Apoptosis versus necrosis in acute pancreatitis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 286, Issue 2 49-2, 2004, Pages

  Bhatia, Madhav ^a,b  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

Acute pancreatitis; Pancreatic acinar cells

Indexed keywords

CASPASE 8;

ACINAR CELL; ACUTE PANCREATITIS; APOPTOSIS; CALCIUM TRANSPORT; CELL DEATH; CELL PROTECTION; DISEASE SEVERITY; DNA DAMAGE; DNA DEGRADATION; EFFECTOR CELL; ENZYME ACTIVATION; HUMAN; INFLAMMATORY CELL; MEDIATOR RELEASE; NECROSIS; OUTER MEMBRANE; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; REVIEW;

EID: 1642498302     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.00304.2003     Document Type: Review

References (95)

1. Adams JM and Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 281: 1322-1326, 1998.
2. Adams JM and Cory S. Life-or-death decisions by the Bcl-2 protein family. Trends Biochem Sci 26: 61-66, 2001.
3. Adrain C and Martin SJ. The mitochondrial apoptosome: a killer unleashed by the cytochrome seas. Trends Biochem Sci 26: 390-397, 2001.
4. Barros LF, Hermosilla T, and Castro J. Necrotic volume increase and the early physiology of necrosis. Comp Biochem Physiol A 130: 401-409, 2001.
5. Barros LF, Stutzin A, Calixto A, Catalan M, Castro J, Hetz C, and Hermosilla T. Nonselective cation channels as effectors of free radical-induced rat liver cell necrosis. Hepatology 33: 114-122, 2001.
6. Bellamy CO, Malcomson RD, Harrison DJ, and Wyllie AH. Cell death in health and disease: the biology and regulation of apoptosis. Semin Cancer Biol 6: 3-16, 1995.
7. Berridge MJ, Lipp P, and Bootman MD. The versatility and universality of calcium signaling. Nat Rev Mol Cell Biol 1: 11-21, 2000.
8. Bhatia M. Novel therapeutic targets for acute pancreatitis and associated multiple organ dysfunction syndrome. Curr Drug Targets Infl Allergy 1: 343-351, 2002.
9. Bhatia M, Brady M, Shokuhi S, Christmas S, Neoptolemos JP, and Slavin J. Inflammatory mediators in acute pancreatitis. J Pathol 190: 117-125, 2000.
10. Bhatia M, Neoptolemos JP, and Slavin J. Inflammatory mediators as therapeutic targets in acute pancreatitis. Curr Opin Investig Drugs 2: 496-501, 2001.
11. Bhatia M and Wallig MA. 1-Cyano-2-hydroxy-3-butene: a plant nitrile that induces apoptosis in pancreatic acinar cells and reduces the severity of acute pancreatitis. Proceedings of The Second International Conference on Natural Products Research. In press.
12. Bhatia M, Wallig MA, Hofbauer B, Lee HS, Frossard JL, Steer ML, and Saluja AK. Induction of apoptosis in pancreatic acinar cells reduces the severity of acute pancreatitis. Biochem Biophys Res Commun 246: 476-483, 1998.
13. Boatright KM, Renatus M, Scott FL, Sperandio S, Shin H, Pedersen IM, Ricci JE, Edris WA, Sutherlin DP, Green DR, and Salvesen GS. A unified model for apical caspase activation. Mol Cell 11: 529-541, 2003.
14. Buja LM, Eigenbrodt ML, and Eigenbrodt EH. Apoptosis and necrosis. Basic types and mechanisms of cell death. Arch Pathol Lab Med 117: 1208-1214, 1993.
15. Carini R, Autelli R, Bellomo G, Dianzani MU, and Albano E. Sodium-mediated cell swelling is associated with irreversible damage in isolated hepatocytes exposed to hypoxia or mitochondrial toxins. Biochem Biophys Res Commun 206: 180-185, 1995.
