Synthesis and biological evaluation of 2,3-diarylpyrazines and quinoxalines as selective COX-2 inhibitors

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 8, 2004, Pages 1881-1893

  Singh, Sunil K ^a   Saibaba, V ^a   Ravikumar, V ^a   Rudrawar, Santosh V ^a   Daga, Pankaj ^a   Rao, C Seshagiri ^a   Akhila, V ^a   Hegde, P ^a   Rao, Y Koteswar ^a  

^a DR REDDY'S LABORATORIES LTD   (India)

Author keywords

2,3 Diarylpyrazines; 2,3 Diarylquinoxalines; COX 2 inhibitors

Indexed keywords

CELECOXIB; CYCLOOXYGENASE 2 INHIBITOR; ETORICOXIB; NIMESULIDE; PARECOXIB; PYRAZINE DERIVATIVE; QUINOXALINE DERIVATIVE; ROFECOXIB; VALDECOXIB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; INFLAMMATION; MALE; NONHUMAN; PHARMACOPHORE; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; DRUG EVALUATION, PRECLINICAL; EDEMA; ISOENZYMES; MALE; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PYRAZINES; QUINOXALINES; RATS; RATS, WISTAR;

ANIMALIA;

EID: 1642502568     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2004.01.033     Document Type: Article

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