimal c-myc-induced apoptosis and cell proliferation of vascular smooth muscle cells

Circulation Research

Volumn 84, Issue 7, 1999, Pages 820-830

  Macdonald, Kirsty ^a   Bennett, Martin R ^a  

^a ADDENBROOKE S HOSPITAL   (United Kingdom)

Author keywords

Adenovirus; Apoptosis; c myc; Phosphatase; Vascular smooth muscle cell

Indexed keywords

CELL CYCLE PROTEIN; PHOSPHATASE;

ADENOVIRUS; ANIMAL CELL; APOPTOSIS; ARTICLE; ATHEROSCLEROSIS; CELL CYCLE; CELL PROLIFERATION; GENE EXPRESSION; NONHUMAN; ONCOGENE C MYC; PRIORITY JOURNAL; RAT; RESTENOSIS; VASCULAR SMOOTH MUSCLE;

EID: 0033574719     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.84.7.820     Document Type: Article

References (59)

1. Bennett MR, Littlewood T, Schwartz S, Weissberg P. Increased sensitivity of human vascular smooth muscle cells from atherosclerotic plaque to p53-mediated apoptosis. Circ Res. 1997;81:591-599.
2. Yonish RE, Grunwald D, Wilder S, Kimchi A, May E, Lawrence JJ, May P, Oren M. p53-mediated cell death: relationship to cell cycle control. Mol Cell Biol. 1993;13:1415-1423.
3. Johnson N, Gardner A, Diener K, Langecarter C, Gleavy J, Jarpe M, Minden A, Karin M, Zon L, Johnson G. Signal-transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death. J Biol Chem. 1996;271:3229-3237.
4. 3K and PKB. Nature. 1997;385:544-548.
5. Meikrantz W, Gisselbrecht S, Tam SW, Schlegel R. Activation of cyclin A-dependent protein kinases during apoptosis. Proc Natl Acad Sci U S A. 1994;91:3754-3758.
6. kip1 mediates apoptosis in endothelial cells through activation of cdk2: role of a caspase cascade. Mol Cell 1998;1:553-563.
7. Meikrantz W, Schlegel R. Apoptosis and the cell-cycle. J Cell Biochem. 1995;58:160-174.
8. Phillips AC, Bates S, Ryan KM, Helin K, Vousden KH. Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes Dev. 1997;11:1853-1863.
9. Hsieh JK, Fredersdorf S, Kouzarides T, Martin K, Lu X. E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev. 1997;11:1840-1852.
10. DeGregori J, Leone G, Miron A, Jakoi L, Nevins J. Distinct roles for E2F proteins in cell growth control and apoptosis. Proc Natl Acad Sci U S A. 1997;94:7245-7250.
11. Bennett MR, Evan GI, Newby AC. Deregulated c-myc oncogene expression blocks vascular smooth muscle cell inhibition mediated by heparin, interferon-γ, mitogen depletion and cyclic nucleotide analogues and induces apoptotic cell death. Circ Res. 1994;74:525-536.
12. Bennett MR, Evan GI, Schwartz SM. Apoptosis of rat vascular smooth muscle cells is regulated by p53 dependent and independent pathways. Circ Res. 1995;77:266-273.
13. Evan GI, Littlewood TD. The role of c-myc in cell growth. Curr Opin Genet Dev. 1993;3:44-49.
14. Bennett MR, Littlewood TD, Hancock DC, Evan GI, Newby AC. Down-regulation of the c-myc proto-oncogene in inhibition of vascular smooth-muscle cell proliferation: a signal for growth arrest ? Biochem J. 1994; 302:701-708.
15. Miano JM, Tota RR, Vlasic N, Danishefsky KJ, Stemerman MB. Early proto-oncogene expression in rat aortic smooth muscle cells following endothelial removal. Am J Pathol. 1990;137:761-765.
16. Bauters C, de Groote P, Adamantidis M, Delcayre C, Hamon M, Lablanche JM, Bertrand ME, Dupuis B, Swynghedauw B. Proto-oncogene expression in rabbit aorta after wall injury: first marker of the cellular process leading to restenosis after angioplasty? Eur Heart J. 1992;13:556-559.
17. Eilers M, Picard D, Yamamoto K, Bishop J. Chimaeras of Myc oncoprotein and steroid receptors cause hormone-dependent transformation of cells. Nature. 1989;340:66-68.
18. Evan GI, Wyllie AH, Gilbert CS, Littlewood TD, Land H, Brooks M, Waters CM, Penn LZ, Hancock DC. Induction of apoptosis in fibroblasts by c-myc protein. Cell. 1992;69:119-128.
19. Bennett MR, Anglin S, McEwan JR, Jagoe R, Newby AC, Evan GI. Inhibition of vascular smooth muscle cell proliferation in vitro and in vivo by c-myc antisense oligodeoxynucleotides. J Clin Invest. 1994;93: 820-828.
20. Shi Y, Fard A, Galeo A, Hutchinson HG, Vermani P, Dodge GR, Hall DJ, Shaheen F, Zalewski A. Transcatheter delivery of c-myc antisense oligomers reduces neointimal formation in a porcine model of coronary artery balloon injury. Circulation. 1994;90:944-951.
21. Harrington EA, Bennett MR, Fanidi A, Evan GI. c-Myc induced apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J. 1994;13: 3286-3295.
22. Fanidi A, Harrington E, Evan G. Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature. 1992;359:554-556.
23. Bissonnette R, Echeverri F, Mahboubi A, Green D. Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature. 1992;359:552-554.
24. Amati B, Dalton S, Brooks M, Littlewood T, Evan G, Land H. Transcriptional activation by c-Myc oncoprotein in yeast requires interaction with Max. Nature. 1992;359:423-426.