16. Chalmers-Redman RM, Fraser AD, Ju WY, Wadia J, Tatton NA, and Tatton WG. Mechanisms of nerve cell death: apoptosis or necrosis after cerebral ischemia. Int Rev Neurobiol 40: 1-25, 1997.
17. Cory S and Adams JM. The Bcl-2 family: regulators of the cellular life and death switch. Nat Rev Cancer 2: 647-656, 2002.
18. Crompton M. The mitochondrial permeability transition pore and its role in cell death. Biochem J 341: 233-249, 1999.
19. Esposti MD and Dive C. Mitochondrial membrane permeabilisation by Bax/Bak. Biochem Biophys Res Commun 304: 455-461, 2003.
20. Frossard JL, Rubbia-Brandt L, Wallig MA, Benathan M, Ott T, Morel P, Hadengue A, Suter S, Willecke K, and Chanson M. Severe acute pancreatitis and reduced acinar cell apoptosis in the exocrine pancreas of mice deficient for the Cx32 gene. Gastroenterology 124: 481-493, 2003.
21. Fulda S, Meyer E, Friesen C, Susin SA, Kroemer G, and Debatin KM. Cell type specific involvement of death receptor and mitochondrial pathways in drug-induced apoptosis. Oncogene 20: 1063-1075, 2001.
22. Gao W, Bentley RC, Madden JF, and Clavien PA. Apoptosis of sinusoidal endothelial cells is a critical mechanism of preservation injury in rat liver transplantation. Hepatology 27: 1652-1660, 1998.
23. 2+ elevations and the mitochondrial permeability transition pore. J Cell Sci 115: 485-497, 2002.
24. Glucksmann A. Cell deaths in normal vertebrate ontogeny. Biol Res 26: 59-86, 1951.
25. Gottlieb RA, Burleson KO, Kloner RA, Babior BM, and Engler RL. Reperfusion injury induces apoptosis in rabbit cardiomyocytes. J Clin Invest 94: 1621-1628, 1994.
26. Green DR. Overview: apoptotic signaling pathways in the immune system. Immunol Rev 193: 5-9, 2003.
27. Gruenbaum Y, Goldman RD, Meyuhas R, Mills E, Margalit A, Fridkin A, Dayani Y, Prokocimer M, and Enosh A. The nuclear lamina and its functions in the nucleus. Int Rev Cytol 226: 1-62, 2003.
28. Gukovskaya AS, Gukovsky I, Jung Y, Mouria M, and Pandol SJ. Cholecystokinin induces caspase activation and mitochondrial dysfunction in pancreatic acinar cells. Roles in cell injury processes of pancreatitis. J Biol Chem 277: 22595-22604, 2002.
29. Gukovskaya AS, Gukovsky I, Zaninovic V, Song M, Sandoval D, Gukovsky S, and Pandol SJ. Pancreatic acinar cells produce, release, and respond to tumor necrosis factor-α. Role in regulating cell death and pancreatitis. J Clin Invest 100: 1853-1862, 1997.
30. Gukovskaya AS, Perkins P, Zaninovic V, Sandoval D, Rutherford R, Fitzsimmons T, Pandol SJ, and Poucell-Hatton S. Mechanisms of cell death after pancreatic duct obstruction in the opossum and the rat. Gastroenterology 110: 875-884, 1996.
31. Gukovsky I, Gukovskaya AS, Blinman TA, Zaninovic V, and Pandol SJ. Early NF-κB activation is associated with hormone-induced pancreatitis. Am J Physiol Gastrointest Liver Physiol 275: G1402-G1414, 1998.
32. Guo K, Searfoss G, Krolikowski D, Pagnoni M, Franks C, Clark K, Yu KT, Jaye M, and Ivashchenko Y. Hypoxia induces the expression of the pro-apoptotic gene BNIP3. Cell Death Differ 8: 367-376, 2001.
33. Haga N, Fujita N, and Tsuruo T. Mitochondrial aggregation precedes cytochrome c release from mitochondria during apoptosis. Oncogene 22: 5579-5585, 2003.
34. Hahm KB, Kim JH, You BM, Kim YS, Cho SW, Yim H, Ahn BO, and Kim WB. Induction of apoptosis with an extract of Artemisia asiatica attenuates the severity of cerulein-induced pancreatitis in rats. Pancreas 17: 153-157, 1998.
35. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ, and Brenner DA. The mitochondrial permeability transition augments Fas-induced apoptosis in mouse hepatocytes. J Biol Chem 275: 11814-11823, 2000.
36. 2 in the rat insulin-secreting cell line CR1-G1. J Physiol 501: 59-66, 1997.
37. Herson PS, Lee K, Pinnock RD, Hughes J, and Ashford ML. Hydrogen peroxide induces intracellular calcium overload by activation of a non-selective cation channel in an insulin-secreting cell line. J Biol Chem 274: 833-841, 1999.
38. Horvitz HR, Shaham S, and Hengartner MO. The genetics of programmed cell death in the nematode Caenorhabditis elegans. Cold Spring Harb Symp Quant Biol 59: 377-385, 1994.
39. Huang DC and Strasser A. BH3-only proteins-essential initiators of apoptotic cell death. Cell 103: 839-842, 2000.
40. Jacobs WR, Sgambati M, Gomez G, Vilaro P, Higdon M, Bell PD, and Mandel LJ. Role of cytosolic Ca in renal tubule damage induced by anoxia. Am J Physiol Cell Physiol 260: C545-C554, 1991.
41. Jarrell VL, Epps D, Wallig MA, and Jeffery EH. Antiproliferative effects of crambene, a nitrile common in cruciferous vegetables (Abstract). FASEB J 13: A918, 1999.
42. Johnstone RJ, Ruefli AA, and Lowe SW. Apoptosis: a link between cancer genetics and chemotherapy. Cell 108: 153-164, 2002.
43. Joza N, Kroemer G, and Penninger JM. Genetic analysis of the mammalian cell death machinery. Trends Genet 18: 142-149, 2002.
44. Kaiser AM, Saluja AK, Sengupta A, Saluja M, and Steer ML. Relationship between severity, necrosis, and apoptosis in five models of experimental acute pancreatitis. Am J Physiol Cell Physiol 269: C1295-C1304, 1995.
45. Kaufmann SH and Hengartner MO. Programmed cell death: alive and well in the new millennium. Trends Cell Biol 11: 526-534, 2001.
46. Kerr JF, Wyllie AH, and Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 26: 239-257, 1972.
47. Kim JJ, Qian T, and Lemasters JJ. Mitochondrial permeability transition in the switch from necrotic to apoptotic cell death in ischemic rat hepatocytes. Gastroenterology 124: 494-503, 2003.
48. Kloppel G and Maillet B. Pathology of acute and chronic pancreatitis. Pancreas 8: 659-670, 1993.
49. Koliwad SK, Elliott SJ, and Kunze DL. Oxidized glutathione mediates cation channel activation in calf vascular endothelial cells during oxidant stress. J Physiol 495: 37-49, 1996.
50. Korsmeyer SJ. Regulators of cell death. Trends Genet 11: 101-105, 1995.
51. Kroemer G. Mitochondrial control of apoptosis: an introduction. Biochem Biophys Res Commun 304: 433-435, 2003.
52. Kroemer G and Reed JC. Mitochondrial control of cell death. Nat Med 6: 513-519, 2000.
53. Lassus P, Opitz-Araya X, and Lazebnik Y. Requirement for caspase-2 in stress-induced apoptosis before mitochondrial permeabilization. Science 297: 1352-1354, 2002.
54. Lemasters JJ, Qian T, Bradham CA, Brenner DA, Cascio WE, Trost LC, Nishimura Y, Nieminen AL, and Herman B. Mitochondrial dysfunction in the pathogenesis of necrotic and apoptotic cell death. J Bioenerg Biomembr 31: 305-319, 1999.
55. Lemasters JJV. Necrapoptosis and the mitochondrial permeability transition: shared pathways to necrosis and apoptosis. Am J Physiol Gastrointest Liver Physiol 276: G1-G6, 1999.