25. Amati B, Brooks M, Levy N, Littlewood T, Evan G, Land H. Oncogenic activity of the c-Myc protein requires dimerization with Max. Cell. 1993;72:233-245.
26. Amati B, Littlewood T, Evan GI, Land H. The c-Myc protein induces cell cycle progression and apoptosis through dimerization with Max. EMBO J. 1993;12:5083-5087.
27. Packham G, Cleveland JL. Ornithine decarboxylase is a mediator of c-Myc-induced apoptosis. Mol Cell Biol. 1994;14:5741-5747.
28. Packham G, Porter C, Cleveland JL. C-myc induces apoptosis and cell cycle progression by separable, yet overlapping, pathways. Oncogene. 1996;13:461-469.
29. Eilers M, Schirm S, Bishop JM. The MYC protein activates transcription of the alpha-prothymosin gene. EMBO J. 1991;10:133-141.
30. Reisman D, Elkind NB, Roy B, Beamon J, Rotter V. c-Myc trans-activates the p53 promoter through a required downstream CACGTG motif. Cell Growth Differ. 1993;4:57-65.
31. Galaktionov K, Chen X, Beach D. Cdc25 cell-cycle phosphatase as a target of c-myc. Nature. 1996;382:511-517.
32. Leng X, Connell-Crowley L, Goodrich D, Harper J. S-phase entry upon ectopic expression of G1 cyclin dependent kinases in the absence of retinoblastoma protein phosphorylation. Curr Biol. 1997;7:709-712.
33. Zhao J, Dynlacht B, Imai T, Hori T, Harlow E. Expression of NPAT, a novel substrate of cyclin E-CDK2, promotes S-phase entry. Genes Dev. 1998;12:456-461.
34. 1 cyclin-cdk complexes. EMBO J. 1995;14: 4814-4826.
35. Alarcon RM, Rupnow BA, Graeber TG, Knox SJ, Giaccia AJ. Modulation of c-myc activity and apoptosis in-vivo. Cancer Res. 1996;56: 4315-4319.
36. Jinno S, Suto K, Nagata A, Igarashi M, Kanaoka Y, Nojima H, Okayama H. Cdc25a is a novel phosphatase functioning early in the cell-cycle. EMBO J 1994;13:1549-1556.
37. 1/S transition. EMBO J. 1994;13:4302-4310.
38. Spitkovsky D, Jansendurr P, Karsenti E, Hoffmann I. S-phase induction by adenovirus E1A requires activation of cdc25a tyrosine phosphatase. Oncogene. 1996; 12:2549-2554.
39. Morgenstern J, Land H. Choice and manipulation of retroviral vectors. In: Murray EJ, ed. Gene Transfer and Expression Protocols. Clifton, NJ: The Humana Press Inc; 1991:181-206.
40. Bennett MR, Evan GI, Schwartz SM. Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaques. J Clin Invest. 1995;95:2266-2274.
41. DeGregori J, Kowalik T, Nevins JR. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol Cell Biol. 1995;15:4215-4224.
42. Murry CE, Kay MA, Bartosek T, Hauschka SD, Schwartz SM. Muscle differentiation during repair of myocardial necrosis in rats via genetransfer with MyoD. J Clin Invest. 1996;98:2209-2217.
43. Waters CM, Littlewood TD, Hancock DC, Moore JP, Evan GI. c-myc protein expression in untransformed fibroblasts. Oncogene. 1991;6: 797-805.
44. Hiebert S, Blake J, Azizkhan J, Nevins J. Role of E2F transcription factor in E1A-mediated trans activation of cellular genes. J Virol. 1991;65: 3547-3552.
45. Nevins J. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science. 1992;258:424-429.
46. Lees E, Faha B, Dulic V, Reed SI, Harlow E. Cyclin E/cdk2 and cyclin A/cdk2 kinases associate with p107 and E2F in a temporally distinct manner. Genes Dev. 1992;6:1874-1885.
47. Johnson D, Schwartz J, Cress W, Nevins J. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature. 1993;365:349-352.
48. Shan B, Lee WH. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol Cell Biol. 1994;14:8166-8173.
49. Qin XQ, Livingston DM, Kaelin WGJ, Adams PD. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci U S A. 1994;91: 10918-10922.
50. Teodoro JG, Branton PE. Regulation of apoptosis by viral gene products. J Virol. 1997;71:1739-1746.
51. waf1/cip1. Genes Dev. 1994;8: 2817-2830.
52. Hiebert S, Packham G, Strom D, Haffner R, Oren M, Zambetti G, Cleveland J. E2F-1/DP-1 induces p53 and overrides survival factors to trigger apoptosis. Mol Cell Biol. 1995;15:6864-6874.
53. Hermeking H, Eick D. Mediation of c-Myc-induced apoptosis by p53. Science. 1994;265:2091-2093.
54. Wu X, Levine AJ. p53, and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci U S A. 1994;91:3602-3606.
55. waf1/cip1/sdi1. Oncogene. 1995;11:1409-1415.
56. Rudolph B, Saffrich R, Zwicker J, Henglein B, Muller R, Ansorge W, Eilers M. Activation of cyclin-dependent kinases by myc mediates induction of cyclin-A, but not apoptosis. EMBO J. 1996;15: 3065-3076.
57. Hiebert SW, Lipp M, Nevins JR. E1A-dependent trans-activation of the human MYC promoter is mediated by the E2F factor. Proc Natl Acad Sci U S A. 1989;86:3594-3598.
58. Galaktionov K, Jessus C, Beach D. Raf1 interaction with cdc25 phosphatase ties mitogenic signal transduction to cell-cycle activation. Genes Dev. 1995;9:1046-1058.
59. Leone G, DeGregori J, Sears R, Jakoi L, Nevins JR. Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F. Nature. 1997;387:422-426.