56. Levitsky J, Gurell D, and Frishman WH. Sodium ion/hydrogen ion exchange inhibition: a new pharmacologic approach to myocardial ischemia and reperfusion injury. J Clin Pharmacol 38: 887-897, 1998.
57. Majno G and Joris I. Apoptosis, oncosis, and necrosis: an overview of cell death. Am J Pathol 146: 3-15, 1995.
58. Martin LJ. Neuronal cell death in nervous system development, disease, and injury. Int J Mol Med 7: 455-478, 2001.
59. Martinou JC and Green DR. Breaking the mitochondrial barrier. Nat Rev Mol Cell Biol 1: 63-67, 2001.
60. McKay CJ, Evans S, Sinclair M, Carter CR, and Imrie CW. High early mortality rate from acute pancreatitis in Scotland, 1984-1995. Br J Surg 86: 1302-1305, 1999.
61. Monks TJ, Hanzlik RP, Cohen GM, Ross D, and Graham DG. Quinone chemistry and toxicity. Toxicol Appl Pharmacol 112: 2-16, 1992.
62. Nagase H, Fukuyama H, Tanaka M, Kawane K, and Nagata S. Mutually regulated expression of caspase-activated DNase and its inhibitor for apoptotic DNA fragmentation. Cell Death Differ 10: 142-143, 2003.
63. Nevalainen TJ and Aho HJ. Standards of morphological evaluation and histological grading in experimental acute pancreatitis. Eur J Surg Res 24, Suppl: 14-23, 1992.
64. Nicholson DW and Thornberry NA. Apoptosis: life and death decisions. Science 299: 214-215, 2003.
65. Niedoborski TE, Klein BP, and Wallig MA. Rapid isolation and purification of 1-cyano-2-hydroxy-3-butene (crambene) from Crambe abyssinica seed meal using immiscible solvent extraction and high-performance liquid chromatography. J Agric Food Chem 49: 3594-3599, 2001.
66. Nomura M, Shimizu S, Ito T, Narita M, Matsuda H, and Tsujimoto Y. Apoptotic cytosol facilitates Bax translocation to mitochondria that involves cytosolic factor regulated by Bcl-2. Cancer Res 59: 5542-5548, 1999.
67. Okada Y, Maeno E, Shimizu T, Dezaki K, Wang J, and Morishima S. Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis. Proc Natl Acad Sci USA 97: 9487-9492, 2000.
68. Okada Y, Maeno E, Shimizu T, Dezaki K, Wang J, and Morishima S. Receptor-mediated control of regulatory volume decrease (RVD) and apoptotic volume decrease (AVD). J Physiol 532: 3-16, 2001.
69. Orrenius S, Zhivotovsky B, and Nicotera P. Regulation of cell death: the calcium-apoptosis link. Nat Rev Mol Cell Biol 4: 552-565, 2003.
70. Padanilam BJ. Cell death induced by acute renal injury: a perspective on the contributions of apoptosis and necrosis. Am J Physiol Renal Physiol 284: F608-F627, 2003.
71. Polster BM, Kinnally KW, and Fiskum G. BH3 death domain peptide induces cell type-selective mitochondrial outer membrane permeability. J Biol Chem 276: 37887-37894, 2001.
72. Rao L, Perez D, and White E. Lamin proteolysis facilitates nuclear events during apoptosis. J Cell Biol 135: 1441-1455, 1996.
73. Reed JC. Apoptosis-based therapies. Nat Rev Drug Discov 1: 111-121, 2002.
74. Rudel T and Bokoch GM. Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science 276: 1571-1574, 1997.
75. Sandler RS, Everhart JE, Donowitz M, Adams E, Cronin K, Goodman C, Gemmen E, Shah S, Avdic A, and Rubin R. The burden of selected digestive diseases in the United States. Gastroenterology 122: 1500-1511, 2002.
76. Sandoval D, Gukovskaya A, Reavey P, Gukovsky S, Sisk A, Braquet P, Pandol SJ, and Poucell-Hatton S. The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis. Gastroenterology 111: 1081-1091, 1996.
77. Scaffidi P, Misteli T, and Bianchi ME. Release of chromatin protein HMGB1 by necrotic cells triggers inflammation. Nature 418: 191-195, 2002.
78. Schonhoff CM, Gaston B, and Mannick JB. Nitrosylation of cytochrome c during apoptosis. J Biol Chem 278: 18265-18270, 2003.
79. Scoggins CR, Meszoely IM, Wada M, Means AL, Yang L, and Leach SD. p53-Dependent acinar cell apoptosis triggers epithelial proliferation in duct-ligated murine pancreas. Am J Physiol Gastrointest Liver Physiol 279: G827-G836, 2000.
80. Strasser A, O'Connor L, and Dixit VM. Apoptosis signaling. Annu Rev Biochem 69: 217-245, 2000.
81. Strasser A, Puthalakath H, Bouillet P, Huang DC, O'Connor L, O'Reilly LA, Cullen L, Cory S, and Adams JM. The role of bim, a proapoptotic BH3-only member of the Bcl-2 family in cell-death control. Ann NY Acad Sci 917: 541-548, 2000.
82. Suzuki M, Youle RJ, and Tjandra N. Structure of Bax: coregulation of dimer formation and intracellular localization. Cell 103: 645-654, 2000.
83. Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K, and Takahashi RA. Serine protease, Htra2, is released from the mitochondria and interacts with xiap, inducing cell death. Mol Cell 8: 613-621, 2001.
84. Thornberry NA and Lazebnik Y. Caspases: enemies within. Science 281: 1312-1316, 1998.
85. Tibbetts MD, Zheng L, and Lenardo MJ. The death effector domain protein family: regulators of cellular homeostasis. Nat Immun 4: 404-409, 2003.
86. Trump BF, Goldblatt PJ, and Stowell RE. Studies of necrosis in vitro of mouse hepatic parenchymal cells. Ultrastructural alterations in endoplasmic reticulum, Golgi apparatus, plasma membrane, and lipid droplets. Lab Invest 14: 2000-2028, 1965.
87. Vande Velde C, Cizeau J, Dubik D, Alimonti J, Brown T, Israels S, Hakem R, and Greenberg AH. BNIP3 and genetic control of necrosis-like cell death through the mitochondrial permeability transition pore. Mol Cell Biol 20: 5454-5468, 2000.
88. Walker NI. Ultrastructure of rat pancreas after experimental duct ligation. I. The role of apoptosis and interepithelial macrophages in acinar cell deletion. Am J Pathol 126: 439-541, 1987.
89. Walker NI, Winterford CM, and Kerr JFR. Ultrastructure of rat pancreas after experimental duct ligation. II. Duct and stromal cell proliferation, differentiation, and deletion. Pancreas 7: 420-434, 1992.
90. Wallig MA, Kingston S, Staack R, and Jefferey EH. Induction of rat pancreatic glutathione S-transferase and quinone reductase activities by a mixture of glucosinolate breakdown derivatives found in Brussels sprouts. Food Chem Toxicol 36: 365-373, 1998.
91. Wang KK. Calpain and caspase: can you tell the difference? Trends Neurosci 23: 20-26, 2000.
92. Wang X. The expanding role of mitochondria in apoptosis. Genes Dev 15: 2922-2933, 2001.
93. Wei MC, Lindsten T, Mootha VK, Weiler S, Gross A, Ashiya M, Thompson CB, and Korsmeyer SJ. tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev 14: 2060-2071, 2000.
94. Wyllie AH. Death from inside out: an overview. Philos Trans R Soc Lond B Biol Sci 345: 237-241, 1994.
95. Zhao Y, Ding WX, Qian T, Watkins S, Lemasters JJ, and Yin XM. Bid activates multiple mitochondrial apoptotic mechanisms in primary hepatocytes after death receptor engagement. Gastroenterology 125: 854-867, 2003.